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The map label for this gene is serA [H]

Identifier: 38233698

GI number: 38233698

Start: 1090278

End: 1091873

Strand: Direct

Name: serA [H]

Synonym: DIP1104

Alternate gene names: 38233698

Gene position: 1090278-1091873 (Clockwise)

Preceding gene: 38233697

Following gene: 38233699

Centisome position: 43.81

GC content: 52.38

Gene sequence:

>1596_bases
GTGAGCCAGAATGGCCGTCCTGTCGTCCTAATTGCAGACAAACTCGCGCAGTCAACTGTTGATGCGCTCGGAGATGCCGT
GGAGGTGCGCTGGGTCGATGGTCCAAATCGCGCAGAGCTGCTTGCAGCGGTTCCAGAGGCTGACGCACTTCTTGTTCGTT
CCGCTACCACCGTAGATGAAGAAGTCCTCAATGCGGCGACCAACCTTAAGATTGTCGGTCGCGCTGGTGTTGGCTTGGAC
AATGTTGATATTGCCACCGCGACTGATAAGGGGGTGATGGTGGCAAATGCCCCAACCTCCAATATTCATTCTGCGTGTGA
GCATGCTATTTCGTTGTTGCTTTCTACTGCACGTCAGATTCCTGCAGCAGATAAAACGCTTCGTGTTGGCGAATGGAAGC
GTTCTTCGTTCAAAGGTGTGGAAATTTTTGGCAAGACCGTTGGTATTGTCGGATTTGGCCATATTGGTCAGCTTTTTGCG
CAACGCCTCGCAGCATTTGAGGCGACTATCATTGCGTACGATCCTTACGCTAATCCAGCGCGTGCTGCGCAGTTGGGTGT
AGAGCTTGTGGATCTAGAATCGCTCATGCAGCGTGCGGATTTTGTCACCATCCACTTGCCTAAGACTGCAGAAACTGCTG
GCATGTTCAATGCCGAGTTGTTGGCTAAGTCCAAACAGGGGCAGATTATTATCAATGCGGCACGTGGCGGGCTTGTCGAC
GAGCAAGCGCTCGCCGATGCTATTGACGCTGGCCGGATTCGTGGCGCTGGTTTCGATGTTTTTGCAACTGAGCCATGCAC
AGATTCGCCACTGTTTAACCGTCCAGAGGTTGTGGTTACTCCGCATTTGGGTGCTTCAACTGTAGAAGCGCAGGATCGTG
CCGGTACGGATGTTGCCGCATCTGTTCTCAAGGCCTTGGCAGGCGAGTTTGTCCCAGATGCAGTGAATGTTTCGGGCGGA
CGCGTTGGCGAAGAAGTTGCTTTGTGGCTTGATTTGGCTCGCAAGCTTGGCGTGGTTGCTGGCAAGCTTTTGGATAAGGC
TCCAGTAGCTGTTGAAGTTGAGGCTCGCGGCGAGCTATCGACGGAAAACATCGATGTCCTAGGTCTGTCGGCATTGCGTG
GCGTCTTCTCTTCGTTTATTGAAGAACCAGTTACGTTTGTCAATGCCCCGCGTATTGCAGAAGAGCGTGGCGTAAAGCTG
GATGTTACTACTGCGTCCGAATCCCTTACACACCGTTCTGTGCTTGAGGTCTGTGTGATTGGAGCCGATGGTTCTAAAGA
ATCCGTCATTGGTGCTTTGACCGGCCTCAATCATGTGGAAAAGATTGTTCGCATTAACAAGCGTGGTTTGGATCTTCGTG
CTCAAGGATTCAATGTGTACTTCCAGTACACCGACACTCCTGGTGCTCTAGGCAAGGTTGGCACAGCATTGGGTGCTCAG
GGGTTCAATATTGACGCGGCTGCTTTGTCTCAGGATTCTGAAGGCGATGGCGCCACGTTGGTGCTTCGTGTTGACAAGCC
TATTCCAGATGCATTGGTCGAAGAGATCGCTGCCGGAATTGGTGCAGAAGCCTTCGCTGTCGACTTTGATGCCTAA

Upstream 100 bases:

>100_bases
TGTTGCAGTCGCGCGCCAGTGAGCAGGCGCGGACCCATTGCTATCTGACGCGGTCGTGCCAGATAGGGGTGGACATGCGG
ATAATTTCCAGGAGAATATC

Downstream 100 bases:

>100_bases
TTTATACACCGACGTTCAACGGACCTTTCCCCCCTAAAAGTACTGGGGGAAAGGTCCGTTTGTGCTTTGGCGTCAGTTTT
TGGGGATCGGTCTGCTACAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRAELLAAVPEADALLVRSATTVDEEVLNAATNLKIVGRAGVGLD
NVDIATATDKGVMVANAPTSNIHSACEHAISLLLSTARQIPAADKTLRVGEWKRSSFKGVEIFGKTVGIVGFGHIGQLFA
QRLAAFEATIIAYDPYANPARAAQLGVELVDLESLMQRADFVTIHLPKTAETAGMFNAELLAKSKQGQIIINAARGGLVD
EQALADAIDAGRIRGAGFDVFATEPCTDSPLFNRPEVVVTPHLGASTVEAQDRAGTDVAASVLKALAGEFVPDAVNVSGG
RVGEEVALWLDLARKLGVVAGKLLDKAPVAVEVEARGELSTENIDVLGLSALRGVFSSFIEEPVTFVNAPRIAEERGVKL
DVTTASESLTHRSVLEVCVIGADGSKESVIGALTGLNHVEKIVRINKRGLDLRAQGFNVYFQYTDTPGALGKVGTALGAQ
GFNIDAAALSQDSEGDGATLVLRVDKPIPDALVEEIAAGIGAEAFAVDFDA

Sequences:

>Translated_531_residues
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRAELLAAVPEADALLVRSATTVDEEVLNAATNLKIVGRAGVGLD
NVDIATATDKGVMVANAPTSNIHSACEHAISLLLSTARQIPAADKTLRVGEWKRSSFKGVEIFGKTVGIVGFGHIGQLFA
QRLAAFEATIIAYDPYANPARAAQLGVELVDLESLMQRADFVTIHLPKTAETAGMFNAELLAKSKQGQIIINAARGGLVD
EQALADAIDAGRIRGAGFDVFATEPCTDSPLFNRPEVVVTPHLGASTVEAQDRAGTDVAASVLKALAGEFVPDAVNVSGG
RVGEEVALWLDLARKLGVVAGKLLDKAPVAVEVEARGELSTENIDVLGLSALRGVFSSFIEEPVTFVNAPRIAEERGVKL
DVTTASESLTHRSVLEVCVIGADGSKESVIGALTGLNHVEKIVRINKRGLDLRAQGFNVYFQYTDTPGALGKVGTALGAQ
GFNIDAAALSQDSEGDGATLVLRVDKPIPDALVEEIAAGIGAEAFAVDFDA
>Mature_530_residues
SQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRAELLAAVPEADALLVRSATTVDEEVLNAATNLKIVGRAGVGLDN
VDIATATDKGVMVANAPTSNIHSACEHAISLLLSTARQIPAADKTLRVGEWKRSSFKGVEIFGKTVGIVGFGHIGQLFAQ
RLAAFEATIIAYDPYANPARAAQLGVELVDLESLMQRADFVTIHLPKTAETAGMFNAELLAKSKQGQIIINAARGGLVDE
QALADAIDAGRIRGAGFDVFATEPCTDSPLFNRPEVVVTPHLGASTVEAQDRAGTDVAASVLKALAGEFVPDAVNVSGGR
VGEEVALWLDLARKLGVVAGKLLDKAPVAVEVEARGELSTENIDVLGLSALRGVFSSFIEEPVTFVNAPRIAEERGVKLD
VTTASESLTHRSVLEVCVIGADGSKESVIGALTGLNHVEKIVRINKRGLDLRAQGFNVYFQYTDTPGALGKVGTALGAQG
FNIDAAALSQDSEGDGATLVLRVDKPIPDALVEEIAAGIGAEAFAVDFDA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=401, Percent_Identity=36.4089775561097, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI4557497, Length=323, Percent_Identity=32.1981424148607, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI61743967, Length=323, Percent_Identity=32.1981424148607, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI145580578, Length=322, Percent_Identity=31.9875776397516, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=322, Percent_Identity=31.9875776397516, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=287, Percent_Identity=32.0557491289199, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI145580575, Length=324, Percent_Identity=31.7901234567901, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789279, Length=308, Percent_Identity=33.7662337662338, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=34.0625, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=32.6530612244898, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788660, Length=281, Percent_Identity=31.6725978647687, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081824, Length=238, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=41.3114754098361, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI25147481, Length=325, Percent_Identity=28.6153846153846, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=281, Percent_Identity=34.8754448398576, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=34.8754448398576, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=32.258064516129, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=296, Percent_Identity=27.3648648648649, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.2147651006711, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=28.4090909090909, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=26.5, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=41.2162162162162, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI28571528, Length=279, Percent_Identity=35.84229390681, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=31.4285714285714, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=31.8327974276527, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28574286, Length=284, Percent_Identity=32.0422535211268, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646446, Length=326, Percent_Identity=30.0613496932515, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646448, Length=326, Percent_Identity=30.0613496932515, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646452, Length=326, Percent_Identity=30.0613496932515, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646450, Length=326, Percent_Identity=30.0613496932515, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI62472511, Length=326, Percent_Identity=30.0613496932515, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55508; Mature: 55376

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRAELLAAVPEADALLVRSATTVDE
CCCCCCEEEEEEHHHHHHHHHHCCCEEEEEECCCCCHHHHEEECCCCCEEEEECCCHHHH
EVLNAATNLKIVGRAGVGLDNVDIATATDKGVMVANAPTSNIHSACEHAISLLLSTARQI
HHHHHHCCEEEEEECCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PAADKTLRVGEWKRSSFKGVEIFGKTVGIVGFGHIGQLFAQRLAAFEATIIAYDPYANPA
CCCCCEEECCCCCCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCHH
RAAQLGVELVDLESLMQRADFVTIHLPKTAETAGMFNAELLAKSKQGQIIINAARGGLVD
HHHHHCCHHCCHHHHHHHCCEEEEECCCCCHHHCCCCHHHHHCCCCCCEEEEECCCCCCC
EQALADAIDAGRIRGAGFDVFATEPCTDSPLFNRPEVVVTPHLGASTVEAQDRAGTDVAA
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHH
SVLKALAGEFVPDAVNVSGGRVGEEVALWLDLARKLGVVAGKLLDKAPVAVEVEARGELS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TENIDVLGLSALRGVFSSFIEEPVTFVNAPRIAEERGVKLDVTTASESLTHRSVLEVCVI
CCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCEEEEECCHHHHHHHHEEEEEEE
GADGSKESVIGALTGLNHVEKIVRINKRGLDLRAQGFNVYFQYTDTPGALGKVGTALGAQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHCCC
GFNIDAAALSQDSEGDGATLVLRVDKPIPDALVEEIAAGIGAEAFAVDFDA
CCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
SQNGRPVVLIADKLAQSTVDALGDAVEVRWVDGPNRAELLAAVPEADALLVRSATTVDE
CCCCCEEEEEEHHHHHHHHHHCCCEEEEEECCCCCHHHHEEECCCCCEEEEECCCHHHH
EVLNAATNLKIVGRAGVGLDNVDIATATDKGVMVANAPTSNIHSACEHAISLLLSTARQI
HHHHHHCCEEEEEECCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PAADKTLRVGEWKRSSFKGVEIFGKTVGIVGFGHIGQLFAQRLAAFEATIIAYDPYANPA
CCCCCEEECCCCCCCCCCCEEEECCEEEEEEEHHHHHHHHHHHHHHEEEEEEECCCCCHH
RAAQLGVELVDLESLMQRADFVTIHLPKTAETAGMFNAELLAKSKQGQIIINAARGGLVD
HHHHHCCHHCCHHHHHHHCCEEEEECCCCCHHHCCCCHHHHHCCCCCCEEEEECCCCCCC
EQALADAIDAGRIRGAGFDVFATEPCTDSPLFNRPEVVVTPHLGASTVEAQDRAGTDVAA
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHH
SVLKALAGEFVPDAVNVSGGRVGEEVALWLDLARKLGVVAGKLLDKAPVAVEVEARGELS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
TENIDVLGLSALRGVFSSFIEEPVTFVNAPRIAEERGVKLDVTTASESLTHRSVLEVCVI
CCCEEEEEHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCEEEEECCHHHHHHHHEEEEEEE
GADGSKESVIGALTGLNHVEKIVRINKRGLDLRAQGFNVYFQYTDTPGALGKVGTALGAQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEEEEECCCCCCHHHHHHHHCCC
GFNIDAAALSQDSEGDGATLVLRVDKPIPDALVEEIAAGIGAEAFAVDFDA
CCCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]