Click here to switch to the map view.

The map label for this gene is argS

Identifier: 38233629

GI number: 38233629

Start: 1013777

End: 1015429

Strand: Direct

Name: argS

Synonym: DIP1034

Alternate gene names: 38233629

Gene position: 1013777-1015429 (Clockwise)

Preceding gene: 38233628

Following gene: 38233630

Centisome position: 40.74

GC content: 52.33

Gene sequence:

>1653_bases
ATGACACCTGCGGATCTTTCTCAACTAATTAAACAAACAGCAATTGATGTTTTGTCGGCGCGTGAGCTCGACACCACGGT
GCTCCCTGAAACTGTCGTGGTGGAGCGCCCACGCAACCCAGAGCATGGAGATTATGCAACAAACGTTGCTCTTCAGATTG
CTAAAAAAGTTGGGATGAATCCGCGAGAGTTAGGCCAGGTGCTTGCCGACTCCCTCGCTGCCAACACGGCAATCGACGAG
GCGTCGATCGCAGGCCCTGGCTTTATTAATATCCGCTTGGCGGCAGCCGCTCAGGGTGAGATCGTCGCGAAGATTTTGGA
GGCGGGTGCAACCTTCGGGCATTCCGATCTTTATCAGGGGCGTCGCGTCAATCTTGAGTTTGTGTCTGCGAACCCAACTG
GCCCAATTCACTTGGGGGGAACACGTTGGGCGGCGGTAGGAGACTCTTTGGGCCGTGTATTGGAAGCCTCCGGTGCACAG
GTCACCCGTGAGTACTACTTCAATGACCACGGACGTCAGATTGATCGCTTTACTAACTCGTTGGTGGCTTCGGCCAAGGG
GGAGCCAACTCCAGAAGATGGTTACGGCGGAGATTACATCAAGGAAATCGCTGATGCAGTAGTTGCGCAGCACCCAGATG
TGTTGGCTCTGGCCGAAGCGGATCTCAATGAAAGGTTCCGTGCAACTGGTGTTGAGATGATGTTCGCGCACATCAAGGAA
TCTCTCCATGAGTTTGGTACTGATTTCGATGTGTACTTCCACGAGAACTCGTTGTTCGAATCGGGAGCAGTAGATAAAGC
TATTCAGACGCTGAAAGACAATGGCAACCTGTATTTCAATGAGGGCGCTTGGTGGCTTAAGTCCTCTGAATATGGTGATG
ACAAAGATCGCGTAGTGATCAAGTCTGATGGCGATGCTGCTTACATTGCCGGTGACATTGCTTATGTTGCGGATAAGTTC
GACCGTGGTCATGACCTGTGCATTTACATGCTTGGTGCAGACCATCACGGTTATATTTCTCGTCTTCGTGCGGCAGCAGC
TGCGATGGGTTACGAGCCTTCCAACGTCGAGGTCCTCATCGGTCAGATGGTTAACCTTGTGCGTGACGGCAAGGCTGTCC
GCATGTCTAAGCGCGCAGGCACCGTTATTACCTTGGACGATCTGGTGGAAGCAATCGGAATCGACGGTGCTCGATACTCG
ATGATTCGCTCTTCGGTTGATTCTAGCTTGGATATTGACTTGCAGCTGTGGGAGCAGCAAAGCAGTGATAACCCTGTTTA
TTACGTTCAGTATGGTCACGCACGTTTGTGCTCGATTGCACGTAAAGCTGCTGATCTCGGTATCACCGCAATCGATCCTG
ACCTTTCGCTTTTGACTCATGACCGTGAAGGCGATTTGATCCGTACACTCGGTGAGTTCCCAGCTGTAGTGAAGGCTGCA
GCAGAGCTACGCGAACCGCACCGCATTGCGCGTTTTGCTGAGGATCTTGCTGGTACGTTCCATCGTTTCTACGATTCCTG
CCAGATTTTGCCTAAAGTAGGCGAGTCTGCTGAGCCTATTCACACTGCACGTTTGGCGCTGGCTAACGCGACGCGTCAGG
TATTGGCTAATGCGCTGAGGCTTGTCGGAGTATCTGCACCGGAGCGTATGTAG

Upstream 100 bases:

>100_bases
GGAAGTACTCCCTCGGACTTCTGGTCTACATCTGCATCATTGCGTACCTTCAGTCCACCCCAATTCTCGGATGGATGGTT
GTGGGCTAAACTTCTAACCC

Downstream 100 bases:

>100_bases
TCATGGATTTCAACGCGCTGCCTTCCCACGTGTGGCCACGACATGCTGCACGTGAGGCTGGGGGAGATGTCAGTGTCGCC
GGTGTATCTTTGGTGTCCAT

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MTPADLSQLIKQTAIDVLSARELDTTVLPETVVVERPRNPEHGDYATNVALQIAKKVGMNPRELGQVLADSLAANTAIDE
ASIAGPGFINIRLAAAAQGEIVAKILEAGATFGHSDLYQGRRVNLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAQ
VTREYYFNDHGRQIDRFTNSLVASAKGEPTPEDGYGGDYIKEIADAVVAQHPDVLALAEADLNERFRATGVEMMFAHIKE
SLHEFGTDFDVYFHENSLFESGAVDKAIQTLKDNGNLYFNEGAWWLKSSEYGDDKDRVVIKSDGDAAYIAGDIAYVADKF
DRGHDLCIYMLGADHHGYISRLRAAAAAMGYEPSNVEVLIGQMVNLVRDGKAVRMSKRAGTVITLDDLVEAIGIDGARYS
MIRSSVDSSLDIDLQLWEQQSSDNPVYYVQYGHARLCSIARKAADLGITAIDPDLSLLTHDREGDLIRTLGEFPAVVKAA
AELREPHRIARFAEDLAGTFHRFYDSCQILPKVGESAEPIHTARLALANATRQVLANALRLVGVSAPERM

Sequences:

>Translated_550_residues
MTPADLSQLIKQTAIDVLSARELDTTVLPETVVVERPRNPEHGDYATNVALQIAKKVGMNPRELGQVLADSLAANTAIDE
ASIAGPGFINIRLAAAAQGEIVAKILEAGATFGHSDLYQGRRVNLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAQ
VTREYYFNDHGRQIDRFTNSLVASAKGEPTPEDGYGGDYIKEIADAVVAQHPDVLALAEADLNERFRATGVEMMFAHIKE
SLHEFGTDFDVYFHENSLFESGAVDKAIQTLKDNGNLYFNEGAWWLKSSEYGDDKDRVVIKSDGDAAYIAGDIAYVADKF
DRGHDLCIYMLGADHHGYISRLRAAAAAMGYEPSNVEVLIGQMVNLVRDGKAVRMSKRAGTVITLDDLVEAIGIDGARYS
MIRSSVDSSLDIDLQLWEQQSSDNPVYYVQYGHARLCSIARKAADLGITAIDPDLSLLTHDREGDLIRTLGEFPAVVKAA
AELREPHRIARFAEDLAGTFHRFYDSCQILPKVGESAEPIHTARLALANATRQVLANALRLVGVSAPERM
>Mature_549_residues
TPADLSQLIKQTAIDVLSARELDTTVLPETVVVERPRNPEHGDYATNVALQIAKKVGMNPRELGQVLADSLAANTAIDEA
SIAGPGFINIRLAAAAQGEIVAKILEAGATFGHSDLYQGRRVNLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAQV
TREYYFNDHGRQIDRFTNSLVASAKGEPTPEDGYGGDYIKEIADAVVAQHPDVLALAEADLNERFRATGVEMMFAHIKES
LHEFGTDFDVYFHENSLFESGAVDKAIQTLKDNGNLYFNEGAWWLKSSEYGDDKDRVVIKSDGDAAYIAGDIAYVADKFD
RGHDLCIYMLGADHHGYISRLRAAAAAMGYEPSNVEVLIGQMVNLVRDGKAVRMSKRAGTVITLDDLVEAIGIDGARYSM
IRSSVDSSLDIDLQLWEQQSSDNPVYYVQYGHARLCSIARKAADLGITAIDPDLSLLTHDREGDLIRTLGEFPAVVKAAA
ELREPHRIARFAEDLAGTFHRFYDSCQILPKVGESAEPIHTARLALANATRQVLANALRLVGVSAPERM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15149476, Length=586, Percent_Identity=23.3788395904437, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1788184, Length=561, Percent_Identity=26.0249554367201, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71985061, Length=582, Percent_Identity=22.5085910652921, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71985068, Length=542, Percent_Identity=22.3247232472325, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320548, Length=560, Percent_Identity=26.25, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321883, Length=560, Percent_Identity=23.75, Blast_Score=109, Evalue=9e-25,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_CORDI (Q6NHU6)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939396.1
- ProteinModelPortal:   Q6NHU6
- GeneID:   2648619
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1034
- NMPDR:   fig|257309.1.peg.987
- HOGENOM:   HBG695395
- OMA:   FDVYFHE
- PhylomeDB:   Q6NHU6
- ProtClustDB:   PRK01611
- BioCyc:   CDIP257309:DIP1034-MONOMER
- BRENDA:   6.1.1.19
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 59841; Mature: 59710

