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The map label for this gene is fbpA [H]

Identifier: 38234873

GI number: 38234873

Start: 2445460

End: 2446680

Strand: Reverse

Name: fbpA [H]

Synonym: DIP2339

Alternate gene names: 38234873

Gene position: 2446680-2445460 (Counterclockwise)

Preceding gene: 38234878

Following gene: 38234863

Centisome position: 98.31

GC content: 57.9

Gene sequence:

>1221_bases
ATGCGATTCCCCTCTATTTCTTCCAGCGTGCGTCGTGCCTGTGCCACAGCCACTGCAGTCATCGCGCTCGCCGGAGTGGC
CGCACCTTCTGCCAACGCCCAGTCCTCAAACCCCATCGAGGCTGGTTCGTCCGCCCTTAACTACGGGGCTAACTCTTTGC
TTGCAGAGTGGTCAAAAAACCCACACCTAGGTGAAGACATCAACTCCTTCTACCGCGGAATGCACATGTACTCCCCATGG
GCACAGTTCCCACTCTGGAACATGTGGGGATCCCCAACCCCCTACCCCATCGAAGCAGAGCGCGACTTTGCCGCACCACG
CCTCGTCAAAGTAGAAAAAGACGAGCGTTTCGACGTCGACCGCCTCTTCATCGAATCGCCCGCCATGCGACGCATCGTGC
AGGTGCAAGTGCAGCACCCCAAAGACCGCACCACCCCAGCGCCCATGCTGTACCTTCTCGACGGCGTCACCGCCCCATCC
CAGTCCGGATGGTTGCGCAAGGGCGACGTACAAGGAGCAATGGCCAACGAACACGTCACCGTGATCATGCCAACCGAGGC
CGGTGGCACCAACTACACCGACTGGAACGAAACCGACCCATACCTCGGCCGCGCCAAGTGGGAAACATTCCTTATTAAGG
AACTGCCCGGTGTGCTAGTACAGCCTGAGACAAAGATTGCGTACAATGGAAAATCCTATATCGGTGGACTCTCCATGGGC
GGCTCCGCTGCCGTGCGTCTAGCAAACCTCTATCCAGAAAAATTTGTGGGCACCTTCGGAGTTTCCGGCTGCTACTCCCC
CGTGAACACCAGTGGACGCGAACTGTTCAACCTCGCAGCCCGCGTGATAGGCGGCAACCCAGACCTCATGTGGGGACGCG
ACATCACCGAACAGCGTCGCCGTAACGACGTAGTAGCCAACCCCTCCGGTATCGCCTCCATGGATACCTATATCTATGTA
GCCAACGGCGTTGCCACCCCATCCGACGTGAACGGGCCAAAAGAAGACGGTCCATTCACCCTCTTTGGCAACATTGTGTT
GGAAAAAATGTCCTACCGCTGCACCCAAGAACTCGAAGCCTCCGTACGTGAAAAGATTGCCGACCCTTCCCGCATCACCT
TCGACTACCACGATGGCGGTGTTCACTCATGGCCATACTACCGCCAGCAGCTCCCCGTTGCCTGGGCAAACGTAAGCAAG
GGGCAGTACACCTACCGCTAG

Upstream 100 bases:

>100_bases
GGCGATGTGCTGAGCTATTCATGGTGTCCAACATAGTGGTCAGTGTGAGTTTCACGTGAAACATTACGGTTTTGCTACCT
AACCCATTAGGATTCTTTGC

Downstream 100 bases:

>100_bases
GTTCGACCTTGCCTTAATGGCTTTTCCGGTTTTAGAGTGCATTGATTTTGTGTCGGATGTTGGCGGCTTGGCTGGGATTG
GCTGGCGTTGGTGGGCGTTG

Product: putative major secreted protein

Products: NA

Alternate protein names: Antigen 85 complex A; 85A; Ag85A; Fibronectin-binding protein A; Mycolyl transferase 85A [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRFPSISSSVRRACATATAVIALAGVAAPSANAQSSNPIEAGSSALNYGANSLLAEWSKNPHLGEDINSFYRGMHMYSPW
AQFPLWNMWGSPTPYPIEAERDFAAPRLVKVEKDERFDVDRLFIESPAMRRIVQVQVQHPKDRTTPAPMLYLLDGVTAPS
QSGWLRKGDVQGAMANEHVTVIMPTEAGGTNYTDWNETDPYLGRAKWETFLIKELPGVLVQPETKIAYNGKSYIGGLSMG
GSAAVRLANLYPEKFVGTFGVSGCYSPVNTSGRELFNLAARVIGGNPDLMWGRDITEQRRRNDVVANPSGIASMDTYIYV
ANGVATPSDVNGPKEDGPFTLFGNIVLEKMSYRCTQELEASVREKIADPSRITFDYHDGGVHSWPYYRQQLPVAWANVSK
GQYTYR

