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The map label for this gene is glyS [H]

Identifier: 38234279

GI number: 38234279

Start: 1745608

End: 1746993

Strand: Reverse

Name: glyS [H]

Synonym: DIP1708

Alternate gene names: 38234279

Gene position: 1746993-1745608 (Counterclockwise)

Preceding gene: 38234282

Following gene: 38234278

Centisome position: 70.2

GC content: 54.62

Gene sequence:

>1386_bases
GTGGCACAGAACAATGTCATTGACACGGTCGTCAACCTCTGTAAGCGTCGTGGCCTCGTTTATCCCTGTGGTGAGATCTA
CGGTGGCACCCGATCCGCATGGGACTATGGTCCATTGGGAATGGAACTGAAAGAAAACATTAAAAAGCAGTGGTGGCGCA
CCTTTGTCCAGGCACGTGCAGACGTCGTAGGTCTCGACTCGTCCATCATCTTGCCTCGTCAGGTATGGGTTGCCTCCGGA
CACGTTGCCACCTTTACCGACCCACTCGTAGAATCCCTTCATACTCACAAGCGCTACCGCGCCGATCACCTGATCGAAGC
GTATGAAGCAAAGCACGGCCATGCGCCAGAAAACGGCCTAGCTGATGTTCCAGACCCAGAAACCGGCCAGCCTGGTAACT
GGACCGAACCACAGATGTTCTCAGGTTTGATGAAGACCTACCTCGGCCCCGTGGACAACGAACAGGGGTTGCACTACCTG
CGTCCGGAGACCGCACAAGGCATCTTTGTAAACTTCAAGAACGTGATGACCACGGCTCGTATGAAGCCACCATTCGGTAT
CGCGCAGGTCGGTAAGTCCTTCCGAAACGAAATCACCCCAGGTAACTTCATCTTCCGTACTCGTGAATTCGAACAGATGG
AGATCGAGTACTTCGTGCCAGAAGAACTGGCCGATCAGAAGTTCAACGAATGGGTCGATGACTGCTGGAACTGGTTCGTT
GATCTAGGCATCAACCCAGACAACATGCGCCGCTTCGACGTTCCAGAAGAAGATCGCGCACACTACTCCAAGGGCACCAT
CGACATGGAGTACAAGTTCGGCTTCCAAGGAAACCCTTGGGGCGAGCTCATGGGAGTTGCAAACCGCACCGACTATGACC
TCGGCTGCCACATCAAGGAATCTGGCGAAGACTTGAGCTACTTCGACCAGACCACCGGTGAACGCTACGTGCCATGGGTT
ATTGAGCCTTCCTTCGGTCTAACCCGTGCACTCATGGCTTTCCTCGTCGACGCATACTGCGAAGACGAAGCACCAAACGC
CAAGGGTGGTGTGGACAAGCGCGTTGTGCTCAAGCTCGATCCACGTCTTGCACCAGTCAAGGTTGCTGTTTTGCCATTGT
CCAAGAAGGACACTTTGACACCAGTCGCAGAAGAAGTTGCCGCAAAACTGCGTCAGTTCTGGAACGTCGACTACGACACC
TCCGGTGCAATCGGTCGTCGTTACCGTCGACAAGACGAGATCGGCACCCCATTCTGCGTGACCGTTGACTTTGACACCCT
CGAAGATAACGCCGTGACCGTTCGCGAACGCGACACCATGACCCAAGAACGTGTGGCACTCGCCGATCTGCAGTCTTACC
TCGCAGCTCGTCTGATCGGCTGCTAA

Upstream 100 bases:

>100_bases
AAAGTACTTGACGGGTTAGACTGTCACGAAGGTGCGGATATAAAAGGAATAACCTCCGTCGCCGTTTTATCTCACTACTT
AAAAGGAGCTGTTCAATCCC

Downstream 100 bases:

>100_bases
TATCTCCTATCTCTGGAAGGAAGCCATGGACTTCACTAGCTGGGGTAATCGTCGGAAAAATCACATCGACCTTTTCGACG
ACCATGACAACACCATTGCG

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAQNNVIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGMELKENIKKQWWRTFVQARADVVGLDSSIILPRQVWVASG
HVATFTDPLVESLHTHKRYRADHLIEAYEAKHGHAPENGLADVPDPETGQPGNWTEPQMFSGLMKTYLGPVDNEQGLHYL
RPETAQGIFVNFKNVMTTARMKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEIEYFVPEELADQKFNEWVDDCWNWFV
DLGINPDNMRRFDVPEEDRAHYSKGTIDMEYKFGFQGNPWGELMGVANRTDYDLGCHIKESGEDLSYFDQTTGERYVPWV
IEPSFGLTRALMAFLVDAYCEDEAPNAKGGVDKRVVLKLDPRLAPVKVAVLPLSKKDTLTPVAEEVAAKLRQFWNVDYDT
SGAIGRRYRRQDEIGTPFCVTVDFDTLEDNAVTVRERDTMTQERVALADLQSYLAARLIGC

Sequences:

