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The map label for this gene is proC [H]

Identifier: 38233008

GI number: 38233008

Start: 360869

End: 361681

Strand: Direct

Name: proC [H]

Synonym: DIP0394

Alternate gene names: 38233008

Gene position: 360869-361681 (Clockwise)

Preceding gene: 38233007

Following gene: 38233009

Centisome position: 14.5

GC content: 55.1

Gene sequence:

>813_bases
GTGTTCGCCATGACTTCAATCGCAGTAATTGGTGGCGGCAAGATTGGCGAGGCATTGATTTCGGGCCTCGTAGCAAGTGG
CATGAGTCCAAAAGATATTCATGTGACTAATCGCAACGCTGAGCGTGCCCAGGAACTCAAGGAACGCTATGGCGTATTGA
CCTTCCTAGAGAACATTGCCGCTGTTGACGACGTAGACATGGTGTTTTTGTGCGTGAAGCCGCAGCAGGTCATTCCCGTT
GTGGAAGAAATCGCAGACGTTGTAGATAACAACACCAGCACCACTATCGTGTCGATGGCCGCTGGCGTGACTAACGCCAT
GATCGAGGAGAGCCTTGCCGCAGGTTCCCCTGTTATCCGTGTGATGCCTAATACTCCTATGTTGGTGGGTAAGGGCATGT
CCGTGGTGGCTCCTGGTCGCTATGCCGATGAGGACACGGTGGCGTCGTTAACGCAGCTGTTGGAGGCTGTGGGCAGCGTG
GAGGTCATCGAGGAGTCGAGCATGGACGCGGTGGTGGCGTTGTCGGGTTCTTCTCCTGCGTATCTCTTTTTGATGGTTGA
GGCTCTTATCGACGCCGGCGTGTTCCTTGGCCTACCACGTGATAAGGCGAAAAACTTGGCTGTTTCTTCCTTTGCTGGCG
CTGCCACGATGTTGGAGCAAACGGGTGAGGAGCCAGCAGTATTGCGTGCAAATGTGAGCTCGCCTGGCGGTACTACGATT
GCTGCTATTCGGGAGTTTGAGGAAAGCGGTTTGCGTGCTGCGGTCTATCGTGCGGCGACTGCTGCGGCGACACGCAACAG
TTCTTTGGGCTAG

Upstream 100 bases:

>100_bases
CCGCAGCATGATGTTGGCTGGTTGCGCTGGCGTGGCCGTTACTTTTGTGCCCATGTTGGTTTCTTAAACTGGTTGCCCAC
TGTGAGGGCTTCGTGGCAGA

Downstream 100 bases:

>100_bases
GGGGGCATGTACCCCTCTTTCTTTAACCTCTACTTGAAGGTTGCATTGTGTTGTTTTTCCAGCAAACCCCTGTGGCCTGT
GGTTTTTAGATGATATCGAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MFAMTSIAVIGGGKIGEALISGLVASGMSPKDIHVTNRNAERAQELKERYGVLTFLENIAAVDDVDMVFLCVKPQQVIPV
VEEIADVVDNNTSTTIVSMAAGVTNAMIEESLAAGSPVIRVMPNTPMLVGKGMSVVAPGRYADEDTVASLTQLLEAVGSV
EVIEESSMDAVVALSGSSPAYLFLMVEALIDAGVFLGLPRDKAKNLAVSSFAGAATMLEQTGEEPAVLRANVSSPGGTTI
AAIREFEESGLRAAVYRAATAAATRNSSLG

Sequences:

>Translated_270_residues
MFAMTSIAVIGGGKIGEALISGLVASGMSPKDIHVTNRNAERAQELKERYGVLTFLENIAAVDDVDMVFLCVKPQQVIPV
VEEIADVVDNNTSTTIVSMAAGVTNAMIEESLAAGSPVIRVMPNTPMLVGKGMSVVAPGRYADEDTVASLTQLLEAVGSV
EVIEESSMDAVVALSGSSPAYLFLMVEALIDAGVFLGLPRDKAKNLAVSSFAGAATMLEQTGEEPAVLRANVSSPGGTTI
AAIREFEESGLRAAVYRAATAAATRNSSLG
>Mature_270_residues
MFAMTSIAVIGGGKIGEALISGLVASGMSPKDIHVTNRNAERAQELKERYGVLTFLENIAAVDDVDMVFLCVKPQQVIPV
VEEIADVVDNNTSTTIVSMAAGVTNAMIEESLAAGSPVIRVMPNTPMLVGKGMSVVAPGRYADEDTVASLTQLLEAVGSV
EVIEESSMDAVVALSGSSPAYLFLMVEALIDAGVFLGLPRDKAKNLAVSSFAGAATMLEQTGEEPAVLRANVSSPGGTTI
AAIREFEESGLRAAVYRAATAAATRNSSLG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=276, Percent_Identity=38.4057971014493, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI24797097, Length=276, Percent_Identity=38.4057971014493, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=36.7272727272727, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=38.7218045112782, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=37.4531835205993, Blast_Score=152, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=275, Percent_Identity=32.7272727272727, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=30.5263157894737, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=40.6716417910448, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24648116, Length=273, Percent_Identity=34.0659340659341, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24647700, Length=165, Percent_Identity=47.8787878787879, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27965; Mature: 27965

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAMTSIAVIGGGKIGEALISGLVASGMSPKDIHVTNRNAERAQELKERYGVLTFLENIA
CCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AVDDVDMVFLCVKPQQVIPVVEEIADVVDNNTSTTIVSMAAGVTNAMIEESLAAGSPVIR
HCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
VMPNTPMLVGKGMSVVAPGRYADEDTVASLTQLLEAVGSVEVIEESSMDAVVALSGSSPA
ECCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCH
YLFLMVEALIDAGVFLGLPRDKAKNLAVSSFAGAATMLEQTGEEPAVLRANVSSPGGTTI
HHHHHHHHHHHCHHEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
AAIREFEESGLRAAVYRAATAAATRNSSLG
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFAMTSIAVIGGGKIGEALISGLVASGMSPKDIHVTNRNAERAQELKERYGVLTFLENIA
CCCEEEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AVDDVDMVFLCVKPQQVIPVVEEIADVVDNNTSTTIVSMAAGVTNAMIEESLAAGSPVIR
HCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
VMPNTPMLVGKGMSVVAPGRYADEDTVASLTQLLEAVGSVEVIEESSMDAVVALSGSSPA
ECCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCH
YLFLMVEALIDAGVFLGLPRDKAKNLAVSSFAGAATMLEQTGEEPAVLRANVSSPGGTTI
HHHHHHHHHHHCHHEECCCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
AAIREFEESGLRAAVYRAATAAATRNSSLG
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]