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The map label for this gene is dcp [H]

Identifier: 38234299

GI number: 38234299

Start: 1768327

End: 1770306

Strand: Reverse

Name: dcp [H]

Synonym: DIP1728

Alternate gene names: 38234299

Gene position: 1770306-1768327 (Counterclockwise)

Preceding gene: 38234301

Following gene: 38234298

Centisome position: 71.14

GC content: 53.18

Gene sequence:

>1980_bases
ATGACTAATCCTTTGCTTCAACCTTCCACCTTGCCGTACCAATTACCGCAATTTGCGGCAATTCGAGTAGAGCATTATCT
CCCAGCTTTTACTGAGGCACTTGCACGCCACAGTGCGGAAATTGCTGCGATTGCGAACAATCCAGAACCTGCCACGTGGG
AAAATACGGTTGAGGAGCTCGAGCGAAGCGGTCGCGATTTGGAACGAGTGGCGGCAGTCTTTTTTAACTTGCATGGCACG
GATTCCAGTGCAGAAATGGATGAGATTGCAGCTGAGATTGCCCCACGGCTTGCCCAGCATTCGGATGAGATGTATCTCAA
CGCTGAGCTGTTCGAAAGAATTAAGCAATGCACACCACCAGCGGATTCAGAGTCGCAGCGTTTGCATGAGCACATTATCA
GGACATTTACTCGCCACGGTGCTGGCCTAGAAGACGTTGCACGTTTGAAAGAAATAAATGCGCGGTTGTCGGTGCTCTCG
GATATGTTTGGCCGTAATTTATTAGAGTCCACGCAGAAATTAGCTGTGGGTTTTTCCTCGAAAGAGGAGCTCGCGGGGCT
AAGTGATGCTCGCATTGAGTCGGCTGCCGCTGATGCGAAAGCATTGGGACGCGACGGCTATGTGCTTCCGCTAGAGCTGC
CGACGGTCCAAGGCGAACAGAGCTCGCTAGAGAATCCGCAGTCTCGGCAGCGGGTATATGAGGCGTCGCAACGCAGAGGC
GCTGATAACAATCCTGAGGTGCTCGTGGAAATGGTGCAGCTACGGGCCGAGCGGGCCGAATTGTTGGGATACCTAACCCA
CGCGGACTATGTGATTTCTGAAGAAACCGCCGGAAGCGCCGAAGCTGCGCGAAAGCTTCTTTACGATTTGGCACCCGCGG
CGACCGCAAATGCGCTGGCGGAAAAGAAGCTGCTGTCGGAGGCTGCAGGAGAAGAGATCAATCCTGCAGATTGGCCGTAC
TGGGAATCTCACGTACGTCTGCGCGATTATGCGCTCAACGAGGAAGAACTATCACAGCATTTCCCGTTGAAGAAAGTGCT
TGTCGACGGAGTCTTCTTCGCCGCACATCGCCTCTACGGTATTACTGTGGAGCCTCGTCCCGACTTAGAAGGCTACGCCC
CTGGTGTCGATGTGTGGGAAGTTAAAGAAGAAGATGGCCGTGGTATCGGGCTATTGCTGACTGATTACTACGGGCGGCCG
TCGAAACGCGGTGGTGCTTGGATGAGTAGCTTTGTCGATCAATCGGAGTTGTTGGGTACAAAGCCTGTTGTGGTCAACGT
TATGGGGTTGACGGCACCAACCGATGGTTCGGATGCACTGCTCAGTATCGATTCGTTGACCACCGTCTTCCACGAGTTTG
GTCACGCGCTGCATGGTTTGCTTTCGCAAGTGCGTTACCCAACGTTTTCTGGCACAAACGTGCCACGCGACTACGTGGAG
TTTCCATCGCAGATCAATGAAAACTGGGCGTTTGAGCCAGAAGTATTGCGTAACTATGCGCCGAATCTTCCTGCACATGT
GGTTGACGCTATTGAAGAAGCCCGCCAGTTTGGTCAAGGATTCGCCACAACTGAATACCTTGCTGCGGCGATCATTGATC
TCGCGTGGCATTCGTTGACCAGCGCACAAGCTCAAAAGTTGTCGGCCTCAGACATAGAAGAATTTGAACGTCGTGCACTC
GAAGACGCCGGAATCGAAGGCGTACAACCTCGCTACAAGTCCACCTACTTTAATCACATTTTCGCAGGTGGATACTCTGC
TGGGTACTACTCCTATCTTTGGGCCGAAGCGCTTGATGCGGATGGATTTGACTGGTTCAAGGAACAACAAGACCCCCGCG
TTGCCGGACGACGATTCCGTGATCTTGTACTTTCACGCGGTGGTGCCGACGACTTCACTGAGGCCTATGAATCACTTCGT
GGTCGCGAAAAAGATGTCGCACCACTGCTACGTCGCAGGGGCCTATCGGGAGCCATGTGA

