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The map label for this gene is glk [H]

Identifier: 38234194

GI number: 38234194

Start: 1652199

End: 1653152

Strand: Reverse

Name: glk [H]

Synonym: DIP1619

Alternate gene names: 38234194

Gene position: 1653152-1652199 (Counterclockwise)

Preceding gene: 38234195

Following gene: 38234193

Centisome position: 66.43

GC content: 54.19

Gene sequence:

>954_bases
ATGACGAATATGTCAGAATCTGTCACTGTCGGATTCGACATCGGTGGAACCAATATGCGGGCAGCGGCGGTGACGGATTC
CGGTTTGATCATCGACTCCGTTTCGGTTCCTACCCCTAAATCTTCTGAGGCTCTGGAAAAAGGCATTATTTCTCTGGTAG
CTCAATTGCGGGAAAAGCATGAGGTTTCGGCTGTAGGTCTTGCCGTTGCAGGTTTTTTGGATCCTGATTGCGAAATCGTT
CGCTTTGCTCCTCATCTGCCGTGGCGTGATCGCCCAGTGCGTGCGGAATTAGAGGACGCGTTGGGACTTCCTGTTCGTCT
TGAACATGATGCGAATTCTGCAGCGTGGGGAGAATACCGCTTCGGAGCGGCACGTGGTTCGCAAAACTGGGTCTTATTTG
CGGTTGGCACTGGTATCGGTGCCACACTGATGCATGAGGGTGAGATCTACCGTGGTGCTTTTGGTACAGCTCCTGAGTTC
GGCCACCTTACCGTTGTCCCTCAAGGTCGGCAGTGTTCTTGTGGCAAGAGTGGCTGTTTGGAACGTTATTGTTCCGGCAC
TGCTATTGAAGCGACAGCGCGTGAGCTTCTCGACGCCGATCGTGGCCGCGACTCGATGGTTGCTGCTGCTTATCATTCGG
GCACATTGAGTGGGAAAACTGTGACCGAAGCGGCCCGCCAGGGTGATGTTTTTGCCATCGAGGTCTTTGATGATTTTGCT
GAATGGATGGGCCGCGCCTTGTCTATCGTGTGTGATGTTTTAGATCCGGGACAGATCGTGATTGGTGGCGGGTTGTCCAC
GTCAAGCGATTTGTTCTTGGAAAAGGCTACTCAGCACATGGCACAGCAGATTGTCGGGGCTGGGTATCGCCCCCTTCCGA
CGGTGGTGTGTGCCGAATTGGGTGGCGATGCCGGTATGATCGGGGTATCTGATCTGGCTCGGCGTCGCGTCTAG

Upstream 100 bases:

>100_bases
GCTGCGTTGTGAAGTTCTGCCGTGTCGTCGATATACTTGGAAAGCTATGGCTTGTGCCATTGTGGCGACCGCTGTTGTCT
ACCATTAACGAGGCGAAACA

Downstream 100 bases:

>100_bases
CTTGAGTTCATCGTGTTAGCACATTCGGCTCGGAAAAATAAGGATGAAGCCATGCATAACAAATGGTATTGGACGTTTAA
GCATATTTTGTGGGGGCCTA

Product: glucose kinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTNMSESVTVGFDIGGTNMRAAAVTDSGLIIDSVSVPTPKSSEALEKGIISLVAQLREKHEVSAVGLAVAGFLDPDCEIV
RFAPHLPWRDRPVRAELEDALGLPVRLEHDANSAAWGEYRFGAARGSQNWVLFAVGTGIGATLMHEGEIYRGAFGTAPEF
GHLTVVPQGRQCSCGKSGCLERYCSGTAIEATARELLDADRGRDSMVAAAYHSGTLSGKTVTEAARQGDVFAIEVFDDFA
EWMGRALSIVCDVLDPGQIVIGGGLSTSSDLFLEKATQHMAQQIVGAGYRPLPTVVCAELGGDAGMIGVSDLARRRV

Sequences:

>Translated_317_residues
MTNMSESVTVGFDIGGTNMRAAAVTDSGLIIDSVSVPTPKSSEALEKGIISLVAQLREKHEVSAVGLAVAGFLDPDCEIV
RFAPHLPWRDRPVRAELEDALGLPVRLEHDANSAAWGEYRFGAARGSQNWVLFAVGTGIGATLMHEGEIYRGAFGTAPEF
GHLTVVPQGRQCSCGKSGCLERYCSGTAIEATARELLDADRGRDSMVAAAYHSGTLSGKTVTEAARQGDVFAIEVFDDFA
EWMGRALSIVCDVLDPGQIVIGGGLSTSSDLFLEKATQHMAQQIVGAGYRPLPTVVCAELGGDAGMIGVSDLARRRV
>Mature_316_residues
TNMSESVTVGFDIGGTNMRAAAVTDSGLIIDSVSVPTPKSSEALEKGIISLVAQLREKHEVSAVGLAVAGFLDPDCEIVR
FAPHLPWRDRPVRAELEDALGLPVRLEHDANSAAWGEYRFGAARGSQNWVLFAVGTGIGATLMHEGEIYRGAFGTAPEFG
HLTVVPQGRQCSCGKSGCLERYCSGTAIEATARELLDADRGRDSMVAAAYHSGTLSGKTVTEAARQGDVFAIEVFDDFAE
WMGRALSIVCDVLDPGQIVIGGGLSTSSDLFLEKATQHMAQQIVGAGYRPLPTVVCAELGGDAGMIGVSDLARRRV

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=273, Percent_Identity=29.3040293040293, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI298566325, Length=273, Percent_Identity=29.3040293040293, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4885285, Length=273, Percent_Identity=29.3040293040293, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI190014632, Length=273, Percent_Identity=29.3040293040293, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786891, Length=285, Percent_Identity=29.4736842105263, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1787878, Length=267, Percent_Identity=26.5917602996255, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI87081733, Length=318, Percent_Identity=27.9874213836478, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787363, Length=272, Percent_Identity=29.7794117647059, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082230, Length=296, Percent_Identity=29.0540540540541, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082127, Length=284, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790522, Length=327, Percent_Identity=23.8532110091743, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33513; Mature: 33382

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNMSESVTVGFDIGGTNMRAAAVTDSGLIIDSVSVPTPKSSEALEKGIISLVAQLREKH
CCCCCCCEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
EVSAVGLAVAGFLDPDCEIVRFAPHLPWRDRPVRAELEDALGLPVRLEHDANSAAWGEYR
HHHHHHEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCEE
FGAARGSQNWVLFAVGTGIGATLMHEGEIYRGAFGTAPEFGHLTVVPQGRQCSCGKSGCL
EEECCCCCCEEEEEECCCCCEEEEECCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHH
ERYCSGTAIEATARELLDADRGRDSMVAAAYHSGTLSGKTVTEAARQGDVFAIEVFDDFA
HHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
EWMGRALSIVCDVLDPGQIVIGGGLSTSSDLFLEKATQHMAQQIVGAGYRPLPTVVCAEL
HHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGDAGMIGVSDLARRRV
CCCCCEEEHHHHHHCCC
>Mature Secondary Structure 
TNMSESVTVGFDIGGTNMRAAAVTDSGLIIDSVSVPTPKSSEALEKGIISLVAQLREKH
CCCCCCEEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
EVSAVGLAVAGFLDPDCEIVRFAPHLPWRDRPVRAELEDALGLPVRLEHDANSAAWGEYR
HHHHHHEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCEE
FGAARGSQNWVLFAVGTGIGATLMHEGEIYRGAFGTAPEFGHLTVVPQGRQCSCGKSGCL
EEECCCCCCEEEEEECCCCCEEEEECCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHH
ERYCSGTAIEATARELLDADRGRDSMVAAAYHSGTLSGKTVTEAARQGDVFAIEVFDDFA
HHHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCEEEEEHHHHHH
EWMGRALSIVCDVLDPGQIVIGGGLSTSSDLFLEKATQHMAQQIVGAGYRPLPTVVCAEL
HHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GGDAGMIGVSDLARRRV
CCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]