Click here to switch to the map view.

The map label for this gene is phoP [H]

Identifier: 38232699

GI number: 38232699

Start: 57664

End: 58386

Strand: Reverse

Name: phoP [H]

Synonym: DIP0064

Alternate gene names: 38232699

Gene position: 58386-57664 (Counterclockwise)

Preceding gene: 38232702

Following gene: 38232698

Centisome position: 2.35

GC content: 66.25

Gene sequence:

>723_bases
ATGGCTGACCACACACCGACCACCGCCACGCCCCCGGGGCGGGTGCTGGTCGTCGATGATGAACAACCCCTGGCTCAGAT
GGTGGCCTCCTACCTCATCCGGGCAGGCTTCGATACCCGTCAGGCGCACACCGGCACCCAGGCCGTGGACGAGGCCCGTC
GCTTTTCCCCCGATGTTGTGGTGCTGGATCTGGGGCTGCCCGAACTCGACGGCCTGGAGGTGTGCCGACGGATCCGCACC
TTCTCGGACTGCTACATCCTCATGCTCACCGCGCGTGGCAGCGAGGACGACAAGATCAGCGGTTTGACCCTGGGGGCGGA
TGACTACATCACCAAACCTTTTAGCATCCGGGAACTGGTGACCCGGGTGCATGCGGTGCTGCGCCGCCCGCGCACCAGCA
CCACCCCACCGCAGGTGACCACCCCCTTGATCGTTGGTGACCTCATCCTTGACCCCGTCGCCCATCAGGTGCGGGTGGAG
GAGACGATCGTGGAGCTCACTCGCACGGAGTTCGAGCTGCTGGTTGCCCTGGCCCTGCGCCCCGGCCAGGCGCTGACCCG
CCACGACCTGGTCACTGAGGTCTGGGACACCACCTGGGTCGGTGATGAGCGCATCGTCGATGTCCACATAGGCAACTTGC
GTCGCAAGCTCGGCACCGACACCCGGGGCCGGGGGTTTATCGACACCGTGCGTGGCGTGGGCTACCGGATGGGGCAGCCA
TGA

Upstream 100 bases:

>100_bases
ATGGCGGTCGAAGGGTGATGTTTGAAGATTTGATGAAGATTCCCCGCCGGGCGCTGCGTGAGGGTGGTATTCCTCCCTGG
CCGGAGCGATACTGGGGTCT

Downstream 100 bases:

>100_bases
ATCCCGGACCCGGCCTGACCTTCCGCTTCCTGGCTGCCCAGGTGTTGGTCGTGGTAATTAGCCTGATGGTGGCCGCGGCC
GTGGCCACGATGGTGGGCCC

Product: putative two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MADHTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRT
FSDCYILMLTARGSEDDKISGLTLGADDYITKPFSIRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVRVE
ETIVELTRTEFELLVALALRPGQALTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRMGQP

Sequences:

>Translated_240_residues
MADHTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRT
FSDCYILMLTARGSEDDKISGLTLGADDYITKPFSIRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVRVE
ETIVELTRTEFELLVALALRPGQALTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRMGQP
>Mature_239_residues
ADHTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRTF
SDCYILMLTARGSEDDKISGLTLGADDYITKPFSIRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVRVEE
TIVELTRTEFELLVALALRPGQALTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRMGQP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=40.8888888888889, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=39.9122807017544, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=39.1111111111111, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=38.6666666666667, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=38.6666666666667, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.280701754386, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=34.6491228070175, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=33.7662337662338, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=36, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.8888888888889, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=32.4561403508772, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=28.2051282051282, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=179, Percent_Identity=27.3743016759777, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26674; Mature: 26543

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVV
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCEE
VLDLGLPELDGLEVCRRIRTFSDCYILMLTARGSEDDKISGLTLGADDYITKPFSIRELV
EEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCHHHHCCCHHHHHHH
TRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVRVEETIVELTRTEFELLVALALR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGQALTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRMGQP
CCCHHHHHHHHHHHHHCEECCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ADHTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCEE
VLDLGLPELDGLEVCRRIRTFSDCYILMLTARGSEDDKISGLTLGADDYITKPFSIRELV
EEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCHHHHCCCHHHHHHH
TRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVRVEETIVELTRTEFELLVALALR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGQALTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRMGQP
CCCHHHHHHHHHHHHHCEECCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]