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The map label for this gene is purH

Identifier: 38233436

GI number: 38233436

Start: 817381

End: 818958

Strand: Direct

Name: purH

Synonym: DIP0839

Alternate gene names: 38233436

Gene position: 817381-818958 (Clockwise)

Preceding gene: 38233435

Following gene: 38233437

Centisome position: 32.84

GC content: 57.54

Gene sequence:

>1578_bases
ATGAGCGATGACCGCAAGCAGATCAAGCGCGCATTAATTAGTGTGTACGACAAGACCGGACTGGAAGATCTGGCCCGTGC
CCTCAATGATGCGGGTGTGGAGATCGTTTCCACCGGCTCGACCGCCGCTAAAATCGCTGATCTCGGAGTCCCTGTAACTC
CCGTAGAGCAACTCACTGGCTTCCCAGAATGTCTTGAAGGCCGTGTGAAGACCCTACACCCCATGGTTCACGCAGGAATC
CTTGCTGACACGCGTAAGGAGGACCACCTCAAGCAACTAGACGAGCTCAACGTAGCGCCGTTCCAGCTCGTGGTCGTCAA
CCTGTACCCATTTACCCAGACCGTTGCCTCGGGTGCCGATTTCGACGCTTGCGTCGAGCAGATCGACATCGGAGGACCAT
CGATGGTCCGTGCTGCGGCTAAGAACCACCCATCGGTAGCGGTCGTTGTATCTCCATCTCGTTACTCTGAGATCATCGCA
GCAGTTGGCAACGGTGGCTTCACCCGTGCTGAGCGCACGGCTTTGGCTGTCGACGCTTTCCGCCACACTGCTTCTTACGA
CGTCGCCGTAGCAACGTGGATGGGCGAGCAAATCGCGGATGCCGATAAACCATTCGCCGAGTGGATCGGAGCAAGCTATG
AGCGCGCCAACATTTTGCGTTACGGCGAAAATCCGCACCAAGCGGCGGCCCTCTACACTGACCCAGCAGCTCCTGCTGGC
CTTGCTCAAGCAACGCAGCTACACGGCAAGGAAATGAGCTACAACAACTACACGGACTCCGACGCAGCTTGGCGTGCTGC
ATGGGATCACGAGCGCCCATGCGTGGCCATCATCAAGCACGCAAACCCCTGCGGTATCGCAGTTTCCGACGTCTCCATTG
CTGAAGCTCACCGCACGGCACACGCGTGTGACCCAGTCTCCGCATTTGGCGGCGTGATCGCTTCCAACCGCGAAGTTAGC
GTAGATATGGCGAAGCAAGTCTCCGAAATCTTTACTGAGGTCATCATCGCCCCTTCCTATGAAGATGGTGCAGTGGACAT
TCTTTCGCAGAAGAAGAACATCCGAATCCTTGTAGCTCCGCAGCCACAGCGCGACGAACTCGAACAACGTCAGATTTCCG
GTGGCGTCCTTGTTCAGCGACGCGACCTCGTCGATGCCGAAGGTGATACCCCAGCTAACTGGACACTTGCTGCCGGTGAA
GGCGCATCTGAGGAATTGCTGGCAGAGCTGGAGTTCGCATGGCGTGCTGTGCGTGCCGTGAAGTCTAACGCTATTTTGCT
CGCGCAAGGCGGGGCAACGGTAGGCGTGGGCATGGGGCAGGTTAACCGTGTCGACGCAGCCAAGCTTGCTGTCGAGCGCG
CTAACTCTCTTGCCGGCGACGAACAGCGTGCCAAGGGATCGGTTGCAGCATCTGATGCATTCTTCCCATTCGCTGACGGT
TTTGAGGTGCTAGCGCAAGCTGGCGTTCGTGCTGTGGTTCAGCCTGGTGGATCTATCCGTGATGCTGAAGTGATCGAGGC
CGCTAACAAGGCTGGTGTGACCATGTACCTTACGGGTGCACGCCACTTCGCTCACTAA

Upstream 100 bases:

>100_bases
CATCTTCATGAAAGAATCAAACAAGTTGAGCGCCAGCTCATCGTGTCCGTGTTGAACTCCGCCGTGACGGAGAAAGAATC
AGGAGAGGTTTCCTTCACTC

Downstream 100 bases:

