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The map label for this gene is trpS [H]

Identifier: 38233242

GI number: 38233242

Start: 605642

End: 606676

Strand: Direct

Name: trpS [H]

Synonym: DIP0635

Alternate gene names: 38233242

Gene position: 605642-606676 (Clockwise)

Preceding gene: 38233241

Following gene: 38233243

Centisome position: 24.34

GC content: 54.2

Gene sequence:

>1035_bases
ATGACTGCAACCGTGCAAGAAAATACGCAGAAGAAGCAACGTGTGCTGTCGGGAATTCAACCAACAGCCGACTCGTACCA
CCTAGGAAACTATTTGGGTGCCCTGAAGCAGTGGATCGAACTTCAGGATAACTACGAGGCGTTTTACTTCATCCCTGATC
TGCACGCCATCACGGTTGATCAAGACCCCCGTGAGCTGCGGGAACGTACCATCGCTGGTGCTGCACAGCTCTTGGCTTTG
GGTATTGATCCTCACAAGAGCACTCTGTTTGTGCAGTCTCACGTGCCGGAACACGCTGAGCTTGGTTGGGTTCTTACGTG
CTTGACCGGTTTCGGCGAAGCGAGCCGCATGACACAGTTCAAGGACAAGTCCGCCAAGCGAGGTGCGGATCGTACCTCAG
CAGGTCTGTTCACTTATCCCATGTTGATGGCTGCGGATATTCTGCTTTACCGTCCGCAGTTTGTGCCGGTGGGCGAGGAC
CAACGCCAGCACTTGGAGCTCACTCGCACGCTTGCTGAGCGTTTTAACTCCCGTTTTAAAAAGACCTTCGTGGTGCCAGA
CGGAATTATTCCTGAGGGTGCTGCCAAGATTTATGATCTTCAAGACCCAACCTCCAAGATGAGCAAGTCGGGTTCGAACC
CCAAGGGCTTGATTAATCTGCTTGATGACCCCAAGGTTTCTGCGAAGCGCATTCGCTCTGCTGTGACCGACAACGACGGC
GAGATCCGTTTTGATAAGGAAAACAAGCCTGGTGTGTCCAACTTGCTGGTCATTCAGTCGGCACTGACGGGCAAGACCAT
CGACTCGCTTGTCGACGCCTACCAAGGCCAGGGTTACGGCGCCTTGAAGGTCGACACCGCCGATGCCCTCGAGGCCTTCG
TTACACCTTTGAAGGCTCAGTACGACATGTACATGTCTGACCGTGCTGAGCTGGAAAATGTGTTGGCTCTTGGCGCCGAA
AAAGCCCGTGAGATTGCATCGCGCACCCTTGCGGACGCCTACGAGCACATCGGTTTTTTGCCGCCAAAGCGCTAA

Upstream 100 bases:

>100_bases
AAGCACACAGCGGATCCGTACCGGAAGACGGTTTTGTTTTACATCAACAGGTGGGGGTCGTATTCCTCGTGTGTTGTGAC
TGCGCTGTAGGATGTTCACC

Downstream 100 bases:

>100_bases
AGCGCTGACAATTACAACTTTGCAACGATCCGACTGCTTCGCCACTATGAGGCAGCCGGATTGCTGTTTCTGCCTATAGT
CTGGATTAAGTCCCCAGCTC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTATVQENTQKKQRVLSGIQPTADSYHLGNYLGALKQWIELQDNYEAFYFIPDLHAITVDQDPRELRERTIAGAAQLLAL
GIDPHKSTLFVQSHVPEHAELGWVLTCLTGFGEASRMTQFKDKSAKRGADRTSAGLFTYPMLMAADILLYRPQFVPVGED
QRQHLELTRTLAERFNSRFKKTFVVPDGIIPEGAAKIYDLQDPTSKMSKSGSNPKGLINLLDDPKVSAKRIRSAVTDNDG
EIRFDKENKPGVSNLLVIQSALTGKTIDSLVDAYQGQGYGALKVDTADALEAFVTPLKAQYDMYMSDRAELENVLALGAE
KAREIASRTLADAYEHIGFLPPKR

Sequences:

>Translated_344_residues
MTATVQENTQKKQRVLSGIQPTADSYHLGNYLGALKQWIELQDNYEAFYFIPDLHAITVDQDPRELRERTIAGAAQLLAL
GIDPHKSTLFVQSHVPEHAELGWVLTCLTGFGEASRMTQFKDKSAKRGADRTSAGLFTYPMLMAADILLYRPQFVPVGED
QRQHLELTRTLAERFNSRFKKTFVVPDGIIPEGAAKIYDLQDPTSKMSKSGSNPKGLINLLDDPKVSAKRIRSAVTDNDG
EIRFDKENKPGVSNLLVIQSALTGKTIDSLVDAYQGQGYGALKVDTADALEAFVTPLKAQYDMYMSDRAELENVLALGAE
KAREIASRTLADAYEHIGFLPPKR
>Mature_343_residues
TATVQENTQKKQRVLSGIQPTADSYHLGNYLGALKQWIELQDNYEAFYFIPDLHAITVDQDPRELRERTIAGAAQLLALG
IDPHKSTLFVQSHVPEHAELGWVLTCLTGFGEASRMTQFKDKSAKRGADRTSAGLFTYPMLMAADILLYRPQFVPVGEDQ
RQHLELTRTLAERFNSRFKKTFVVPDGIIPEGAAKIYDLQDPTSKMSKSGSNPKGLINLLDDPKVSAKRIRSAVTDNDGE
IRFDKENKPGVSNLLVIQSALTGKTIDSLVDAYQGQGYGALKVDTADALEAFVTPLKAQYDMYMSDRAELENVLALGAEK
AREIASRTLADAYEHIGFLPPKR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=330, Percent_Identity=42.1212121212121, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI41352700, Length=180, Percent_Identity=51.6666666666667, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1789786, Length=328, Percent_Identity=54.2682926829268, Blast_Score=352, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI71982800, Length=331, Percent_Identity=37.4622356495468, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71982793, Length=331, Percent_Identity=37.4622356495468, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320474, Length=344, Percent_Identity=38.953488372093, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24666151, Length=336, Percent_Identity=43.1547619047619, Blast_Score=271, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38163; Mature: 38032

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATVQENTQKKQRVLSGIQPTADSYHLGNYLGALKQWIELQDNYEAFYFIPDLHAITVD
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECC
QDPRELRERTIAGAAQLLALGIDPHKSTLFVQSHVPEHAELGWVLTCLTGFGEASRMTQF
CCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHH
KDKSAKRGADRTSAGLFTYPMLMAADILLYRPQFVPVGEDQRQHLELTRTLAERFNSRFK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KTFVVPDGIIPEGAAKIYDLQDPTSKMSKSGSNPKGLINLLDDPKVSAKRIRSAVTDNDG
EEEECCCCCCCCCCHHEEECCCHHHHHHCCCCCCCHHEECCCCCCHHHHHHHHHHCCCCC
EIRFDKENKPGVSNLLVIQSALTGKTIDSLVDAYQGQGYGALKVDTADALEAFVTPLKAQ
CEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHH
YDMYMSDRAELENVLALGAEKAREIASRTLADAYEHIGFLPPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TATVQENTQKKQRVLSGIQPTADSYHLGNYLGALKQWIELQDNYEAFYFIPDLHAITVD
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECC
QDPRELRERTIAGAAQLLALGIDPHKSTLFVQSHVPEHAELGWVLTCLTGFGEASRMTQF
CCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHH
KDKSAKRGADRTSAGLFTYPMLMAADILLYRPQFVPVGEDQRQHLELTRTLAERFNSRFK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KTFVVPDGIIPEGAAKIYDLQDPTSKMSKSGSNPKGLINLLDDPKVSAKRIRSAVTDNDG
EEEECCCCCCCCCCHHEEECCCHHHHHHCCCCCCCHHEECCCCCCHHHHHHHHHHCCCCC
EIRFDKENKPGVSNLLVIQSALTGKTIDSLVDAYQGQGYGALKVDTADALEAFVTPLKAQ
CEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHH
YDMYMSDRAELENVLALGAEKAREIASRTLADAYEHIGFLPPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]