Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 38233429

GI number: 38233429

Start: 807862

End: 809505

Strand: Reverse

Name: pgi

Synonym: DIP0832

Alternate gene names: 38233429

Gene position: 809505-807862 (Counterclockwise)

Preceding gene: 38233431

Following gene: 38233427

Centisome position: 32.53

GC content: 54.44

Gene sequence:

>1644_bases
ATGTCCTTCGATGTTACGACCACTGAGCCATGGGCTACGCTCTCTGAGCGCTACACCGCCATGAAGGCAACCACTCTTCG
TGATTTGTTTGCTAGCAACCCCAACCGCGCGCAGGAGTTGAGCTTCGAGGCAGCAGGTCTTCATGTCGACTTGTCCAAGA
ACTTGATCGATGCCGAAACCGTGGCTGCGTTTACTGCGCTGGCTAAGGCCTCTGGTATGCGCGAAAAAATCAAGGCCATG
TTTGATGGTGAGCACATTAACAACACCGAAGACCGCGCTGTGCTTCACACCGCACTTCGCCTTGCAGTCGATGCCGAGCT
TAACGTTGATGGCCAAGACGTAGCTGCAGATGTGCACGAGGTACTCGGCCGCATGCGCGACTTTGCTACGTCTTTGCGTA
ATGGCTCTTGGCGCGGTTACTCCAACCACACCATCAAGACCATTGTGAACATTGGTATCGGCGGATCTGACCTTGGCCCT
GCGATGGCAACGAAGGCGTTGCGTACTTATGCAACAGCCGGTATCAACGCGAAGTTTGTTTCCAACGTCGACCCAGCTGA
TATGCATGCGGTTCTCGACGAGCTCGATCCAGAGTCCACACTTTTCGTCGTCGCCTCCAAGACCTTTACCACCCAAGAGA
CTCTGGCTAATGCCCACGCAGCGAAGCGTTGGCTGGTTGCAGCTGCCGGTGGGGATGAATCTGCAGTGGCTAAGCACTTT
GTTGCGGTATCGACGAATGCAGAAAAAGTCGCAGAGTTTGGTATCGACACCAAGAACATGTTCGGTTTCTGGAACTGGGT
GGGTGGTCGTTACTCCGTAGATTCCGCAATTGGCTTGTCACTGATGTCTGTTATCGGACCGATGGACTTCATGCGATTCC
TTGATGGCTTCCGTGCCATGGATGAGCACTTCCGAACCGCCGATTTTGAGTCCAACATCCCTGTACTCATGGGGATGCTC
AACGTGTTCTACAACGATTTCTTCGGTGCAGAAACGCACGCGGTTCTCCCCTATTCTCAAGATTTGGGTCGCTTCCCTGC
TTATCTGCAACAGCTGACCATGGAGTCCAACGGCAAGTCTGTTCGCCACGACGGTAGCGCTGTGACCACCAACACCGGTG
AGATCTACTGGGGCGAGCCAGGCACTAATGGTCAGCACGCGTTCTTCCAGCTGATTCACCAAGGCACCAAGCTGATTCCG
GCCGACTTCATTGGTTTTGCGCGCCCGAAGGAAGACCTGCCTACTGCCAGCGGCGAAGGCTCCATGCATGATCTGCTCAT
GAGCAACTTCTTCGCACAAACCAAGGTTTTGGCTTTTGGTAAGACTGCCGAAGAAATCGCTGCAGAAGGCGTTTCTCCAG
AACTTGTAGCTCACAAGGTCATGCCTGGTAACCGTCCTACCACCACCATCATGGCTGAGGAACTTACACCTTTCGCTCTC
GGCGCACTGATCGCGCTCTACGAGCACATCGTGTTTGTCGAAGGCGTGATCTGGGACATCAACTCCTTCGATCAGTGGGG
TGTTGAGCTTGGCAAGCAGCAGGCTAATGATCTAGCCCCAGCTGTTGCCGGCGAGGTTGCTGTTGACTCCGGCGATAGCT
CCACCGATGCGTTGATCTCTTGGTACCGCTCCCACCGCGGCTAA

