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The map label for this gene is ndk [H]

Identifier: 38234354

GI number: 38234354

Start: 1827843

End: 1828277

Strand: Reverse

Name: ndk [H]

Synonym: DIP1783

Alternate gene names: 38234354

Gene position: 1828277-1827843 (Counterclockwise)

Preceding gene: 38234355

Following gene: 38234353

Centisome position: 73.47

GC content: 58.39

Gene sequence:

>435_bases
TTGCGTTGGCTACACTATCCAACCATGACTGAACGTACCCTGATTCTGATCAAGCCAGACGGTGTTGAGCGCGGCCTCAT
CGGTGAAATCATCGCCCGCATCGAGCGCAAAGGCCTGAAAATCTCCGCTCTTGACCTGCGCGTTGCAGACCGCGAGACTG
CCGAGAAGCACTATGCAGAACACGCTGACAAGCCATTCTTCGGTGAGCTGGTGAACTTCATCACCTCCGCACCACTGATC
GCAGGCGTTGTTGAGGGCCCACGCGCTATCGAGGCATGGCGCCAACTTGCTGGTGGCACCGACCCAGTTGCCAAGGCAAC
CCCAGGTACCATCCGCGGCGACTTCGCTCTTGAGGTTTCCACCAACGTGGTTCACGGTTCCGACTCCCCAGAGTCCGCCG
AGCGCGAGATCTCCATCTGGTTCCCTAACCTGTAA

Upstream 100 bases:

>100_bases
AATCCTAGGCGTTGGCATTATCGACGGCTACAATCGCACCGAAATGCGGGCGTGCTAGGCGTTCTACTGGGGGCAAGAAG
TGTGATTGTGAACGCCGCCG

Downstream 100 bases:

>100_bases
AAACACTTACTTTGAGGGAGCGTGTACACACCCCGTGCATGCTCCCTTTTTGCTATGTGAGCAAGCCTGCCTGAACTTTT
CGTCACCGATGTGCCAGAAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MRWLHYPTMTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAEHADKPFFGELVNFITSAPLI
AGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVSTNVVHGSDSPESAEREISIWFPNL

Sequences:

>Translated_144_residues
MRWLHYPTMTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAEHADKPFFGELVNFITSAPLI
AGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVSTNVVHGSDSPESAEREISIWFPNL
>Mature_144_residues
MRWLHYPTMTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAEHADKPFFGELVNFITSAPLI
AGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVSTNVVHGSDSPESAEREISIWFPNL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=52.6717557251908, Blast_Score=142, Evalue=7e-35,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=50.381679389313, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=50.381679389313, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=50.381679389313, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=50.381679389313, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=50.381679389313, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI38045913, Length=132, Percent_Identity=49.2424242424242, Blast_Score=139, Evalue=6e-34,
Organism=Homo sapiens, GI4557797, Length=132, Percent_Identity=49.2424242424242, Blast_Score=139, Evalue=6e-34,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=44.8529411764706, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=37.7777777777778, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=37.037037037037, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI5031951, Length=146, Percent_Identity=37.6712328767123, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4505413, Length=141, Percent_Identity=34.0425531914894, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=46.5648854961832, Blast_Score=116, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=49.2424242424242, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322783, Length=134, Percent_Identity=51.4925373134328, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45549037, Length=131, Percent_Identity=51.9083969465649, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI18860097, Length=144, Percent_Identity=34.0277777777778, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15886; Mature: 15886

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWLHYPTMTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAE
CCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHH
HADKPFFGELVNFITSAPLIAGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVS
HCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
TNVVHGSDSPESAEREISIWFPNL
CEEEECCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRWLHYPTMTERTLILIKPDGVERGLIGEIIARIERKGLKISALDLRVADRETAEKHYAE
CCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHH
HADKPFFGELVNFITSAPLIAGVVEGPRAIEAWRQLAGGTDPVAKATPGTIRGDFALEVS
HCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEE
TNVVHGSDSPESAEREISIWFPNL
CEEEECCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]