Sequences:

>Translated_406_residues
MRFPSISSSVRRACATATAVIALAGVAAPSANAQSSNPIEAGSSALNYGANSLLAEWSKNPHLGEDINSFYRGMHMYSPW
AQFPLWNMWGSPTPYPIEAERDFAAPRLVKVEKDERFDVDRLFIESPAMRRIVQVQVQHPKDRTTPAPMLYLLDGVTAPS
QSGWLRKGDVQGAMANEHVTVIMPTEAGGTNYTDWNETDPYLGRAKWETFLIKELPGVLVQPETKIAYNGKSYIGGLSMG
GSAAVRLANLYPEKFVGTFGVSGCYSPVNTSGRELFNLAARVIGGNPDLMWGRDITEQRRRNDVVANPSGIASMDTYIYV
ANGVATPSDVNGPKEDGPFTLFGNIVLEKMSYRCTQELEASVREKIADPSRITFDYHDGGVHSWPYYRQQLPVAWANVSK
GQYTYR
>Mature_406_residues
MRFPSISSSVRRACATATAVIALAGVAAPSANAQSSNPIEAGSSALNYGANSLLAEWSKNPHLGEDINSFYRGMHMYSPW
AQFPLWNMWGSPTPYPIEAERDFAAPRLVKVEKDERFDVDRLFIESPAMRRIVQVQVQHPKDRTTPAPMLYLLDGVTAPS
QSGWLRKGDVQGAMANEHVTVIMPTEAGGTNYTDWNETDPYLGRAKWETFLIKELPGVLVQPETKIAYNGKSYIGGLSMG
GSAAVRLANLYPEKFVGTFGVSGCYSPVNTSGRELFNLAARVIGGNPDLMWGRDITEQRRRNDVVANPSGIASMDTYIYV
ANGVATPSDVNGPKEDGPFTLFGNIVLEKMSYRCTQELEASVREKIADPSRITFDYHDGGVHSWPYYRQQLPVAWANVSK
GQYTYR

Specific function: Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintain

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial A85 antigen family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 44794; Mature: 44794

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFPSISSSVRRACATATAVIALAGVAAPSANAQSSNPIEAGSSALNYGANSLLAEWSKN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCC
PHLGEDINSFYRGMHMYSPWAQFPLWNMWGSPTPYPIEAERDFAAPRLVKVEKDERFDVD
CCCCHHHHHHHHHHHCCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHH
RLFIESPAMRRIVQVQVQHPKDRTTPAPMLYLLDGVTAPSQSGWLRKGDVQGAMANEHVT
HHHHCCHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCEEE
VIMPTEAGGTNYTDWNETDPYLGRAKWETFLIKELPGVLVQPETKIAYNGKSYIGGLSMG
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCEEEECCCHHCCCCCCC
GSAAVRLANLYPEKFVGTFGVSGCYSPVNTSGRELFNLAARVIGGNPDLMWGRDITEQRR
CHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHH
RNDVVANPSGIASMDTYIYVANGVATPSDVNGPKEDGPFTLFGNIVLEKMSYRCTQELEA
HCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
SVREKIADPSRITFDYHDGGVHSWPYYRQQLPVAWANVSKGQYTYR
HHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCEEEECCCCCCEECC
>Mature Secondary Structure
MRFPSISSSVRRACATATAVIALAGVAAPSANAQSSNPIEAGSSALNYGANSLLAEWSKN
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCC
PHLGEDINSFYRGMHMYSPWAQFPLWNMWGSPTPYPIEAERDFAAPRLVKVEKDERFDVD
CCCCHHHHHHHHHHHCCCCHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHH
RLFIESPAMRRIVQVQVQHPKDRTTPAPMLYLLDGVTAPSQSGWLRKGDVQGAMANEHVT
HHHHCCHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCCEEE
VIMPTEAGGTNYTDWNETDPYLGRAKWETFLIKELPGVLVQPETKIAYNGKSYIGGLSMG
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCEEEECCCHHCCCCCCC
GSAAVRLANLYPEKFVGTFGVSGCYSPVNTSGRELFNLAARVIGGNPDLMWGRDITEQRR
CHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHH
RNDVVANPSGIASMDTYIYVANGVATPSDVNGPKEDGPFTLFGNIVLEKMSYRCTQELEA
HCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
SVREKIADPSRITFDYHDGGVHSWPYYRQQLPVAWANVSKGQYTYR
HHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCEEEECCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7725062; 12788972 [H]