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The map label for this gene is argH

Identifier: 38233764

GI number: 38233764

Start: 1166704

End: 1168137

Strand: Direct

Name: argH

Synonym: DIP1174

Alternate gene names: 38233764

Gene position: 1166704-1168137 (Clockwise)

Preceding gene: 38233763

Following gene: 38233765

Centisome position: 46.88

GC content: 50.21

Gene sequence:

>1434_bases
GTGCAAAAACACGGTACTAATGAAGGCGCGCTTTGGGGCGGCCGCTTCTCTGGCGGCCCTTCAGAGGCGATGTTCGCGTT
ATCTGTATCTACGCACTTTGACTGGGTTTTAGCTCCGTACGATGTTCTAGCCTCAAAAGCCCATGCTCGTGTTTTGAACA
AGGCGAAACTACTTTCTGACTCCGATTTAGAGACAATGCTTGGCGGTCTCGACAAGTTGGGTAAGGCTGTAGCTTCTGGT
GAATTCAAGCCATTGCCGACCGATGAGGACGTCCATGGCGCAATGGAGCGCGGACTTATCGACATCGTGGGCCCTGAAGT
AGGCGGACGCCTGCGTGCTGGTCGTTCCCGAAACGATCAGGTTGCCACCTTGTTCAGGATGTGGGTTCGTGATGCCGTGC
GTTCAGTAGCCTTGCAGGTTACCGAGCTTGTCGATGCCTTGGCATATCAAGCGACTCAGCATCCTCGTGCGATTATGCCT
GGAAAGACGCATTCCCAAGCAGCCCAGCCTGTTTTGCTAGCACATCAGTTGCTCGCTCATGCGCAGCCGTTGCTTCGTGA
CATCGATCGTATTCGAGATCTAGATAAACGCCTTGCTATTTCTCCATATGGTTCAGGTGCATTAGCTGGTTCATCTTTAC
ACTTGGATCCTGAGGCGATTGCCCAGGAGTTAGGATTCGACTCAGCGTGTGATAACTCGATTGATGGTACGTCTTCGCGT
GACTTTGCAGCGGAAACTGCATATGTTCTCGCGCAAATTGCCATTGACATGTCGCGATTAGCTGAAGAAATTATTTACTG
GTGTACACCAGAGTACGGCTATGTAACTCTTTCTGATGCTTGGTCAACTGGCTCATCAATCATGCCGCAAAAGAAGAATC
CTGATGTTGCTGAATTAACTCGAGGCAAGACTGGACGCTTGATCGGAAATCTTTCAGGGCTTTTGGCAACGCTTAAAGCT
CAGCCGCTTGCCTACAACAGAGATCTTCAGGAAGATAAAGAGCCGATTGTTGATTCGTTTGCTCAGTTGAATTTGTTGCT
TCCAGCTATGACTGGTCTCGTTTCTACGCTTACTTTCCACGAAGACCGACTTCTTTCTTTAGCACCAGCAGGATTTACTC
TTGCTACTGACTTGGCTGAGTGGATGGTACGTCAAGGTGTTCCATTCCGCGAAGCTCACGAAGCTTCCGGTGCATGCGTT
AGGATCGCAGAATCTCGTGGTGTAGGCCTCGACGAGCTGACTGATGATGAACTCGCTTCCGTAGATGTACGCTTGACGCC
CGAGGTACGTACAGTGCTTACTGTCGAAGGTGCTGTTGCATCGCGAGCTACACGCGGTGGGACAGCAGGTGTAAGAGTTG
AAGAACAACGTTCTCGAGTAGAATCCACCTCTCAATCTTTTAAAGAATGGGCGCTAACTCCTGTTCGTAAATGA

Upstream 100 bases:

>100_bases
ACACCGGTGATACCTTCGACCAGACCTTGGCTAAGGGCTTTGTGGAACTTCACGGTTTGTCATCCAAGATCTCGAACAAG
CGTGACCGTGAGGCACAATA

Downstream 100 bases:

>100_bases
CATTGAAAATGCCAGTGAATAGATACACTGGCATTTTTCTTATTTGGGGTAGCGATATCAGTATTGCCTTTTGAGATAGG
TACAATGCCAATCATGAGTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MQKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHARVLNKAKLLSDSDLETMLGGLDKLGKAVASG
EFKPLPTDEDVHGAMERGLIDIVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRSVALQVTELVDALAYQATQHPRAIMP
GKTHSQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAISPYGSGALAGSSLHLDPEAIAQELGFDSACDNSIDGTSSR
DFAAETAYVLAQIAIDMSRLAEEIIYWCTPEYGYVTLSDAWSTGSSIMPQKKNPDVAELTRGKTGRLIGNLSGLLATLKA
QPLAYNRDLQEDKEPIVDSFAQLNLLLPAMTGLVSTLTFHEDRLLSLAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVGLDELTDDELASVDVRLTPEVRTVLTVEGAVASRATRGGTAGVRVEEQRSRVESTSQSFKEWALTPVRK

Sequences:

