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The map label for this gene is pccB [H]

Identifier: 38234729

GI number: 38234729

Start: 2266345

End: 2267895

Strand: Reverse

Name: pccB [H]

Synonym: DIP2188

Alternate gene names: 38234729

Gene position: 2267895-2266345 (Counterclockwise)

Preceding gene: 38234730

Following gene: 38234723

Centisome position: 91.13

GC content: 54.8

Gene sequence:

>1551_bases
GTGAGTACGACTGCGGAAAAGCTCGCTGACCTTCGGGCGCGCCTAGAAAAGGCGCAGGATCCAGGTAGTGAGCGGGCGCG
GGCTAAGCGCGACGAGGCTGGTTTTACAACCCCCCGCCAGCGTATTAACCGTCTTCTAGATGCTGGCTCTTTCGTAGAAA
TCGGTGCTTTAGGTCGTACTCCAGGTGAGCCCGATGCCCCTTACGGTGACGGTGTTGTTACTGGCTATGGTCGTATCGAC
GGCCGTCCCGTGGCCATCTATGCCCATGACAAGACCGTTTACGGTGGTTCGGTGGGCGAGACGTTTGGCCGCAAGGTATG
TGAGGTCATGGATATGGCCATCAAGATTGGATGCCCTGTGATTGGTATCCAGGATTCTGGTGGTGCTCGTATCCAGGACG
CTGTTACTTCGCTGGCTATGTACTCTGAGATTTCGCGTCGTCAGTTGCCATTGAGCGGCCGTAGCCCACAGATTTCCATC
ATGATGGGTAAGTCTGCCGGTGGTGCTGTATATGCTCCTGTGACCACTGATTTTGTGGTGGCTGTGGATGGTCGCGCGGA
AATGTATGTCACTGGCCCTGCTGTGATTAAGGAAGTCACGGGTGAAGACATCACTTCTCATGATCTGGGTTCTGCGCGTC
AGCAGGAACTCAACGGCAACGTGTCGTATGTGGCCGCCGATGAGGATGATGCCTTTAACTATGTGCATGATTTGTTGCAG
CATTTGCCGCTTACCTGCAATGATCCCAACCCTGAGTATTGGGCGCCGTCGGATGAGGACATCATGGCGGCGGATCAGAG
CTTGGATACCTTCATGCCGGATGACACCAATGCTGGCTATGATATGCATTCGCTGCTCAAGTTGATCTTCGACGAGGATG
ATTTCCTTGAGATTCAGCCGAACTTTGCCCCCAACATCATTGTGGGCTTCTCGCGTATCGACGGCCGCAGCGTGGGTGTG
GTTGCTAACCAACCGCTGGAATACGCAGGGTGTATCGACGCCGATGCAGCCGATAAGGCGGCTCGCTTTATCCGTATTTG
CGATGCTTATAACATCCCAATCCTCTTCGTTGTGGATACCCCTGGTTATCTGCCTGGTGTGGACCAAGAAAAGGTTGGTT
TAATTCACCGTGGCGCAAAGCTGGCCTTCGCCCTGGTAGAGGCCACTGTGCCGAAGATTTCTCTTATCGTGCGTAAGGCT
TATGGCGGAGCTTATGCGGTGATGGGATCGAAGAACCTTTCCGGTGATATTAACTTGGCGTGGCCTACTGCCCAGATCGC
CGTGATGGGTGCCGCTGCTGCTTCGGTGATGATTCAGGGCAAGCAGCTGGCTGCTGTGGAAGATCCTGCGCAGCGCGCCA
TGATGAAGAAGCTGTTCATGGACTTCTATGACGAGAACATGACGTCGCCGTATGTTGCGGCAGAGCGCGGCTACATTGAC
GCCATGATTCAGCCGCACGAGACGCGCATTGCGTTACGACGTGCCCTGCGTCAGCTGGAAACCAAGGACGTTCACGATCT
GCCTAAGAAGCACACCATCGCACCGATGTAG

