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The map label for this gene is murA

Identifier: 38234457

GI number: 38234457

Start: 1937107

End: 1938363

Strand: Reverse

Name: murA

Synonym: DIP1887

Alternate gene names: 38234457

Gene position: 1938363-1937107 (Counterclockwise)

Preceding gene: 38234459

Following gene: 38234456

Centisome position: 77.89

GC content: 56.25

Gene sequence:

>1257_bases
GTGAAGGAAAGATTTCTAGTTACCGGCGGTGCTCGACTTGAAGGAACCGTCCATGTCAGCGGCGCGAAAAACAGCGTGCT
CAAGCTGATGGCGGCTGCACTTCTTGCCGAAGGCACCACGACGTTGACCAATTGCCCGAAGATCTTGGACGTTCCTTATA
TGGTTCGCGTCCTCGAAGGCCTAGGTTGTTCTGTTGTCCACTCCGGTTCAACGGTGGAAATTACAACGCCAGCCGAAATT
TCCAGTAACGCCGACTTTGATGCCGTGCGGCAATTCCGCGCCTCTGTATGCGTACTCGGCCCATTGACCTCGCGCTGCGG
CAAGGCAGTCGTTGCATTGCCCGGCGGAGACGCCATCGGATCGCGCCCTTTGGATATGCACCAAAGCGGCCTAGAAAAGC
TGGGTGCTAAAACCCACATCGAACATGGTGCGGTTGTGGCCCAAGCAGATCAGCTGCGTGGCGCCAATATTCACCTTGAC
TTCCCATCGGTCGGAGCGACCGAAAATATTTTGACCGCGGCCGTTCTCGCAGAAGGCACGACCGTTCTTGATAACGCTGC
GCGCGAGCCAGAAATTCTTGATTTATGCGTCATGCTCAAAGAAATGGGCGCGGATATTGAAGGCGAGGGTACCTCGACCA
TCACCATCCGTGGCGTAGAAAAACTGCACCCCACCCAGCACGAAGTTATTGGCGACCGCATCGTTGCCGGTACATGGGCA
TATGCCGCAGCGATGACCCAAGGCGACATCACTGTCGGTGGCATTGCACCACGCAACCTGCACTTGGCATTGGAAAAACT
CAAGGTCGCAGGCGCCGAGGTGACCACGTACGATCACGGATTCCGCGTGCGCATGGACCGTCGCCCCATGGCGGTGGACT
ATCAAACGCTCCCATTCCCAGGGTTCCCAACTGATCTTCAGCCAATGGCCATTGGTATTTCGACGGTTGCAGATGGCGTT
TCAGTTATCACGGAAAACATCTTCGAGGCACGCTTCCGCTTCGTCGACGAACTCGTCCGCTTAGGTGCCGACGCCACTGT
CGACGGTCACCATGTAGTTATGAGGGGAGTGGAGAAGCTTTCTTCGACACCAGTGTGGAGCTCAGACATCCGAGCCGGAG
CCGGGCTCGTGTTGGCGGCTTTGTGCGCTGATGGGGTGACAGAAGTAAACGATGTGTTCCACATCGACCGCGGATACCCC
AACTTTGTAGAGGATCTTCAGCGCTTGGGCGCCCAGATCGAACGAGTGCAAGTTTAA

Upstream 100 bases:

>100_bases
GACAATGCAGTCGTGCCGTCGTCGCCAGTACGTGTGTAGATCTTTGTCAAATGAACAGCCATACTCCAAACCTACGCGAT
AACTCAGTAGGGTTGGAGGG

Downstream 100 bases:

>100_bases
AAACCTCTCTGACCTGCGGAGTTGTGTCAACAGGTCGTGGTGTGTACATTTAATCAAGTCGCCGCGACCGACACCGCCCC
TCACACAAGTGAGAGCAGGT

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKERFLVTGGARLEGTVHVSGAKNSVLKLMAAALLAEGTTTLTNCPKILDVPYMVRVLEGLGCSVVHSGSTVEITTPAEI
SSNADFDAVRQFRASVCVLGPLTSRCGKAVVALPGGDAIGSRPLDMHQSGLEKLGAKTHIEHGAVVAQADQLRGANIHLD
FPSVGATENILTAAVLAEGTTVLDNAAREPEILDLCVMLKEMGADIEGEGTSTITIRGVEKLHPTQHEVIGDRIVAGTWA
YAAAMTQGDITVGGIAPRNLHLALEKLKVAGAEVTTYDHGFRVRMDRRPMAVDYQTLPFPGFPTDLQPMAIGISTVADGV
SVITENIFEARFRFVDELVRLGADATVDGHHVVMRGVEKLSSTPVWSSDIRAGAGLVLAALCADGVTEVNDVFHIDRGYP
NFVEDLQRLGAQIERVQV

Sequences:

