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The map label for this gene is prsA [H]

Identifier: 39995127

GI number: 39995127

Start: 24354

End: 25295

Strand: Reverse

Name: prsA [H]

Synonym: GSU0016

Alternate gene names: 39995127

Gene position: 25295-24354 (Counterclockwise)

Preceding gene: 39995128

Following gene: 39995126

Centisome position: 0.66

GC content: 59.77

Gene sequence:

>942_bases
GTGAAGAGACACACTATCGTCACCATCCTTTCGGTCTCCCTCTGTCTGGCTGCCCTCGGCGGCTGCAAGGGCAAGACCGA
GTCCGGCACGACGGCAGCTCCGGCCAAAAAAGCAGGCCAGGTACTCGTGGAAGTCAACGGTGACGCCATCACCGTGGAAA
ATTTCAACAAGGAGCTTGAGGGACTGCCTCCTTACCTGAAGCCCATGGCGGATACGCCGGAAGGGAAAAAGGAGCTGCTG
GACACCATGGTGGTGCGCGAACTCCTCTACCAGCAGGCTAAGAAGGACGGGGTCGACAAGAGCGCCGAGATTGCCGACCG
GGTGGAAGAGCTCAAGAAGCGCGTCGTGGTTGAGGCTTATCTCAAGAAGAAGGTCGAGGAGCAGGTCCAGGTATCCGACG
AGGAACTCAAGAAGTTCTACGATCAGAATAAGGACAAATTCAAGTCCGGCGCCCAGATCAAGGCCAGCCACATTCTCGTG
CGGGATGAGAAGCTCGCTCAGGAGATCGTGAAGGAGCTCAAGGGCGGTGCCAATTTCGAGGAGTTGGCCAAGAAGCACTC
CATCGACTCCGCCGCCGCCAAGGGTGGCGATCTGGGCTGGTTCAGCAAGGGGAACATGGTCCCCGAATTCGAGAAAGTCG
CCTTCGGCCTCAAGGAAGGGGAGACCTCCGGCATCGTCAGGACCCAGTTCGGCTACCACATCATCAAGGTGACCGGCAAG
CGTCCCGCCGGCGAGCGCACCTTTGAAGAAGTGAAGGACCAGATCAAGGCAGCAGTCCTGCCGGGCAAGCAGCAGGAAGT
CTTCCAGAAGCTCAAGGAAGACATCAAGAAGGGCGCGACGATCTCCATCAAGGAAGACGTGCTCAAGGGGCTCGGCGGCC
AGAGCGCAGCGGCCGAGCATCCTGCTCCCGCGCAGCCTGCCGCGACACCCGCCGCCAAGTAG

Upstream 100 bases:

>100_bases
CCTGGCCGAAGCCAGAAATCTCTTGAAAAGGCTGGGGTGATATGCTAGCTTCCGTAAGATTGTTCGGTATTTAAATCATT
TAGCTAAAAGGAGTTCGTCC

Downstream 100 bases:

>100_bases
TGACGTAATTACCTTCAAGAGGGGGCGGGACCGCACCAGGGGTCGCCCCCTCCTCTTTCGTGCTCAGACAACGGACCATG
ATCAAACGCCTCATACCTTT

Product: peptidyl-prolyl cis-trans isomerase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKRHTIVTILSVSLCLAALGGCKGKTESGTTAAPAKKAGQVLVEVNGDAITVENFNKELEGLPPYLKPMADTPEGKKELL
DTMVVRELLYQQAKKDGVDKSAEIADRVEELKKRVVVEAYLKKKVEEQVQVSDEELKKFYDQNKDKFKSGAQIKASHILV
RDEKLAQEIVKELKGGANFEELAKKHSIDSAAAKGGDLGWFSKGNMVPEFEKVAFGLKEGETSGIVRTQFGYHIIKVTGK
RPAGERTFEEVKDQIKAAVLPGKQQEVFQKLKEDIKKGATISIKEDVLKGLGGQSAAAEHPAPAQPAATPAAK

