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The map label for this gene is manA [H]

Identifier: 38233296

GI number: 38233296

Start: 663663

End: 664832

Strand: Direct

Name: manA [H]

Synonym: DIP0689

Alternate gene names: 38233296

Gene position: 663663-664832 (Clockwise)

Preceding gene: 38233295

Following gene: 38233298

Centisome position: 26.67

GC content: 53.08

Gene sequence:

>1170_bases
ATGCAGCTACTAGCACCAGCAACTCAAGCCTATGCTTGGGGCTCTCGAACGCTAATTCAACAGCTTCGGGGAGATGCGGC
CGATTCTCGGCCCATCGCAGAACTCTGGTACGGGGCTCATCCAAGTGGTCCATCTGTGATTGATGGCGAGCGGACTCTTG
CTGACGTCATTGCACAAGACCCTGCCACGCAGCTTGGGCACCGTGTTGTTACCGAGCACGGTAACCGACTTCCATTCCTT
CTTAAACTTCTCGCGGCTGATCAACCGCTATCCTTGCAGGCGCACCCATCAAAGCAGCAGGCAGAAGAAGGATTTAGCCG
CGAAAATGATCTCGGTATTGCGCTTGGTGCGAGCAACCGAAACTACAAGGATGACAACCATAAGCCAGAACTTTTGGTAG
CACTTACTGAGTTCCATGCGATGGCAGGTTTCCGGCCATTGGATAAAACTCGGGAGCTTTTCCAAGCATTGCAGTGCGAG
AAGCTCAACCGCTACGTAGGAATGCTCGATTCTTCCCCAGAACATGAAGGCGAGAATCTTCGTGCGCTGTTTACCACATG
GATCACGATCCCCGTAGCAAGTCGCCAGCAGCTTATTGCCGCCATTATCGAGGCTATCGACGGGCTGAGCACCACGAGTC
CTGAGTGGATCCAGGTAGCGGCTCGCAATGTTGCCCAGCTTAATGATCGCTACCCCAATGACATCGGAGTTCTGGGGGCG
TTATTGCTCAACTATGTGGTGCTCCAACCGGGAGAAGCCATTTACCTCAGTGCCGGTAACCTGCATGCTTATGTCAAAGG
TTTGGGCGTAGAGATCATGGCAAACTCGGATAACGTGCTGCGTGGTGGCCTAACCCCAAAGTATGTGGATGTTCCCGAGT
TGGTTCGAGTGCTTCGTTTTGAGTCTCTCGAAGATCCCATTGTGCGGTCTGTGGCGGGACGCTACGAGGTTCCTATTAAT
GAGTTTGCGCTTCAGCGTTTGCACATCGATTCTGAGGCAGAGCACAATGCGCGCCTCGAGCATGATGGTCCGATGATCGC
GGTGTGCACCTCCGGTGAGTTGACTATTAATGATGTCGTGCTAGCACCTACCCAAGCACTGTGGATTTCTGCTGACGATC
CAGCAGTTGAAGTTACAGGATCAGGTGAGCTTTTCGTCGCTTCCGTATAG

Upstream 100 bases:

>100_bases
CATCAGGATGTTGGCTCGAGGTTATGCAGCGACGGCATTTTTTGGTGCCACAGATGCATAAAACTTCTCGGGGGATACTT
GTTGTGGAGGAACAACTACG

Downstream 100 bases:

>100_bases
CTTTAGCAGGCTCTGAGCTGCGCTATTACTGCGCAGCGGGAGCCGCGGGGCGCGCATCAGCAGATGGTGCGGGGCTAGGT
TTTGCATTTTGCTTGCGCGG

Product: putative mannose-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MQLLAPATQAYAWGSRTLIQQLRGDAADSRPIAELWYGAHPSGPSVIDGERTLADVIAQDPATQLGHRVVTEHGNRLPFL
LKLLAADQPLSLQAHPSKQQAEEGFSRENDLGIALGASNRNYKDDNHKPELLVALTEFHAMAGFRPLDKTRELFQALQCE
KLNRYVGMLDSSPEHEGENLRALFTTWITIPVASRQQLIAAIIEAIDGLSTTSPEWIQVAARNVAQLNDRYPNDIGVLGA
LLLNYVVLQPGEAIYLSAGNLHAYVKGLGVEIMANSDNVLRGGLTPKYVDVPELVRVLRFESLEDPIVRSVAGRYEVPIN
EFALQRLHIDSEAEHNARLEHDGPMIAVCTSGELTINDVVLAPTQALWISADDPAVEVTGSGELFVASV

Sequences:

