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The map label for this gene is sdhA [H]

Identifier: 38232987

GI number: 38232987

Start: 338927

End: 340942

Strand: Direct

Name: sdhA [H]

Synonym: DIP0371

Alternate gene names: 38232987

Gene position: 338927-340942 (Clockwise)

Preceding gene: 38232986

Following gene: 38232988

Centisome position: 13.62

GC content: 57.94

Gene sequence:

>2016_bases
ATGAGCATTAACTCTGACACCACTGTTAGCACCGACTTCACCCAACCAGCATCCATCGTTGATGGTGTGAAGCTCGGCAG
CATCCTCGAGTCTCATGAGCCCAAGGGCGTTCCTACCAAGGACATGTGGGAGTACCAAAAGAACCACATGAACCTCGTGT
CGCCTTTGAACCGTCGTAAGTTCCGCGTCCTCGTGGTCGGCACCGGCCTGTCCGGTGGCGGCGCTGCGGCTGCTCTCGGC
GAGCTCGGCTACGACGTCAAGGTGTTCACCTACCACGACGCACCACGTCGTGCACACTCCGTCGCTGCACAGGGTGGCGT
CAACGCTGCTCGCGGCAAGAAGGTGGACAACGACGGTGCATACCGCCACGTCAAAGACACCGTTAAGGGCGGCGACTACC
GCTGCCGTGAGTCCGACTGCTGGCGCTTGGCATACGAGTCCGTCCGCGTGATCGACCACATGAACGCCATTGGTGCACCA
TTCGCTCGCGAATACGGCGGAACCCTGGCAACCCGTTCTTTCGGTGGCGTGCAGGTTTCCCGCACCTACTACACCCGTGG
TCAAACAGGTCAGCAGCTGCAGCTGGCTGGTGCTGCTGCTCTGCAGCGCCAGATCGGCTTGGGCACCGTGGAGATCTTCA
CCCACAATGACCTGGCAGACTTGGTTCTCACCGAGAAGGACGGCAAGAAGCGCTGTGAAGGTGTGGTTATGCGTAACCTC
ATCACCGGCGAGCTCACCGCTCACACCGGCCACGCAGTGATCTTGGCAACCGGTGGCTACGGCAACGTATTCCACATGTC
CACCTTGGCTAAGAACTCCAACGCATCCGCAATGATGCGTGCATACGATCACGGTGCATATCTCGCATCGCCATCGTTCA
TCCAGTTCCACCCAACCGGTCTTCCTGTGAACTCCGAGTGGCAGTCCAAGACCATCTTGATGTCCGAGTCTTTGCGTAAC
GACGGTCGCATTTGGTCGCCACTGGAGCCAAAGGATGACCGCGACCCGAACACCATCCCTGAGGAAGAGCGCGACTACTT
CCTGGAGCGTCGTTACCCAGCATTCGGTAACTTGGTTCCTCGTGACGTTGCATCTCGTGCAATCTCTCAGCAGATCAACA
AGGGCCTCGGCGTTGGACCTCTGCACAACTCCGCTTACTTGGACTTCCGCGATGCCATCAGCCGCCTCGGCGAAGATACC
ATCCGTGAGCGTTACTCCAACCTCTTCCAGATGTACGAAGAGGCCATTGGTGAGAACCCATACAAGGCGCCAATGCGTAT
TGCTCCTACCTGCCACTTCACCATGGGTGGCCTGTGGACCGACTTCAATGAGATGACCTCCATTGATGGCCTGTTTGCAG
CAGGTGAGTGCTCGTGGACCTACCACGGTGCTAACCGCCTGGGTGCAAACTCCCTCCTGTCTGCTTCCGTTGACGGCTGG
TTCACCCTGCCGTTCACCATCCCTAACTACTTGGCAAACCACCTTGGTGAGCCACGTTTGGCTGAGGATTCTGCAGAGGC
ACAGGAAGCTGTTAACCGCGCCAAAGCACGCATTGACAAGCTGATGAACATCAAGGGCAATGATCCTCACGGCCCTGAGT
TCTTCCACCGCCAGCTGGGCGAGATCCTCTACTTCTCTTGTGGCGTTGCCCGCAACGTTGAGGACCTCAAGACCGGTATT
CAGAAGATCCGCGCTCTGCGCAAGGAATTCTGGGCAAACCTGCGTATCACCGGCGCTGCCGATGAGATGAACCAGGTTCT
CGAGTACGCATCCCGCGTTGCTGACTACATCGACTTGGGCGAGCTCATGTGCGTCGACGCACTTGACCGCGATGAGTCCT
GTGGTGCCCACTTCCGTGACGATCACCTCTCCGAAGAAGGCGAGGCAGAGCGTGACGACGACAACTGGTGCTTCGTTTCC
GCATGGGAGCCAGGTGCAGTCGAGGGCGAGTTCATTCGCCACGCTGAACCACTCACATTCGAAGCGATCCCGCTGATGAC
AAGGAATTACAAGTAA