Upstream 100 bases:

>100_bases
GACGGCGTCGAAACGCGCTGCGTTGCCGTGGATGGTTCCGGTGTACGGTCCCATGGTGATCTGCTCGGACATGGCGTTAA
CTTTAGTACGATTGCACTTT

Downstream 100 bases:

>100_bases
TGTCCATCTTTGACACCCCCAGCCAGATACTCACCACAGCACCACTGTGGATTCAAACCCCTGTGGTGCTGATCGTGGCC
GTGCCATTGTGCGCGGCGCT

Product: putative peptidase

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 659; Mature: 658

Protein sequence:

>659_residues
MTNPLLQPSTLPYQLPQFAAIRVEHYLPAFTEALARHSAEIAAIANNPEPATWENTVEELERSGRDLERVAAVFFNLHGT
DSSAEMDEIAAEIAPRLAQHSDEMYLNAELFERIKQCTPPADSESQRLHEHIIRTFTRHGAGLEDVARLKEINARLSVLS
DMFGRNLLESTQKLAVGFSSKEELAGLSDARIESAAADAKALGRDGYVLPLELPTVQGEQSSLENPQSRQRVYEASQRRG
ADNNPEVLVEMVQLRAERAELLGYLTHADYVISEETAGSAEAARKLLYDLAPAATANALAEKKLLSEAAGEEINPADWPY
WESHVRLRDYALNEEELSQHFPLKKVLVDGVFFAAHRLYGITVEPRPDLEGYAPGVDVWEVKEEDGRGIGLLLTDYYGRP
SKRGGAWMSSFVDQSELLGTKPVVVNVMGLTAPTDGSDALLSIDSLTTVFHEFGHALHGLLSQVRYPTFSGTNVPRDYVE
FPSQINENWAFEPEVLRNYAPNLPAHVVDAIEEARQFGQGFATTEYLAAAIIDLAWHSLTSAQAQKLSASDIEEFERRAL
EDAGIEGVQPRYKSTYFNHIFAGGYSAGYYSYLWAEALDADGFDWFKEQQDPRVAGRRFRDLVLSRGGADDFTEAYESLR
GREKDVAPLLRRRGLSGAM

Sequences:

>Translated_659_residues
MTNPLLQPSTLPYQLPQFAAIRVEHYLPAFTEALARHSAEIAAIANNPEPATWENTVEELERSGRDLERVAAVFFNLHGT
DSSAEMDEIAAEIAPRLAQHSDEMYLNAELFERIKQCTPPADSESQRLHEHIIRTFTRHGAGLEDVARLKEINARLSVLS
DMFGRNLLESTQKLAVGFSSKEELAGLSDARIESAAADAKALGRDGYVLPLELPTVQGEQSSLENPQSRQRVYEASQRRG
ADNNPEVLVEMVQLRAERAELLGYLTHADYVISEETAGSAEAARKLLYDLAPAATANALAEKKLLSEAAGEEINPADWPY
WESHVRLRDYALNEEELSQHFPLKKVLVDGVFFAAHRLYGITVEPRPDLEGYAPGVDVWEVKEEDGRGIGLLLTDYYGRP
SKRGGAWMSSFVDQSELLGTKPVVVNVMGLTAPTDGSDALLSIDSLTTVFHEFGHALHGLLSQVRYPTFSGTNVPRDYVE
FPSQINENWAFEPEVLRNYAPNLPAHVVDAIEEARQFGQGFATTEYLAAAIIDLAWHSLTSAQAQKLSASDIEEFERRAL
EDAGIEGVQPRYKSTYFNHIFAGGYSAGYYSYLWAEALDADGFDWFKEQQDPRVAGRRFRDLVLSRGGADDFTEAYESLR
GREKDVAPLLRRRGLSGAM
>Mature_658_residues
TNPLLQPSTLPYQLPQFAAIRVEHYLPAFTEALARHSAEIAAIANNPEPATWENTVEELERSGRDLERVAAVFFNLHGTD
SSAEMDEIAAEIAPRLAQHSDEMYLNAELFERIKQCTPPADSESQRLHEHIIRTFTRHGAGLEDVARLKEINARLSVLSD
MFGRNLLESTQKLAVGFSSKEELAGLSDARIESAAADAKALGRDGYVLPLELPTVQGEQSSLENPQSRQRVYEASQRRGA
DNNPEVLVEMVQLRAERAELLGYLTHADYVISEETAGSAEAARKLLYDLAPAATANALAEKKLLSEAAGEEINPADWPYW
ESHVRLRDYALNEEELSQHFPLKKVLVDGVFFAAHRLYGITVEPRPDLEGYAPGVDVWEVKEEDGRGIGLLLTDYYGRPS
KRGGAWMSSFVDQSELLGTKPVVVNVMGLTAPTDGSDALLSIDSLTTVFHEFGHALHGLLSQVRYPTFSGTNVPRDYVEF
PSQINENWAFEPEVLRNYAPNLPAHVVDAIEEARQFGQGFATTEYLAAAIIDLAWHSLTSAQAQKLSASDIEEFERRALE
DAGIEGVQPRYKSTYFNHIFAGGYSAGYYSYLWAEALDADGFDWFKEQQDPRVAGRRFRDLVLSRGGADDFTEAYESLRG
REKDVAPLLRRRGLSGAM