>Translated_418_residues
MKERFLVTGGARLEGTVHVSGAKNSVLKLMAAALLAEGTTTLTNCPKILDVPYMVRVLEGLGCSVVHSGSTVEITTPAEI
SSNADFDAVRQFRASVCVLGPLTSRCGKAVVALPGGDAIGSRPLDMHQSGLEKLGAKTHIEHGAVVAQADQLRGANIHLD
FPSVGATENILTAAVLAEGTTVLDNAAREPEILDLCVMLKEMGADIEGEGTSTITIRGVEKLHPTQHEVIGDRIVAGTWA
YAAAMTQGDITVGGIAPRNLHLALEKLKVAGAEVTTYDHGFRVRMDRRPMAVDYQTLPFPGFPTDLQPMAIGISTVADGV
SVITENIFEARFRFVDELVRLGADATVDGHHVVMRGVEKLSSTPVWSSDIRAGAGLVLAALCADGVTEVNDVFHIDRGYP
NFVEDLQRLGAQIERVQV
>Mature_418_residues
MKERFLVTGGARLEGTVHVSGAKNSVLKLMAAALLAEGTTTLTNCPKILDVPYMVRVLEGLGCSVVHSGSTVEITTPAEI
SSNADFDAVRQFRASVCVLGPLTSRCGKAVVALPGGDAIGSRPLDMHQSGLEKLGAKTHIEHGAVVAQADQLRGANIHLD
FPSVGATENILTAAVLAEGTTVLDNAAREPEILDLCVMLKEMGADIEGEGTSTITIRGVEKLHPTQHEVIGDRIVAGTWA
YAAAMTQGDITVGGIAPRNLHLALEKLKVAGAEVTTYDHGFRVRMDRRPMAVDYQTLPFPGFPTDLQPMAIGISTVADGV
SVITENIFEARFRFVDELVRLGADATVDGHHVVMRGVEKLSSTPVWSSDIRAGAGLVLAALCADGVTEVNDVFHIDRGYP
NFVEDLQRLGAQIERVQV

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=417, Percent_Identity=45.5635491606715, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_CORDI (Q6NFK1)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940224.1
- ProteinModelPortal:   Q6NFK1
- SMR:   Q6NFK1
- GeneID:   2649266
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1887
- NMPDR:   fig|257309.1.peg.1815
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   CDIP257309:DIP1887-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 44400; Mature: 44400

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERFLVTGGARLEGTVHVSGAKNSVLKLMAAALLAEGTTTLTNCPKILDVPYMVRVLEG
CCCCEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHC
LGCSVVHSGSTVEITTPAEISSNADFDAVRQFRASVCVLGPLTSRCGKAVVALPGGDAIG
CCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCEEEECCHHHHCCCEEEEECCCCCCC
SRPLDMHQSGLEKLGAKTHIEHGAVVAQADQLRGANIHLDFPSVGATENILTAAVLAEGT
CCCCHHHHHHHHHCCCHHCCCCCCEEEEHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCC
TVLDNAAREPEILDLCVMLKEMGADIEGEGTSTITIRGVEKLHPTQHEVIGDRIVAGTWA
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHHHHCCHHEECHHH
YAAAMTQGDITVGGIAPRNLHLALEKLKVAGAEVTTYDHGFRVRMDRRPMAVDYQTLPFP
HHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCEECEEECCCC
GFPTDLQPMAIGISTVADGVSVITENIFEARFRFVDELVRLGADATVDGHHVVMRGVEKL
CCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SSTPVWSSDIRAGAGLVLAALCADGVTEVNDVFHIDRGYPNFVEDLQRLGAQIERVQV
HCCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKERFLVTGGARLEGTVHVSGAKNSVLKLMAAALLAEGTTTLTNCPKILDVPYMVRVLEG
CCCCEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHC
LGCSVVHSGSTVEITTPAEISSNADFDAVRQFRASVCVLGPLTSRCGKAVVALPGGDAIG
CCCEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCEEEECCHHHHCCCEEEEECCCCCCC
SRPLDMHQSGLEKLGAKTHIEHGAVVAQADQLRGANIHLDFPSVGATENILTAAVLAEGT
CCCCHHHHHHHHHCCCHHCCCCCCEEEEHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCC
TVLDNAAREPEILDLCVMLKEMGADIEGEGTSTITIRGVEKLHPTQHEVIGDRIVAGTWA
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHHHHCCHHEECHHH
YAAAMTQGDITVGGIAPRNLHLALEKLKVAGAEVTTYDHGFRVRMDRRPMAVDYQTLPFP
HHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCEECEEECCCC
GFPTDLQPMAIGISTVADGVSVITENIFEARFRFVDELVRLGADATVDGHHVVMRGVEKL
CCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
SSTPVWSSDIRAGAGLVLAALCADGVTEVNDVFHIDRGYPNFVEDLQRLGAQIERVQV
HCCCCCCHHHCCCHHHHHHHHHHCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910