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The map label for this gene is serS

Identifier: 38234776

GI number: 38234776

Start: 2329968

End: 2331227

Strand: Reverse

Name: serS

Synonym: DIP2240

Alternate gene names: 38234776

Gene position: 2331227-2329968 (Counterclockwise)

Preceding gene: 38234781

Following gene: 38234775

Centisome position: 93.67

GC content: 58.25

Gene sequence:

>1260_bases
GTGATTGATCTAAAGTTACTCCGCGAAAACCCTGATGTCGTCCGCGAGTCCCAGCGCATTCGTGGCGAAGACCCAGCTCT
GGTGGATCAGCTCCTCGAGGCTGACGAGAAGCGCCGCGAGGCCATTAAGTCTGCCGACGACCTGCGCGCCGAGCACAAGG
CCTTTGGCAAGAAGATTAGCCAGGCCTCCCCAGAAGAGCGTCCCGCTTTGCTGGAGGGCTCTAACGAGCTGAAGTCCCGC
GTGAAGGCGGCGGAGGAGGCCGAGGCTGAAGCGTTGGCCAAGGTCAACGAGATCCAAATGCTGTTCGGCAACGTTGTTAC
CGATGCCCCAGCTGGTGGCGAGGATGACTACATCGTTTTGGAGCACGTAGGCACCCCACGTACCTTTGATTTCGAGCCAA
AGGATCACCTCGATCTTGGTGAGTCGCTTGGGCTTATCGACGTCAAACGCGGCACCAAGGTTGGTGGTGCACGCTTCTAC
TACCTCACCGGCGATGGCGCATTCCTACAGCTGGGCATGCTGAATCTTGCGGCGCAAAAGGCCCGCGAGAATGGCTTCCA
GCTGATGATCCCACCTGTGCTTGTCCGCCCAGAGGTCATGTCCGGTACCGGTTTCTTGGGTGCTCACTCAGATGAGATCT
ACTACCTTGAGCGCGATGACCTCTACCTCGTGGGTACCTCCGAGGTGGCGTTGGCTGGTTACCACCAGGATGAGATCATC
GATTTGTCTGATGGTCCTATCAAGTACGCGGGCTGGTCGAGCTGCTTCCGTCGTGAAGCGGGCTCCTACGGCAAGGACAC
CCGCGGTATTTTGCGCGTGCACCAGTTCGACAAGCTGGAGATGTTTGTTTACTGCAAGCCAGAAGAGGCTGTTGCGCAGC
ACCAAGCTCTGTTGAACATGGAGCGCGAGATGTTGGCTGCTGTTGAGGTGCCTTACCGCATTATCGACGTCGCCGGCGGC
GACCTTGGTTCCTCTGCTGCCCGCAAGTTTGACACTGAGGCATGGATTCCAACCCAGAACACCTACCGTGAGCTGACCTC
GACCTCGAACTGCACCACCTTCCAGGCACGTCGTCTGCGCACCCGCTACCGTGACGAGTCTGGCAAGGCACACACTGCAG
CAACCCTGAACGGTACCTTGGCTACCACGCGTTGGCTGGTCGCTATCCTTGAGAACAACCAGCAGGCTGATGGCTCGGTG
ATCGTTCCTGAGGCACTGCGCCCATTCGTGGGCAAGGAAGTACTCGAGCCAAAGAAGTAA

Upstream 100 bases:

>100_bases
CATAACCAGCGAGGGTTTCTGGTGTGATCTTTGAACCATTGCGGGGTCTGGGGCGGTCCGAACCACCCTCTTAACTCAGG
AACGCGGTAGTGTAAGTTTT

Downstream 100 bases:

>100_bases
TTTCCCAGCGAAAAGATACAAGGAGAGCGATGAGCGCACTTATTGTCAGCGATATCGACGGAACGCTCATCGACTCTCGG
GAACGCATCCCCAGTGCTGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MIDLKLLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKISQASPEERPALLEGSNELKSR
VKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVLEHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFY
YLTGDGAFLQLGMLNLAAQKARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEII
DLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNMEREMLAAVEVPYRIIDVAGG
DLGSSAARKFDTEAWIPTQNTYRELTSTSNCTTFQARRLRTRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSV
IVPEALRPFVGKEVLEPKK

