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The map label for this gene is sstT [H]

Identifier: 38234883

GI number: 38234883

Start: 2454544

End: 2455788

Strand: Reverse

Name: sstT [H]

Synonym: DIP2349

Alternate gene names: 38234883

Gene position: 2455788-2454544 (Counterclockwise)

Preceding gene: 38234892

Following gene: 38234882

Centisome position: 98.68

GC content: 57.51

Gene sequence:

>1245_bases
ATGGACATCAAGCGTCTCTCCTCGTCGCTGCTTTTCAGGATCATCGTCGCGATCATCCTCGGCATCCTATGCAGCTTCTT
CTTCCCCGATGGGCTTGCCCGCGTCTTTGTCACCTTTAACGGACTCTTCGGCAACTTCCTCGGCTTCTTCATCCCTGTCC
TGATCTTCGCCCTCATCACCCCAGCCATCGCAGGACTCGGCCGTGGTGCCGGCAAATGGCTCGCCATCACCACCGGTATC
GCCTACGGCTCAGCCCTAGTATCTGGCCTCATCTCCTGGGGTGTTGCCACCGCCTTGTACCCATGGTTGCTCGCAAGCCA
AACTAGCGTTGCAGCTGCAGACATCGAGGAAGGCGCTCTCAGCCCTTACATCTCGGTCGAAATGCCAGCACCCATGCAGG
TGATGACGGCCCTCATCCTCGCTTTCGTTGTAGGCGTGGCTATGACCACCGTTAAGTCCGACACCCTCTTCTCCGGCGTT
ACCGACCTGCGCCGCGTAGTAATGAAGGTGATCTCCTCCTTTATCGTCCCACTGCTGCCGATCTACATCTTCGGCATGTT
CCTCTCCCTCGGAATGAACGGCAACCTCGCATCAGTGCTCACCGCCTTTGCCAAGGTTCTCCTCCTCGCCATCCTCATGA
GCTTCGTGCTGCTAATCCTGCAGTTCCTCCTCGCAGGCACCCTAGCAACCCGCAACCCCTTCGCCTCGCTGAAGAACATG
ATGCCGGCATACTTCACCGCACTGGGAACCTCTTCTTCCGCAGCAACCATCCCAGTGACCTACGAATGTGCACGTAAAAA
CGGTGTCAGCCAGTCTGTTGCAGGTTTCGTGGTTCCATTGTGCGCCACCATCCACCTCTCCGGGTCGATGATGAAGATTA
CGCTGTTCGCCTTCGCCATCATGTTTATGGACGGCATGGACATCCCACTTGCCACCGCACTCGGCTTCATTCTCATGCTC
GGTGTGACCATGGTGGCAGCCCCAGGTGTTCCCGGTGGTGCAATCATGGCAGCTGTTGGTCTGTTGTCCTCCAACCTCGG
CTTCAATGACGACCAGGTGGCACTGATGATCGCCGCTTACATCGCCATCGACTCCTTCGGTACTGCCTGCAATGTTACTG
GCGACGGTGCCATCGCCATGGTGGTGGACAAGTTTGCCAAGGGCGCGATCTCTCGCCACGATCTTGATGACGCCGACGAT
CTCGGCCTTGCTACCGCAATCGCTGGCATCGATGACGATGCCTAA

Upstream 100 bases:

>100_bases
AGTTATTTCTCAACTCCTTGAACGGCCCAGCACCCAGTGGGACACGATTAAGGTCACCCCATAATTTGAACAACTAACGA
AAAATATTAGGTAACCCTAC

Downstream 100 bases:

>100_bases
TGCGATAGCCTAGCGCGATACATTTCTCACGCCCCCGCGAGGGGGCGTTTTTGTTTAGCCGATGAGCAATTTTTGTACCC
TAAGCCAGCAAAACCGCAGG

Product: putative integral membrane transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDIKRLSSSLLFRIIVAIILGILCSFFFPDGLARVFVTFNGLFGNFLGFFIPVLIFALITPAIAGLGRGAGKWLAITTGI
AYGSALVSGLISWGVATALYPWLLASQTSVAAADIEEGALSPYISVEMPAPMQVMTALILAFVVGVAMTTVKSDTLFSGV
TDLRRVVMKVISSFIVPLLPIYIFGMFLSLGMNGNLASVLTAFAKVLLLAILMSFVLLILQFLLAGTLATRNPFASLKNM
MPAYFTALGTSSSAATIPVTYECARKNGVSQSVAGFVVPLCATIHLSGSMMKITLFAFAIMFMDGMDIPLATALGFILML
GVTMVAAPGVPGGAIMAAVGLLSSNLGFNDDQVALMIAAYIAIDSFGTACNVTGDGAIAMVVDKFAKGAISRHDLDDADD
LGLATAIAGIDDDA

Sequences:

