BacMap

Definition	Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome.
Accession	NC_002935
Length	2,488,635

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The map label for this gene is drrA [H]

Identifier: 38233557

GI number: 38233557

Start: 933702

End: 934397

Strand: Direct

Name: drrA [H]

Synonym: DIP0961

Alternate gene names: 38233557

Gene position: 933702-934397 (Clockwise)

Preceding gene: 38233556

Following gene: 38233558

Centisome position: 37.52

GC content: 45.26

Gene sequence:

>696_bases
ATGCTTGAGCTTCAGAATGTCAAAGTTAGACGCTCCGGAAAGCTTTTACTCGATGTACCATCGTTAAAGATCGATTCTCG
TGCCACACTTTTATTGGGGGTAAACGGCGCAGGAAAATCAACACTTCTATCAATTTTGGCAGGGCGTTTAGCACCTTCTG
CGGGGCGTGTAAACGGATCTAAATCGGTTATTAGCGTGGAGCAGCAATTTAAACCCATCATTGGTTTTACGTGTGTTGAA
TACTGTGCATATGTTGGCTGGTTGGGTGGACAAGCTTGGTCAGTTGCACGTCAAAAGGCGTCATACTGGCTTGAGTTTGT
TGGAATTGAACATCTAATGCATCAGCGTTGTGAAAAACTAAGCGGTGGTGAACGTTCGCGCTTAGCCATTGCTACCGCAC
TAAACTCCGGTGCCGATATGTTGCTTTTGGATGAACCCAGCGCTGCATTAGATCCAGTGAGTAAGCAAGCGATTAGCGAC
TTATATTGTCAAATAGTCGAATATGGACAATCGTTATTGGTATCAACTCACGATAGCGCTGATTTGAAGTTCCCGTTTGA
GCGCGTGATCGTTCTCGATGCTGGTCAAGTCCGATTTGATGGCTCATGTGCTGAGTTTCAAGATCTGTCGTTGCAGCAAG
GAGATTCTCCAGCTCATATACTTTCTAAAGCATTCAAGAAAAGGGAGCGTAGGTAG

Upstream 100 bases:

>100_bases
GTAACTGGGGGCGAGTTGCTGCTGGTGACTACTATGCTGTTGTGGGTACTTTTGATTGGAATCGCCTGACTATTAACTGG
CTAAAGGTAGGTTACTGACG

Downstream 100 bases:

>100_bases
TATGTGGAAATTCCCTAGATCGCACTGGATAAAACGTCCCTCTTTATGGTGTTGCATAGGCGCTCTTTTAGTATGTTTTT
TGCCGCTATCTCAGTGGACT

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLELQNVKVRRSGKLLLDVPSLKIDSRATLLLGVNGAGKSTLLSILAGRLAPSAGRVNGSKSVISVEQQFKPIIGFTCVE
YCAYVGWLGGQAWSVARQKASYWLEFVGIEHLMHQRCEKLSGGERSRLAIATALNSGADMLLLDEPSAALDPVSKQAISD
LYCQIVEYGQSLLVSTHDSADLKFPFERVIVLDAGQVRFDGSCAEFQDLSLQQGDSPAHILSKAFKKRERR

Sequences:

>Translated_231_residues
MLELQNVKVRRSGKLLLDVPSLKIDSRATLLLGVNGAGKSTLLSILAGRLAPSAGRVNGSKSVISVEQQFKPIIGFTCVE
YCAYVGWLGGQAWSVARQKASYWLEFVGIEHLMHQRCEKLSGGERSRLAIATALNSGADMLLLDEPSAALDPVSKQAISD
LYCQIVEYGQSLLVSTHDSADLKFPFERVIVLDAGQVRFDGSCAEFQDLSLQQGDSPAHILSKAFKKRERR
>Mature_231_residues
MLELQNVKVRRSGKLLLDVPSLKIDSRATLLLGVNGAGKSTLLSILAGRLAPSAGRVNGSKSVISVEQQFKPIIGFTCVE
YCAYVGWLGGQAWSVARQKASYWLEFVGIEHLMHQRCEKLSGGERSRLAIATALNSGADMLLLDEPSAALDPVSKQAISD
LYCQIVEYGQSLLVSTHDSADLKFPFERVIVLDAGQVRFDGSCAEFQDLSLQQGDSPAHILSKAFKKRERR

Specific function: Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP or GTP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=192, Percent_Identity=32.2916666666667, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI105990541, Length=194, Percent_Identity=30.4123711340206, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI45446740, Length=206, Percent_Identity=30.5825242718447, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI47078218, Length=206, Percent_Identity=30.5825242718447, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI150417984, Length=181, Percent_Identity=32.5966850828729, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI31657092, Length=186, Percent_Identity=27.9569892473118, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI30795238, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI27881501, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21536376, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI27477115, Length=200, Percent_Identity=31, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786345, Length=222, Percent_Identity=30.6306306306306, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790544, Length=209, Percent_Identity=32.5358851674641, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1786703, Length=166, Percent_Identity=33.7349397590361, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787029, Length=220, Percent_Identity=30, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081834, Length=166, Percent_Identity=33.1325301204819, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789032, Length=195, Percent_Identity=27.1794871794872, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI2367384, Length=216, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789751, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786253, Length=190, Percent_Identity=31.0526315789474, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787164, Length=178, Percent_Identity=32.5842696629214, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786563, Length=208, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790467, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786872, Length=226, Percent_Identity=28.7610619469027, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789672, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081791, Length=209, Percent_Identity=30.1435406698565, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789593, Length=224, Percent_Identity=28.125, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=213, Percent_Identity=27.6995305164319, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI87082268, Length=182, Percent_Identity=33.5164835164835, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081782, Length=159, Percent_Identity=27.0440251572327, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787370, Length=188, Percent_Identity=27.1276595744681, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788450, Length=184, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790739, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789873, Length=184, Percent_Identity=28.2608695652174, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081709, Length=225, Percent_Identity=26.2222222222222, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788225, Length=231, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788644, Length=112, Percent_Identity=32.1428571428571, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=186, Percent_Identity=26.3440860215054, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565586, Length=201, Percent_Identity=28.8557213930348, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71983523, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510237, Length=194, Percent_Identity=24.2268041237113, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320296, Length=170, Percent_Identity=30, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321121, Length=223, Percent_Identity=28.6995515695067, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24643674, Length=216, Percent_Identity=26.8518518518519, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666092, Length=191, Percent_Identity=28.7958115183246, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007184, Length=206, Percent_Identity=27.1844660194175, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221500365, Length=206, Percent_Identity=27.1844660194175, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574150, Length=218, Percent_Identity=24.7706422018349, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007328, Length=218, Percent_Identity=24.7706422018349, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574744, Length=186, Percent_Identity=29.0322580645161, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650853, Length=161, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650855, Length=161, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648314, Length=199, Percent_Identity=24.6231155778894, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281362751, Length=161, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=226, Percent_Identity=26.1061946902655, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580930, Length=226, Percent_Identity=26.1061946902655, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR005894 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 25223; Mature: 25223

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELQNVKVRRSGKLLLDVPSLKIDSRATLLLGVNGAGKSTLLSILAGRLAPSAGRVNGS
CCCCCCEEEECCCCEEEECCCCEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
KSVISVEQQFKPIIGFTCVEYCAYVGWLGGQAWSVARQKASYWLEFVGIEHLMHQRCEKL
CCEEEHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGERSRLAIATALNSGADMLLLDEPSAALDPVSKQAISDLYCQIVEYGQSLLVSTHDSA
CCCCCHHEEEEEECCCCCCEEEEECCCHHHCHHHHHHHHHHHHHHHHHCHHHEEECCCCC
DLKFPFERVIVLDAGQVRFDGSCAEFQDLSLQQGDSPAHILSKAFKKRERR
CCCCCCEEEEEEECCCEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLELQNVKVRRSGKLLLDVPSLKIDSRATLLLGVNGAGKSTLLSILAGRLAPSAGRVNGS
CCCCCCEEEECCCCEEEECCCCEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
KSVISVEQQFKPIIGFTCVEYCAYVGWLGGQAWSVARQKASYWLEFVGIEHLMHQRCEKL
CCEEEHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGERSRLAIATALNSGADMLLLDEPSAALDPVSKQAISDLYCQIVEYGQSLLVSTHDSA
CCCCCHHEEEEEECCCCCCEEEEECCCHHHCHHHHHHHHHHHHHHHHHCHHHEEECCCCC
DLKFPFERVIVLDAGQVRFDGSCAEFQDLSLQQGDSPAHILSKAFKKRERR
CCCCCCEEEEEEECCCEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]