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=644, Percent_Identity=28.1055900621118, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI14149738, Length=642, Percent_Identity=27.7258566978193, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI156105687, Length=578, Percent_Identity=23.7024221453287, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI1787819, Length=680, Percent_Identity=38.3823529411765, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1789913, Length=689, Percent_Identity=30.9143686502177, Blast_Score=296, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI32565901, Length=499, Percent_Identity=24.0480961923848, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319793, Length=614, Percent_Identity=25.5700325732899, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21356111, Length=694, Percent_Identity=22.1902017291066, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI20129717, Length=401, Percent_Identity=27.1820448877805, Blast_Score=105, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 73238; Mature: 73107

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLQPSTLPYQLPQFAAIRVEHYLPAFTEALARHSAEIAAIANNPEPATWENTVEEL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
ERSGRDLERVAAVFFNLHGTDSSAEMDEIAAEIAPRLAQHSDEMYLNAELFERIKQCTPP
HHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCC
ADSESQRLHEHIIRTFTRHGAGLEDVARLKEINARLSVLSDMFGRNLLESTQKLAVGFSS
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KEELAGLSDARIESAAADAKALGRDGYVLPLELPTVQGEQSSLENPQSRQRVYEASQRRG
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCC
ADNNPEVLVEMVQLRAERAELLGYLTHADYVISEETAGSAEAARKLLYDLAPAATANALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
EKKLLSEAAGEEINPADWPYWESHVRLRDYALNEEELSQHFPLKKVLVDGVFFAAHRLYG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHEE
ITVEPRPDLEGYAPGVDVWEVKEEDGRGIGLLLTDYYGRPSKRGGAWMSSFVDQSELLGT
EEECCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
KPVVVNVMGLTAPTDGSDALLSIDSLTTVFHEFGHALHGLLSQVRYPTFSGTNVPRDYVE
CCCEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FPSQINENWAFEPEVLRNYAPNLPAHVVDAIEEARQFGQGFATTEYLAAAIIDLAWHSLT
CHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SAQAQKLSASDIEEFERRALEDAGIEGVQPRYKSTYFNHIFAGGYSAGYYSYLWAEALDA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DGFDWFKEQQDPRVAGRRFRDLVLSRGGADDFTEAYESLRGREKDVAPLLRRRGLSGAM
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TNPLLQPSTLPYQLPQFAAIRVEHYLPAFTEALARHSAEIAAIANNPEPATWENTVEEL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHH
ERSGRDLERVAAVFFNLHGTDSSAEMDEIAAEIAPRLAQHSDEMYLNAELFERIKQCTPP
HHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCC
ADSESQRLHEHIIRTFTRHGAGLEDVARLKEINARLSVLSDMFGRNLLESTQKLAVGFSS
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KEELAGLSDARIESAAADAKALGRDGYVLPLELPTVQGEQSSLENPQSRQRVYEASQRRG
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCC
ADNNPEVLVEMVQLRAERAELLGYLTHADYVISEETAGSAEAARKLLYDLAPAATANALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
EKKLLSEAAGEEINPADWPYWESHVRLRDYALNEEELSQHFPLKKVLVDGVFFAAHRLYG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHEE
ITVEPRPDLEGYAPGVDVWEVKEEDGRGIGLLLTDYYGRPSKRGGAWMSSFVDQSELLGT
EEECCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
KPVVVNVMGLTAPTDGSDALLSIDSLTTVFHEFGHALHGLLSQVRYPTFSGTNVPRDYVE
CCCEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FPSQINENWAFEPEVLRNYAPNLPAHVVDAIEEARQFGQGFATTEYLAAAIIDLAWHSLT
CHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SAQAQKLSASDIEEFERRALEDAGIEGVQPRYKSTYFNHIFAGGYSAGYYSYLWAEALDA
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DGFDWFKEQQDPRVAGRRFRDLVLSRGGADDFTEAYESLRGREKDVAPLLRRRGLSGAM
CCCHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]