Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 38233666

GI number: 38233666

Start: 1053532

End: 1054668

Strand: Direct

Name: iscS [H]

Synonym: DIP1072

Alternate gene names: 38233666

Gene position: 1053532-1054668 (Clockwise)

Preceding gene: 38233665

Following gene: 38233668

Centisome position: 42.33

GC content: 54.09

Gene sequence:

>1137_bases
ATGCAGACTCGCTACTTTGATCATGCCGCAACAACTCCAATCCGTGAGACAGCTCGTGCTGCATGGCTCGAGTACGCAGG
CATGGCTAATCCTGCTAGCCAATATGCTTCTGGCCGTGCTGCTCGCAGCGTGCTTGATACGGCACGTGAACAGATCTCTC
AGTTGTTGGGCTGTGAGCCTATTGAAGTAATTTTCACAGCCTCGGGCACCGAATCTGACAATATTGGGGTCCATGGCTTG
TGGAAGTCCCGTCAGGGACAAGCTCCCAACCGGATTGTGACCACAGCAATTGAACATCCAGGCGTGTTAGAAACAGTCAA
AGCATTGGAAGCGCATGGTGCCAACTTAGATTTCCTTCCCGTCGACTCTCATGGAGCGATTGCAAATGTTGATGCGTTAA
GCACGCCAGCCGCTGTTGCAGCGGTCATGTGGGCAAATAATGAAACTGGTGCGATTCAACCTATTGAAAAGGTCATCGCA
GCCGCTAAAGAAGTAGACACTCCTGTCCACGTTGATGCAGTGCAAGTGGTAGGACACCAGCACATTAATTTCGATGTATT
GGGAGCTACGACTCTTGCGGCCAGTGCTCACAAATTCGGAGGGCCACGTGGAGTTGGCCTACTACTCGCACGGCGTTCGC
CAGCGCCACAACCTGTCATGTTTGGCGGCGGGCAAGAACGCAGTATTCGTTCGGGAACTGTCGACGTAGCTGGGGCGGCG
GCAACCGCGGCCGCACTGGCAGAAGCGGTAAACGAGGTCGACGAAGAAACTACGCGGTTGCGTTATCTGGTTAATAAGTT
GCGAGATCACGTCGTCGCTACAATCGACAACACCGTTGTCCACACCCCGCGCCATAGCTTGCCAGGCCATCTTCACCTGT
CATTCCCCGGTGCGGAAGGCGACAGCCTCATCATGTTGTTGGATTCTTTGGGGCTTGAGGCTTCAACGGGCTCTGCATGC
TCCAACGGAGTAAACAGGGCAAGCCATGTGCTTCTTGCGATGGGAGTTTCAGAATCTACTGCGCGAAGCACGGTACGCTT
TACACTTGGTGCCACCACGACCGAGGAGGACGTCGATACGCTTATTGCTCAGCTTCCTGATGTGGTTGCGCGTGCTCGTC
TTGCAGGAATGGCTTAA

Upstream 100 bases:

>100_bases
GAAATAATCCAACTTCGTTAACTCAGCCGCACATAAACGAACAGCCATTATCGCGGCGTGGACGTAGAGTGAGCACGAGA
CGGTAGTAAACTACCTCAAC

Downstream 100 bases:

>100_bases
TCGTGTCGTGCGGTGGATGAGGAACTGAAATTCTTTGTCCAGTTGCCACCCTTAAATTGGGCGGGTACTCCGCCGCCGAG
AAGTAGGCGTGTTAATACTT

Product: putative aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MQTRYFDHAATTPIRETARAAWLEYAGMANPASQYASGRAARSVLDTAREQISQLLGCEPIEVIFTASGTESDNIGVHGL
WKSRQGQAPNRIVTTAIEHPGVLETVKALEAHGANLDFLPVDSHGAIANVDALSTPAAVAAVMWANNETGAIQPIEKVIA
AAKEVDTPVHVDAVQVVGHQHINFDVLGATTLAASAHKFGGPRGVGLLLARRSPAPQPVMFGGGQERSIRSGTVDVAGAA
ATAAALAEAVNEVDEETTRLRYLVNKLRDHVVATIDNTVVHTPRHSLPGHLHLSFPGAEGDSLIMLLDSLGLEASTGSAC
SNGVNRASHVLLAMGVSESTARSTVRFTLGATTTEEDVDTLIAQLPDVVARARLAGMA

Sequences:

>Translated_378_residues
MQTRYFDHAATTPIRETARAAWLEYAGMANPASQYASGRAARSVLDTAREQISQLLGCEPIEVIFTASGTESDNIGVHGL
WKSRQGQAPNRIVTTAIEHPGVLETVKALEAHGANLDFLPVDSHGAIANVDALSTPAAVAAVMWANNETGAIQPIEKVIA
AAKEVDTPVHVDAVQVVGHQHINFDVLGATTLAASAHKFGGPRGVGLLLARRSPAPQPVMFGGGQERSIRSGTVDVAGAA
ATAAALAEAVNEVDEETTRLRYLVNKLRDHVVATIDNTVVHTPRHSLPGHLHLSFPGAEGDSLIMLLDSLGLEASTGSAC
SNGVNRASHVLLAMGVSESTARSTVRFTLGATTTEEDVDTLIAQLPDVVARARLAGMA
>Mature_378_residues
MQTRYFDHAATTPIRETARAAWLEYAGMANPASQYASGRAARSVLDTAREQISQLLGCEPIEVIFTASGTESDNIGVHGL
WKSRQGQAPNRIVTTAIEHPGVLETVKALEAHGANLDFLPVDSHGAIANVDALSTPAAVAAVMWANNETGAIQPIEKVIA
AAKEVDTPVHVDAVQVVGHQHINFDVLGATTLAASAHKFGGPRGVGLLLARRSPAPQPVMFGGGQERSIRSGTVDVAGAA
ATAAALAEAVNEVDEETTRLRYLVNKLRDHVVATIDNTVVHTPRHSLPGHLHLSFPGAEGDSLIMLLDSLGLEASTGSAC
SNGVNRASHVLLAMGVSESTARSTVRFTLGATTTEEDVDTLIAQLPDVVARARLAGMA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=34.9081364829396, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=29.2270531400966, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI48994898, Length=379, Percent_Identity=34.3007915567282, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789175, Length=353, Percent_Identity=24.3626062322946, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=374, Percent_Identity=34.7593582887701, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17533177, Length=320, Percent_Identity=28.4375, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319831, Length=377, Percent_Identity=33.6870026525199, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=34.6560846560847, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39577; Mature: 39577

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRYFDHAATTPIRETARAAWLEYAGMANPASQYASGRAARSVLDTAREQISQLLGCEP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
IEVIFTASGTESDNIGVHGLWKSRQGQAPNRIVTTAIEHPGVLETVKALEAHGANLDFLP
EEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEE
VDSHGAIANVDALSTPAAVAAVMWANNETGAIQPIEKVIAAAKEVDTPVHVDAVQVVGHQ
ECCCCCEEECHHCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
HINFDVLGATTLAASAHKFGGPRGVGLLLARRSPAPQPVMFGGGQERSIRSGTVDVAGAA
CCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCHHH
ATAAALAEAVNEVDEETTRLRYLVNKLRDHVVATIDNTVVHTPRHSLPGHLHLSFPGAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCCCCEEEEEECCCCC
DSLIMLLDSLGLEASTGSACSNGVNRASHVLLAMGVSESTARSTVRFTLGATTTEEDVDT
CEEEEEEECCCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHCCEEEEEECCCCCHHHHHH
LIAQLPDVVARARLAGMA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTRYFDHAATTPIRETARAAWLEYAGMANPASQYASGRAARSVLDTAREQISQLLGCEP
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
IEVIFTASGTESDNIGVHGLWKSRQGQAPNRIVTTAIEHPGVLETVKALEAHGANLDFLP
EEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEE
VDSHGAIANVDALSTPAAVAAVMWANNETGAIQPIEKVIAAAKEVDTPVHVDAVQVVGHQ
ECCCCCEEECHHCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
HINFDVLGATTLAASAHKFGGPRGVGLLLARRSPAPQPVMFGGGQERSIRSGTVDVAGAA
CCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCHHH
ATAAALAEAVNEVDEETTRLRYLVNKLRDHVVATIDNTVVHTPRHSLPGHLHLSFPGAEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECCCCCCCCEEEEEECCCCC
DSLIMLLDSLGLEASTGSACSNGVNRASHVLLAMGVSESTARSTVRFTLGATTTEEDVDT
CEEEEEEECCCCCCCCCCHHHHHHHHHHEEEEEECCCCHHHCCEEEEEECCCCCHHHHHH
LIAQLPDVVARARLAGMA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA