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The map label for this gene is dnaX [H]

Identifier: 38232882

GI number: 38232882

Start: 221399

End: 223522

Strand: Direct

Name: dnaX [H]

Synonym: DIP0259

Alternate gene names: 38232882

Gene position: 221399-223522 (Clockwise)

Preceding gene: 38232881

Following gene: 38232883

Centisome position: 8.9

GC content: 62.15

Gene sequence:

>2124_bases
GTGGCTTTATATCGGAAGTATCGACCAGCGTCGTTCGCAGAGGTCGTGGGGCAAGAACAGGTAACTCAACCACTATCGGT
GGCATTGGACAGTGGCCGAATCAACCACGCCTACCTTTTCTCGGGTCCACGTGGCTGCGGAAAGACGTCGTCGGCACGCA
TTATGGCGCGCTCCCTGAACTGCGTCGAAGGCCCCACCTCCACTCCTTGTGGCAAATGCAACTCTTGTATTTCGCTTGCC
CCCAACGGGCCCGGCAACCTCGATGTTACCGAGCTCGACGCGGCAAGTAACCGCAGCGTAGATGACATGCGCGAGCTCCG
TGACCGCGCCATGTACGCCCCCGCCGAATCGCGCTATCGCATTTTCATTATCGACGAAGCGCACATGATTACTCGCGACG
GCGCCAACGCCCTACTCAAAATCGTCGAAGAGCCACCGGCGCACCTCATCTTTATTTTCGCTACCACCGAGCCGGAGAAA
ATCCTTCCCACAATCCGCTCGCGTACCCACCACTATCCCTTCCGCCTGCTGACCCCGCAATCCATGCGTGGCCTGCTGGA
ACGCACCGTGGCTAGCGAACACGTCGCGGTGGAAGACTCCGTCTACCCACTCGTGATCCGCGCCGGCGGCGGCTCCCCGC
GCGACACCCTCTCCATCCTCGACCAGCTCATCGCCGGCGCAGGCCCCGACGGCCTCGACTACAACCTCGCCCGCATGCTG
CTCGGCGCCACCGATGACACCCTCATCGACACCACCATCGACGCCCTCGCCGGCAACGACAACGCCGCCCTGTTCCAAGT
CGTCGACGATGCCATCGAAGCCGGCCTCGACCCCCGCCGCTTCGCCACCGACCTCCTCGACCGCTTCCGCGACCTCATGG
TTCTCCAATCGGTCCCCGACGCCCTCACCCTCGGGCTTGTCGACGCCCCCACCGACCGCGGTGACATCCTCCGCGACCAA
GCCACACACCTACCCGCGGGCGAAGCCGCCCGACTAGCAGCACTGGTCAACGACGGCCTCCGCGGACTTAAAGGAGCAAC
CTCGCCACGCCTGCTCCTCGAAATCCTCTGCGCAAAAATGCTCCTGCCCAGCGCACAACCCGCAGCAACTGCCACTGCAC
CTGCTGCCGCTGCGCCGGCCCCTGCGCCCACCGAGATCCCCGCTAAATACGAGCGCCGTTCCGTCCGCTTGGCTAGGGAA
GCAGCCGCACGCAAGAACGCCGAAGCACCTGCTCCCGAGCCTGCTCCTGAACCGAAACCCGAACCAAAGCCGGAGCCTCG
TGATGGGTTTGCCACTATTCAAGAGAAGTGGGCAACGATCAGCGATGTGATCTTCAAAGCCAACTCCGTGGCAGGCATTT
TGCTTAGCCAAGCCACCTTGCTGGGCTTGCGTGACGATTCCACTCTTGTGATCGGTCACAACACCGGTGCGCTGGCGCAT
CGGATCAACGACCCACAGCATGCAGGCTCCATCGTTACTGCAATTAAGCAGGAAACTGATCTCGATGTGACCATTGAGTG
CGTAGTAGGTACGGACCCCAAAGCTGCTGGTTTTAGCGAACCAGAAAACAAAAAGGTGTGGAACCCAGAGCCCAAGCCGG
AACCCAAGCCCGAGCCCAAGCCGGAACCAAAACCGGAGCCGGAACCGGCTCCTGCCAGCGATAATGTCTGGGGCGCACCT
GCGCCGCTCGGTGGTGGACAACCAGCTACGCCTCCGCCACCGCCGGTAGAGCGATTTAGTCCTGCCAAGGCGACCGCACC
ACAACCTCCAGCTGCGCCGCAACCTGTGCAAGAAGCTCCGAAACCCCGCTGGCAGCAGGCCGCTGAACGTGGCATGCGCA
AGATGGAGGAGCGCGCCAAGCGGCCGTCGTTCTCCGATGGTGTGCCGCTGCCGCCCGAGCCGGAGGAACCGGATGTGCCG
CCGGACCTCTACGGCTACCCCGCAGATGAGGGGATACCGGAACCTCAGACCCCTCAGGCTACGTCTAACTATGTAGTGGA
CCATGATGAGGAAGAGGAGATGGTTAGGGAAGCGGCACAGGGCGTGGGTAATCGTGACCATCGCGATGCTATGACCGTTG
CCGTGGACATTCTCTCCGAAGAGCTAGGTGCTCGACAGCTTTAG

Upstream 100 bases:

>100_bases
GAGTTCGATTACGCGGTCACCTATGGCATTCCGGAACTCCAGTCGGAGATTGCGCGGTCGGGAATCGATCTACTGGATTG
GAGTCGGTAGGCTAGGGCAC

Downstream 100 bases:

>100_bases
GTACACTATTCGAATGACCGCCGTCGCACAGCAGGTGTGGCGGATACTAAAAACAATGCGAAAGGCAGTTGAATGACTCA
GCCGGATATGTCCCAGATCC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MALYRKYRPASFAEVVGQEQVTQPLSVALDSGRINHAYLFSGPRGCGKTSSARIMARSLNCVEGPTSTPCGKCNSCISLA
PNGPGNLDVTELDAASNRSVDDMRELRDRAMYAPAESRYRIFIIDEAHMITRDGANALLKIVEEPPAHLIFIFATTEPEK
ILPTIRSRTHHYPFRLLTPQSMRGLLERTVASEHVAVEDSVYPLVIRAGGGSPRDTLSILDQLIAGAGPDGLDYNLARML
LGATDDTLIDTTIDALAGNDNAALFQVVDDAIEAGLDPRRFATDLLDRFRDLMVLQSVPDALTLGLVDAPTDRGDILRDQ
ATHLPAGEAARLAALVNDGLRGLKGATSPRLLLEILCAKMLLPSAQPAATATAPAAAAPAPAPTEIPAKYERRSVRLARE
AAARKNAEAPAPEPAPEPKPEPKPEPRDGFATIQEKWATISDVIFKANSVAGILLSQATLLGLRDDSTLVIGHNTGALAH
RINDPQHAGSIVTAIKQETDLDVTIECVVGTDPKAAGFSEPENKKVWNPEPKPEPKPEPKPEPKPEPEPAPASDNVWGAP
APLGGGQPATPPPPPVERFSPAKATAPQPPAAPQPVQEAPKPRWQQAAERGMRKMEERAKRPSFSDGVPLPPEPEEPDVP
PDLYGYPADEGIPEPQTPQATSNYVVDHDEEEEMVREAAQGVGNRDHRDAMTVAVDILSEELGARQL

Sequences:

>Translated_707_residues
MALYRKYRPASFAEVVGQEQVTQPLSVALDSGRINHAYLFSGPRGCGKTSSARIMARSLNCVEGPTSTPCGKCNSCISLA
PNGPGNLDVTELDAASNRSVDDMRELRDRAMYAPAESRYRIFIIDEAHMITRDGANALLKIVEEPPAHLIFIFATTEPEK
ILPTIRSRTHHYPFRLLTPQSMRGLLERTVASEHVAVEDSVYPLVIRAGGGSPRDTLSILDQLIAGAGPDGLDYNLARML
LGATDDTLIDTTIDALAGNDNAALFQVVDDAIEAGLDPRRFATDLLDRFRDLMVLQSVPDALTLGLVDAPTDRGDILRDQ
ATHLPAGEAARLAALVNDGLRGLKGATSPRLLLEILCAKMLLPSAQPAATATAPAAAAPAPAPTEIPAKYERRSVRLARE
AAARKNAEAPAPEPAPEPKPEPKPEPRDGFATIQEKWATISDVIFKANSVAGILLSQATLLGLRDDSTLVIGHNTGALAH
RINDPQHAGSIVTAIKQETDLDVTIECVVGTDPKAAGFSEPENKKVWNPEPKPEPKPEPKPEPKPEPEPAPASDNVWGAP
APLGGGQPATPPPPPVERFSPAKATAPQPPAAPQPVQEAPKPRWQQAAERGMRKMEERAKRPSFSDGVPLPPEPEEPDVP
PDLYGYPADEGIPEPQTPQATSNYVVDHDEEEEMVREAAQGVGNRDHRDAMTVAVDILSEELGARQL
>Mature_706_residues
ALYRKYRPASFAEVVGQEQVTQPLSVALDSGRINHAYLFSGPRGCGKTSSARIMARSLNCVEGPTSTPCGKCNSCISLAP
NGPGNLDVTELDAASNRSVDDMRELRDRAMYAPAESRYRIFIIDEAHMITRDGANALLKIVEEPPAHLIFIFATTEPEKI
LPTIRSRTHHYPFRLLTPQSMRGLLERTVASEHVAVEDSVYPLVIRAGGGSPRDTLSILDQLIAGAGPDGLDYNLARMLL
GATDDTLIDTTIDALAGNDNAALFQVVDDAIEAGLDPRRFATDLLDRFRDLMVLQSVPDALTLGLVDAPTDRGDILRDQA
THLPAGEAARLAALVNDGLRGLKGATSPRLLLEILCAKMLLPSAQPAATATAPAAAAPAPAPTEIPAKYERRSVRLAREA
AARKNAEAPAPEPAPEPKPEPKPEPRDGFATIQEKWATISDVIFKANSVAGILLSQATLLGLRDDSTLVIGHNTGALAHR
INDPQHAGSIVTAIKQETDLDVTIECVVGTDPKAAGFSEPENKKVWNPEPKPEPKPEPKPEPKPEPEPAPASDNVWGAPA
PLGGGQPATPPPPPVERFSPAKATAPQPPAAPQPVQEAPKPRWQQAAERGMRKMEERAKRPSFSDGVPLPPEPEEPDVPP
DLYGYPADEGIPEPQTPQATSNYVVDHDEEEEMVREAAQGVGNRDHRDAMTVAVDILSEELGARQL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI194306571, Length=220, Percent_Identity=26.3636363636364, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI194306567, Length=220, Percent_Identity=26.3636363636364, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=300, Percent_Identity=40.3333333333333, Blast_Score=234, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71986063, Length=208, Percent_Identity=25.4807692307692, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19921076, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 75875; Mature: 75744

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYRKYRPASFAEVVGQEQVTQPLSVALDSGRINHAYLFSGPRGCGKTSSARIMARSLN
CCCCCCCCCCHHHHHHCHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCH
CVEGPTSTPCGKCNSCISLAPNGPGNLDVTELDAASNRSVDDMRELRDRAMYAPAESRYR
HCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEE
IFIIDEAHMITRDGANALLKIVEEPPAHLIFIFATTEPEKILPTIRSRTHHYPFRLLTPQ
EEEEECCCEEECCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECHH
SMRGLLERTVASEHVAVEDSVYPLVIRAGGGSPRDTLSILDQLIAGAGPDGLDYNLARML
HHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGATDDTLIDTTIDALAGNDNAALFQVVDDAIEAGLDPRRFATDLLDRFRDLMVLQSVPD
HCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ALTLGLVDAPTDRGDILRDQATHLPAGEAARLAALVNDGLRGLKGATSPRLLLEILCAKM
HHEECCEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLPSAQPAATATAPAAAAPAPAPTEIPAKYERRSVRLAREAAARKNAEAPAPEPAPEPKP
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EPKPEPRDGFATIQEKWATISDVIFKANSVAGILLSQATLLGLRDDSTLVIGHNTGALAH
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCEEEEECCCCHHHH
RINDPQHAGSIVTAIKQETDLDVTIECVVGTDPKAAGFSEPENKKVWNPEPKPEPKPEPK
HCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPKPEPEPAPASDNVWGAPAPLGGGQPATPPPPPVERFSPAKATAPQPPAAPQPVQEAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCC
KPRWQQAAERGMRKMEERAKRPSFSDGVPLPPEPEEPDVPPDLYGYPADEGIPEPQTPQA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TSNYVVDHDEEEEMVREAAQGVGNRDHRDAMTVAVDILSEELGARQL
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALYRKYRPASFAEVVGQEQVTQPLSVALDSGRINHAYLFSGPRGCGKTSSARIMARSLN
CCCCCCCCCHHHHHHCHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCH
CVEGPTSTPCGKCNSCISLAPNGPGNLDVTELDAASNRSVDDMRELRDRAMYAPAESRYR
HCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEE
IFIIDEAHMITRDGANALLKIVEEPPAHLIFIFATTEPEKILPTIRSRTHHYPFRLLTPQ
EEEEECCCEEECCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECHH
SMRGLLERTVASEHVAVEDSVYPLVIRAGGGSPRDTLSILDQLIAGAGPDGLDYNLARML
HHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGATDDTLIDTTIDALAGNDNAALFQVVDDAIEAGLDPRRFATDLLDRFRDLMVLQSVPD
HCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ALTLGLVDAPTDRGDILRDQATHLPAGEAARLAALVNDGLRGLKGATSPRLLLEILCAKM
HHEECCEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLPSAQPAATATAPAAAAPAPAPTEIPAKYERRSVRLAREAAARKNAEAPAPEPAPEPKP
HCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EPKPEPRDGFATIQEKWATISDVIFKANSVAGILLSQATLLGLRDDSTLVIGHNTGALAH
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCEEEEECCCCHHHH
RINDPQHAGSIVTAIKQETDLDVTIECVVGTDPKAAGFSEPENKKVWNPEPKPEPKPEPK
HCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PEPKPEPEPAPASDNVWGAPAPLGGGQPATPPPPPVERFSPAKATAPQPPAAPQPVQEAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCC
KPRWQQAAERGMRKMEERAKRPSFSDGVPLPPEPEEPDVPPDLYGYPADEGIPEPQTPQA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TSNYVVDHDEEEEMVREAAQGVGNRDHRDAMTVAVDILSEELGARQL
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]