Upstream 100 bases:

>100_bases
GCGACCACCTAGCAGTGGTGGATGAGCCGGAGATCGGTAAGGTTGGTGTGGCGCTCACCAACAGGATTGAACAGCTACAG
GGTAAGTAGGAGATTGGACT

Downstream 100 bases:

>100_bases
GAGAATTTATTATTATTTTCACTGATTTTTAGGAGAGCTAGTGAAAATTTGCCGTTATGCTGTGTCCTTGGCTGTTGCAA
CCTCGATGGTTATAGGCGGG

Product: propionyl-CoA carboxylase complex B subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSTTAEKLADLRARLEKAQDPGSERARAKRDEAGFTTPRQRINRLLDAGSFVEIGALGRTPGEPDAPYGDGVVTGYGRID
GRPVAIYAHDKTVYGGSVGETFGRKVCEVMDMAIKIGCPVIGIQDSGGARIQDAVTSLAMYSEISRRQLPLSGRSPQISI
MMGKSAGGAVYAPVTTDFVVAVDGRAEMYVTGPAVIKEVTGEDITSHDLGSARQQELNGNVSYVAADEDDAFNYVHDLLQ
HLPLTCNDPNPEYWAPSDEDIMAADQSLDTFMPDDTNAGYDMHSLLKLIFDEDDFLEIQPNFAPNIIVGFSRIDGRSVGV
VANQPLEYAGCIDADAADKAARFIRICDAYNIPILFVVDTPGYLPGVDQEKVGLIHRGAKLAFALVEATVPKISLIVRKA
YGGAYAVMGSKNLSGDINLAWPTAQIAVMGAAAASVMIQGKQLAAVEDPAQRAMMKKLFMDFYDENMTSPYVAAERGYID
AMIQPHETRIALRRALRQLETKDVHDLPKKHTIAPM

Sequences:

>Translated_516_residues
MSTTAEKLADLRARLEKAQDPGSERARAKRDEAGFTTPRQRINRLLDAGSFVEIGALGRTPGEPDAPYGDGVVTGYGRID
GRPVAIYAHDKTVYGGSVGETFGRKVCEVMDMAIKIGCPVIGIQDSGGARIQDAVTSLAMYSEISRRQLPLSGRSPQISI
MMGKSAGGAVYAPVTTDFVVAVDGRAEMYVTGPAVIKEVTGEDITSHDLGSARQQELNGNVSYVAADEDDAFNYVHDLLQ
HLPLTCNDPNPEYWAPSDEDIMAADQSLDTFMPDDTNAGYDMHSLLKLIFDEDDFLEIQPNFAPNIIVGFSRIDGRSVGV
VANQPLEYAGCIDADAADKAARFIRICDAYNIPILFVVDTPGYLPGVDQEKVGLIHRGAKLAFALVEATVPKISLIVRKA
YGGAYAVMGSKNLSGDINLAWPTAQIAVMGAAAASVMIQGKQLAAVEDPAQRAMMKKLFMDFYDENMTSPYVAAERGYID
AMIQPHETRIALRRALRQLETKDVHDLPKKHTIAPM
>Mature_515_residues
STTAEKLADLRARLEKAQDPGSERARAKRDEAGFTTPRQRINRLLDAGSFVEIGALGRTPGEPDAPYGDGVVTGYGRIDG
RPVAIYAHDKTVYGGSVGETFGRKVCEVMDMAIKIGCPVIGIQDSGGARIQDAVTSLAMYSEISRRQLPLSGRSPQISIM
MGKSAGGAVYAPVTTDFVVAVDGRAEMYVTGPAVIKEVTGEDITSHDLGSARQQELNGNVSYVAADEDDAFNYVHDLLQH
LPLTCNDPNPEYWAPSDEDIMAADQSLDTFMPDDTNAGYDMHSLLKLIFDEDDFLEIQPNFAPNIIVGFSRIDGRSVGVV
ANQPLEYAGCIDADAADKAARFIRICDAYNIPILFVVDTPGYLPGVDQEKVGLIHRGAKLAFALVEATVPKISLIVRKAY
GGAYAVMGSKNLSGDINLAWPTAQIAVMGAAAASVMIQGKQLAAVEDPAQRAMMKKLFMDFYDENMTSPYVAAERGYIDA
MIQPHETRIALRRALRQLETKDVHDLPKKHTIAPM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=44.5759368836292, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=43.0740037950664, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI11545863, Length=500, Percent_Identity=29.4, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1788655, Length=193, Percent_Identity=29.0155440414508, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=519, Percent_Identity=42.7745664739884, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI25147362, Length=519, Percent_Identity=42.7745664739884, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17552936, Length=519, Percent_Identity=28.7090558766859, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24586065, Length=524, Percent_Identity=28.6259541984733, Blast_Score=198, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55868; Mature: 55737