Sequences:

>Translated_313_residues
MKRHTIVTILSVSLCLAALGGCKGKTESGTTAAPAKKAGQVLVEVNGDAITVENFNKELEGLPPYLKPMADTPEGKKELL
DTMVVRELLYQQAKKDGVDKSAEIADRVEELKKRVVVEAYLKKKVEEQVQVSDEELKKFYDQNKDKFKSGAQIKASHILV
RDEKLAQEIVKELKGGANFEELAKKHSIDSAAAKGGDLGWFSKGNMVPEFEKVAFGLKEGETSGIVRTQFGYHIIKVTGK
RPAGERTFEEVKDQIKAAVLPGKQQEVFQKLKEDIKKGATISIKEDVLKGLGGQSAAAEHPAPAQPAATPAAK
>Mature_313_residues
MKRHTIVTILSVSLCLAALGGCKGKTESGTTAAPAKKAGQVLVEVNGDAITVENFNKELEGLPPYLKPMADTPEGKKELL
DTMVVRELLYQQAKKDGVDKSAEIADRVEELKKRVVVEAYLKKKVEEQVQVSDEELKKFYDQNKDKFKSGAQIKASHILV
RDEKLAQEIVKELKGGANFEELAKKHSIDSAAAKGGDLGWFSKGNMVPEFEKVAFGLKEGETSGIVRTQFGYHIIKVTGK
RPAGERTFEEVKDQIKAAVLPGKQQEVFQKLKEDIKKGATISIKEDVLKGLGGQSAAAEHPAPAQPAATPAAK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=98, Percent_Identity=40.8163265306122, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=55.421686746988, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786645, Length=152, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786238, Length=145, Percent_Identity=24.8275862068966, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17537235, Length=106, Percent_Identity=39.622641509434, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322478, Length=62, Percent_Identity=53.2258064516129, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356303, Length=100, Percent_Identity=40, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 34036; Mature: 34036

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRHTIVTILSVSLCLAALGGCKGKTESGTTAAPAKKAGQVLVEVNGDAITVENFNKELE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEEECCCEEEECCHHHHHH
GLPPYLKPMADTPEGKKELLDTMVVRELLYQQAKKDGVDKSAEIADRVEELKKRVVVEAY
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKKKVEEQVQVSDEELKKFYDQNKDKFKSGAQIKASHILVRDEKLAQEIVKELKGGANFE
HHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCEEHHHEEEHHHHHHHHHHHHHHCCCCHH
ELAKKHSIDSAAAKGGDLGWFSKGNMVPEFEKVAFGLKEGETSGIVRTQFGYHIIKVTGK
HHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEEEEECC
RPAGERTFEEVKDQIKAAVLPGKQQEVFQKLKEDIKKGATISIKEDVLKGLGGQSAAAEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCCCC
PAPAQPAATPAAK
CCCCCCCCCCCCC
>Mature Secondary Structure
MKRHTIVTILSVSLCLAALGGCKGKTESGTTAAPAKKAGQVLVEVNGDAITVENFNKELE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEEECCCEEEECCHHHHHH
GLPPYLKPMADTPEGKKELLDTMVVRELLYQQAKKDGVDKSAEIADRVEELKKRVVVEAY
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LKKKVEEQVQVSDEELKKFYDQNKDKFKSGAQIKASHILVRDEKLAQEIVKELKGGANFE
HHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCEEHHHEEEHHHHHHHHHHHHHHCCCCHH
ELAKKHSIDSAAAKGGDLGWFSKGNMVPEFEKVAFGLKEGETSGIVRTQFGYHIIKVTGK
HHHHHHCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEEEEECC
RPAGERTFEEVKDQIKAAVLPGKQQEVFQKLKEDIKKGATISIKEDVLKGLGGQSAAAEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCCCC
PAPAQPAATPAAK
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]