Upstream 100 bases:

>100_bases
CTTGGCATACCTCGTCCCAGCAATTGTCATGATCGGCAACATCGCTATTCCGCTGTCCATCGCACTTGGCTTGGTCGGCT
AGGGGAGAAGGTAAATAACA

Downstream 100 bases:

>100_bases
TGAAACTCCATCTTGAAATCTGGCGTCAGGCCGGTCCAAACAGCGAAGGTCACTTCGAGCCCATCGACGTCAACGACGCC
GTTCCTCAGATGTCGGTCCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSINSDTTVSTDFTQPASIVDGVKLGSILESHEPKGVPTKDMWEYQKNHMNLVSPLNRRKFRVLVVGTGLSGGGAAAALG
ELGYDVKVFTYHDAPRRAHSVAAQGGVNAARGKKVDNDGAYRHVKDTVKGGDYRCRESDCWRLAYESVRVIDHMNAIGAP
FAREYGGTLATRSFGGVQVSRTYYTRGQTGQQLQLAGAAALQRQIGLGTVEIFTHNDLADLVLTEKDGKKRCEGVVMRNL
ITGELTAHTGHAVILATGGYGNVFHMSTLAKNSNASAMMRAYDHGAYLASPSFIQFHPTGLPVNSEWQSKTILMSESLRN
DGRIWSPLEPKDDRDPNTIPEEERDYFLERRYPAFGNLVPRDVASRAISQQINKGLGVGPLHNSAYLDFRDAISRLGEDT
IRERYSNLFQMYEEAIGENPYKAPMRIAPTCHFTMGGLWTDFNEMTSIDGLFAAGECSWTYHGANRLGANSLLSASVDGW
FTLPFTIPNYLANHLGEPRLAEDSAEAQEAVNRAKARIDKLMNIKGNDPHGPEFFHRQLGEILYFSCGVARNVEDLKTGI
QKIRALRKEFWANLRITGAADEMNQVLEYASRVADYIDLGELMCVDALDRDESCGAHFRDDHLSEEGEAERDDDNWCFVS
AWEPGAVEGEFIRHAEPLTFEAIPLMTRNYK

Sequences:

>Translated_671_residues
MSINSDTTVSTDFTQPASIVDGVKLGSILESHEPKGVPTKDMWEYQKNHMNLVSPLNRRKFRVLVVGTGLSGGGAAAALG
ELGYDVKVFTYHDAPRRAHSVAAQGGVNAARGKKVDNDGAYRHVKDTVKGGDYRCRESDCWRLAYESVRVIDHMNAIGAP
FAREYGGTLATRSFGGVQVSRTYYTRGQTGQQLQLAGAAALQRQIGLGTVEIFTHNDLADLVLTEKDGKKRCEGVVMRNL
ITGELTAHTGHAVILATGGYGNVFHMSTLAKNSNASAMMRAYDHGAYLASPSFIQFHPTGLPVNSEWQSKTILMSESLRN
DGRIWSPLEPKDDRDPNTIPEEERDYFLERRYPAFGNLVPRDVASRAISQQINKGLGVGPLHNSAYLDFRDAISRLGEDT
IRERYSNLFQMYEEAIGENPYKAPMRIAPTCHFTMGGLWTDFNEMTSIDGLFAAGECSWTYHGANRLGANSLLSASVDGW
FTLPFTIPNYLANHLGEPRLAEDSAEAQEAVNRAKARIDKLMNIKGNDPHGPEFFHRQLGEILYFSCGVARNVEDLKTGI
QKIRALRKEFWANLRITGAADEMNQVLEYASRVADYIDLGELMCVDALDRDESCGAHFRDDHLSEEGEAERDDDNWCFVS
AWEPGAVEGEFIRHAEPLTFEAIPLMTRNYK
>Mature_670_residues
SINSDTTVSTDFTQPASIVDGVKLGSILESHEPKGVPTKDMWEYQKNHMNLVSPLNRRKFRVLVVGTGLSGGGAAAALGE
LGYDVKVFTYHDAPRRAHSVAAQGGVNAARGKKVDNDGAYRHVKDTVKGGDYRCRESDCWRLAYESVRVIDHMNAIGAPF
AREYGGTLATRSFGGVQVSRTYYTRGQTGQQLQLAGAAALQRQIGLGTVEIFTHNDLADLVLTEKDGKKRCEGVVMRNLI
TGELTAHTGHAVILATGGYGNVFHMSTLAKNSNASAMMRAYDHGAYLASPSFIQFHPTGLPVNSEWQSKTILMSESLRND
GRIWSPLEPKDDRDPNTIPEEERDYFLERRYPAFGNLVPRDVASRAISQQINKGLGVGPLHNSAYLDFRDAISRLGEDTI
RERYSNLFQMYEEAIGENPYKAPMRIAPTCHFTMGGLWTDFNEMTSIDGLFAAGECSWTYHGANRLGANSLLSASVDGWF
TLPFTIPNYLANHLGEPRLAEDSAEAQEAVNRAKARIDKLMNIKGNDPHGPEFFHRQLGEILYFSCGVARNVEDLKTGIQ
KIRALRKEFWANLRITGAADEMNQVLEYASRVADYIDLGELMCVDALDRDESCGAHFRDDHLSEEGEAERDDDNWCFVSA
WEPGAVEGEFIRHAEPLTFEAIPLMTRNYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=419, Percent_Identity=28.4009546539379, Blast_Score=140, Evalue=5e-33,
Organism=Escherichia coli, GI1790597, Length=558, Percent_Identity=31.7204301075269, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1786942, Length=607, Percent_Identity=27.0181219110379, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788928, Length=587, Percent_Identity=26.0647359454855, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17505833, Length=555, Percent_Identity=29.9099099099099, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17550100, Length=554, Percent_Identity=29.6028880866426, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322701, Length=587, Percent_Identity=29.4718909710392, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=614, Percent_Identity=28.3387622149837, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6320788, Length=473, Percent_Identity=26.0042283298097, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137288, Length=553, Percent_Identity=28.0289330922242, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24655642, Length=553, Percent_Identity=28.0289330922242, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24655647, Length=553, Percent_Identity=28.0289330922242, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24663005, Length=592, Percent_Identity=26.1824324324324, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 74439; Mature: 74308