>Translated_414_residues
MDIKRLSSSLLFRIIVAIILGILCSFFFPDGLARVFVTFNGLFGNFLGFFIPVLIFALITPAIAGLGRGAGKWLAITTGI
AYGSALVSGLISWGVATALYPWLLASQTSVAAADIEEGALSPYISVEMPAPMQVMTALILAFVVGVAMTTVKSDTLFSGV
TDLRRVVMKVISSFIVPLLPIYIFGMFLSLGMNGNLASVLTAFAKVLLLAILMSFVLLILQFLLAGTLATRNPFASLKNM
MPAYFTALGTSSSAATIPVTYECARKNGVSQSVAGFVVPLCATIHLSGSMMKITLFAFAIMFMDGMDIPLATALGFILML
GVTMVAAPGVPGGAIMAAVGLLSSNLGFNDDQVALMIAAYIAIDSFGTACNVTGDGAIAMVVDKFAKGAISRHDLDDADD
LGLATAIAGIDDDA
>Mature_414_residues
MDIKRLSSSLLFRIIVAIILGILCSFFFPDGLARVFVTFNGLFGNFLGFFIPVLIFALITPAIAGLGRGAGKWLAITTGI
AYGSALVSGLISWGVATALYPWLLASQTSVAAADIEEGALSPYISVEMPAPMQVMTALILAFVVGVAMTTVKSDTLFSGV
TDLRRVVMKVISSFIVPLLPIYIFGMFLSLGMNGNLASVLTAFAKVLLLAILMSFVLLILQFLLAGTLATRNPFASLKNM
MPAYFTALGTSSSAATIPVTYECARKNGVSQSVAGFVVPLCATIHLSGSMMKITLFAFAIMFMDGMDIPLATALGFILML
GVTMVAAPGVPGGAIMAAVGLLSSNLGFNDDQVALMIAAYIAIDSFGTACNVTGDGAIAMVVDKFAKGAISRHDLDDADD
LGLATAIAGIDDDA

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=189, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI66773030, Length=223, Percent_Identity=30.4932735426009, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4827012, Length=170, Percent_Identity=30, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI194239697, Length=183, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI40254478, Length=188, Percent_Identity=28.7234042553192, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=27.5092936802974, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI223468566, Length=269, Percent_Identity=27.1375464684015, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI5032093, Length=273, Percent_Identity=26.3736263736264, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI21314632, Length=279, Percent_Identity=23.6559139784946, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789947, Length=425, Percent_Identity=24.4705882352941, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983106, Length=304, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983099, Length=304, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=181, Percent_Identity=30.3867403314917, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=173, Percent_Identity=30.635838150289, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193206505, Length=217, Percent_Identity=26.2672811059908, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193206654, Length=186, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24583025, Length=173, Percent_Identity=27.7456647398844, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137668, Length=173, Percent_Identity=27.7456647398844, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583023, Length=173, Percent_Identity=27.7456647398844, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43185; Mature: 43185

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKRLSSSLLFRIIVAIILGILCSFFFPDGLARVFVTFNGLFGNFLGFFIPVLIFALIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAIAGLGRGAGKWLAITTGIAYGSALVSGLISWGVATALYPWLLASQTSVAAADIEEGAL
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
SPYISVEMPAPMQVMTALILAFVVGVAMTTVKSDTLFSGVTDLRRVVMKVISSFIVPLLP
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYIFGMFLSLGMNGNLASVLTAFAKVLLLAILMSFVLLILQFLLAGTLATRNPFASLKNM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MPAYFTALGTSSSAATIPVTYECARKNGVSQSVAGFVVPLCATIHLSGSMMKITLFAFAI
HHHHHHHHCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MFMDGMDIPLATALGFILMLGVTMVAAPGVPGGAIMAAVGLLSSNLGFNDDQVALMIAAY
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAIDSFGTACNVTGDGAIAMVVDKFAKGAISRHDLDDADDLGLATAIAGIDDDA
HHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDIKRLSSSLLFRIIVAIILGILCSFFFPDGLARVFVTFNGLFGNFLGFFIPVLIFALIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAIAGLGRGAGKWLAITTGIAYGSALVSGLISWGVATALYPWLLASQTSVAAADIEEGAL
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
SPYISVEMPAPMQVMTALILAFVVGVAMTTVKSDTLFSGVTDLRRVVMKVISSFIVPLLP
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYIFGMFLSLGMNGNLASVLTAFAKVLLLAILMSFVLLILQFLLAGTLATRNPFASLKNM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MPAYFTALGTSSSAATIPVTYECARKNGVSQSVAGFVVPLCATIHLSGSMMKITLFAFAI
HHHHHHHHCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MFMDGMDIPLATALGFILMLGVTMVAAPGVPGGAIMAAVGLLSSNLGFNDDQVALMIAAY
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
IAIDSFGTACNVTGDGAIAMVVDKFAKGAISRHDLDDADDLGLATAIAGIDDDA
HHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA