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The map label for this gene is menA [H]

Identifier: 38233032

GI number: 38233032

Start: 382906

End: 383769

Strand: Reverse

Name: menA [H]

Synonym: DIP0418

Alternate gene names: 38233032

Gene position: 383769-382906 (Counterclockwise)

Preceding gene: 38233034

Following gene: 38233030

Centisome position: 15.42

GC content: 57.64

Gene sequence:

>864_bases
ATGTCTCAAGCAACCTTTGCCGATTGGAAAGAAGGAGCTCGCCCACACACTTGGGCAAACGCCTTCGCGCCCGTCATCGT
GGGAACCGGTGCAGCCGGGGCCGGAATCGTATGGTGGAAAGCCTTACTCGCACTCATCGTGGCCTGGGCCCTCATCATCG
GGGTCAACTACGCCAACGATTACTCCGACGGCATCCGCGGCACGGATGACGACCGCACCGGCCCCCTCCGCCTCACGGGA
TCCGGACTTGCCGAGCCGGCAGCAGTAAAACGCGCAGCATTTATCGCCTTCGGAGTCGCCGGCATCGCAGGAATTGCCCT
ATCCCTCACCAGCGCATGGTGGCTCATAGCAATCGGCTTCCTATGCGTCGCGGGAGCATGGTTCTACACCGGCGGAAAAA
ATCCATACGGCTACCGCGGACTTGGCGAGGTTGCCGTCTTCATTTTCTTCGGCCTAGTCGCAGTCATGGGCACACAATTC
ACCCAGCTTGGGCACGTCACATACCCAGGATTCGCTTGCTCGGTCGCGATCGGCGCAATGTCCGCAGGAGTAAACCTAGT
AAACAACCTGCGCGATATCCCCACAGACAAAGAATCCGGCAAGATCACCCTTGCTGTCCGACTCGGCGATCCCGCAACCC
GCATTGTGTATTACGTGCTCATCACCTTGCCGTTTCTCGCTTCCATATCGTTTTTCTCTTGGGGATCACTAGGCTTACTC
GCACTCCCCCTAGCGGTCAAAGCTGCACAGCCCGTAAAAAATGGTGCCACAGGAAAGGATCTCATCCCCGTCCTTGGCAC
CACCGGAAAAGCCATGCTGGCATGGTCACTACTGACCACTATCGGTTTGACAGTTCTCGCTTAA

Upstream 100 bases:

>100_bases
CGCCCCTAACATTTACCCCCACTTGCGTGTTCGAACCTTTGTTCGCTACTATCCAACTATAAATTAACCACACAAGAAAC
GCAATGGAAGAATAGACAAC

Downstream 100 bases:

>100_bases
CCCAATCCTTTTCCGCCTTGCGCTGCTCACTCCACAAAGCCACAGCCTGAGTGGCGCGAACCCGAACACCCTTAAAAAGG
AAAACAGATAGCGGCATAGC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSQATFADWKEGARPHTWANAFAPVIVGTGAAGAGIVWWKALLALIVAWALIIGVNYANDYSDGIRGTDDDRTGPLRLTG
SGLAEPAAVKRAAFIAFGVAGIAGIALSLTSAWWLIAIGFLCVAGAWFYTGGKNPYGYRGLGEVAVFIFFGLVAVMGTQF
TQLGHVTYPGFACSVAIGAMSAGVNLVNNLRDIPTDKESGKITLAVRLGDPATRIVYYVLITLPFLASISFFSWGSLGLL
ALPLAVKAAQPVKNGATGKDLIPVLGTTGKAMLAWSLLTTIGLTVLA

Sequences:

>Translated_287_residues
MSQATFADWKEGARPHTWANAFAPVIVGTGAAGAGIVWWKALLALIVAWALIIGVNYANDYSDGIRGTDDDRTGPLRLTG
SGLAEPAAVKRAAFIAFGVAGIAGIALSLTSAWWLIAIGFLCVAGAWFYTGGKNPYGYRGLGEVAVFIFFGLVAVMGTQF
TQLGHVTYPGFACSVAIGAMSAGVNLVNNLRDIPTDKESGKITLAVRLGDPATRIVYYVLITLPFLASISFFSWGSLGLL
ALPLAVKAAQPVKNGATGKDLIPVLGTTGKAMLAWSLLTTIGLTVLA
>Mature_286_residues
SQATFADWKEGARPHTWANAFAPVIVGTGAAGAGIVWWKALLALIVAWALIIGVNYANDYSDGIRGTDDDRTGPLRLTGS
GLAEPAAVKRAAFIAFGVAGIAGIALSLTSAWWLIAIGFLCVAGAWFYTGGKNPYGYRGLGEVAVFIFFGLVAVMGTQFT
QLGHVTYPGFACSVAIGAMSAGVNLVNNLRDIPTDKESGKITLAVRLGDPATRIVYYVLITLPFLASISFFSWGSLGLLA
LPLAVKAAQPVKNGATGKDLIPVLGTTGKAMLAWSLLTTIGLTVLA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=271, Percent_Identity=26.5682656826568, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790365, Length=296, Percent_Identity=39.8648648648649, Blast_Score=159, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17737429, Length=214, Percent_Identity=27.1028037383178, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 29911; Mature: 29780

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQATFADWKEGARPHTWANAFAPVIVGTGAAGAGIVWWKALLALIVAWALIIGVNYAND
CCCCCCCHHHCCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDDRTGPLRLTGSGLAEPAAVKRAAFIAFGVAGIAGIALSLTSAWWLIAIGF
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCVAGAWFYTGGKNPYGYRGLGEVAVFIFFGLVAVMGTQFTQLGHVTYPGFACSVAIGAM
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SAGVNLVNNLRDIPTDKESGKITLAVRLGDPATRIVYYVLITLPFLASISFFSWGSLGLL
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALPLAVKAAQPVKNGATGKDLIPVLGTTGKAMLAWSLLTTIGLTVLA
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQATFADWKEGARPHTWANAFAPVIVGTGAAGAGIVWWKALLALIVAWALIIGVNYAND
CCCCCCHHHCCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDDRTGPLRLTGSGLAEPAAVKRAAFIAFGVAGIAGIALSLTSAWWLIAIGF
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCVAGAWFYTGGKNPYGYRGLGEVAVFIFFGLVAVMGTQFTQLGHVTYPGFACSVAIGAM
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SAGVNLVNNLRDIPTDKESGKITLAVRLGDPATRIVYYVLITLPFLASISFFSWGSLGLL
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ALPLAVKAAQPVKNGATGKDLIPVLGTTGKAMLAWSLLTTIGLTVLA
HHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]