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The map label for this gene is nhaK [H]

Identifier: 38233783

GI number: 38233783

Start: 1191785

End: 1193359

Strand: Direct

Name: nhaK [H]

Synonym: DIP1193

Alternate gene names: 38233783

Gene position: 1191785-1193359 (Clockwise)

Preceding gene: 38233782

Following gene: 38233784

Centisome position: 47.89

GC content: 48.44

Gene sequence:

>1575_bases
ATGGAAATTCTTATTGGTTTGCTAGCGTTGCTTTTTGCAACGGTCATCATGGTCGCCGTCGGAGACCGAACCGGTCTGCC
ATGGCCTGTGTTACTTACCTTGGTTGCTGCCGGTGGAATTTTTCTTCCGTGGCTTCCCGAAGTAGCGATTCCTGAAGAGA
TGATCCTCCCGATTTTTATTCCGCCATTGCTATGGGCACTGGCGCGACATAGCAGCTGGGCGTCGATTAAAAGGCAGTGG
CGAACCGTAGTTTTGCTTTCAGTTCTATTAGTTATAGTTACTGCAGTTACGGTGGGTCTTGTCGCATATTTATTAGTACC
AACTCTCTCATTTGCAGCTGCGGTTGTTATTGGCGCAGCCATTTCTCCTCCAGACCCCGTAGCTGTTGATGCTGTTGCAG
AACCGGCAGGTGTTCCACGACGATTATCTAATACGCTTCAAGTTGAAGGCCTCTTTAATGATGCTGCTTCGATCGTCGTT
TTTAATTTGGCATTGTCAGTGGTGCAGTCTGGGCACGATATCACTTGGTGGTCGGCGCTATCTACATTGGTATATTCAGC
AGCGGTCGCCGTGGTTATTGGTTTTGTCTTGGGAACCGGATGTGCAAAACTCCATTCTTGGATGACTTCATCAGTTGCTA
GGAATGCATTCACGTGGGTCATTCCGTTTGCTACTTTTATCGCTGCTGAGGAATTGCATGCTTCGGGTGTTATTGCCATC
GTTATTGCTGCGATCCAATTTAATTCCAAGAGTCAAGCTGGTGCCGAGGATAGATTGTCTGGATCGGCTTTTTGGCAGGT
AGTTGAGCTGCTTTTTACTGGTGTGGCATTCGGACTCATTGGAATTTCGGTGCGTGATGCGATCCATTCTGCTGGAGCGA
ACCTGTGGCATGGGGTGTGGTTCGGCCTAGTGCTGGCATTGACTGCCATCGCAGTGCGGGCACTGTGGCTGTACTTGCTC
TATGTAGGGAACAAAAAGGCGGGTAGACGAACTGGTGCACCGTTACGACTCCAAGAAGTACTGTTACTAACTTGGGGTGG
AATGCGTGGATTAGTCACTTTGGCGCTCGTATTGTCAATCCCGATGACTACCGGATTTGCAATTTACCGAGAGCTTTCTA
TTGTCGCACTTACTGTTTTGCTTGTAACGATGGTGATTCCTGGCCTGACACTTCCTGCTCTCATGAGGGTATTAAACCTC
GAAGAAGGTCCGGATGCTTTTGGCGATTACGCACGTGAAAAGCTATTTGTTCGCGCCAGATTTGCTGCACGACAAGTGCT
GGATTCCTATTCTCATGACATCCCAGAAGAATTTATGGCTTCCTTACGGCGTCGCTTCGAACATGACATTAATGCTGATG
AAGATGACGACGATGCCATGACACCTGAAGAGCGTCGCAAGATTCAAGAGCGTCGTTTTGCTCTGTTTAATAAAGTACGG
CTTGAAGCCTTGTATGCTTCTCAAGCTGAGTTACTTCGAGCCAGAAGCGAGCGGGACGTCGATCCGATGATTGTTGACGA
AGTTCTGTTTGAAATCGACAGCCAGATCATCGCCGCCGAGAAATCAACGAGATAA

Upstream 100 bases:

>100_bases
CCCCCTGATCGACCGGGCGGTGAGCTCCTTAGAGATAGTGCAATCGCTATGATTGATTACGTCACTGTACTCAGTTAATT
CAAGGAGCTCATCGGGTTAG

Downstream 100 bases:

>100_bases
TAAGGGCATTTCTTCATCATGATGACAGTACTGAGATCGCAAATTGAATCGATCTTGTTGGTCGTGGACCAACCGGCTTC
TGTTGCTGCCTTGGCGCGAG

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MEILIGLLALLFATVIMVAVGDRTGLPWPVLLTLVAAGGIFLPWLPEVAIPEEMILPIFIPPLLWALARHSSWASIKRQW
RTVVLLSVLLVIVTAVTVGLVAYLLVPTLSFAAAVVIGAAISPPDPVAVDAVAEPAGVPRRLSNTLQVEGLFNDAASIVV
FNLALSVVQSGHDITWWSALSTLVYSAAVAVVIGFVLGTGCAKLHSWMTSSVARNAFTWVIPFATFIAAEELHASGVIAI
VIAAIQFNSKSQAGAEDRLSGSAFWQVVELLFTGVAFGLIGISVRDAIHSAGANLWHGVWFGLVLALTAIAVRALWLYLL
YVGNKKAGRRTGAPLRLQEVLLLTWGGMRGLVTLALVLSIPMTTGFAIYRELSIVALTVLLVTMVIPGLTLPALMRVLNL
EEGPDAFGDYAREKLFVRARFAARQVLDSYSHDIPEEFMASLRRRFEHDINADEDDDDAMTPEERRKIQERRFALFNKVR
LEALYASQAELLRARSERDVDPMIVDEVLFEIDSQIIAAEKSTR

Sequences:

>Translated_524_residues
MEILIGLLALLFATVIMVAVGDRTGLPWPVLLTLVAAGGIFLPWLPEVAIPEEMILPIFIPPLLWALARHSSWASIKRQW
RTVVLLSVLLVIVTAVTVGLVAYLLVPTLSFAAAVVIGAAISPPDPVAVDAVAEPAGVPRRLSNTLQVEGLFNDAASIVV
FNLALSVVQSGHDITWWSALSTLVYSAAVAVVIGFVLGTGCAKLHSWMTSSVARNAFTWVIPFATFIAAEELHASGVIAI
VIAAIQFNSKSQAGAEDRLSGSAFWQVVELLFTGVAFGLIGISVRDAIHSAGANLWHGVWFGLVLALTAIAVRALWLYLL
YVGNKKAGRRTGAPLRLQEVLLLTWGGMRGLVTLALVLSIPMTTGFAIYRELSIVALTVLLVTMVIPGLTLPALMRVLNL
EEGPDAFGDYAREKLFVRARFAARQVLDSYSHDIPEEFMASLRRRFEHDINADEDDDDAMTPEERRKIQERRFALFNKVR
LEALYASQAELLRARSERDVDPMIVDEVLFEIDSQIIAAEKSTR
>Mature_524_residues
MEILIGLLALLFATVIMVAVGDRTGLPWPVLLTLVAAGGIFLPWLPEVAIPEEMILPIFIPPLLWALARHSSWASIKRQW
RTVVLLSVLLVIVTAVTVGLVAYLLVPTLSFAAAVVIGAAISPPDPVAVDAVAEPAGVPRRLSNTLQVEGLFNDAASIVV
FNLALSVVQSGHDITWWSALSTLVYSAAVAVVIGFVLGTGCAKLHSWMTSSVARNAFTWVIPFATFIAAEELHASGVIAI
VIAAIQFNSKSQAGAEDRLSGSAFWQVVELLFTGVAFGLIGISVRDAIHSAGANLWHGVWFGLVLALTAIAVRALWLYLL
YVGNKKAGRRTGAPLRLQEVLLLTWGGMRGLVTLALVLSIPMTTGFAIYRELSIVALTVLLVTMVIPGLTLPALMRVLNL
EEGPDAFGDYAREKLFVRARFAARQVLDSYSHDIPEEFMASLRRRFEHDINADEDDDDAMTPEERRKIQERRFALFNKVR
LEALYASQAELLRARSERDVDPMIVDEVLFEIDSQIIAAEKSTR

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=403, Percent_Identity=23.8213399503722, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI148727259, Length=382, Percent_Identity=23.5602094240838, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790501, Length=554, Percent_Identity=25.2707581227437, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25147678, Length=300, Percent_Identity=24, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25150332, Length=392, Percent_Identity=21.9387755102041, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=370, Percent_Identity=23.5135135135135, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999817, Length=370, Percent_Identity=23.5135135135135, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71999821, Length=370, Percent_Identity=23.5135135135135, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 57092; Mature: 57092

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA