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The map label for this gene is fumC [H]

Identifier: 38233534

GI number: 38233534

Start: 908959

End: 910362

Strand: Reverse

Name: fumC [H]

Synonym: DIP0938

Alternate gene names: 38233534

Gene position: 910362-908959 (Counterclockwise)

Preceding gene: 38233535

Following gene: 38233533

Centisome position: 36.58

GC content: 59.26

Gene sequence:

>1404_bases
ATGACTGAGCAGCAGTACCGCATCGAGCACGACACCATGGGTGAAGTTAAGGTGCCTATCGACGCCCTCTGGCGCGCACA
GACCCAGCGCGCTGTTGAGAACTTCCCAATTTCTGGCCGTGGCCTCGAAGCCGCACAGATCCGCGCTATGGGGCTGCTCA
AGGCCGCTTGTGCTCAGGTTAATAAGGACCGCGGACTTCTGGCTCCAGAGCAGGCTGATGCAATCATCGCCGCAGCTACC
GAGGTAGCCGAGGGCAAGCACGACGACCAGTTCCCTATCGACGTCTTCCAGACCGGTTCCGGCACCTCGTCGAACATGAA
CTCCAACGAGGTTATCGCCTCGATCGCTAAGGCTAACGGCGTTGAGGTTCACCCTAACGACCACGTCAACATGGGCCAGT
CCTCCAACGACACCTTCCCAACTGCTACTCACATCGCCGCAACTGAGGCCGCCGTCAAGGACCTCATTCCAGGTCTGAAG
GTTCTCCATGCCTCCCTAGCCAAGAAAGCTGCCGAGTGGGAGAACGTTGTAAAGTCCGGCCGTACCCACCTAATGGATGC
CGTTCCAGTTACCTTGGGCCAGGAGTTCTCCGGCTACGCTCGCCAGATTGAGGCTGGCATCGAGCGCGTCGAGGCATGCT
TGCCACGTCTTGGCGAGCTCTCCATCGGCGGCACCGCTGTAGGCACCGGCCTGAACACCCCAGCAGACTTCGGCCAGAAG
GTCACTGCCGAGCTCGTTAAGCTGACCGGGGTTTCTGAACTTCGCGAGTGCGTGAACCACTTTGAGGCTCAGGCAAGCCG
CGACGGCCTCGTCGAGTTCTCCGGCGCAATGCGCACCATCGCTGTGTCTTTGACCAAGATTGCTAACGACATCCGCTGGA
TGGGATCCGGCCCGCTGACTGGCCTCGGCGAGATCCACTTGCCAGACCTGCAGCCAGGTTCTTCCATCATGCCAGGCAAG
GTCAACCCAGTTCTGTGCGAAACCGCAACTCAGGTGGCAGCTCAGGTTATTGGTAACGACGCAGCCATCGCTTTCGGCGG
CGCACAGGGCGCATTCGAGCTCAACGTCTTCATTCCAATGATGGCCCGCAACGTCCTCGAGTCCTCTCGCCTGTTGGCTA
ACACCGCCCGCGTATTCGCAGAGCGTCTTGTCGACGGCATCCATCCAAATGAGGAGCGCATGCGCACCTTGGCCGAGTCT
TCCCCATCGATCGTTACCCCACTGAACTCCGCTATCGGCTATGAAGCTGCAGCGAAGGTGGCAAAGACCGCGCTAAAGGA
AGGCAAGACCATCCGCCAGACTGTCATCGACTTGGGCTTTGTTGATGGCGAAAAGCTCACCGAGGAAGAGCTGGACAAGC
GCCTCAACGTTCTCGCAATGGCCAACACCGATCGCGACAAGTAA

Upstream 100 bases:

>100_bases
TTGGGCATACTGGTAGGCATGTGTGCACGTGTCCCGCTTACCCGAGCTACCACGCGCACAGATTTCTGCAACTTTCTACT
GACAAAGGTGGATACAACTT

Downstream 100 bases:

>100_bases
GTCTTTAACCTGCCGCATCTGACAACAGAGTGCGCCTCCTAGTCACCTTCAGACCGGGAGGCGCATTTTCTTTTACCTGC
AGTTTTGTAGACACATAAAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTEQQYRIEHDTMGEVKVPIDALWRAQTQRAVENFPISGRGLEAAQIRAMGLLKAACAQVNKDRGLLAPEQADAIIAAAT
EVAEGKHDDQFPIDVFQTGSGTSSNMNSNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHIAATEAAVKDLIPGLK
VLHASLAKKAAEWENVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEACLPRLGELSIGGTAVGTGLNTPADFGQK
VTAELVKLTGVSELRECVNHFEAQASRDGLVEFSGAMRTIAVSLTKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGK
VNPVLCETATQVAAQVIGNDAAIAFGGAQGAFELNVFIPMMARNVLESSRLLANTARVFAERLVDGIHPNEERMRTLAES
SPSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLNVLAMANTDRDK

Sequences:

>Translated_467_residues
MTEQQYRIEHDTMGEVKVPIDALWRAQTQRAVENFPISGRGLEAAQIRAMGLLKAACAQVNKDRGLLAPEQADAIIAAAT
EVAEGKHDDQFPIDVFQTGSGTSSNMNSNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHIAATEAAVKDLIPGLK
VLHASLAKKAAEWENVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEACLPRLGELSIGGTAVGTGLNTPADFGQK
VTAELVKLTGVSELRECVNHFEAQASRDGLVEFSGAMRTIAVSLTKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGK
VNPVLCETATQVAAQVIGNDAAIAFGGAQGAFELNVFIPMMARNVLESSRLLANTARVFAERLVDGIHPNEERMRTLAES
SPSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLNVLAMANTDRDK
>Mature_466_residues
TEQQYRIEHDTMGEVKVPIDALWRAQTQRAVENFPISGRGLEAAQIRAMGLLKAACAQVNKDRGLLAPEQADAIIAAATE
VAEGKHDDQFPIDVFQTGSGTSSNMNSNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHIAATEAAVKDLIPGLKV
LHASLAKKAAEWENVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVEACLPRLGELSIGGTAVGTGLNTPADFGQKV
TAELVKLTGVSELRECVNHFEAQASRDGLVEFSGAMRTIAVSLTKIANDIRWMGSGPLTGLGEIHLPDLQPGSSIMPGKV
NPVLCETATQVAAQVIGNDAAIAFGGAQGAFELNVFIPMMARNVLESSRLLANTARVFAERLVDGIHPNEERMRTLAESS
PSIVTPLNSAIGYEAAAKVAKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLNVLAMANTDRDK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=456, Percent_Identity=53.5087719298246, Blast_Score=457, Evalue=1e-129,
Organism=Escherichia coli, GI1787896, Length=453, Percent_Identity=50.551876379691, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=39.6551724137931, Blast_Score=309, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=51.9736842105263, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=53.8940809968847, Blast_Score=333, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324993, Length=456, Percent_Identity=51.0964912280702, Blast_Score=432, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=50.8658008658009, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=50.6493506493506, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=50.2164502164502, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24662684, Length=447, Percent_Identity=49.2170022371365, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24583245, Length=441, Percent_Identity=43.3106575963719, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49760; Mature: 49629

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQYRIEHDTMGEVKVPIDALWRAQTQRAVENFPISGRGLEAAQIRAMGLLKAACAQV
CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
NKDRGLLAPEQADAIIAAATEVAEGKHDDQFPIDVFQTGSGTSSNMNSNEVIASIAKANG
CCCCCCCCCCHHCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCC
VEVHPNDHVNMGQSSNDTFPTATHIAATEAAVKDLIPGLKVLHASLAKKAAEWENVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFSGYARQIEAGIERVEACLPRLGELSIGGTAVGTGLNTPADFGQK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHH
VTAELVKLTGVSELRECVNHFEAQASRDGLVEFSGAMRTIAVSLTKIANDIRWMGSGPLT
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLGEIHLPDLQPGSSIMPGKVNPVLCETATQVAAQVIGNDAAIAFGGAQGAFELNVFIPM
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHH
MARNVLESSRLLANTARVFAERLVDGIHPNEERMRTLAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLNVLAMANTDRDK
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCEEEECCCCCCC
>Mature Secondary Structure 
TEQQYRIEHDTMGEVKVPIDALWRAQTQRAVENFPISGRGLEAAQIRAMGLLKAACAQV
CCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
NKDRGLLAPEQADAIIAAATEVAEGKHDDQFPIDVFQTGSGTSSNMNSNEVIASIAKANG
CCCCCCCCCCHHCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCC
VEVHPNDHVNMGQSSNDTFPTATHIAATEAAVKDLIPGLKVLHASLAKKAAEWENVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFSGYARQIEAGIERVEACLPRLGELSIGGTAVGTGLNTPADFGQK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHH
VTAELVKLTGVSELRECVNHFEAQASRDGLVEFSGAMRTIAVSLTKIANDIRWMGSGPLT
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLGEIHLPDLQPGSSIMPGKVNPVLCETATQVAAQVIGNDAAIAFGGAQGAFELNVFIPM
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEHHHH
MARNVLESSRLLANTARVFAERLVDGIHPNEERMRTLAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALKEGKTIRQTVIDLGFVDGEKLTEEELDKRLNVLAMANTDRDK
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]