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The map label for this gene is pyc [H]

Identifier: 38233253

GI number: 38233253

Start: 617693

End: 621118

Strand: Direct

Name: pyc [H]

Synonym: DIP0646

Alternate gene names: 38233253

Gene position: 617693-621118 (Clockwise)

Preceding gene: 38233252

Following gene: 38233258

Centisome position: 24.82

GC content: 57.53

Gene sequence:

>3426_bases
GTGTCTCAACAATCATCTGAACGTGGAACCTCTACGGTAAATCCATTGTCAAAGATCCTCGTTGCTAACCGTGGCGAGAT
CGCCGTGCGAGCTTTTCGTGCAGCCTTTGAAACCGGTGCTGCCACGGTAGCTGTCTACCCGAACGAAGACCGTAATTCAT
TCCACCGATCGTTTGCCTCTGAAGCTGTCCTCATTGGTGAGGGCGGATCTGCGGTCAAAGCGTACCTCGATATCGACGAA
ATCATCCGTGCTGCTAAACAAACGGGTGCCGACGCAATTTACCCAGGCTACGGCTTCCTTTCCGAAAACGCCCAGCTTGC
TCGTGAGTGCGCTGAAAACGGCATAACCTTTATCGGTCCACCTCCATCAGTGCTGGAGCTTACCGGTGATAAAGCAGCTG
CTGTTACCGCAGCACGCGAGGCAGGTTTGCCCACGCTGACTGAGACAGAAGCAACAGACGATCCAAAGAAGCTCGCAGAG
CTGACCAAGGGGCAGACCTACCCGCTATTCGTCAAAGCCGTTGCCGGTGGTGGTGGCCGCGGCATGCGTTTTGTCGACGC
CCCCGAAAACCTAGAAAAGCTAGCAGCAGAAGCCTCCCGTGAGGCGGCTGCAGCATTCGGCGATGGCCGAGTCTACGCCG
AGCGTGCAGTAATCAATCCTCAGCATATTGAGGTCCAGATCCTTGGTGACTCCGCTGGCAACATCATCCACCTGTACGAG
CGTGATTGCTCGCTGCAGCGTCGCCACCAAAAGGTCGTAGAGATCGCCCCAGCACAGCACTTGGCGCCCGGACTACGCGA
AAAGATTTGTGCAGACGCAGTCGCGTTTGCACGCCACATCGGTTACCAAGGTGCAGGCACGGTCGAGTTCCTAGTCGATG
AGGAAGGCAACCACGTCTTCATCGAGATGAACCCTCGTATCCAGGTCGAACACACCGTGACCGAAGAGGTCACCCAAGTC
GACTTGGTGAAGTCCCAGATCATGATCGCCTCCGGTGCGACACTCGAAGATCTCGGTCTGCGCCAAGAAGACATCCACAC
CGAAGGCGCTGCCCTGCAGTGCCGTATTACTACTGAAGACCCCAACAACGGTTTCCGTCCTGACACCGGAACGATTACCG
CTTATCGTTCCCCAGGTGGCGCAGGTGTTCGTCTCGACGGTGCTGCCATGCTCGGTGGTGAGATCACCCCGAATTTCGAC
TCCATGCTGGTCAAGATGACCTGCCGTGGTGCCGATTTCGCCACCGCAGTCGCTCGCGCTCAGCGTGCACTCGCAGAATT
CGTTGTCTCAGGTGTTGCTACCAACATCGGATTCCTGCGTGCTTTGCTACGCGAAGAAGACTTCCAGCACAAGCGCATCG
CCACTGGCTTCATCGCAGATCACCCATGGCTGCTGCAGGCACCACCTGCCGACGATGAGCCTGGCCGCATTTTGAACTAC
CTAGCTGATGTGACTGTGAACAAGCCTCATGGTCTACGCCCAGCCGTGATCAACCCGGTAGAAAAGCTCCCAGCAGAGAT
CAAAGGTGAGCTACCACGTGGTTCCCGTGATCGCCTGCTCCAGCTCGGCCCAGAGGGATTTGCGCGCGCACTGCGTAAAC
AGGATGCGCTCGCGGTTACGGATACCACCTTCCGTGATGCACATCAGTCGCTTCTCGCAACCCGCGTGCGCTCCAACACG
CTGATCGACGCAGCACGGCACGTCGCAAAGCTCACCCCAGAGCTGCTCTCTGTAGAAGCATGGGGTGGTGCTACCTATGA
CGTTGCTATGCGCTTCCTACATGAGGACCCCTGGGAGCGTCTCGACCACCTGCGTGAGGCCATGCCCAACGTCAACATTC
AGATGCTGCTGCGAGGCCGCAACACAGTCGGCTACACACCGTACCCAGATTCTGTATGCAAGGCTTTTGTCGACGAAGCC
GCACGCTCTGGTGTTGATATCTTCCGCATCTTCGACGCGCTTAACGACGTCTCCCAGATGCGTCCAGCAATCGACGCAGT
GCTCGAAACCAACACCACGATTGCCGAAGTCGCAATGGCCTACTCCGGTGATCTGACCAACCCAAGTGAGAAGCTCTACA
CACTGGATTACTACCTTAAGCTTGCCGAGGAAATCGTTAAGTCCGGTGCACATGTTCTAGCCATTAAAGACATGGCTGGA
CTGATGAAGCCAGCCGCAGCAACCAAGCTGGTCACCGAACTACGACGCAACTTCGACCTGCCGGTTCATGTTCACACCCA
CGACACTGCTGGTGGCCAGCTGGCTACGTATTGGGCTGCAGCAGCCGCTGGTGCAGATGCCGTCGATGGTGCCTCCGCGC
CACTGTCGGGCACAACGTCGCAGCCATCGTTGTCTGCAATTGTGGCAGCATTCGCTAACACCTACCGCGATACGGGTCTC
TCTCTGGACGCAGTCGGATCGATGGAACCGTACTGGGAAGCAGTGCGCAAACTCTACGCACCCTTCGAATCCGGAACCCC
AGGACCAACTGGCCGCGTCTACCAGCACGAAATCCCAGGCGGCCAGCTGTCCAATCTGCGCGCACAGGCAACTGCACTCG
GCTTGGCAGATCGCTTCGAGCTCATCGAGGACTACTACGCAGCCGTTAATGAGATGCTGGGACGCCCCACCAAGGTCACC
CCGTCCTCAAAGGTCGTTGGCGATCTTGCACTCTACCTAGTCGGCGCAGGAGTTAACCCAGCGGACTTTGCAGCAGATCC
CCAAAAGTACGATATTCCTGACTCCGTCATTGCCTTCCTCCGTGGTGAGCTCGGCACCCCTCCAGGCGGCTGGCCAGAAG
AACTGCGTGCTAAGGCATTGGCAGGACGTAAGGAATCAAAGGACACATTGGCCCCGCTGCCAGCAGAAGATGAAGCTCTG
CTCGCAGATCGTGCGACCGTTCGCCCAACGCTGGATCGCCTGCTCTTCCCGAAGCCTGCGGCAGAATTCGCAGAGCACCG
CCGTCAGTTTGGCGATACCACCAAACTCGGTGACGCAGAATTCCTCTATGGCCTCAAAGAAGGCAAAGAAACGGTCATTC
GTACCGCAGACAGTAGCGTCCCAATGCTGGTGCGTCTCGATGCCGTCGGCGAGCCCGACGAAAAGGGCATGCGCAACGTT
GTGTGCAATGTCAACGGCCAGATTCGCCCCATCCTCGTGCGTGATCGCAGCGTAGAGTCAGTGACCGCCTCGGTGGAAAA
GGCTGATCCTTCCAACGCCGGACACGTAGCAGCACCATTCGCAGGCGTTGTCACAGTGACAATCGAGGAAGGCGCTACCG
TCAAAGCCGGCGATCCAGTTGCTGTCATTGAGGCAATGAAGATGGAGGCAACGATCTCTGCCACCACAGACGGAACCGTC
GACCGTATCGTCTTGACGCAGGCCACCAAGGTCGAAGGTGGAGACTTGCTCCTCGTGATCAAGTAG

Upstream 100 bases:

>100_bases
GCGATCACAGATTTCGCCGTCGTGCGAATCAAGGTACATGGTCTAGTGCTTTGTTTCACAAAAGCGCTGACTTTCTTTTT
CAAACAAGGACAAACTAACA

Downstream 100 bases:

>100_bases
CCATCACCGTCTAACAGTTAGACGCACAGCAGCCGGTTCGATTATCTCCCGCGCGGAGATTCGAACCGGCTGCTGTTATT
TTCGTGTGTTTAATCCGTTA

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1141; Mature: 1140

Protein sequence:

>1141_residues
MSQQSSERGTSTVNPLSKILVANRGEIAVRAFRAAFETGAATVAVYPNEDRNSFHRSFASEAVLIGEGGSAVKAYLDIDE
IIRAAKQTGADAIYPGYGFLSENAQLARECAENGITFIGPPPSVLELTGDKAAAVTAAREAGLPTLTETEATDDPKKLAE
LTKGQTYPLFVKAVAGGGGRGMRFVDAPENLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDSAGNIIHLYE
RDCSLQRRHQKVVEIAPAQHLAPGLREKICADAVAFARHIGYQGAGTVEFLVDEEGNHVFIEMNPRIQVEHTVTEEVTQV
DLVKSQIMIASGATLEDLGLRQEDIHTEGAALQCRITTEDPNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEITPNFD
SMLVKMTCRGADFATAVARAQRALAEFVVSGVATNIGFLRALLREEDFQHKRIATGFIADHPWLLQAPPADDEPGRILNY
LADVTVNKPHGLRPAVINPVEKLPAEIKGELPRGSRDRLLQLGPEGFARALRKQDALAVTDTTFRDAHQSLLATRVRSNT
LIDAARHVAKLTPELLSVEAWGGATYDVAMRFLHEDPWERLDHLREAMPNVNIQMLLRGRNTVGYTPYPDSVCKAFVDEA
ARSGVDIFRIFDALNDVSQMRPAIDAVLETNTTIAEVAMAYSGDLTNPSEKLYTLDYYLKLAEEIVKSGAHVLAIKDMAG
LMKPAAATKLVTELRRNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTSQPSLSAIVAAFANTYRDTGL
SLDAVGSMEPYWEAVRKLYAPFESGTPGPTGRVYQHEIPGGQLSNLRAQATALGLADRFELIEDYYAAVNEMLGRPTKVT
PSSKVVGDLALYLVGAGVNPADFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRAKALAGRKESKDTLAPLPAEDEAL
LADRATVRPTLDRLLFPKPAAEFAEHRRQFGDTTKLGDAEFLYGLKEGKETVIRTADSSVPMLVRLDAVGEPDEKGMRNV
VCNVNGQIRPILVRDRSVESVTASVEKADPSNAGHVAAPFAGVVTVTIEEGATVKAGDPVAVIEAMKMEATISATTDGTV
DRIVLTQATKVEGGDLLLVIK

Sequences:

>Translated_1141_residues
MSQQSSERGTSTVNPLSKILVANRGEIAVRAFRAAFETGAATVAVYPNEDRNSFHRSFASEAVLIGEGGSAVKAYLDIDE
IIRAAKQTGADAIYPGYGFLSENAQLARECAENGITFIGPPPSVLELTGDKAAAVTAAREAGLPTLTETEATDDPKKLAE
LTKGQTYPLFVKAVAGGGGRGMRFVDAPENLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDSAGNIIHLYE
RDCSLQRRHQKVVEIAPAQHLAPGLREKICADAVAFARHIGYQGAGTVEFLVDEEGNHVFIEMNPRIQVEHTVTEEVTQV
DLVKSQIMIASGATLEDLGLRQEDIHTEGAALQCRITTEDPNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEITPNFD
SMLVKMTCRGADFATAVARAQRALAEFVVSGVATNIGFLRALLREEDFQHKRIATGFIADHPWLLQAPPADDEPGRILNY
LADVTVNKPHGLRPAVINPVEKLPAEIKGELPRGSRDRLLQLGPEGFARALRKQDALAVTDTTFRDAHQSLLATRVRSNT
LIDAARHVAKLTPELLSVEAWGGATYDVAMRFLHEDPWERLDHLREAMPNVNIQMLLRGRNTVGYTPYPDSVCKAFVDEA
ARSGVDIFRIFDALNDVSQMRPAIDAVLETNTTIAEVAMAYSGDLTNPSEKLYTLDYYLKLAEEIVKSGAHVLAIKDMAG
LMKPAAATKLVTELRRNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTSQPSLSAIVAAFANTYRDTGL
SLDAVGSMEPYWEAVRKLYAPFESGTPGPTGRVYQHEIPGGQLSNLRAQATALGLADRFELIEDYYAAVNEMLGRPTKVT
PSSKVVGDLALYLVGAGVNPADFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRAKALAGRKESKDTLAPLPAEDEAL
LADRATVRPTLDRLLFPKPAAEFAEHRRQFGDTTKLGDAEFLYGLKEGKETVIRTADSSVPMLVRLDAVGEPDEKGMRNV
VCNVNGQIRPILVRDRSVESVTASVEKADPSNAGHVAAPFAGVVTVTIEEGATVKAGDPVAVIEAMKMEATISATTDGTV
DRIVLTQATKVEGGDLLLVIK
>Mature_1140_residues
SQQSSERGTSTVNPLSKILVANRGEIAVRAFRAAFETGAATVAVYPNEDRNSFHRSFASEAVLIGEGGSAVKAYLDIDEI
IRAAKQTGADAIYPGYGFLSENAQLARECAENGITFIGPPPSVLELTGDKAAAVTAAREAGLPTLTETEATDDPKKLAEL
TKGQTYPLFVKAVAGGGGRGMRFVDAPENLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDSAGNIIHLYER
DCSLQRRHQKVVEIAPAQHLAPGLREKICADAVAFARHIGYQGAGTVEFLVDEEGNHVFIEMNPRIQVEHTVTEEVTQVD
LVKSQIMIASGATLEDLGLRQEDIHTEGAALQCRITTEDPNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEITPNFDS
MLVKMTCRGADFATAVARAQRALAEFVVSGVATNIGFLRALLREEDFQHKRIATGFIADHPWLLQAPPADDEPGRILNYL
ADVTVNKPHGLRPAVINPVEKLPAEIKGELPRGSRDRLLQLGPEGFARALRKQDALAVTDTTFRDAHQSLLATRVRSNTL
IDAARHVAKLTPELLSVEAWGGATYDVAMRFLHEDPWERLDHLREAMPNVNIQMLLRGRNTVGYTPYPDSVCKAFVDEAA
RSGVDIFRIFDALNDVSQMRPAIDAVLETNTTIAEVAMAYSGDLTNPSEKLYTLDYYLKLAEEIVKSGAHVLAIKDMAGL
MKPAAATKLVTELRRNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTSQPSLSAIVAAFANTYRDTGLS
LDAVGSMEPYWEAVRKLYAPFESGTPGPTGRVYQHEIPGGQLSNLRAQATALGLADRFELIEDYYAAVNEMLGRPTKVTP
SSKVVGDLALYLVGAGVNPADFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRAKALAGRKESKDTLAPLPAEDEALL
ADRATVRPTLDRLLFPKPAAEFAEHRRQFGDTTKLGDAEFLYGLKEGKETVIRTADSSVPMLVRLDAVGEPDEKGMRNVV
CNVNGQIRPILVRDRSVESVTASVEKADPSNAGHVAAPFAGVVTVTIEEGATVKAGDPVAVIEAMKMEATISATTDGTVD
RIVLTQATKVEGGDLLLVIK

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1146, Percent_Identity=46.5968586387435, Blast_Score=969, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1146, Percent_Identity=46.5968586387435, Blast_Score=969, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1146, Percent_Identity=46.5968586387435, Blast_Score=969, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=461, Percent_Identity=40.7809110629067, Blast_Score=353, Evalue=6e-97,
Organism=Homo sapiens, GI189095269, Length=452, Percent_Identity=41.3716814159292, Blast_Score=322, Evalue=1e-87,
Organism=Homo sapiens, GI65506442, Length=448, Percent_Identity=41.5178571428571, Blast_Score=321, Evalue=3e-87,
Organism=Homo sapiens, GI295821183, Length=448, Percent_Identity=41.5178571428571, Blast_Score=320, Evalue=5e-87,
Organism=Homo sapiens, GI38679960, Length=501, Percent_Identity=31.3373253493014, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI38679971, Length=501, Percent_Identity=31.3373253493014, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI38679977, Length=501, Percent_Identity=31.3373253493014, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI38679967, Length=501, Percent_Identity=31.3373253493014, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI38679974, Length=501, Percent_Identity=31.3373253493014, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=30.3571428571429, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1789654, Length=440, Percent_Identity=47.2727272727273, Blast_Score=357, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17562816, Length=1154, Percent_Identity=46.3604852686308, Blast_Score=970, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=41.978021978022, Blast_Score=328, Evalue=9e-90,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=40.625, Blast_Score=314, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=31.2757201646091, Blast_Score=219, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=28.5148514851485, Blast_Score=205, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=505, Percent_Identity=28.5148514851485, Blast_Score=204, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1154, Percent_Identity=44.5407279029463, Blast_Score=916, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1154, Percent_Identity=45.1473136915078, Blast_Score=913, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=38.2222222222222, Blast_Score=298, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323863, Length=440, Percent_Identity=31.5909090909091, Blast_Score=204, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=29.5499021526419, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24652212, Length=1148, Percent_Identity=44.7735191637631, Blast_Score=940, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1148, Percent_Identity=44.7735191637631, Blast_Score=940, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1148, Percent_Identity=44.7735191637631, Blast_Score=940, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1148, Percent_Identity=44.7735191637631, Blast_Score=940, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1148, Percent_Identity=44.7735191637631, Blast_Score=940, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1162, Percent_Identity=44.2340791738382, Blast_Score=935, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1162, Percent_Identity=44.2340791738382, Blast_Score=935, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1162, Percent_Identity=44.2340791738382, Blast_Score=935, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1162, Percent_Identity=44.2340791738382, Blast_Score=935, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1162, Percent_Identity=44.2340791738382, Blast_Score=935, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=468, Percent_Identity=39.957264957265, Blast_Score=335, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24651759, Length=427, Percent_Identity=38.6416861826698, Blast_Score=292, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=31.434184675835, Blast_Score=202, Evalue=9e-52,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=31.434184675835, Blast_Score=202, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=31.434184675835, Blast_Score=202, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=31.434184675835, Blast_Score=202, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 122432; Mature: 122301

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQSSERGTSTVNPLSKILVANRGEIAVRAFRAAFETGAATVAVYPNEDRNSFHRSFAS
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHC
EAVLIGEGGSAVKAYLDIDEIIRAAKQTGADAIYPGYGFLSENAQLARECAENGITFIGP
CEEEEECCCCEEEEEECHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHCCCEEECC
PPSVLELTGDKAAAVTAAREAGLPTLTETEATDDPKKLAELTKGQTYPLFVKAVAGGGGR
CCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCC
GMRFVDAPENLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDSAGNIIHLYE
CCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEC
RDCSLQRRHQKVVEIAPAQHLAPGLREKICADAVAFARHIGYQGAGTVEFLVDEEGNHVF
CCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEE
IEMNPRIQVEHTVTEEVTQVDLVKSQIMIASGATLEDLGLRQEDIHTEGAALQCRITTED
EEECCCEEEEEHHHHHHHHHHHHHHHEEEECCCCHHHHCCCHHHCCCCCCEEEEEEEECC
PNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEITPNFDSMLVKMTCRGADFATAVARA
CCCCCCCCCCCEEEEECCCCCCEEECCCEEECCCCCCCHHHEEEEEEECCCHHHHHHHHH
QRALAEFVVSGVATNIGFLRALLREEDFQHKRIATGFIADHPWLLQAPPADDEPGRILNY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEECCCCEEEECCCCCCCCHHHHHH
LADVTVNKPHGLRPAVINPVEKLPAEIKGELPRGSRDRLLQLGPEGFARALRKQDALAVT
HHHCEECCCCCCCCHHCCCHHHCCHHHCCCCCCCCHHHHEEECCHHHHHHHHHCCCEEEE
DTTFRDAHQSLLATRVRSNTLIDAARHVAKLTPELLSVEAWGGATYDVAMRFLHEDPWER
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHCCHHHH
LDHLREAMPNVNIQMLLRGRNTVGYTPYPDSVCKAFVDEAARSGVDIFRIFDALNDVSQM
HHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RPAIDAVLETNTTIAEVAMAYSGDLTNPSEKLYTLDYYLKLAEEIVKSGAHVLAIKDMAG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHCCCEEEEEHHHHH
LMKPAAATKLVTELRRNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTS
HHCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
QPSLSAIVAAFANTYRDTGLSLDAVGSMEPYWEAVRKLYAPFESGTPGPTGRVYQHEIPG
CCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
GQLSNLRAQATALGLADRFELIEDYYAAVNEMLGRPTKVTPSSKVVGDLALYLVGAGVNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCH
ADFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRAKALAGRKESKDTLAPLPAEDEAL
HHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
LADRATVRPTLDRLLFPKPAAEFAEHRRQFGDTTKLGDAEFLYGLKEGKETVIRTADSSV
HHCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHEEEECCCCC
PMLVRLDAVGEPDEKGMRNVVCNVNGQIRPILVRDRSVESVTASVEKADPSNAGHVAAPF
CEEEEECCCCCCCHHCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEECCC
AGVVTVTIEEGATVKAGDPVAVIEAMKMEATISATTDGTVDRIVLTQATKVEGGDLLLVI
CCEEEEEEECCCEEECCCCHHHHHHHHHHEEEEECCCCCEEEEEEEEEEEECCCCEEEEE
K
C
>Mature Secondary Structure 
SQQSSERGTSTVNPLSKILVANRGEIAVRAFRAAFETGAATVAVYPNEDRNSFHRSFAS
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHC
EAVLIGEGGSAVKAYLDIDEIIRAAKQTGADAIYPGYGFLSENAQLARECAENGITFIGP
CEEEEECCCCEEEEEECHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHCCCEEECC
PPSVLELTGDKAAAVTAAREAGLPTLTETEATDDPKKLAELTKGQTYPLFVKAVAGGGGR
CCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCC
GMRFVDAPENLEKLAAEASREAAAAFGDGRVYAERAVINPQHIEVQILGDSAGNIIHLYE
CCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEC
RDCSLQRRHQKVVEIAPAQHLAPGLREKICADAVAFARHIGYQGAGTVEFLVDEEGNHVF
CCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEE
IEMNPRIQVEHTVTEEVTQVDLVKSQIMIASGATLEDLGLRQEDIHTEGAALQCRITTED
EEECCCEEEEEHHHHHHHHHHHHHHHEEEECCCCHHHHCCCHHHCCCCCCEEEEEEEECC
PNNGFRPDTGTITAYRSPGGAGVRLDGAAMLGGEITPNFDSMLVKMTCRGADFATAVARA
CCCCCCCCCCCEEEEECCCCCCEEECCCEEECCCCCCCHHHEEEEEEECCCHHHHHHHHH
QRALAEFVVSGVATNIGFLRALLREEDFQHKRIATGFIADHPWLLQAPPADDEPGRILNY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCEECCCCEEEECCCCCCCCHHHHHH
LADVTVNKPHGLRPAVINPVEKLPAEIKGELPRGSRDRLLQLGPEGFARALRKQDALAVT
HHHCEECCCCCCCCHHCCCHHHCCHHHCCCCCCCCHHHHEEECCHHHHHHHHHCCCEEEE
DTTFRDAHQSLLATRVRSNTLIDAARHVAKLTPELLSVEAWGGATYDVAMRFLHEDPWER
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHCCHHHH
LDHLREAMPNVNIQMLLRGRNTVGYTPYPDSVCKAFVDEAARSGVDIFRIFDALNDVSQM
HHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RPAIDAVLETNTTIAEVAMAYSGDLTNPSEKLYTLDYYLKLAEEIVKSGAHVLAIKDMAG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHCCCEEEEEHHHHH
LMKPAAATKLVTELRRNFDLPVHVHTHDTAGGQLATYWAAAAAGADAVDGASAPLSGTTS
HHCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
QPSLSAIVAAFANTYRDTGLSLDAVGSMEPYWEAVRKLYAPFESGTPGPTGRVYQHEIPG
CCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
GQLSNLRAQATALGLADRFELIEDYYAAVNEMLGRPTKVTPSSKVVGDLALYLVGAGVNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEECCCCH
ADFAADPQKYDIPDSVIAFLRGELGTPPGGWPEELRAKALAGRKESKDTLAPLPAEDEAL
HHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
LADRATVRPTLDRLLFPKPAAEFAEHRRQFGDTTKLGDAEFLYGLKEGKETVIRTADSSV
HHCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHEEEECCCCC
PMLVRLDAVGEPDEKGMRNVVCNVNGQIRPILVRDRSVESVTASVEKADPSNAGHVAAPF
CEEEEECCCCCCCHHCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEECCC
AGVVTVTIEEGATVKAGDPVAVIEAMKMEATISATTDGTVDRIVLTQATKVEGGDLLLVI
CCEEEEEEECCCEEECCCCHHHHHHHHHHEEEEECCCCCEEEEEEEEEEEECCCCEEEEE
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]