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The map label for this gene is moeA1 [H]

Identifier: 38233460

GI number: 38233460

Start: 835162

End: 836427

Strand: Direct

Name: moeA1 [H]

Synonym: DIP0863

Alternate gene names: 38233460

Gene position: 835162-836427 (Clockwise)

Preceding gene: 38233459

Following gene: 38233461

Centisome position: 33.56

GC content: 56.79

Gene sequence:

>1266_bases
GTGCGCTCAGTGGAGCAGCAGCTAGCCCTTGTCACCCAATCTGCGGTAGCGCCAGAGCCTGTACGCATCGCTATCGCTGA
GGCACTGGGGCTTATGTGTGCTGAGGAAGTGCAGGCATCGCGTGCACTTCCTGGTTTCGACCAAGCTGCGATTGACGGAT
ATGCGGTCCGTGCGGTCGACGTTGGTGGTGAACGCGGCCTTGGCCGGCCTATCGACGCCCCTATTGGTCCGATCGAAACG
TCGTTGCCAGTTGTCGGTGAGGTCCCTGCGGGATCGCAGCGTCCGTTGCGTCTGCAACCCAAACAAGCCGTGCGAGTGCA
TACGGGTGCGCCGTTGCCCACGCTTTCTGATGCTGTTATCCCACTGGAGTGGACAGATTGTGGTCGTAAACGAATGACTG
CCCATCGGCCGGTGCGCTCTGGGGAGTTTGTGCGTCATGCTGGCGATGACATTCGTCCTGGTGATGTTGCGGTAAGCGAC
GGTGCGATTCTGAGTCCTGCTCACATCGGATTGTTGGCGGCTGTGGGGCGCTCAAAGGTGTTGGTGTATCCGCGTCCTCG
CATGTCGGTGATCTCTGTAGGACATGAGTTAGTAGAAATCGACCGCGAGCCTAGCTTGGGTCAAGTATTTGATGTGAACT
CCTATGCGTTAGCGGCTGCAGGACGTGATGCTGGTGCCGACGTACACCGTGTGGGCATTGCAGCCGGCGAGCCACGTCGC
CTCCGCGAGATTGTGGAATCACAACTTTTGCGTAGCGAAATCATTGTTATCGCCGGAGCAGTTGGTGGTTCTGGATCTGA
GGAGATTCGTCGTATTTTGTCTGATCTGGGAGAAATCGATACCACACGCGTTGCTATGCACCCAGGTTCTGTCCAAGGTT
TTGGGTTGCTAGGAGAAAACCAGACCCCAGTCTTCTTGCTTCCTAGTAACACTGTGTCGTCGTTGGTCATTTTCGAGATG
TTCATCCGTCCAGTCGTGCGCATGAGTTTGGGCAAGCGATCGTCGCAACGCCGTTTGGTGCGTGCGCGTGCGCTTAACCA
TGTGGGCTCGAAGGTGGGGCGTCGTGGTTACATTCGTGCTCGATTGATGCGTGACGCCCAGACACAGGACTATCTGGTGG
AAGGCTTAGGTGGTGCGAACGGTGCACCGGCCCACTTGTTGGCGGGCTTGGCTGAAGCGAATGCGATGATCAAAATCCCA
GAAGACGTCAACGAGGTCCGTCCAGGAGACATCGTCGAAGTTCTGTTTATGTCCCAAGGACGCTAG

Upstream 100 bases:

>100_bases
TTAAAAGTCACCCTGTGGGGTAAGCGCAGGTGTTGTGTGTTTTCGTGAGAAAGGGCACACTGCCTAGGAGAGAAGTTCAC
CAGTTTTAAAGGAGTCGGAC

Downstream 100 bases:

>100_bases
CGCGTATGCCTCGCTTATTTTCTCGGGTCAAGGAGATGCGATCCGATCGCGCTGCTGTCCATCCCCGTCATCCTGGTTGG
CCGGAGGCCACTCCCGCGGT

Product: putative molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGLGRPIDAPIGPIET
SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD
GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR
LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGENQTPVFLLPSNTVSSLVIFEM
FIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTQDYLVEGLGGANGAPAHLLAGLAEANAMIKIP
EDVNEVRPGDIVEVLFMSQGR

Sequences:

>Translated_421_residues
MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGLGRPIDAPIGPIET
SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD
GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR
LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGENQTPVFLLPSNTVSSLVIFEM
FIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTQDYLVEGLGGANGAPAHLLAGLAEANAMIKIP
EDVNEVRPGDIVEVLFMSQGR
>Mature_421_residues
MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVDVGGERGLGRPIDAPIGPIET
SLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVIPLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSD
GAILSPAHIGLLAAVGRSKVLVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR
LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGENQTPVFLLPSNTVSSLVIFEM
FIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRARLMRDAQTQDYLVEGLGGANGAPAHLLAGLAEANAMIKIP
EDVNEVRPGDIVEVLFMSQGR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=410, Percent_Identity=28.2926829268293, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI66932975, Length=410, Percent_Identity=28.2926829268293, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=28.0104712041885, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=30.7471264367816, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562606, Length=336, Percent_Identity=22.9166666666667, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136978, Length=404, Percent_Identity=23.5148514851485, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24638841, Length=404, Percent_Identity=23.5148514851485, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44855; Mature: 44855

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVD
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEE
VGGERGLGRPIDAPIGPIETSLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVI
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCHHHEEEECCCCCCCCCCCEE
PLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAAVGRSKV
EEEECCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCEEECCCCEECHHHHHHHHHCCCCEE
LVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR
EEECCCCHHHHHHCHHHHHCCCCCCCCCEEECCCEEEEECCCCCCCCEEEEECCCCCCHH
LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGEN
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCC
QTPVFLLPSNTVSSLVIFEMFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RLMRDAQTQDYLVEGLGGANGAPAHLLAGLAEANAMIKIPEDVNEVRPGDIVEVLFMSQG
HHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCCHHEEHEECCCC
R
C
>Mature Secondary Structure
MRSVEQQLALVTQSAVAPEPVRIAIAEALGLMCAEEVQASRALPGFDQAAIDGYAVRAVD
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEE
VGGERGLGRPIDAPIGPIETSLPVVGEVPAGSQRPLRLQPKQAVRVHTGAPLPTLSDAVI
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCHHHEEEECCCCCCCCCCCEE
PLEWTDCGRKRMTAHRPVRSGEFVRHAGDDIRPGDVAVSDGAILSPAHIGLLAAVGRSKV
EEEECCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCEEECCCCEECHHHHHHHHHCCCCEE
LVYPRPRMSVISVGHELVEIDREPSLGQVFDVNSYALAAAGRDAGADVHRVGIAAGEPRR
EEECCCCHHHHHHCHHHHHCCCCCCCCCEEECCCEEEEECCCCCCCCEEEEECCCCCCHH
LREIVESQLLRSEIIVIAGAVGGSGSEEIRRILSDLGEIDTTRVAMHPGSVQGFGLLGEN
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCC
QTPVFLLPSNTVSSLVIFEMFIRPVVRMSLGKRSSQRRLVRARALNHVGSKVGRRGYIRA
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RLMRDAQTQDYLVEGLGGANGAPAHLLAGLAEANAMIKIPEDVNEVRPGDIVEVLFMSQG
HHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCHHHHHCCCCHHEEHEECCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]