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The map label for this gene is supH [H]

Identifier: 38233481

GI number: 38233481

Start: 858062

End: 858862

Strand: Reverse

Name: supH [H]

Synonym: DIP0884

Alternate gene names: 38233481

Gene position: 858862-858062 (Counterclockwise)

Preceding gene: 38233483

Following gene: 38233480

Centisome position: 34.51

GC content: 56.3

Gene sequence:

>801_bases
ATGACTCCACGCATCATTGTCACAGATATGGACGGCACCTTACTCAATAGCGAGCACGAAATACCGGCGCGCTTTTGGCC
GCTTCTCGACGAGATGCACGAGCAAGGAATCGTGTTCGCTCCGGCAAGCGGCCGCCAGCTCTACACTCTGTTGGATCAAT
TTGCGCAGGCCGGAAAAGATTTAAGTGTGATCGCAGAAAATGGCACCGTGGTCTATCACGAGGGCGAGATCATTTCCGTG
ACCACCATCGACCCCGAGGTAGCGCACCGCGTCATTCGTACCATGGCGCACAGCGATCTCGACTGGGGCGTCGTTGTCTG
CCGTGTCGACGGTGCGTTCATTGCGCGTGGCGACGTCGAGTTCCTCACCGAAACCGTGCGCTACTACGCAAAACTTGATG
TGGTTGACGACCTCCACAGCGTTGTCAACGATCAGGTCATCAAACTCGCCATCTATTCCTTCCCCGATGCTGAGACAGTA
GCAGCCCCTGCTCTCGCCGAAAGCGTGGGCGACCATACCCTCGCTATCTCCGGGGCGCATTGGATCGACATCATGAGTCC
CCACGCGAACAAAGGCGTCGCACTCCAGCAACTAGCAGACAACCTCGGAGTTCCCATTGAGCACACCGCCGCCTTCGGCG
ACTACCTCAACGACTACGAACTGCTCCACACTGCCGGAACCGCCTATGCCATGTCCAACGCACACCCTGATATTAAAGAC
ATTGCTGATCACGTCGTCGGTTCCAACGATGAAGAATCAGTGCTCACAACAATCCACAGCCTCCTGACCGCAGCAAAGTA
A

Upstream 100 bases:

>100_bases
TGTCCGCCAGTGTTCCACATCACCCGCTATTGTGCATGTGGTTTCCGACACCGGACGGCGAACGCTCGAGTCCCCACGCA
GATAGGTAAAGTGGTTTCTT

Downstream 100 bases:

>100_bases
CCCCCTCGACACCATCACCGTGAATATTCTCAATCAACTCCTCAACGCCACCCTCTACATCGGAGGAATTCCAATCCTGT
GGCGAGAAATCATCGGAAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTPRIIVTDMDGTLLNSEHEIPARFWPLLDEMHEQGIVFAPASGRQLYTLLDQFAQAGKDLSVIAENGTVVYHEGEIISV
TTIDPEVAHRVIRTMAHSDLDWGVVVCRVDGAFIARGDVEFLTETVRYYAKLDVVDDLHSVVNDQVIKLAIYSFPDAETV
AAPALAESVGDHTLAISGAHWIDIMSPHANKGVALQQLADNLGVPIEHTAAFGDYLNDYELLHTAGTAYAMSNAHPDIKD
IADHVVGSNDEESVLTTIHSLLTAAK

Sequences:

>Translated_266_residues
MTPRIIVTDMDGTLLNSEHEIPARFWPLLDEMHEQGIVFAPASGRQLYTLLDQFAQAGKDLSVIAENGTVVYHEGEIISV
TTIDPEVAHRVIRTMAHSDLDWGVVVCRVDGAFIARGDVEFLTETVRYYAKLDVVDDLHSVVNDQVIKLAIYSFPDAETV
AAPALAESVGDHTLAISGAHWIDIMSPHANKGVALQQLADNLGVPIEHTAAFGDYLNDYELLHTAGTAYAMSNAHPDIKD
IADHVVGSNDEESVLTTIHSLLTAAK
>Mature_265_residues
TPRIIVTDMDGTLLNSEHEIPARFWPLLDEMHEQGIVFAPASGRQLYTLLDQFAQAGKDLSVIAENGTVVYHEGEIISVT
TIDPEVAHRVIRTMAHSDLDWGVVVCRVDGAFIARGDVEFLTETVRYYAKLDVVDDLHSVVNDQVIKLAIYSFPDAETVA
APALAESVGDHTLAISGAHWIDIMSPHANKGVALQQLADNLGVPIEHTAAFGDYLNDYELLHTAGTAYAMSNAHPDIKDI
ADHVVGSNDEESVLTTIHSLLTAAK

Specific function: Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently, but it remains uncertain if this is the real substrate in vivo [H]

COG id: COG0561

COG function: function code R; Predicted hydrolases of the HAD superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787043, Length=270, Percent_Identity=29.2592592592593, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87081790, Length=267, Percent_Identity=28.8389513108614, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081741, Length=255, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367265, Length=270, Percent_Identity=24.8148148148148, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994981, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006379
- InterPro:   IPR000150 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.23 [H]

Molecular weight: Translated: 28949; Mature: 28818

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS01228 COF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRIIVTDMDGTLLNSEHEIPARFWPLLDEMHEQGIVFAPASGRQLYTLLDQFAQAGKD
CCCCEEEECCCCCEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCC
LSVIAENGTVVYHEGEIISVTTIDPEVAHRVIRTMAHSDLDWGVVVCRVDGAFIARGDVE
EEEEECCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCHH
FLTETVRYYAKLDVVDDLHSVVNDQVIKLAIYSFPDAETVAAPALAESVGDHTLAISGAH
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCE
WIDIMSPHANKGVALQQLADNLGVPIEHTAAFGDYLNDYELLHTAGTAYAMSNAHPDIKD
EEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCHHH
IADHVVGSNDEESVLTTIHSLLTAAK
HHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPRIIVTDMDGTLLNSEHEIPARFWPLLDEMHEQGIVFAPASGRQLYTLLDQFAQAGKD
CCCEEEECCCCCEECCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCC
LSVIAENGTVVYHEGEIISVTTIDPEVAHRVIRTMAHSDLDWGVVVCRVDGAFIARGDVE
EEEEECCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECCCHH
FLTETVRYYAKLDVVDDLHSVVNDQVIKLAIYSFPDAETVAAPALAESVGDHTLAISGAH
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCE
WIDIMSPHANKGVALQQLADNLGVPIEHTAAFGDYLNDYELLHTAGTAYAMSNAHPDIKD
EEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCHHH
IADHVVGSNDEESVLTTIHSLLTAAK
HHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]