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The map label for this gene is clpX

Identifier: 38234360

GI number: 38234360

Start: 1835403

End: 1836695

Strand: Reverse

Name: clpX

Synonym: DIP1789

Alternate gene names: 38234360

Gene position: 1836695-1835403 (Counterclockwise)

Preceding gene: 38234361

Following gene: 38234358

Centisome position: 73.8

GC content: 53.44

Gene sequence:

>1293_bases
ATGACACGTATGCAAGAAAGCGCTGATCTCCTCAAATGTTCTTTCTGCGGGAAGAGCCAAAAACAGGTGAAGAAGCTCAT
CGCCGGTGGTGGCGTGTACATCTGCGATGAATGCATCGAGCTGTGCAATGAGATCATCGAAGAGGAGCTCAACTCGTCGG
CAGCAGAAGCCAAAGATAACGGTGACCGCCTGCCTCGACCTTCACAGATCTCCGCCTTCTTGGACAAGTACGTGATCGGT
CAAGATGATGCCAAGCGCATCCTCTCGGTGGCTGTGTACAACCACTACAAGCGGGTGCGTGCTGAGGAATCACGCACGAC
GCACAAGCGTGCCTCGGAGGAAGAAACCGAACTCCAAAAATCCAACATTCTCATGTTGGGGCCCACCGGATCCGGTAAGA
CCTACCTCGCCCAAACTCTTGCGCGGCTTCTCGACGTCCCCTTCGCGATCGCCGATGCTACCTCACTGACCGAAGCCGGT
TACGTGGGCGAAGACGTAGAAAACATTTTGCTCAAACTCCTGCAGGCAGCAGACTTTGATGTTCAGCGCGCCCAGCGTGG
CATTATCTACGTCGACGAAGTAGATAAGATTTCCCGTAAATCGGATAACCCATCGATTACTCGCGATGTGTCCGGCGAAG
GCGTCCAGCAAGCACTGCTGAAAATCCTCGAGGGAACCGTGGCCTCTATCCCGCCTCAGGGTGGGCGTAAGCACCCCAAC
CAGGACTTTATTCAGCTCGATACTTCCAACATCTTGTTCATTGTGGCCGGTGCATTTGCAGGTCTAGAAAAAGTGATCGA
AGAACGTCGCGGCAAAAAGGGTATTGGCTTCGGCGCTGAGTTGACCACAAAAGCAGACACCGATGCAGTCGATGTGTTCC
GCGATGTTCTACCCGAAGACTTGGTCAAATTCGGGTTGATCCCAGAATTTATTGGTCGTCTTCCCATCGTGGCTACCGTC
AACAACTTGGACCAAGCTTCCCTTGTTAAGGTGCTGACCGAGCCACGAAACTCACTGGTCAAGCAATATCAACGACTATT
TGATATGGATCGCGTAGATCTAGAATTTGATCCCGAGGCACTGCAAGCCATCGCCGATCTGGCCATCGACCGTGGTACGG
GTGCGCGTGGACTTCGCGCGATCATGGAAGAACTCCTAGTGCCAGTGATGTATGACATCCCTGACCGTGAGGATGTCGCA
GTGGTGCGTATCAACGAGGCCGCAGTTCGAGGGCTGCAGGAACCCGAGATGATCTTGCACAGCCAGAAAGACGAAGAGGA
GAAGACAGCCTAA

Upstream 100 bases:

>100_bases
TGTTTGGTAATGAAGGAAACTGCAATTACCATCGAACTTCCTCTTTACGGGAATGCCGTAGAGAACGCACCCCTTAAGAA
TTGAGAGACTCCTACCTCTT

Downstream 100 bases:

>100_bases
GGCTATCTTCTCCTCAACAGGGGGAAAGAATTTTTTTTAAGAGAAGGGGTCGGCAGCTACTTCGTAGGAGCCCTCCTCAT
CCACGTGTTCAGTGACAGTG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDNGDRLPRPSQISAFLDKYVIG
QDDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQKSNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAG
YVGEDVENILLKLLQAADFDVQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPN
QDFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPEDLVKFGLIPEFIGRLPIVATV
NNLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEALQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVA
VVRINEAAVRGLQEPEMILHSQKDEEEKTA

Sequences:

>Translated_430_residues
MTRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDNGDRLPRPSQISAFLDKYVIG
QDDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQKSNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAG
YVGEDVENILLKLLQAADFDVQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPN
QDFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPEDLVKFGLIPEFIGRLPIVATV
NNLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEALQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVA
VVRINEAAVRGLQEPEMILHSQKDEEEKTA
>Mature_429_residues
TRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDNGDRLPRPSQISAFLDKYVIGQ
DDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQKSNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAGY
VGEDVENILLKLLQAADFDVQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPNQ
DFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPEDLVKFGLIPEFIGRLPIVATVN
NLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEALQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVAV
VRINEAAVRGLQEPEMILHSQKDEEEKTA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=518, Percent_Identity=39.3822393822394, Blast_Score=328, Evalue=8e-90,
Organism=Escherichia coli, GI1786642, Length=418, Percent_Identity=61.7224880382775, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1790366, Length=111, Percent_Identity=43.2432432432432, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982905, Length=317, Percent_Identity=46.0567823343849, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71982908, Length=317, Percent_Identity=46.0567823343849, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=415, Percent_Identity=37.1084337349398, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71988660, Length=260, Percent_Identity=38.8461538461538, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319704, Length=452, Percent_Identity=39.3805309734513, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24648291, Length=319, Percent_Identity=47.6489028213166, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24648289, Length=319, Percent_Identity=47.6489028213166, Blast_Score=297, Evalue=8e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_CORDI (Q6NFU7)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940127.1
- ProteinModelPortal:   Q6NFU7
- GeneID:   2649414
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1789
- NMPDR:   fig|257309.1.peg.1718
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q6NFU7
- ProtClustDB:   PRK05342
- BioCyc:   CDIP257309:DIP1789-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47502; Mature: 47370

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDN
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GDRLPRPSQISAFLDKYVIGQDDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQK
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAGYVGEDVENILLKLLQAADFD
CCEEEECCCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCC
VQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPN
HHHHHCCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCC
QDFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPED
CCEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LVKFGLIPEFIGRLPIVATVNNLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEA
HHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVAVVRINEAAVRGLQEPEMILH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHCCCCCHHHHHH
SQKDEEEKTA
CCCCCCCCCC
>Mature Secondary Structure 
TRMQESADLLKCSFCGKSQKQVKKLIAGGGVYICDECIELCNEIIEEELNSSAAEAKDN
CCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GDRLPRPSQISAFLDKYVIGQDDAKRILSVAVYNHYKRVRAEESRTTHKRASEEETELQK
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SNILMLGPTGSGKTYLAQTLARLLDVPFAIADATSLTEAGYVGEDVENILLKLLQAADFD
CCEEEECCCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCC
VQRAQRGIIYVDEVDKISRKSDNPSITRDVSGEGVQQALLKILEGTVASIPPQGGRKHPN
HHHHHCCCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCC
QDFIQLDTSNILFIVAGAFAGLEKVIEERRGKKGIGFGAELTTKADTDAVDVFRDVLPED
CCEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LVKFGLIPEFIGRLPIVATVNNLDQASLVKVLTEPRNSLVKQYQRLFDMDRVDLEFDPEA
HHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
LQAIADLAIDRGTGARGLRAIMEELLVPVMYDIPDREDVAVVRINEAAVRGLQEPEMILH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHCCCCCHHHHHH
SQKDEEEKTA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910