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The map label for this gene is uppS1

Identifier: 38233525

GI number: 38233525

Start: 901021

End: 901818

Strand: Direct

Name: uppS1

Synonym: DIP0929

Alternate gene names: 38233525

Gene position: 901021-901818 (Clockwise)

Preceding gene: 38233524

Following gene: 38233526

Centisome position: 36.21

GC content: 52.88

Gene sequence:

>798_bases
ATGCGCACACTAAAAAAGTTCTCTCTCCGCGACCTTGCTTATAACGCTGCATATCCTTTCTACGAGAAACGACTGATGCG
AGAAATTCAAGGGGTGCGGCAGCCTGAGCACGTTGCCATCATGTGTGATGGCAATCGCCGGTGGGCTCGTGAGGCCGGAT
TTGCCGATGTTACCCATGGGCATCGCGTAGGTGCTAAGAAAATTGGCGAAATGGTGCGGTGGTGTGCGCATACTGATGTT
GAACTCGTAACCGTCTACCTGCTATCGACGGAAAACCTAGGTCGAGCCTCCGACGAACTACAAATGTTGTTCGACATCAT
TGGCGACGTCGTAGATGAGCTCGCCTCCCCAGAAACCAATTGTCGTCTGCGGCTTGTCGGACACCTTGATTTACTGCCTG
ACGACGTCTCCCGGCGTCTCACCCAAGCCCAAGACAGCACCAACGACAACACCGGAGTCTTCGTCAACGTTGCCGTTGGC
TATGGCGGCCGCCAAGAAATCGTCGATGCGGTGCGCGAGCTTATCGACGCCGAAGCTGCAGCAGGAACAACAGCTACAGA
AATGGCCGAGAAAATCTCCGTCGATTCCATTTCCAAGCATCTGTATACATCGGGTCAACCAGACCCAGATCTTGTGATTC
GTACCTCAGGCGAACAACGCCTCTCTGGCTTTTTGTTGTGGCAGGCTGCGTATTCAGAAATCTGGTTCACCGATACCTAC
TGGCCAGCTTTCCGACGCGTTGATTTTTTGCGAGCATTGCGAGAATACTCAAAGCGAAGCCGACGCTTCGGTAAATAA

Upstream 100 bases:

>100_bases
GTTTGATCATGAGGCGATTGATAAAGCAATGGCTGAAGCAGGAGTTCTCGATCAAAGTAAAAAGTACTGGTTGTGATTAC
TTAAGGGAGTAGACATCATA

Downstream 100 bases:

>100_bases
CGCACACGCATTCTTCTCGTTCTAGGAAGGGGACCATTCCTCAGCCATGGTTCATATTCGCTTCCACTCCGTTTATGGCT
CTACAGCGCGCTACGCACAC

Product: putative undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MRTLKKFSLRDLAYNAAYPFYEKRLMREIQGVRQPEHVAIMCDGNRRWAREAGFADVTHGHRVGAKKIGEMVRWCAHTDV
ELVTVYLLSTENLGRASDELQMLFDIIGDVVDELASPETNCRLRLVGHLDLLPDDVSRRLTQAQDSTNDNTGVFVNVAVG
YGGRQEIVDAVRELIDAEAAAGTTATEMAEKISVDSISKHLYTSGQPDPDLVIRTSGEQRLSGFLLWQAAYSEIWFTDTY
WPAFRRVDFLRALREYSKRSRRFGK

Sequences:

>Translated_265_residues
MRTLKKFSLRDLAYNAAYPFYEKRLMREIQGVRQPEHVAIMCDGNRRWAREAGFADVTHGHRVGAKKIGEMVRWCAHTDV
ELVTVYLLSTENLGRASDELQMLFDIIGDVVDELASPETNCRLRLVGHLDLLPDDVSRRLTQAQDSTNDNTGVFVNVAVG
YGGRQEIVDAVRELIDAEAAAGTTATEMAEKISVDSISKHLYTSGQPDPDLVIRTSGEQRLSGFLLWQAAYSEIWFTDTY
WPAFRRVDFLRALREYSKRSRRFGK
>Mature_265_residues
MRTLKKFSLRDLAYNAAYPFYEKRLMREIQGVRQPEHVAIMCDGNRRWAREAGFADVTHGHRVGAKKIGEMVRWCAHTDV
ELVTVYLLSTENLGRASDELQMLFDIIGDVVDELASPETNCRLRLVGHLDLLPDDVSRRLTQAQDSTNDNTGVFVNVAVG
YGGRQEIVDAVRELIDAEAAAGTTATEMAEKISVDSISKHLYTSGQPDPDLVIRTSGEQRLSGFLLWQAAYSEIWFTDTY
WPAFRRVDFLRALREYSKRSRRFGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=33.920704845815, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=33.920704845815, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=37.3913043478261, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71993029, Length=249, Percent_Identity=30.1204819277108, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=33.1797235023041, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=26.9406392694064, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18857969, Length=247, Percent_Identity=34.8178137651822, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS1_CORDI (P60480)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939292.1
- ProteinModelPortal:   P60480
- SMR:   P60480
- GeneID:   2649969
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0929
- NMPDR:   fig|257309.1.peg.883
- HOGENOM:   HBG627837
- OMA:   HLYTSGQ
- ProtClustDB:   CLSK2760917
- BioCyc:   CDIP257309:DIP0929-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 30093; Mature: 30093

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 43-43

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLKKFSLRDLAYNAAYPFYEKRLMREIQGVRQPEHVAIMCDGNRRWAREAGFADVTHG
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCC
HRVGAKKIGEMVRWCAHTDVELVTVYLLSTENLGRASDELQMLFDIIGDVVDELASPETN
CCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
CRLRLVGHLDLLPDDVSRRLTQAQDSTNDNTGVFVNVAVGYGGRQEIVDAVRELIDAEAA
CEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHC
AGTTATEMAEKISVDSISKHLYTSGQPDPDLVIRTSGEQRLSGFLLWQAAYSEIWFTDTY
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEECCCC
WPAFRRVDFLRALREYSKRSRRFGK
CHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLKKFSLRDLAYNAAYPFYEKRLMREIQGVRQPEHVAIMCDGNRRWAREAGFADVTHG
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCCCCC
HRVGAKKIGEMVRWCAHTDVELVTVYLLSTENLGRASDELQMLFDIIGDVVDELASPETN
CCCCHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
CRLRLVGHLDLLPDDVSRRLTQAQDSTNDNTGVFVNVAVGYGGRQEIVDAVRELIDAEAA
CEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHC
AGTTATEMAEKISVDSISKHLYTSGQPDPDLVIRTSGEQRLSGFLLWQAAYSEIWFTDTY
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEECCCC
WPAFRRVDFLRALREYSKRSRRFGK
CHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910