>Translated_477_residues
MQKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHARVLNKAKLLSDSDLETMLGGLDKLGKAVASG
EFKPLPTDEDVHGAMERGLIDIVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRSVALQVTELVDALAYQATQHPRAIMP
GKTHSQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAISPYGSGALAGSSLHLDPEAIAQELGFDSACDNSIDGTSSR
DFAAETAYVLAQIAIDMSRLAEEIIYWCTPEYGYVTLSDAWSTGSSIMPQKKNPDVAELTRGKTGRLIGNLSGLLATLKA
QPLAYNRDLQEDKEPIVDSFAQLNLLLPAMTGLVSTLTFHEDRLLSLAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVGLDELTDDELASVDVRLTPEVRTVLTVEGAVASRATRGGTAGVRVEEQRSRVESTSQSFKEWALTPVRK
>Mature_477_residues
MQKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHARVLNKAKLLSDSDLETMLGGLDKLGKAVASG
EFKPLPTDEDVHGAMERGLIDIVGPEVGGRLRAGRSRNDQVATLFRMWVRDAVRSVALQVTELVDALAYQATQHPRAIMP
GKTHSQAAQPVLLAHQLLAHAQPLLRDIDRIRDLDKRLAISPYGSGALAGSSLHLDPEAIAQELGFDSACDNSIDGTSSR
DFAAETAYVLAQIAIDMSRLAEEIIYWCTPEYGYVTLSDAWSTGSSIMPQKKNPDVAELTRGKTGRLIGNLSGLLATLKA
QPLAYNRDLQEDKEPIVDSFAQLNLLLPAMTGLVSTLTFHEDRLLSLAPAGFTLATDLAEWMVRQGVPFREAHEASGACV
RIAESRGVGLDELTDDELASVDVRLTPEVRTVLTVEGAVASRATRGGTAGVRVEEQRSRVESTSQSFKEWALTPVRK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=462, Percent_Identity=42.2077922077922, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI68303542, Length=462, Percent_Identity=42.2077922077922, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI68303549, Length=462, Percent_Identity=40.04329004329, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI68303547, Length=462, Percent_Identity=39.6103896103896, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1790398, Length=447, Percent_Identity=39.5973154362416, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=39.647577092511, Blast_Score=330, Evalue=2e-91,
Organism=Drosophila melanogaster, GI221473854, Length=446, Percent_Identity=38.7892376681614, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI78706858, Length=446, Percent_Identity=38.7892376681614, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_CORDI (Q6NHG4)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939531.1
- ProteinModelPortal:   Q6NHG4
- SMR:   Q6NHG4
- GeneID:   2649726
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1174
- NMPDR:   fig|257309.1.peg.1122
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- ProtClustDB:   PRK00855
- BioCyc:   CDIP257309:DIP1174-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51574; Mature: 51574

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHARVLNKAKLLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
SDLETMLGGLDKLGKAVASGEFKPLPTDEDVHGAMERGLIDIVGPEVGGRLRAGRSRNDQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCHH
VATLFRMWVRDAVRSVALQVTELVDALAYQATQHPRAIMPGKTHSQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAISPYGSGALAGSSLHLDPEAIAQELGFDSACDNSIDGTSSR
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
DFAAETAYVLAQIAIDMSRLAEEIIYWCTPEYGYVTLSDAWSTGSSIMPQKKNPDVAELT
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKTGRLIGNLSGLLATLKAQPLAYNRDLQEDKEPIVDSFAQLNLLLPAMTGLVSTLTFH
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EDRLLSLAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVGLDELTDDELAS
CCHHHEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHE
VDVRLTPEVRTVLTVEGAVASRATRGGTAGVRVEEQRSRVESTSQSFKEWALTPVRK
EEEEECCCEEEEEEECCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQKHGTNEGALWGGRFSGGPSEAMFALSVSTHFDWVLAPYDVLASKAHARVLNKAKLLSD
CCCCCCCCCCEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHCCC
SDLETMLGGLDKLGKAVASGEFKPLPTDEDVHGAMERGLIDIVGPEVGGRLRAGRSRNDQ
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCCCCHH
VATLFRMWVRDAVRSVALQVTELVDALAYQATQHPRAIMPGKTHSQAAQPVLLAHQLLAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQPLLRDIDRIRDLDKRLAISPYGSGALAGSSLHLDPEAIAQELGFDSACDNSIDGTSSR
HHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
DFAAETAYVLAQIAIDMSRLAEEIIYWCTPEYGYVTLSDAWSTGSSIMPQKKNPDVAELT
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
RGKTGRLIGNLSGLLATLKAQPLAYNRDLQEDKEPIVDSFAQLNLLLPAMTGLVSTLTFH
CCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EDRLLSLAPAGFTLATDLAEWMVRQGVPFREAHEASGACVRIAESRGVGLDELTDDELAS
CCHHHEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHE
VDVRLTPEVRTVLTVEGAVASRATRGGTAGVRVEEQRSRVESTSQSFKEWALTPVRK
EEEEECCCEEEEEEECCHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910