>100_bases
TTTCTTATCAACACGCCACGATGTACGACTGCACCGTGGCGTGTTTTCTTGTGCTTTTATGGGCTGCTTTCTGGGCAACG
ATGGGGGTAACCTTTATTAA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTGFPECLEGRVKTLHPMVHAGI
LADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGADFDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIA
AVGNGGFTRAERTALAVDAFRHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAG
LAQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTAHACDPVSAFGGVIASNREVS
VDMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAPQPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGE
GASEELLAELEFAWRAVRAVKSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADG
FEVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH

Sequences:

>Translated_525_residues
MSDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTGFPECLEGRVKTLHPMVHAGI
LADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGADFDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIA
AVGNGGFTRAERTALAVDAFRHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAG
LAQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTAHACDPVSAFGGVIASNREVS
VDMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAPQPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGE
GASEELLAELEFAWRAVRAVKSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADG
FEVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH
>Mature_524_residues
SDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTGFPECLEGRVKTLHPMVHAGIL
ADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGADFDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIAA
VGNGGFTRAERTALAVDAFRHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAGL
AQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTAHACDPVSAFGGVIASNREVSV
DMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAPQPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGEG
ASEELLAELEFAWRAVRAVKSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADGF
EVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=477, Percent_Identity=36.4779874213836, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1790439, Length=537, Percent_Identity=45.2513966480447, Blast_Score=425, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71985564, Length=476, Percent_Identity=34.8739495798319, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI71985574, Length=307, Percent_Identity=27.3615635179153, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323768, Length=480, Percent_Identity=35.8333333333333, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323056, Length=482, Percent_Identity=34.2323651452282, Blast_Score=232, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24649832, Length=479, Percent_Identity=34.446764091858, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_CORDI (Q6NID8)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939203.1
- HSSP:   P31939
- ProteinModelPortal:   Q6NID8
- SMR:   Q6NID8
- GeneID:   2649301
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0839
- NMPDR:   fig|257309.1.peg.794
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   CDIP257309:DIP0839-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 55796; Mature: 55665

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTG
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCHHHHCC
FPECLEGRVKTLHPMVHAGILADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGAD
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHCCCC
FDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIAAVGNGGFTRAERTALAVDAF
HHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAG
HHCCCCCEEEEHHHCHHHHCCCCCHHHHHCCCCCCCHHEECCCCCCCEEEEEECCCCCCC
LAQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTA
HHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHH
HACDPVSAFGGVIASNREVSVDMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAP
HCCCCHHHHCCCEECCCEEEHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCCEEEEECC
QPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGEGASEELLAELEFAWRAVRAV
CCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
KSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADG
HCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCCCH
FEVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH
HHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECCHHCCC
>Mature Secondary Structure 
SDDRKQIKRALISVYDKTGLEDLARALNDAGVEIVSTGSTAAKIADLGVPVTPVEQLTG
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCHHHHCC
FPECLEGRVKTLHPMVHAGILADTRKEDHLKQLDELNVAPFQLVVVNLYPFTQTVASGAD
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHCCCC
FDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPSRYSEIIAAVGNGGFTRAERTALAVDAF
HHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RHTASYDVAVATWMGEQIADADKPFAEWIGASYERANILRYGENPHQAAALYTDPAAPAG
HHCCCCCEEEEHHHCHHHHCCCCCHHHHHCCCCCCCHHEECCCCCCCEEEEEECCCCCCC
LAQATQLHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDVSIAEAHRTA
HHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHH
HACDPVSAFGGVIASNREVSVDMAKQVSEIFTEVIIAPSYEDGAVDILSQKKNIRILVAP
HCCCCHHHHCCCEECCCEEEHHHHHHHHHHHHHHEECCCCCCCCHHHHCCCCCEEEEECC
QPQRDELEQRQISGGVLVQRRDLVDAEGDTPANWTLAAGEGASEELLAELEFAWRAVRAV
CCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
KSNAILLAQGGATVGVGMGQVNRVDAAKLAVERANSLAGDEQRAKGSVAASDAFFPFADG
HCCEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCCCH
FEVLAQAGVRAVVQPGGSIRDAEVIEAANKAGVTMYLTGARHFAH
HHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910