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The map label for this gene is upp

Identifier: 38233249

GI number: 38233249

Start: 612990

End: 613625

Strand: Direct

Name: upp

Synonym: DIP0642

Alternate gene names: 38233249

Gene position: 612990-613625 (Clockwise)

Preceding gene: 38233245

Following gene: 38233250

Centisome position: 24.63

GC content: 57.55

Gene sequence:

>636_bases
ATGGAAATTCGGATCGTCGACCACCCCTTGGCAGCTTCACGTCTTACCATCATGCGCGATAAGCGCACTAACAATGCGGG
ATTCCGTGCTGCGCTTGCAGATCTCGGCGCCATGCTCGTGTATGAGGCGTCTCGTGATCTCGCAATTGAGCAGTTCCCAG
TCAGCACCCCTGTTGCTGATACGCAGGGGACTCGTTTGCAGGATCCTCCCATTATCGTGCCGATCATTCGTGCCGGTTTG
GGCATGGTGGATCCAGCGTTGTCGATGATCCCTGATGCCCAGGTGGGCTTTATTGGCATGGCGCGTGATGAGGCTACTCA
TCAGCCTGTTCCTTATCTTGAAGCGTTGCCCGACGATCTCAGCGGTCGCACCGTGTTCTGCGTGGATCCGATGCTAGCTA
CGGGGGGTTCTTTGCTACACGCCATTAAGCTGCTGGCGGATCGTGGCGCTACCGATATCACCGCTATTTGTATGGTGTCG
GCGCAGGAGGGTGTTGATGCCTTGGCTGAGTCGGGTCTGCCTTGCCGTTTGGTCACGGCCACCATCGACCCCGAGCTTAA
CGACGACGCCTACATCGTGCCTGGCCTAGGTGATGCGGGCGATCGTCTCTACGGGCCACGTAACATCGACCTCTAA

Upstream 100 bases:

>100_bases
CATGAGAGGTACGTCGATGGTGATGTGAGAGTCCATATATGTTTAGACGTAATGAGTGTGGGTTCTGGTTCCCACGCATT
CCGGCGCTACGATGGCTGGT

Downstream 100 bases:

>100_bases
AACTGCTTCGTAGCGTCTCGTAGTCGTTTCCCCCTGCTTGTCGTCGCCATGTGATTGTGCATGGCCTGCGGCTGGCATGG
GGGATTTTTATTATGTGTAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVADTQGTRLQDPPIIVPIIRAGL
GMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDLSGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVS
AQEGVDALAESGLPCRLVTATIDPELNDDAYIVPGLGDAGDRLYGPRNIDL

Sequences:

>Translated_211_residues
MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVADTQGTRLQDPPIIVPIIRAGL
GMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDLSGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVS
AQEGVDALAESGLPCRLVTATIDPELNDDAYIVPGLGDAGDRLYGPRNIDL
>Mature_211_residues
MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVADTQGTRLQDPPIIVPIIRAGL
GMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDLSGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVS
AQEGVDALAESGLPCRLVTATIDPELNDDAYIVPGLGDAGDRLYGPRNIDL

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=195, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI57863312, Length=195, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=39.9038461538462, Blast_Score=167, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17539892, Length=200, Percent_Identity=26, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=200, Percent_Identity=26, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=34.375, Blast_Score=105, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45550449, Length=169, Percent_Identity=29.585798816568, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573516, Length=169, Percent_Identity=29.585798816568, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573514, Length=169, Percent_Identity=29.585798816568, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573512, Length=169, Percent_Identity=29.585798816568, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CORDI (Q6NIX4)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_939016.1
- ProteinModelPortal:   Q6NIX4
- SMR:   Q6NIX4
- GeneID:   2649953
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0642
- NMPDR:   fig|257309.1.peg.607
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- PhylomeDB:   Q6NIX4
- ProtClustDB:   PRK00129
- BioCyc:   CDIP257309:DIP0642-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22415; Mature: 22415

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 192-192 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVAD
CEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEEEECCCCCEEEECCCCCCCCC
TQGTRLQDPPIIVPIIRAGLGMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDL
CCCCCCCCCCEEHHHHHCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCC
SGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVSAQEGVDALAESGLPCRLVTA
CCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHCCCCEEEEEE
TIDPELNDDAYIVPGLGDAGDRLYGPRNIDL
EECCCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIRIVDHPLAASRLTIMRDKRTNNAGFRAALADLGAMLVYEASRDLAIEQFPVSTPVAD
CEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEEEECCCCCEEEECCCCCCCCC
TQGTRLQDPPIIVPIIRAGLGMVDPALSMIPDAQVGFIGMARDEATHQPVPYLEALPDDL
CCCCCCCCCCEEHHHHHCCCCCCCHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCC
SGRTVFCVDPMLATGGSLLHAIKLLADRGATDITAICMVSAQEGVDALAESGLPCRLVTA
CCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHCCCCEEEEEE
TIDPELNDDAYIVPGLGDAGDRLYGPRNIDL
EECCCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910