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The map label for this gene is dnaX [H]

Identifier: 38232954

GI number: 38232954

Start: 304045

End: 305310

Strand: Direct

Name: dnaX [H]

Synonym: DIP0333

Alternate gene names: 38232954

Gene position: 304045-305310 (Clockwise)

Preceding gene: 38232952

Following gene: 38232955

Centisome position: 12.22

GC content: 62.95

Gene sequence:

>1266_bases
ATGCCCACTACTTTAACGGTCGGCTACTACAAGCGATACTCTATTGAAGTAATGAGCACGGAAATAACTGGGTCGGACAT
CTTTGCGCAGATGGGCGTGAGCGAACACATCGCCCCCATATTGCGAACCGCCGCGCGCGCCGCACGCAACCACGACATCG
GCAGCGCCATGACACACGCATGGCTATTTACCGGCCCGCCTGGGTCAGGGCGCTCCGTCGCGGCCGTCGCATTCGCCGCC
GCCCTCGAATGCACAGACCCCACCATGGTCGGCTGCGGGCGCTGCGAACAATGCCGCGCCGTGCTTCACGACGCCCACGG
CGACGTCCTCCACATCGTCCCACGCGAACTTTCCATCCCCGTCGAAATGATGCGTGACGACGTCGTCGAACCCGCCGCAA
AACGCCCCACCGTCGGACAATGGCGAGTAGTCATCCTCGACAACGCCGACCGCCTCACCCCCGAATCCGCCAACGCCCTG
CTCAAAACCGTCGAAGAGCCCCCAGCGCACACCGTCATCATCCTCTGCGCACCCTCCACAGACCCCACCGACATCATCCC
CACACTCCGCTCCCGCAGCCGCCACCTCTACGTCCCCCAACCCTCCATCGACGAAGCCGTAGCAGTACTCACCCGCGACG
GAACCATCCCCGAACCCGCCGCACGCCTAGCAGCAGCCACCACCGGTGGACACATCGGACGCGCACGCTGGCTAGCCACC
AACAAAGACGCCCAAATGCGACGCTCCGCAGTACTCAACATCGCAGAACTCGTCTTCCACGGCGACCAAGCCTTCCGCGC
CGGCGGCAGCCTAGTGAAACAAATAACAAAACAAGCAGAAGCCCAGCTCAAAGAAGAAAACGAAGAAGAAATCGACAAAC
TCCGCAACGCCCTCGGCATGGGATCCCGCGGCAAAGGAGTACACAAAGCCCTCCGCGGAGCCGACTCCGCCATCCGCGAC
CTCGAAGCACTACAAAAGAAACGCAAAACCCGCTTCGTCCGCGACCACCTCGACATGGCACTCGTCGACCTCTCCGGCAT
CTACCGCGACGCCATCATGACCCACACCCACGCCACAGTCGGACTGATCCACCCCGACCTCAGCGGCCTATCCGCCGAAC
TCGCCCAACGCGTCCCCCTAGCCGGACTCGTTGCCTGCCTCGACGCCATCACCATCTGCCGCGAACAAATCCCGAACAAC
GTGCGCCCCGAAGCCGCCTTCGACGCCATGCTCGGCCGCATCCGAATCGCCTGCGGAGCCACCTAA

Upstream 100 bases:

>100_bases
GACCCCCACCGCGCCCAACACATTGGAGCCCAATACCGTGGTTGCGTATAACGGCCACGAAGTCTTAAACAGCCACTTGA
AGGCGCGCCATAGTTTGGTC

Downstream 100 bases:

>100_bases
CCGGCGCAGCACCCCGCTCATGCTCTGCGGTTTTCATATTTTGGCAACCCATACGGTATAGTTGTCGCCGGATAACACAC
CCATACGTTTTATCCGTGCC

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MPTTLTVGYYKRYSIEVMSTEITGSDIFAQMGVSEHIAPILRTAARAARNHDIGSAMTHAWLFTGPPGSGRSVAAVAFAA
ALECTDPTMVGCGRCEQCRAVLHDAHGDVLHIVPRELSIPVEMMRDDVVEPAAKRPTVGQWRVVILDNADRLTPESANAL
LKTVEEPPAHTVIILCAPSTDPTDIIPTLRSRSRHLYVPQPSIDEAVAVLTRDGTIPEPAARLAAATTGGHIGRARWLAT
NKDAQMRRSAVLNIAELVFHGDQAFRAGGSLVKQITKQAEAQLKEENEEEIDKLRNALGMGSRGKGVHKALRGADSAIRD
LEALQKKRKTRFVRDHLDMALVDLSGIYRDAIMTHTHATVGLIHPDLSGLSAELAQRVPLAGLVACLDAITICREQIPNN
VRPEAAFDAMLGRIRIACGAT

Sequences:

>Translated_421_residues
MPTTLTVGYYKRYSIEVMSTEITGSDIFAQMGVSEHIAPILRTAARAARNHDIGSAMTHAWLFTGPPGSGRSVAAVAFAA
ALECTDPTMVGCGRCEQCRAVLHDAHGDVLHIVPRELSIPVEMMRDDVVEPAAKRPTVGQWRVVILDNADRLTPESANAL
LKTVEEPPAHTVIILCAPSTDPTDIIPTLRSRSRHLYVPQPSIDEAVAVLTRDGTIPEPAARLAAATTGGHIGRARWLAT
NKDAQMRRSAVLNIAELVFHGDQAFRAGGSLVKQITKQAEAQLKEENEEEIDKLRNALGMGSRGKGVHKALRGADSAIRD
LEALQKKRKTRFVRDHLDMALVDLSGIYRDAIMTHTHATVGLIHPDLSGLSAELAQRVPLAGLVACLDAITICREQIPNN
VRPEAAFDAMLGRIRIACGAT
>Mature_420_residues
PTTLTVGYYKRYSIEVMSTEITGSDIFAQMGVSEHIAPILRTAARAARNHDIGSAMTHAWLFTGPPGSGRSVAAVAFAAA
LECTDPTMVGCGRCEQCRAVLHDAHGDVLHIVPRELSIPVEMMRDDVVEPAAKRPTVGQWRVVILDNADRLTPESANALL
KTVEEPPAHTVIILCAPSTDPTDIIPTLRSRSRHLYVPQPSIDEAVAVLTRDGTIPEPAARLAAATTGGHIGRARWLATN
KDAQMRRSAVLNIAELVFHGDQAFRAGGSLVKQITKQAEAQLKEENEEEIDKLRNALGMGSRGKGVHKALRGADSAIRDL
EALQKKRKTRFVRDHLDMALVDLSGIYRDAIMTHTHATVGLIHPDLSGLSAELAQRVPLAGLVACLDAITICREQIPNNV
RPEAAFDAMLGRIRIACGAT

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=172, Percent_Identity=31.9767441860465, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787341, Length=225, Percent_Identity=31.5555555555556, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 45496; Mature: 45365

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTLTVGYYKRYSIEVMSTEITGSDIFAQMGVSEHIAPILRTAARAARNHDIGSAMTHA
CCCEEEECCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHE
WLFTGPPGSGRSVAAVAFAAALECTDPTMVGCGRCEQCRAVLHDAHGDVLHIVPRELSIP
EEEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCC
VEMMRDDVVEPAAKRPTVGQWRVVILDNADRLTPESANALLKTVEEPPAHTVIILCAPST
HHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCC
DPTDIIPTLRSRSRHLYVPQPSIDEAVAVLTRDGTIPEPAARLAAATTGGHIGRARWLAT
CCHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
NKDAQMRRSAVLNIAELVFHGDQAFRAGGSLVKQITKQAEAQLKEENEEEIDKLRNALGM
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GSRGKGVHKALRGADSAIRDLEALQKKRKTRFVRDHLDMALVDLSGIYRDAIMTHTHATV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
GLIHPDLSGLSAELAQRVPLAGLVACLDAITICREQIPNNVRPEAAFDAMLGRIRIACGA
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECC
T
C
>Mature Secondary Structure 
PTTLTVGYYKRYSIEVMSTEITGSDIFAQMGVSEHIAPILRTAARAARNHDIGSAMTHA
CCEEEECCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHE
WLFTGPPGSGRSVAAVAFAAALECTDPTMVGCGRCEQCRAVLHDAHGDVLHIVPRELSIP
EEEECCCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCC
VEMMRDDVVEPAAKRPTVGQWRVVILDNADRLTPESANALLKTVEEPPAHTVIILCAPST
HHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCC
DPTDIIPTLRSRSRHLYVPQPSIDEAVAVLTRDGTIPEPAARLAAATTGGHIGRARWLAT
CCHHHHHHHHCCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
NKDAQMRRSAVLNIAELVFHGDQAFRAGGSLVKQITKQAEAQLKEENEEEIDKLRNALGM
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GSRGKGVHKALRGADSAIRDLEALQKKRKTRFVRDHLDMALVDLSGIYRDAIMTHTHATV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
GLIHPDLSGLSAELAQRVPLAGLVACLDAITICREQIPNNVRPEAAFDAMLGRIRIACGA
EEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]