Sequences:

>Translated_419_residues
MIDLKLLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKISQASPEERPALLEGSNELKSR
VKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVLEHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFY
YLTGDGAFLQLGMLNLAAQKARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEII
DLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNMEREMLAAVEVPYRIIDVAGG
DLGSSAARKFDTEAWIPTQNTYRELTSTSNCTTFQARRLRTRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSV
IVPEALRPFVGKEVLEPKK
>Mature_419_residues
MIDLKLLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKISQASPEERPALLEGSNELKSR
VKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVLEHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFY
YLTGDGAFLQLGMLNLAAQKARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEII
DLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNMEREMLAAVEVPYRIIDVAGG
DLGSSAARKFDTEAWIPTQNTYRELTSTSNCTTFQARRLRTRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSV
IVPEALRPFVGKEVLEPKK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=313, Percent_Identity=40.8945686900958, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI225579074, Length=313, Percent_Identity=40.8945686900958, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=33.1896551724138, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=38.8372093023256, Blast_Score=255, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=34.4827586206897, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17542084, Length=321, Percent_Identity=33.0218068535826, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=439, Percent_Identity=32.3462414578588, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=37.1527777777778, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=31.6348195329087, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17737985, Length=285, Percent_Identity=35.4385964912281, Blast_Score=171, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CORDI (Q6NEN2)

Other databases:

- EMBL:   BX248360
- RefSeq:   NP_940543.1
- HSSP:   P34945
- ProteinModelPortal:   Q6NEN2
- SMR:   Q6NEN2
- GeneID:   2650036
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP2240
- NMPDR:   fig|257309.1.peg.2134
- HOGENOM:   HBG629391
- OMA:   IAREFIV
- PhylomeDB:   Q6NEN2
- ProtClustDB:   PRK05431
- BioCyc:   CDIP257309:DIP2240-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46546; Mature: 46546

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 273-273 BINDING 280-280 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKLLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKIS
CCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QASPEERPALLEGSNELKSRVKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
EHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFYYLTGDGAFLQLGMLNLAAQK
EECCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
ARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEII
HHHCCCEEEECCEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCEE
DLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNM
ECCCCCEEECCHHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEEECCHHHHHHHHHHHHH
EREMLAAVEVPYRIIDVAGGDLGSSAARKFDTEAWIPTQNTYRELTSTSNCTTFQARRLR
HHHHHHHHHCCEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
TRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSVIVPEALRPFVGKEVLEPKK
HHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIDLKLLRENPDVVRESQRIRGEDPALVDQLLEADEKRREAIKSADDLRAEHKAFGKKIS
CCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QASPEERPALLEGSNELKSRVKAAEEAEAEALAKVNEIQMLFGNVVTDAPAGGEDDYIVL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
EHVGTPRTFDFEPKDHLDLGESLGLIDVKRGTKVGGARFYYLTGDGAFLQLGMLNLAAQK
EECCCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCEEEHHHHHHHHHH
ARENGFQLMIPPVLVRPEVMSGTGFLGAHSDEIYYLERDDLYLVGTSEVALAGYHQDEII
HHHCCCEEEECCEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCEE
DLSDGPIKYAGWSSCFRREAGSYGKDTRGILRVHQFDKLEMFVYCKPEEAVAQHQALLNM
ECCCCCEEECCHHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEEECCHHHHHHHHHHHHH
EREMLAAVEVPYRIIDVAGGDLGSSAARKFDTEAWIPTQNTYRELTSTSNCTTFQARRLR
HHHHHHHHHCCEEEEEECCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
TRYRDESGKAHTAATLNGTLATTRWLVAILENNQQADGSVIVPEALRPFVGKEVLEPKK
HHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910