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The map label for this gene is bioA [H]

Identifier: 38233781

GI number: 38233781

Start: 1189692

End: 1190987

Strand: Direct

Name: bioA [H]

Synonym: DIP1191

Alternate gene names: 38233781

Gene position: 1189692-1190987 (Clockwise)

Preceding gene: 38233779

Following gene: 38233782

Centisome position: 47.81

GC content: 48.38

Gene sequence:

>1296_bases
TTGGAAAATAATTCATTCGCACAATTTGATCGTGATCATATTTGGCATCCTTATGGCCCGATGCCGGCTACGGTTGCCCC
CTACGTAGTTGCAGCCACTAACAACACGGACATCATTCTAGACAACGGAACGCGCTTAATCGACGGAATGAGTTCATGGT
GGGCTGCCGCCTTCGGGCATGGGAACGAGAGGCTTAAAGCGGCTGCTCATCGCCAAATTGACGTGATGAGCCATGTCATG
TTTGGTGGCTTGACGCATGTGCCTGCGATTAAGCTTGCACGTCAATTGTGTGAACTTACGGACGAACCTCTTACCAAGGT
TTTCTTTTCTGATTCGGGATCTGTTGCCGTAGAAGTGGCACTGAAGATGGTGTATCAATACCAGCTTGGGCAAGGGCATC
CCGAACGGCGTCGTATGTTGACCTGGCGTGGTGGGTATCACGGCGACACCTTTGCCACGATGAGCTTGTGTGATCCAGAG
GGGGGAATGCACGCAATGTGGGAGGGGCGCGTAATGGATAATGTTTTTGCGTCTCGGCCGCCGCTGTGGGGCGCTGCATC
AAATGAAATTTCTGCATACATAGATCATCTCGATTCGTTGATTGATTCAACAATTGCCGGCATCATCGTTGAACCCGTTG
TTCAAGGAGCTGGTGGCATGCGATTCCACGCTCCAGAGATTCTCAAAGGTATTCGACAGCTTTGTGATCAACATGGAATT
TTATTTATCGCAGATGAAATTGCGACTGGTTTTGGTAGAACGGGTAACTTATTTGCCACTCAAGCTGCAAAAGTAACTCC
TGACATTCTTTGTGTTGGAAAGTCATTAACTGGCGGGTTTATGTCGTTAGCTGCAACCATCACCACGGATGCTGTGGCAG
AAAGTATTTCTTCCGCTGCCGGAGGAGGAGCACTAATGCATGGACCAACATTTATGGGAAACCCGTTGGCATGTGCTGTT
GCTAGCGAAGCATTAAGCATTATTGCAGAAGGTGATTGGAAGCAGCAGGTTGCAGAAATTGAAAGCGAGCTAAAAAAAGG
GCTTGTTCCGCTAGCTTCCAACCCTGCTGTTCGTGACGTAAGAGTCCTCGGTGCAATTGGTGTAGTTGAAATGAAAGAAC
CTGTTGACATGAAACGTGCTACTCATGCTGCTGTGAACGCAGGTGTATGGCTCCGTCCTTTCGGCAGGCTCGTATACACA
ATGCCTCCATTTGTCTGTACTCATAAACAAATACAAAAGATTTCGTGTGCAATTGCTTCTATCGTGCATACGGAGCAGGA
ACGTTTCGAACGCTAA

Upstream 100 bases:

>100_bases
GAACGCTGTTCAATTAATTGCATACCGTACATTATTACCAAAAGGGGAACAATTGTCAGTCGATTGGTCGTACAATTAAA
CGGTGTTCAATACTGATGAG

Downstream 100 bases:

>100_bases
AGGAGAAATGTAATGGCAATCGTAGTTGTAACCGGTACAAACACAGATGTAGGAAAGACAATCGCTTCCGCTGCAGTATG
TCAGCATTATTCACGACAAG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MENNSFAQFDRDHIWHPYGPMPATVAPYVVAATNNTDIILDNGTRLIDGMSSWWAAAFGHGNERLKAAAHRQIDVMSHVM
FGGLTHVPAIKLARQLCELTDEPLTKVFFSDSGSVAVEVALKMVYQYQLGQGHPERRRMLTWRGGYHGDTFATMSLCDPE
GGMHAMWEGRVMDNVFASRPPLWGAASNEISAYIDHLDSLIDSTIAGIIVEPVVQGAGGMRFHAPEILKGIRQLCDQHGI
LFIADEIATGFGRTGNLFATQAAKVTPDILCVGKSLTGGFMSLAATITTDAVAESISSAAGGGALMHGPTFMGNPLACAV
ASEALSIIAEGDWKQQVAEIESELKKGLVPLASNPAVRDVRVLGAIGVVEMKEPVDMKRATHAAVNAGVWLRPFGRLVYT
MPPFVCTHKQIQKISCAIASIVHTEQERFER

Sequences:

>Translated_431_residues
MENNSFAQFDRDHIWHPYGPMPATVAPYVVAATNNTDIILDNGTRLIDGMSSWWAAAFGHGNERLKAAAHRQIDVMSHVM
FGGLTHVPAIKLARQLCELTDEPLTKVFFSDSGSVAVEVALKMVYQYQLGQGHPERRRMLTWRGGYHGDTFATMSLCDPE
GGMHAMWEGRVMDNVFASRPPLWGAASNEISAYIDHLDSLIDSTIAGIIVEPVVQGAGGMRFHAPEILKGIRQLCDQHGI
LFIADEIATGFGRTGNLFATQAAKVTPDILCVGKSLTGGFMSLAATITTDAVAESISSAAGGGALMHGPTFMGNPLACAV
ASEALSIIAEGDWKQQVAEIESELKKGLVPLASNPAVRDVRVLGAIGVVEMKEPVDMKRATHAAVNAGVWLRPFGRLVYT
MPPFVCTHKQIQKISCAIASIVHTEQERFER
>Mature_431_residues
MENNSFAQFDRDHIWHPYGPMPATVAPYVVAATNNTDIILDNGTRLIDGMSSWWAAAFGHGNERLKAAAHRQIDVMSHVM
FGGLTHVPAIKLARQLCELTDEPLTKVFFSDSGSVAVEVALKMVYQYQLGQGHPERRRMLTWRGGYHGDTFATMSLCDPE
GGMHAMWEGRVMDNVFASRPPLWGAASNEISAYIDHLDSLIDSTIAGIIVEPVVQGAGGMRFHAPEILKGIRQLCDQHGI
LFIADEIATGFGRTGNLFATQAAKVTPDILCVGKSLTGGFMSLAATITTDAVAESISSAAGGGALMHGPTFMGNPLACAV
ASEALSIIAEGDWKQQVAEIESELKKGLVPLASNPAVRDVRVLGAIGVVEMKEPVDMKRATHAAVNAGVWLRPFGRLVYT
MPPFVCTHKQIQKISCAIASIVHTEQERFER

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=360, Percent_Identity=29.7222222222222, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=27.2289156626506, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI284507298, Length=218, Percent_Identity=33.4862385321101, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI37574042, Length=365, Percent_Identity=26.027397260274, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI226442709, Length=347, Percent_Identity=26.2247838616715, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI226442705, Length=365, Percent_Identity=25.7534246575342, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI24119277, Length=360, Percent_Identity=25.5555555555556, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=52.9832935560859, Blast_Score=440, Evalue=1e-125,
Organism=Escherichia coli, GI1789016, Length=332, Percent_Identity=32.2289156626506, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=30.1790281329923, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788044, Length=304, Percent_Identity=32.5657894736842, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI145693181, Length=348, Percent_Identity=30.1724137931034, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1787560, Length=386, Percent_Identity=31.0880829015544, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786349, Length=376, Percent_Identity=26.5957446808511, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=25.9953161592506, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=411, Percent_Identity=25.3041362530414, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=357, Percent_Identity=23.249299719888, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541228, Length=216, Percent_Identity=27.3148148148148, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=39.6929824561403, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324432, Length=344, Percent_Identity=28.7790697674419, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323470, Length=369, Percent_Identity=26.8292682926829, Blast_Score=105, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=26.491646778043, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161085790, Length=378, Percent_Identity=28.042328042328, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28574759, Length=378, Percent_Identity=28.042328042328, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356575, Length=370, Percent_Identity=25.9459459459459, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46593; Mature: 46593

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNSFAQFDRDHIWHPYGPMPATVAPYVVAATNNTDIILDNGTRLIDGMSSWWAAAFGH
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCHHHHHHHHHCC
GNERLKAAAHRQIDVMSHVMFGGLTHVPAIKLARQLCELTDEPLTKVFFSDSGSVAVEVA
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHH
LKMVYQYQLGQGHPERRRMLTWRGGYHGDTFATMSLCDPEGGMHAMWEGRVMDNVFASRP
HHHHHHHHCCCCCHHHHCEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHCCC
PLWGAASNEISAYIDHLDSLIDSTIAGIIVEPVVQGAGGMRFHAPEILKGIRQLCDQHGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCE
LFIADEIATGFGRTGNLFATQAAKVTPDILCVGKSLTGGFMSLAATITTDAVAESISSAA
EEEEHHHHHCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
GGGALMHGPTFMGNPLACAVASEALSIIAEGDWKQQVAEIESELKKGLVPLASNPAVRDV
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RVLGAIGVVEMKEPVDMKRATHAAVNAGVWLRPFGRLVYTMPPFVCTHKQIQKISCAIAS
HHHHHCCEEECCCCCHHHHHHHHHHCCCEEECHHHCCHHCCCCHHHHHHHHHHHHHHHHH
IVHTEQERFER
HHHHHHHHHCC
>Mature Secondary Structure
MENNSFAQFDRDHIWHPYGPMPATVAPYVVAATNNTDIILDNGTRLIDGMSSWWAAAFGH
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCHHHHHHHHHCC
GNERLKAAAHRQIDVMSHVMFGGLTHVPAIKLARQLCELTDEPLTKVFFSDSGSVAVEVA
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHH
LKMVYQYQLGQGHPERRRMLTWRGGYHGDTFATMSLCDPEGGMHAMWEGRVMDNVFASRP
HHHHHHHHCCCCCHHHHCEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHCCC
PLWGAASNEISAYIDHLDSLIDSTIAGIIVEPVVQGAGGMRFHAPEILKGIRQLCDQHGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCE
LFIADEIATGFGRTGNLFATQAAKVTPDILCVGKSLTGGFMSLAATITTDAVAESISSAA
EEEEHHHHHCCCCCCCEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
GGGALMHGPTFMGNPLACAVASEALSIIAEGDWKQQVAEIESELKKGLVPLASNPAVRDV
CCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RVLGAIGVVEMKEPVDMKRATHAAVNAGVWLRPFGRLVYTMPPFVCTHKQIQKISCAIAS
HHHHHCCEEECCCCCHHHHHHHHHHCCCEEECHHHCCHHCCCCHHHHHHHHHHHHHHHHH
IVHTEQERFER
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8161820; 12948626 [H]