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The map label for this gene is pdxR [H]

Identifier: 38232852

GI number: 38232852

Start: 192614

End: 193987

Strand: Reverse

Name: pdxR [H]

Synonym: DIP0226

Alternate gene names: 38232852

Gene position: 193987-192614 (Counterclockwise)

Preceding gene: 38232855

Following gene: 38232813

Centisome position: 7.79

GC content: 62.01

Gene sequence:

>1374_bases
ATGCGCCCCGACCTCGTGACCAACCTCCCCATAACTCTCAACCGCACCAGCACCGACCCCATCCCCACCCAAATAGCCGA
CCACATCCGCACCCTCGTAGGTCGTGGCCTGCTCAAACCCGGCGACCACGTCCCCAGCACCCGCGCACTGAGCACCCAAC
TAGACATATCCCGAGGTAGCGCAGTCACTGCCTATGAACAACTACTCGCCGAAGGCTTCCTCATCGCCGCGCGCGGCTCC
GGCACATGCATTAACCCCGACCTCACCCCCACACCACCCCCTGCACACTCCCCTACGCCACCCCCAGAACCGCCAGCTAT
CGACCTCACCCCAGGGCTTCCAGACACCACCACCCTCGCCAACTCCTCCTGGCGCGCAGCATGGCGGATCGCCTGCACCC
AACCACCCGCGCACACCCCACCCCAAGGGCTACTTCACCTACGCGAACAAGTAGCAGACCACCTCCGCCGCATGCGCGCC
GTAGTAGCAAGCCCCGACCACATCATCATCACCGCCGGCGCCCGCGAAGGCTTCTCCCTGATCCTCCACGCGCTCGGACA
GGACTTACGCGTTGGAGTGGAGTCACCGGGTTACCCCAGCTTAAGGCGAGTGCCGGAAGCACTCGGCTCCACCACCGTCC
CCCTTCCCACAGACAACGACGGCCTAATTACCCACGATCTCCCCGACCTCGATGCAATCTTGGTCACCCCCAGCCACCAA
TACCCCCACGGCGGCTCACTGCCCGCTTATCGACGCACCCAACTCACTACTTGGGCCAACCGCACCGCAGGACTGATCAT
CGAAGACGACTTTGATTCCGAACTACGCCACATAGGCCAACCACTACCCGCCCTTTTTGCCCTTGCCCCACAACGCACTG
CACTTCTCGGCACATTTTCTTCGGTTATCTCTCCACAAGTCTCCTGCGGATACATAGTGGCCCCACCCCACCTAGTGCCA
CATTTAATTGAATTGCGCACAATATTTGGCAATACCGCCAGCGGCATCACCCAAGAAGCGCTCGCTCAATACCTCAGCAC
CGGTGCTTTACGGCGCCGCACCCAAAACCTCCGCCGCACCTACCGCCGCCGCCGCGACACCGTCATCTCCACCCTCGGAT
CCATCCCCGGCACCACACTCTCCCCCATCGTCGGCGGCCTCCACGCCGTACTCACCTGCACCCGCCCCGAAGCAGACATC
CTCCAGCGCTGCCGCCAACGCGGAATCATCGTCGAGGGGCTCTCCAACTACTGGAGCCAACACCCCGATTCCGACCTGAG
CAACGGTATCGTCATAGGATTTGGATCCCACGACGATACCACCCTGACAGAAGCCCTCCATCACTTAGCCTGGGCAGTAA
ATTACCGACCGTAA

Upstream 100 bases:

>100_bases
CTTGAGTCATAGTGAACATCCAAGCCTATAAAAGTGGACTAACACTAGATCCAAATTAAGCATGTTGCAATAGACCACTT
TTGCACATCACAATACCTCT

Downstream 100 bases:

>100_bases
TACACCTCACCAGGAACAGTCTGCCCCAACAGCTGCGACACCGTCACCAGCGTGTAACCCTGCTCCTTTAAGCGGTCAAT
AATCCCCGGCAACGCCTCAG

Product: GntR family regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRPDLVTNLPITLNRTSTDPIPTQIADHIRTLVGRGLLKPGDHVPSTRALSTQLDISRGSAVTAYEQLLAEGFLIAARGS
GTCINPDLTPTPPPAHSPTPPPEPPAIDLTPGLPDTTTLANSSWRAAWRIACTQPPAHTPPQGLLHLREQVADHLRRMRA
VVASPDHIIITAGAREGFSLILHALGQDLRVGVESPGYPSLRRVPEALGSTTVPLPTDNDGLITHDLPDLDAILVTPSHQ
YPHGGSLPAYRRTQLTTWANRTAGLIIEDDFDSELRHIGQPLPALFALAPQRTALLGTFSSVISPQVSCGYIVAPPHLVP
HLIELRTIFGNTASGITQEALAQYLSTGALRRRTQNLRRTYRRRRDTVISTLGSIPGTTLSPIVGGLHAVLTCTRPEADI
LQRCRQRGIIVEGLSNYWSQHPDSDLSNGIVIGFGSHDDTTLTEALHHLAWAVNYRP

Sequences:

>Translated_457_residues
MRPDLVTNLPITLNRTSTDPIPTQIADHIRTLVGRGLLKPGDHVPSTRALSTQLDISRGSAVTAYEQLLAEGFLIAARGS
GTCINPDLTPTPPPAHSPTPPPEPPAIDLTPGLPDTTTLANSSWRAAWRIACTQPPAHTPPQGLLHLREQVADHLRRMRA
VVASPDHIIITAGAREGFSLILHALGQDLRVGVESPGYPSLRRVPEALGSTTVPLPTDNDGLITHDLPDLDAILVTPSHQ
YPHGGSLPAYRRTQLTTWANRTAGLIIEDDFDSELRHIGQPLPALFALAPQRTALLGTFSSVISPQVSCGYIVAPPHLVP
HLIELRTIFGNTASGITQEALAQYLSTGALRRRTQNLRRTYRRRRDTVISTLGSIPGTTLSPIVGGLHAVLTCTRPEADI
LQRCRQRGIIVEGLSNYWSQHPDSDLSNGIVIGFGSHDDTTLTEALHHLAWAVNYRP
>Mature_457_residues
MRPDLVTNLPITLNRTSTDPIPTQIADHIRTLVGRGLLKPGDHVPSTRALSTQLDISRGSAVTAYEQLLAEGFLIAARGS
GTCINPDLTPTPPPAHSPTPPPEPPAIDLTPGLPDTTTLANSSWRAAWRIACTQPPAHTPPQGLLHLREQVADHLRRMRA
VVASPDHIIITAGAREGFSLILHALGQDLRVGVESPGYPSLRRVPEALGSTTVPLPTDNDGLITHDLPDLDAILVTPSHQ
YPHGGSLPAYRRTQLTTWANRTAGLIIEDDFDSELRHIGQPLPALFALAPQRTALLGTFSSVISPQVSCGYIVAPPHLVP
HLIELRTIFGNTASGITQEALAQYLSTGALRRRTQNLRRTYRRRRDTVISTLGSIPGTTLSPIVGGLHAVLTCTRPEADI
LQRCRQRGIIVEGLSNYWSQHPDSDLSNGIVIGFGSHDDTTLTEALHHLAWAVNYRP

Specific function: May have a regulatory function in pyridoxine biosynthesis. Is said to also have an aminotransferase activity in valine biosynthesis as a double inactivation of ilvE and pdxR results in an auxotrophic requirement for valine [H]

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787710, Length=375, Percent_Identity=27.7333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790797, Length=377, Percent_Identity=24.9336870026525, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 49444; Mature: 49444

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS50949 HTH_GNTR ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDLVTNLPITLNRTSTDPIPTQIADHIRTLVGRGLLKPGDHVPSTRALSTQLDISRGS
CCCCCEECCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEECCCCC
AVTAYEQLLAEGFLIAARGSGTCINPDLTPTPPPAHSPTPPPEPPAIDLTPGLPDTTTLA
HHHHHHHHHHCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHC
NSSWRAAWRIACTQPPAHTPPQGLLHLREQVADHLRRMRAVVASPDHIIITAGAREGFSL
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
ILHALGQDLRVGVESPGYPSLRRVPEALGSTTVPLPTDNDGLITHDLPDLDAILVTPSHQ
HHHHCCHHHEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCEEEECCCCC
YPHGGSLPAYRRTQLTTWANRTAGLIIEDDFDSELRHIGQPLPALFALAPQRTALLGTFS
CCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
SVISPQVSCGYIVAPPHLVPHLIELRTIFGNTASGITQEALAQYLSTGALRRRTQNLRRT
HHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YRRRRDTVISTLGSIPGTTLSPIVGGLHAVLTCTRPEADILQRCRQRGIIVEGLSNYWSQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHCCEEEECHHHHHHC
HPDSDLSNGIVIGFGSHDDTTLTEALHHLAWAVNYRP
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRPDLVTNLPITLNRTSTDPIPTQIADHIRTLVGRGLLKPGDHVPSTRALSTQLDISRGS
CCCCCEECCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEECCCCC
AVTAYEQLLAEGFLIAARGSGTCINPDLTPTPPPAHSPTPPPEPPAIDLTPGLPDTTTLA
HHHHHHHHHHCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHC
NSSWRAAWRIACTQPPAHTPPQGLLHLREQVADHLRRMRAVVASPDHIIITAGAREGFSL
CCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
ILHALGQDLRVGVESPGYPSLRRVPEALGSTTVPLPTDNDGLITHDLPDLDAILVTPSHQ
HHHHCCHHHEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCEEEECCCCC
YPHGGSLPAYRRTQLTTWANRTAGLIIEDDFDSELRHIGQPLPALFALAPQRTALLGTFS
CCCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
SVISPQVSCGYIVAPPHLVPHLIELRTIFGNTASGITQEALAQYLSTGALRRRTQNLRRT
HHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YRRRRDTVISTLGSIPGTTLSPIVGGLHAVLTCTRPEADILQRCRQRGIIVEGLSNYWSQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHCCEEEECHHHHHHC
HPDSDLSNGIVIGFGSHDDTTLTEALHHLAWAVNYRP
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948641; 12948626 [H]