>Translated_389_residues
MQLLAPATQAYAWGSRTLIQQLRGDAADSRPIAELWYGAHPSGPSVIDGERTLADVIAQDPATQLGHRVVTEHGNRLPFL
LKLLAADQPLSLQAHPSKQQAEEGFSRENDLGIALGASNRNYKDDNHKPELLVALTEFHAMAGFRPLDKTRELFQALQCE
KLNRYVGMLDSSPEHEGENLRALFTTWITIPVASRQQLIAAIIEAIDGLSTTSPEWIQVAARNVAQLNDRYPNDIGVLGA
LLLNYVVLQPGEAIYLSAGNLHAYVKGLGVEIMANSDNVLRGGLTPKYVDVPELVRVLRFESLEDPIVRSVAGRYEVPIN
EFALQRLHIDSEAEHNARLEHDGPMIAVCTSGELTINDVVLAPTQALWISADDPAVEVTGSGELFVASV
>Mature_389_residues
MQLLAPATQAYAWGSRTLIQQLRGDAADSRPIAELWYGAHPSGPSVIDGERTLADVIAQDPATQLGHRVVTEHGNRLPFL
LKLLAADQPLSLQAHPSKQQAEEGFSRENDLGIALGASNRNYKDDNHKPELLVALTEFHAMAGFRPLDKTRELFQALQCE
KLNRYVGMLDSSPEHEGENLRALFTTWITIPVASRQQLIAAIIEAIDGLSTTSPEWIQVAARNVAQLNDRYPNDIGVLGA
LLLNYVVLQPGEAIYLSAGNLHAYVKGLGVEIMANSDNVLRGGLTPKYVDVPELVRVLRFESLEDPIVRSVAGRYEVPIN
EFALQRLHIDSEAEHNARLEHDGPMIAVCTSGELTINDVVLAPTQALWISADDPAVEVTGSGELFVASV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=384, Percent_Identity=29.9479166666667, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787899, Length=399, Percent_Identity=37.844611528822, Blast_Score=251, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71997620, Length=315, Percent_Identity=35.2380952380952, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17557650, Length=369, Percent_Identity=28.7262872628726, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320839, Length=393, Percent_Identity=32.824427480916, Blast_Score=169, Evalue=7e-43,
Organism=Drosophila melanogaster, GI21356061, Length=348, Percent_Identity=31.3218390804598, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 42495; Mature: 42495

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00965 PMI_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLAPATQAYAWGSRTLIQQLRGDAADSRPIAELWYGAHPSGPSVIDGERTLADVIAQD
CCCCCCCHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
PATQLGHRVVTEHGNRLPFLLKLLAADQPLSLQAHPSKQQAEEGFSRENDLGIALGASNR
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCHHHHHHCCCCCCCCEEEEECCCC
NYKDDNHKPELLVALTEFHAMAGFRPLDKTRELFQALQCEKLNRYVGMLDSSPEHEGENL
CCCCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RALFTTWITIPVASRQQLIAAIIEAIDGLSTTSPEWIQVAARNVAQLNDRYPNDIGVLGA
HEEEEEEHEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLLNYVVLQPGEAIYLSAGNLHAYVKGLGVEIMANSDNVLRGGLTPKYVDVPELVRVLRF
HHHHHHHCCCCCEEEEECCCEEEEEECCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHH
ESLEDPIVRSVAGRYEVPINEFALQRLHIDSEAEHNARLEHDGPMIAVCTSGELTINDVV
HCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCEEEEEEE
LAPTQALWISADDPAVEVTGSGELFVASV
ECCCEEEEEECCCCEEEEECCCCEEEEEC
>Mature Secondary Structure
MQLLAPATQAYAWGSRTLIQQLRGDAADSRPIAELWYGAHPSGPSVIDGERTLADVIAQD
CCCCCCCHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
PATQLGHRVVTEHGNRLPFLLKLLAADQPLSLQAHPSKQQAEEGFSRENDLGIALGASNR
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCHHHHHHCCCCCCCCEEEEECCCC
NYKDDNHKPELLVALTEFHAMAGFRPLDKTRELFQALQCEKLNRYVGMLDSSPEHEGENL
CCCCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RALFTTWITIPVASRQQLIAAIIEAIDGLSTTSPEWIQVAARNVAQLNDRYPNDIGVLGA
HEEEEEEHEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLLNYVVLQPGEAIYLSAGNLHAYVKGLGVEIMANSDNVLRGGLTPKYVDVPELVRVLRF
HHHHHHHCCCCCEEEEECCCEEEEEECCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHH
ESLEDPIVRSVAGRYEVPINEFALQRLHIDSEAEHNARLEHDGPMIAVCTSGELTINDVV
HCCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEEEECCCEEEEEEE
LAPTQALWISADDPAVEVTGSGELFVASV
ECCCEEEEEECCCCEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]