Upstream 100 bases:

>100_bases
ATCCGACAGGACAGGCGTATTTTCGATACCGTGGGAAGTGAGCGATTGCCACACTATCTGGGCACAAACTCGCATAAACC
AACAGAAATGGAGCAATGCA

Downstream 100 bases:

>100_bases
GACTGCATTAGCTCCCTAAAATAACGGGCCCTCACACAAGCATTATTGATGTGCTGATGTGAGGGCCCTGTGTGGATTCT
TGGGCTACATAGAGCTCATA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSFDVTTTEPWATLSERYTAMKATTLRDLFASNPNRAQELSFEAAGLHVDLSKNLIDAETVAAFTALAKASGMREKIKAM
FDGEHINNTEDRAVLHTALRLAVDAELNVDGQDVAADVHEVLGRMRDFATSLRNGSWRGYSNHTIKTIVNIGIGGSDLGP
AMATKALRTYATAGINAKFVSNVDPADMHAVLDELDPESTLFVVASKTFTTQETLANAHAAKRWLVAAAGGDESAVAKHF
VAVSTNAEKVAEFGIDTKNMFGFWNWVGGRYSVDSAIGLSLMSVIGPMDFMRFLDGFRAMDEHFRTADFESNIPVLMGML
NVFYNDFFGAETHAVLPYSQDLGRFPAYLQQLTMESNGKSVRHDGSAVTTNTGEIYWGEPGTNGQHAFFQLIHQGTKLIP
ADFIGFARPKEDLPTASGEGSMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVSPELVAHKVMPGNRPTTTIMAEELTPFAL
GALIALYEHIVFVEGVIWDINSFDQWGVELGKQQANDLAPAVAGEVAVDSGDSSTDALISWYRSHRG

Sequences:

>Translated_547_residues
MSFDVTTTEPWATLSERYTAMKATTLRDLFASNPNRAQELSFEAAGLHVDLSKNLIDAETVAAFTALAKASGMREKIKAM
FDGEHINNTEDRAVLHTALRLAVDAELNVDGQDVAADVHEVLGRMRDFATSLRNGSWRGYSNHTIKTIVNIGIGGSDLGP
AMATKALRTYATAGINAKFVSNVDPADMHAVLDELDPESTLFVVASKTFTTQETLANAHAAKRWLVAAAGGDESAVAKHF
VAVSTNAEKVAEFGIDTKNMFGFWNWVGGRYSVDSAIGLSLMSVIGPMDFMRFLDGFRAMDEHFRTADFESNIPVLMGML
NVFYNDFFGAETHAVLPYSQDLGRFPAYLQQLTMESNGKSVRHDGSAVTTNTGEIYWGEPGTNGQHAFFQLIHQGTKLIP
ADFIGFARPKEDLPTASGEGSMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVSPELVAHKVMPGNRPTTTIMAEELTPFAL
GALIALYEHIVFVEGVIWDINSFDQWGVELGKQQANDLAPAVAGEVAVDSGDSSTDALISWYRSHRG
>Mature_546_residues
SFDVTTTEPWATLSERYTAMKATTLRDLFASNPNRAQELSFEAAGLHVDLSKNLIDAETVAAFTALAKASGMREKIKAMF
DGEHINNTEDRAVLHTALRLAVDAELNVDGQDVAADVHEVLGRMRDFATSLRNGSWRGYSNHTIKTIVNIGIGGSDLGPA
MATKALRTYATAGINAKFVSNVDPADMHAVLDELDPESTLFVVASKTFTTQETLANAHAAKRWLVAAAGGDESAVAKHFV
AVSTNAEKVAEFGIDTKNMFGFWNWVGGRYSVDSAIGLSLMSVIGPMDFMRFLDGFRAMDEHFRTADFESNIPVLMGMLN
VFYNDFFGAETHAVLPYSQDLGRFPAYLQQLTMESNGKSVRHDGSAVTTNTGEIYWGEPGTNGQHAFFQLIHQGTKLIPA
DFIGFARPKEDLPTASGEGSMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVSPELVAHKVMPGNRPTTTIMAEELTPFALG
ALIALYEHIVFVEGVIWDINSFDQWGVELGKQQANDLAPAVAGEVAVDSGDSSTDALISWYRSHRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=533, Percent_Identity=51.4071294559099, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI296080693, Length=533, Percent_Identity=48.4052532833021, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1790457, Length=552, Percent_Identity=52.7173913043478, Blast_Score=555, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI71996708, Length=536, Percent_Identity=52.0522388059702, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71996703, Length=536, Percent_Identity=52.0522388059702, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6319673, Length=550, Percent_Identity=49.8181818181818, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=51.0989010989011, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=51.0989010989011, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=51.0989010989011, Blast_Score=519, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CORDI (Q6NIE5)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939196.1
- ProteinModelPortal:   Q6NIE5
- SMR:   Q6NIE5
- GeneID:   2649294
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0832
- NMPDR:   fig|257309.1.peg.787
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- PhylomeDB:   Q6NIE5
- ProtClustDB:   PRK00179
- BioCyc:   CDIP257309:DIP0832-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59411; Mature: 59280