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINSDTTVSTDFTQPASIVDGVKLGSILESHEPKGVPTKDMWEYQKNHMNLVSPLNRRK
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHCCCCCCE
FRVLVVGTGLSGGGAAAALGELGYDVKVFTYHDAPRRAHSVAAQGGVNAARGKKVDNDGA
EEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHCCCCCCCCCC
YRHVKDTVKGGDYRCRESDCWRLAYESVRVIDHMNAIGAPFAREYGGTLATRSFGGVQVS
HHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEE
RTYYTRGQTGQQLQLAGAAALQRQIGLGTVEIFTHNDLADLVLTEKDGKKRCEGVVMRNL
EEEEECCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCHHHEEEECCCCHHHHHHHHHHHH
ITGELTAHTGHAVILATGGYGNVFHMSTLAKNSNASAMMRAYDHGAYLASPSFIQFHPTG
HHCCEEECCCCEEEEEECCCCCEEEHHHHHCCCCHHHHHHHHHCCCEECCCCEEEECCCC
LPVNSEWQSKTILMSESLRNDGRIWSPLEPKDDRDPNTIPEEERDYFLERRYPAFGNLVP
CCCCCCCCCCEEEEHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCCCCC
RDVASRAISQQINKGLGVGPLHNSAYLDFRDAISRLGEDTIRERYSNLFQMYEEAIGENP
HHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
YKAPMRIAPTCHFTMGGLWTDFNEMTSIDGLFAAGECSWTYHGANRLGANSLLSASVDGW
CCCCEEECCEEEEECCCCCCCHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHCCCCCE
FTLPFTIPNYLANHLGEPRLAEDSAEAQEAVNRAKARIDKLMNIKGNDPHGPEFFHRQLG
EEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EILYFSCGVARNVEDLKTGIQKIRALRKEFWANLRITGAADEMNQVLEYASRVADYIDLG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
ELMCVDALDRDESCGAHFRDDHLSEEGEAERDDDNWCFVSAWEPGAVEGEFIRHAEPLTF
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCEE
EAIPLMTRNYK
EEECCCCCCCC
>Mature Secondary Structure 
SINSDTTVSTDFTQPASIVDGVKLGSILESHEPKGVPTKDMWEYQKNHMNLVSPLNRRK
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHCCCCCCE
FRVLVVGTGLSGGGAAAALGELGYDVKVFTYHDAPRRAHSVAAQGGVNAARGKKVDNDGA
EEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHCCCCCCCCCC
YRHVKDTVKGGDYRCRESDCWRLAYESVRVIDHMNAIGAPFAREYGGTLATRSFGGVQVS
HHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCEEEE
RTYYTRGQTGQQLQLAGAAALQRQIGLGTVEIFTHNDLADLVLTEKDGKKRCEGVVMRNL
EEEEECCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCHHHEEEECCCCHHHHHHHHHHHH
ITGELTAHTGHAVILATGGYGNVFHMSTLAKNSNASAMMRAYDHGAYLASPSFIQFHPTG
HHCCEEECCCCEEEEEECCCCCEEEHHHHHCCCCHHHHHHHHHCCCEECCCCEEEECCCC
LPVNSEWQSKTILMSESLRNDGRIWSPLEPKDDRDPNTIPEEERDYFLERRYPAFGNLVP
CCCCCCCCCCEEEEHHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCHHCCCCC
RDVASRAISQQINKGLGVGPLHNSAYLDFRDAISRLGEDTIRERYSNLFQMYEEAIGENP
HHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCC
YKAPMRIAPTCHFTMGGLWTDFNEMTSIDGLFAAGECSWTYHGANRLGANSLLSASVDGW
CCCCEEECCEEEEECCCCCCCHHHHHCCCCEEECCCCEEEECCCCCCCCHHHHHCCCCCE
FTLPFTIPNYLANHLGEPRLAEDSAEAQEAVNRAKARIDKLMNIKGNDPHGPEFFHRQLG
EEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
EILYFSCGVARNVEDLKTGIQKIRALRKEFWANLRITGAADEMNQVLEYASRVADYIDLG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
ELMCVDALDRDESCGAHFRDDHLSEEGEAERDDDNWCFVSAWEPGAVEGEFIRHAEPLTF
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCEE
EAIPLMTRNYK
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]