>Translated_461_residues
MAQNNVIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGMELKENIKKQWWRTFVQARADVVGLDSSIILPRQVWVASG
HVATFTDPLVESLHTHKRYRADHLIEAYEAKHGHAPENGLADVPDPETGQPGNWTEPQMFSGLMKTYLGPVDNEQGLHYL
RPETAQGIFVNFKNVMTTARMKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEIEYFVPEELADQKFNEWVDDCWNWFV
DLGINPDNMRRFDVPEEDRAHYSKGTIDMEYKFGFQGNPWGELMGVANRTDYDLGCHIKESGEDLSYFDQTTGERYVPWV
IEPSFGLTRALMAFLVDAYCEDEAPNAKGGVDKRVVLKLDPRLAPVKVAVLPLSKKDTLTPVAEEVAAKLRQFWNVDYDT
SGAIGRRYRRQDEIGTPFCVTVDFDTLEDNAVTVRERDTMTQERVALADLQSYLAARLIGC
>Mature_460_residues
AQNNVIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGMELKENIKKQWWRTFVQARADVVGLDSSIILPRQVWVASGH
VATFTDPLVESLHTHKRYRADHLIEAYEAKHGHAPENGLADVPDPETGQPGNWTEPQMFSGLMKTYLGPVDNEQGLHYLR
PETAQGIFVNFKNVMTTARMKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEIEYFVPEELADQKFNEWVDDCWNWFVD
LGINPDNMRRFDVPEEDRAHYSKGTIDMEYKFGFQGNPWGELMGVANRTDYDLGCHIKESGEDLSYFDQTTGERYVPWVI
EPSFGLTRALMAFLVDAYCEDEAPNAKGGVDKRVVLKLDPRLAPVKVAVLPLSKKDTLTPVAEEVAAKLRQFWNVDYDTS
GAIGRRYRRQDEIGTPFCVTVDFDTLEDNAVTVRERDTMTQERVALADLQSYLAARLIGC

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=356, Percent_Identity=31.7415730337079, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI70887790, Length=432, Percent_Identity=22.9166666666667, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564541, Length=401, Percent_Identity=29.426433915212, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17554996, Length=401, Percent_Identity=29.426433915212, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325338, Length=465, Percent_Identity=25.5913978494624, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319597, Length=138, Percent_Identity=42.0289855072464, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24664462, Length=360, Percent_Identity=31.3888888888889, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21357965, Length=360, Percent_Identity=31.3888888888889, Blast_Score=154, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 52448; Mature: 52317

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50862 AA_TRNA_LIGASE_II ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNNVIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGMELKENIKKQWWRTFVQARA
CCCCHHHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DVVGLDSSIILPRQVWVASGHVATFTDPLVESLHTHKRYRADHLIEAYEAKHGHAPENGL
HEEECCCCEECCHHEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ADVPDPETGQPGNWTEPQMFSGLMKTYLGPVDNEQGLHYLRPETAQGIFVNFKNVMTTAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHC
MKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEIEYFVPEELADQKFNEWVDDCWNWFV
CCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHE
DLGINPDNMRRFDVPEEDRAHYSKGTIDMEYKFGFQGNPWGELMGVANRTDYDLGCHIKE
ECCCCCCCCEECCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCEEECC
SGEDLSYFDQTTGERYVPWVIEPSFGLTRALMAFLVDAYCEDEAPNAKGGVDKRVVLKLD
CCCCHHHHHHCCCCEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
PRLAPVKVAVLPLSKKDTLTPVAEEVAAKLRQFWNVDYDTSGAIGRRYRRQDEIGTPFCV
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
TVDFDTLEDNAVTVRERDTMTQERVALADLQSYLAARLIGC
EEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQNNVIDTVVNLCKRRGLVYPCGEIYGGTRSAWDYGPLGMELKENIKKQWWRTFVQARA
CCCHHHHHHHHHHHHCCCCEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DVVGLDSSIILPRQVWVASGHVATFTDPLVESLHTHKRYRADHLIEAYEAKHGHAPENGL
HEEECCCCEECCHHEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ADVPDPETGQPGNWTEPQMFSGLMKTYLGPVDNEQGLHYLRPETAQGIFVNFKNVMTTAR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHC
MKPPFGIAQVGKSFRNEITPGNFIFRTREFEQMEIEYFVPEELADQKFNEWVDDCWNWFV
CCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHE
DLGINPDNMRRFDVPEEDRAHYSKGTIDMEYKFGFQGNPWGELMGVANRTDYDLGCHIKE
ECCCCCCCCEECCCCCHHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCEEECC
SGEDLSYFDQTTGERYVPWVIEPSFGLTRALMAFLVDAYCEDEAPNAKGGVDKRVVLKLD
CCCCHHHHHHCCCCEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
PRLAPVKVAVLPLSKKDTLTPVAEEVAAKLRQFWNVDYDTSGAIGRRYRRQDEIGTPFCV
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEE
TVDFDTLEDNAVTVRERDTMTQERVALADLQSYLAARLIGC
EEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]