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTAEKLADLRARLEKAQDPGSERARAKRDEAGFTTPRQRINRLLDAGSFVEIGALGRT
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCC
PGEPDAPYGDGVVTGYGRIDGRPVAIYAHDKTVYGGSVGETFGRKVCEVMDMAIKIGCPV
CCCCCCCCCCCEEEECCCCCCEEEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCE
IGIQDSGGARIQDAVTSLAMYSEISRRQLPLSGRSPQISIMMGKSAGGAVYAPVTTDFVV
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCCCEEE
AVDGRAEMYVTGPAVIKEVTGEDITSHDLGSARQQELNGNVSYVAADEDDAFNYVHDLLQ
EECCCCEEEEECHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHH
HLPLTCNDPNPEYWAPSDEDIMAADQSLDTFMPDDTNAGYDMHSLLKLIFDEDDFLEIQP
HCCCEECCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECC
NFAPNIIVGFSRIDGRSVGVVANQPLEYAGCIDADAADKAARFIRICDAYNIPILFVVDT
CCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
PGYLPGVDQEKVGLIHRGAKLAFALVEATVPKISLIVRKAYGGAYAVMGSKNLSGDINLA
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHEEEEEHHCCCEEEEECCCCCCCCEEEE
WPTAQIAVMGAAAASVMIQGKQLAAVEDPAQRAMMKKLFMDFYDENMTSPYVAAERGYID
CCCCEEEEHHHHHHHEEECCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEE
AMIQPHETRIALRRALRQLETKDVHDLPKKHTIAPM
EEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
STTAEKLADLRARLEKAQDPGSERARAKRDEAGFTTPRQRINRLLDAGSFVEIGALGRT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCCC
PGEPDAPYGDGVVTGYGRIDGRPVAIYAHDKTVYGGSVGETFGRKVCEVMDMAIKIGCPV
CCCCCCCCCCCEEEECCCCCCEEEEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCE
IGIQDSGGARIQDAVTSLAMYSEISRRQLPLSGRSPQISIMMGKSAGGAVYAPVTTDFVV
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCCCEEE
AVDGRAEMYVTGPAVIKEVTGEDITSHDLGSARQQELNGNVSYVAADEDDAFNYVHDLLQ
EECCCCEEEEECHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHH
HLPLTCNDPNPEYWAPSDEDIMAADQSLDTFMPDDTNAGYDMHSLLKLIFDEDDFLEIQP
HCCCEECCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECC
NFAPNIIVGFSRIDGRSVGVVANQPLEYAGCIDADAADKAARFIRICDAYNIPILFVVDT
CCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECC
PGYLPGVDQEKVGLIHRGAKLAFALVEATVPKISLIVRKAYGGAYAVMGSKNLSGDINLA
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCHHEEEEEHHCCCEEEEECCCCCCCCEEEE
WPTAQIAVMGAAAASVMIQGKQLAAVEDPAQRAMMKKLFMDFYDENMTSPYVAAERGYID
CCCCEEEEHHHHHHHEEECCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEE
AMIQPHETRIALRRALRQLETKDVHDLPKKHTIAPM
EEECCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]