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The map label for this gene is hmuU [H]

Identifier: 38233234

GI number: 38233234

Start: 595775

End: 596827

Strand: Direct

Name: hmuU [H]

Synonym: DIP0627

Alternate gene names: 38233234

Gene position: 595775-596827 (Clockwise)

Preceding gene: 38233233

Following gene: 38233235

Centisome position: 23.94

GC content: 48.81

Gene sequence:

>1053_bases
ATGACCCACAGGTATAGCAAGCGTAGCGACGACGTGTTCGTTCTTCGGGCACGTCGTCGAGTGATGTTGTTTGTTGTCTT
AGTGGTGTTGGTGTTGGCGTCAGTTATTACGTCGTTGGCGTTGGGGCAGTACTATGTTCCGCTTCGCGACTTATTGACGA
TTCTTACTCAGCCTGATTCAAGCAGTTTGATGCACAACGTTATTTGGGAGATCCGTCTTCCTCGAATTGTGTTGGGTTTG
TTGGTTGGTGCATGCCTTGGTGTGGCTGGCACTCTGATGCAAGCCGTTTTTGCGAATCCGCTTGCGGAGCCGTCGATTAT
CGGAGTTACTTCTGGAGCCGGTGTGGGTGCAGCAGCGGTGATCGTATTCAACGTGGGAATTTTGGGTACTTTTACTGTTC
CTGCGGCAGCATTTTTGAGTGCGGTTGTTGTGACGGTGATTATCTATCAGCTGGCTCGACATCAAGGTAAGGTTGCGATC
GTCAATTTAATTTTGACTGGTATTGCCATCAATGCCGTGTGTAATGCATTGATTTCTTTTCTTGTGTACCTTGCTCCTAC
GTCGAATCGTGAAGAGATTGTTTTTTGGCAGATGGGATCGCTTAATGGAGCACAGTGGAAACACGTCTGGGTAGTTGCCC
CTATTGCACTGGTAGGAATCGTCATTTCTTCCCAAATCGGTAAACAACTAGATGTGCTAGCTCTTGGCGAACGCGCGGCA
GGGCACACGGGTATCAATGTTGGACGATTGCGCATTATTGCTATTGCTGCCTCGACGATTTTGACTGCAGCGGCTGTGTC
GTTTGCTGGATTGATTGGTTTTGTTGGTTTGATTGTTCCTCACTTGCTGCGGAGTATTTCTGGCCCAGAGAATCGTCTAC
TCCTTCCAGCATCTGCGTTGGCAGGAGCGGTATTGATCGCGTGCGCGGATGTTGCTGCGCGTACGATGATTCCGTTTGCG
GATTTGCCGATTGGTATCTTTACGGCACTTGTTGGTGGCCCAACATTTTTTGTTTTGTTACGTCGAATGTTGAAGAAAGG
CTCTGTCCATTGA

Upstream 100 bases:

>100_bases
GCTGGAAAGAATCGTCGAGTCATTACGATCCCTGATGGACAATCTTTGGCGTTCGGTCCGATGACTGGTCAGACGCTTCT
TCGCACGGCACAGGCTTTGT

Downstream 100 bases:

>100_bases
GCGCTGATGATCAAAGTAGCGTGCAGCCTGAGTCGTTGGTTCGTGTCCGTGATCTATCGGTCTCTGTTGGGCAGAAGCGC
TTACTGTGCGATATCAATTT

Product: Iron-related transport system membrane protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTHRYSKRSDDVFVLRARRRVMLFVVLVVLVLASVITSLALGQYYVPLRDLLTILTQPDSSSLMHNVIWEIRLPRIVLGL
LVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAAAVIVFNVGILGTFTVPAAAFLSAVVVTVIIYQLARHQGKVAI
VNLILTGIAINAVCNALISFLVYLAPTSNREEIVFWQMGSLNGAQWKHVWVVAPIALVGIVISSQIGKQLDVLALGERAA
GHTGINVGRLRIIAIAASTILTAAAVSFAGLIGFVGLIVPHLLRSISGPENRLLLPASALAGAVLIACADVAARTMIPFA
DLPIGIFTALVGGPTFFVLLRRMLKKGSVH

Sequences:

>Translated_350_residues
MTHRYSKRSDDVFVLRARRRVMLFVVLVVLVLASVITSLALGQYYVPLRDLLTILTQPDSSSLMHNVIWEIRLPRIVLGL
LVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAAAVIVFNVGILGTFTVPAAAFLSAVVVTVIIYQLARHQGKVAI
VNLILTGIAINAVCNALISFLVYLAPTSNREEIVFWQMGSLNGAQWKHVWVVAPIALVGIVISSQIGKQLDVLALGERAA
GHTGINVGRLRIIAIAASTILTAAAVSFAGLIGFVGLIVPHLLRSISGPENRLLLPASALAGAVLIACADVAARTMIPFA
DLPIGIFTALVGGPTFFVLLRRMLKKGSVH
>Mature_349_residues
THRYSKRSDDVFVLRARRRVMLFVVLVVLVLASVITSLALGQYYVPLRDLLTILTQPDSSSLMHNVIWEIRLPRIVLGLL
VGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAAAVIVFNVGILGTFTVPAAAFLSAVVVTVIIYQLARHQGKVAIV
NLILTGIAINAVCNALISFLVYLAPTSNREEIVFWQMGSLNGAQWKHVWVVAPIALVGIVISSQIGKQLDVLALGERAAG
HTGINVGRLRIIAIAASTILTAAAVSFAGLIGFVGLIVPHLLRSISGPENRLLLPASALAGAVLIACADVAARTMIPFAD
LPIGIFTALVGGPTFFVLLRRMLKKGSVH

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=37.8571428571429, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1790740, Length=322, Percent_Identity=36.3354037267081, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1790741, Length=287, Percent_Identity=33.7979094076655, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786804, Length=289, Percent_Identity=30.7958477508651, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=32.7526132404181, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786347, Length=284, Percent_Identity=28.169014084507, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36883; Mature: 36752

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHRYSKRSDDVFVLRARRRVMLFVVLVVLVLASVITSLALGQYYVPLRDLLTILTQPDS
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHHHHHHCCCCH
SSLMHNVIWEIRLPRIVLGLLVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHH
IVFNVGILGTFTVPAAAFLSAVVVTVIIYQLARHQGKVAIVNLILTGIAINAVCNALISF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVYLAPTSNREEIVFWQMGSLNGAQWKHVWVVAPIALVGIVISSQIGKQLDVLALGERAA
HHHHCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHEECCCCC
GHTGINVGRLRIIAIAASTILTAAAVSFAGLIGFVGLIVPHLLRSISGPENRLLLPASAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
AGAVLIACADVAARTMIPFADLPIGIFTALVGGPTFFVLLRRMLKKGSVH
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THRYSKRSDDVFVLRARRRVMLFVVLVVLVLASVITSLALGQYYVPLRDLLTILTQPDS
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHHHHHHCCCCH
SSLMHNVIWEIRLPRIVLGLLVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHH
IVFNVGILGTFTVPAAAFLSAVVVTVIIYQLARHQGKVAIVNLILTGIAINAVCNALISF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVYLAPTSNREEIVFWQMGSLNGAQWKHVWVVAPIALVGIVISSQIGKQLDVLALGERAA
HHHHCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHEECCCCC
GHTGINVGRLRIIAIAASTILTAAAVSFAGLIGFVGLIVPHLLRSISGPENRLLLPASAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
AGAVLIACADVAARTMIPFADLPIGIFTALVGGPTFFVLLRRMLKKGSVH
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]