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The map label for this gene is hpt [H]

Identifier: 38234567

GI number: 38234567

Start: 2051613

End: 2052176

Strand: Reverse

Name: hpt [H]

Synonym: DIP2003

Alternate gene names: 38234567

Gene position: 2052176-2051613 (Counterclockwise)

Preceding gene: 38234568

Following gene: 38234566

Centisome position: 82.46

GC content: 52.13

Gene sequence:

>564_bases
GTGCCAGCCAACCCCTACGGTAACGACGTGAAAGAAGTACTGATCACCGAAGATCAACTTCAAAACCGCATCCAAGAACT
GGCTGACCTCGTATCTGAGAAGTACCGCGATGAAAAAGAAGACCTGGTACTGATTTGTGTGCTCAAGGGTGCAGTGTTCT
TCCTCACTGACTTTGCGCGCAAACTGAGCATTCCATGCCAGATCGAATTCATGTCCGTCAGCTCCTACGGCAACTCGGCG
TCGTCGTCAGGCGTGGTACGAATCCTTAAAGACCTCGACCGTGACGTCGCAGGCTGCAACGTTGTGATCGTTGAAGACAT
CATCGACTCCGGCCTCACCTTGAAATGGCTGATCAAGAACCTCTCCGGACGCAAACCAAAGTCCCTAGAAATTGTTACCC
TCTTGCGCAAGCCAGAAGCAGTAAAGACCACCATCGACTGCCTCGACATAGGCTTTGACCTGCCCAACGAGTTCGTCATT
GGCTACGGCCTCGACTTCGCAGAAAAGTACCGCGACCTCCCCTTTGTCGCATCCTTGAACGAGAACGTGTACACCGAACA
ATAG

Upstream 100 bases:

>100_bases
CAGTGGGAAACGGGTTGGAAGTGACCCGCAAAGATGGCAGACTTTCGGTTAGCTGATTATGAAAGGTGAAACCCCTATGC
ACGATTCGAAGGAACTTCCA

Downstream 100 bases:

>100_bases
GGTAGGGGCACCTCAAAAGAAACCAGCTGGGAACGTCTGGCTGGTTTTATGCGTTACTAAAGGCAGAACCTTTTAGTAGC
TTTTCCACATTCATTTAAGA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MPANPYGNDVKEVLITEDQLQNRIQELADLVSEKYRDEKEDLVLICVLKGAVFFLTDFARKLSIPCQIEFMSVSSYGNSA
SSSGVVRILKDLDRDVAGCNVVIVEDIIDSGLTLKWLIKNLSGRKPKSLEIVTLLRKPEAVKTTIDCLDIGFDLPNEFVI
GYGLDFAEKYRDLPFVASLNENVYTEQ

Sequences:

>Translated_187_residues
MPANPYGNDVKEVLITEDQLQNRIQELADLVSEKYRDEKEDLVLICVLKGAVFFLTDFARKLSIPCQIEFMSVSSYGNSA
SSSGVVRILKDLDRDVAGCNVVIVEDIIDSGLTLKWLIKNLSGRKPKSLEIVTLLRKPEAVKTTIDCLDIGFDLPNEFVI
GYGLDFAEKYRDLPFVASLNENVYTEQ
>Mature_186_residues
PANPYGNDVKEVLITEDQLQNRIQELADLVSEKYRDEKEDLVLICVLKGAVFFLTDFARKLSIPCQIEFMSVSSYGNSAS
SSGVVRILKDLDRDVAGCNVVIVEDIIDSGLTLKWLIKNLSGRKPKSLEIVTLLRKPEAVKTTIDCLDIGFDLPNEFVIG
YGLDFAEKYRDLPFVASLNENVYTEQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=191, Percent_Identity=34.5549738219895, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI9910262, Length=190, Percent_Identity=32.1052631578947, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI87081689, Length=168, Percent_Identity=45.2380952380952, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17510817, Length=186, Percent_Identity=30.6451612903226, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20969; Mature: 20838

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANPYGNDVKEVLITEDQLQNRIQELADLVSEKYRDEKEDLVLICVLKGAVFFLTDFAR
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
KLSIPCQIEFMSVSSYGNSASSSGVVRILKDLDRDVAGCNVVIVEDIIDSGLTLKWLIKN
HCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCHHHCCCCEEEEHHHHCCCCHHHHHHHH
LSGRKPKSLEIVTLLRKPEAVKTTIDCLDIGFDLPNEFVIGYGLDFAEKYRDLPFVASLN
HCCCCCCCCCEEEEHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCEEEECC
ENVYTEQ
CCCCCCC
>Mature Secondary Structure 
PANPYGNDVKEVLITEDQLQNRIQELADLVSEKYRDEKEDLVLICVLKGAVFFLTDFAR
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
KLSIPCQIEFMSVSSYGNSASSSGVVRILKDLDRDVAGCNVVIVEDIIDSGLTLKWLIKN
HCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCHHHCCCCEEEEHHHHCCCCHHHHHHHH
LSGRKPKSLEIVTLLRKPEAVKTTIDCLDIGFDLPNEFVIGYGLDFAEKYRDLPFVASLN
HCCCCCCCCCEEEEHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCEEEECC
ENVYTEQ
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]