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The map label for this gene is hisN [H]

Identifier: 38233350

GI number: 38233350

Start: 720098

End: 720886

Strand: Reverse

Name: hisN [H]

Synonym: DIP0744

Alternate gene names: 38233350

Gene position: 720886-720098 (Counterclockwise)

Preceding gene: 38233351

Following gene: 38233343

Centisome position: 28.97

GC content: 56.91

Gene sequence:

>789_bases
ATGAGTTACCACGACGATCTTGCGTTCGCTCTCCAGCTTGCAGATGCCGCAGACGCCATCACCTTGGCACGATTTGCAGC
CTCTGACCTGAAGGTTTCTTCTAAACCAGATATGACGCCGGTCAGCGATGCCGATATTGCCACGGAGCGTGAGCTTCGAG
ATCTCATCGCGCAGCGCTTCCCCGAGGACGCAATTCTCGGCGAGGAATTTGGTGGCACCGCCGAGTTCACCGGCCGGCAG
TGGATCATCGACCCCATCGATGGCACCAAAAACTACGTTCGCGGTGTTCCCGTGTGGGCCACACTTATCGCATTGCTTGT
CGACGGCCACCCTGTTGTTGGCGTGGTGTCTGCGCCAGCCATTGCGCATCGTTGGTGGGCTGCTCAAGGAGAAGGCGCAT
GGCGCAGCAATCCAGCTCAAGAATCCCGCCGCATCCACGTCAGTAACGTAGCGCAGCTAACCGACGCCTCCGTTTCGTTC
TCCTCCCTCGATGGTTGGAAAGAACGCGGTCTGTTGAACAACTTTGTCGCTCTTTCCGACGAGACGTGGCGTCTACGCGG
ATTCGGTGACTTCTTCTCCTACTGCCTCGTTGCCGAAGGCGCAGTCGATATTGCTGCGGAACCAGAAGTATCTCTGTGGG
ATCTAGCTCCCTTGTCCATCTTGGTTGAAGAAGCCGGCGGAGTGTTTAGTTCCCTCGACGGAGCCCTAGGACCTCATGGT
GGAAACGCATTGGCTACTAATGGGCTGCTTCACGATGAAGTCCGCACAATGCTGACCTCATCGCGATAA

Upstream 100 bases:

>100_bases
ATCCACAAGCAACCGATGAAGTCGCAGCAATGTTATCTCGCTAATACTGTCCTTACATCTCTCTAGTTTTCCGGCTATTT
TCAGGAGCACGTACCACCCC

Downstream 100 bases:

>100_bases
CAACTCCCCCGCTATCTATTAAGAGTTAGCAAGCCGGAAACCGTGTCCGACTGATTTCTTAGAATTGAGGTCGGATACGA
TTGCATCCATGTTCGTGCTG

Product: hypothetical protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSYHDDLAFALQLADAADAITLARFAASDLKVSSKPDMTPVSDADIATERELRDLIAQRFPEDAILGEEFGGTAEFTGRQ
WIIDPIDGTKNYVRGVPVWATLIALLVDGHPVVGVVSAPAIAHRWWAAQGEGAWRSNPAQESRRIHVSNVAQLTDASVSF
SSLDGWKERGLLNNFVALSDETWRLRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVEEAGGVFSSLDGALGPHG
GNALATNGLLHDEVRTMLTSSR

Sequences:

>Translated_262_residues
MSYHDDLAFALQLADAADAITLARFAASDLKVSSKPDMTPVSDADIATERELRDLIAQRFPEDAILGEEFGGTAEFTGRQ
WIIDPIDGTKNYVRGVPVWATLIALLVDGHPVVGVVSAPAIAHRWWAAQGEGAWRSNPAQESRRIHVSNVAQLTDASVSF
SSLDGWKERGLLNNFVALSDETWRLRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVEEAGGVFSSLDGALGPHG
GNALATNGLLHDEVRTMLTSSR
>Mature_261_residues
SYHDDLAFALQLADAADAITLARFAASDLKVSSKPDMTPVSDADIATERELRDLIAQRFPEDAILGEEFGGTAEFTGRQW
IIDPIDGTKNYVRGVPVWATLIALLVDGHPVVGVVSAPAIAHRWWAAQGEGAWRSNPAQESRRIHVSNVAQLTDASVSFS
SLDGWKERGLLNNFVALSDETWRLRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVEEAGGVFSSLDGALGPHGG
NALATNGLLHDEVRTMLTSSR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=238, Percent_Identity=30.2521008403361, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221625487, Length=238, Percent_Identity=30.2521008403361, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7657236, Length=245, Percent_Identity=28.1632653061224, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788882, Length=270, Percent_Identity=28.5185185185185, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790659, Length=198, Percent_Identity=29.7979797979798, Blast_Score=71, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=240, Percent_Identity=28.3333333333333, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193202570, Length=243, Percent_Identity=28.8065843621399, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320493, Length=206, Percent_Identity=30.0970873786408, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357329, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357957, Length=251, Percent_Identity=29.8804780876494, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664926, Length=208, Percent_Identity=32.2115384615385, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664918, Length=211, Percent_Identity=31.2796208530806, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664922, Length=209, Percent_Identity=30.1435406698565, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357303, Length=232, Percent_Identity=28.0172413793103, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28204; Mature: 28073

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYHDDLAFALQLADAADAITLARFAASDLKVSSKPDMTPVSDADIATERELRDLIAQRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
PEDAILGEEFGGTAEFTGRQWIIDPIDGTKNYVRGVPVWATLIALLVDGHPVVGVVSAPA
CCCHHCCCCCCCCEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEEECCCH
IAHRWWAAQGEGAWRSNPAQESRRIHVSNVAQLTDASVSFSSLDGWKERGLLNNFVALSD
HHHHHHCCCCCCCCCCCCHHHHCEEEHHHHHHHHCCCCCHHHCCCHHHCCHHHHHEEECC
ETWRLRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVEEAGGVFSSLDGALGPHG
CCEEEEEHHHHHHHHHHHCCCEEECCCCCCCEECCCHHHHHHHHHCCHHHHHCCCCCCCC
GNALATNGLLHDEVRTMLTSSR
CCEEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SYHDDLAFALQLADAADAITLARFAASDLKVSSKPDMTPVSDADIATERELRDLIAQRF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
PEDAILGEEFGGTAEFTGRQWIIDPIDGTKNYVRGVPVWATLIALLVDGHPVVGVVSAPA
CCCHHCCCCCCCCEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEEECCCH
IAHRWWAAQGEGAWRSNPAQESRRIHVSNVAQLTDASVSFSSLDGWKERGLLNNFVALSD
HHHHHHCCCCCCCCCCCCHHHHCEEEHHHHHHHHCCCCCHHHCCCHHHCCHHHHHEEECC
ETWRLRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVEEAGGVFSSLDGALGPHG
CCEEEEEHHHHHHHHHHHCCCEEECCCCCCCEECCCHHHHHHHHHCCHHHHHCCCCCCCC
GNALATNGLLHDEVRTMLTSSR
CCEEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]