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPADLSQLIKQTAIDVLSARELDTTVLPETVVVERPRNPEHGDYATNVALQIAKKVGMN
CCHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
PRELGQVLADSLAANTAIDEASIAGPGFINIRLAAAAQGEIVAKILEAGATFGHSDLYQG
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHCCC
RRVNLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAQVTREYYFNDHGRQIDRFTNS
CEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
LVASAKGEPTPEDGYGGDYIKEIADAVVAQHPDVLALAEADLNERFRATGVEMMFAHIKE
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
SLHEFGTDFDVYFHENSLFESGAVDKAIQTLKDNGNLYFNEGAWWLKSSEYGDDKDRVVI
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCEEEE
KSDGDAAYIAGDIAYVADKFDRGHDLCIYMLGADHHGYISRLRAAAAAMGYEPSNVEVLI
ECCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
GQMVNLVRDGKAVRMSKRAGTVITLDDLVEAIGIDGARYSMIRSSVDSSLDIDLQLWEQQ
HHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCC
SSDNPVYYVQYGHARLCSIARKAADLGITAIDPDLSLLTHDREGDLIRTLGEFPAVVKAA
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHH
AELREPHRIARFAEDLAGTFHRFYDSCQILPKVGESAEPIHTARLALANATRQVLANALR
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVGVSAPERM
HHCCCCCCCC
>Mature Secondary Structure 
TPADLSQLIKQTAIDVLSARELDTTVLPETVVVERPRNPEHGDYATNVALQIAKKVGMN
CHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
PRELGQVLADSLAANTAIDEASIAGPGFINIRLAAAAQGEIVAKILEAGATFGHSDLYQG
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHCCC
RRVNLEFVSANPTGPIHLGGTRWAAVGDSLGRVLEASGAQVTREYYFNDHGRQIDRFTNS
CEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
LVASAKGEPTPEDGYGGDYIKEIADAVVAQHPDVLALAEADLNERFRATGVEMMFAHIKE
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
SLHEFGTDFDVYFHENSLFESGAVDKAIQTLKDNGNLYFNEGAWWLKSSEYGDDKDRVVI
HHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCEEEE
KSDGDAAYIAGDIAYVADKFDRGHDLCIYMLGADHHGYISRLRAAAAAMGYEPSNVEVLI
ECCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHH
GQMVNLVRDGKAVRMSKRAGTVITLDDLVEAIGIDGARYSMIRSSVDSSLDIDLQLWEQQ
HHHHHHHHCCCCEEECCCCCCEEEHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCC
SSDNPVYYVQYGHARLCSIARKAADLGITAIDPDLSLLTHDREGDLIRTLGEFPAVVKAA
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHH
AELREPHRIARFAEDLAGTFHRFYDSCQILPKVGESAEPIHTARLALANATRQVLANALR
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVGVSAPERM
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910