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 386-386 ACT_SITE 512-512

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDVTTTEPWATLSERYTAMKATTLRDLFASNPNRAQELSFEAAGLHVDLSKNLIDAET
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCEEEECCCCCCHHHH
VAAFTALAKASGMREKIKAMFDGEHINNTEDRAVLHTALRLAVDAELNVDGQDVAADVHE
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VLGRMRDFATSLRNGSWRGYSNHTIKTIVNIGIGGSDLGPAMATKALRTYATAGINAKFV
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEE
SNVDPADMHAVLDELDPESTLFVVASKTFTTQETLANAHAAKRWLVAAAGGDESAVAKHF
CCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHH
VAVSTNAEKVAEFGIDTKNMFGFWNWVGGRYSVDSAIGLSLMSVIGPMDFMRFLDGFRAM
EEECCCHHHHHHHCCCCHHHCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
DEHFRTADFESNIPVLMGMLNVFYNDFFGAETHAVLPYSQDLGRFPAYLQQLTMESNGKS
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCE
VRHDGSAVTTNTGEIYWGEPGTNGQHAFFQLIHQGTKLIPADFIGFARPKEDLPTASGEG
EECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHCCCCCCCC
SMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVSPELVAHKVMPGNRPTTTIMAEELTPFAL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEHHHCCHHHH
GALIALYEHIVFVEGVIWDINSFDQWGVELGKQQANDLAPAVAGEVAVDSGDSSTDALIS
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHH
WYRSHRG
HHHHCCC
>Mature Secondary Structure 
SFDVTTTEPWATLSERYTAMKATTLRDLFASNPNRAQELSFEAAGLHVDLSKNLIDAET
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCEEEECCCCCCHHHH
VAAFTALAKASGMREKIKAMFDGEHINNTEDRAVLHTALRLAVDAELNVDGQDVAADVHE
HHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VLGRMRDFATSLRNGSWRGYSNHTIKTIVNIGIGGSDLGPAMATKALRTYATAGINAKFV
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEE
SNVDPADMHAVLDELDPESTLFVVASKTFTTQETLANAHAAKRWLVAAAGGDESAVAKHF
CCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEECCCCHHHHHHHH
VAVSTNAEKVAEFGIDTKNMFGFWNWVGGRYSVDSAIGLSLMSVIGPMDFMRFLDGFRAM
EEECCCHHHHHHHCCCCHHHCCHHHCCCCCEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
DEHFRTADFESNIPVLMGMLNVFYNDFFGAETHAVLPYSQDLGRFPAYLQQLTMESNGKS
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCE
VRHDGSAVTTNTGEIYWGEPGTNGQHAFFQLIHQGTKLIPADFIGFARPKEDLPTASGEG
EECCCCEEEECCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHCCCCCCCC
SMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVSPELVAHKVMPGNRPTTTIMAEELTPFAL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEHHHCCHHHH
GALIALYEHIVFVEGVIWDINSFDQWGVELGKQQANDLAPAVAGEVAVDSGDSSTDALIS
HHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHH
WYRSHRG
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910