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The map label for this gene is purK [H]

Identifier: 37681403

GI number: 37681403

Start: 3309416

End: 3310549

Strand: Direct

Name: purK [H]

Synonym: VV3219

Alternate gene names: 37681403

Gene position: 3309416-3310549 (Clockwise)

Preceding gene: 37681402

Following gene: 37681409

Centisome position: 98.66

GC content: 47.97

Gene sequence:

>1134_bases
ATGCACGTATTGGTTTTAGGCGCAGGGCAATTGGCACGTATGATGTCGTTAGCCGGTGCACCTTTGAATATTCAGATTTC
TGCCTACGATGTGACAACGGGTGATGTCGTTCATCCTTTGACATTGCATCTCCTTGGCCACGGCTTGGAGCAAGCGATTG
AACACGTTGATGTGATCACAGCAGAGTTTGAACACATTCCTCATGACATATTGGCGATCTGCCAAGCGAGTGGCAAGTTT
CTTCCAAGCAGTGAGGCGATTAAGGCTGGCGGTGATCGTCGTTTGGAAAAAACCTTGCTTGACCATGCAGGCGTACGCAA
TGCCAATTACTACGTCATTGAAACGCGTGAAGACTTCAATAAAGCGATTGAACACGTTGGGATACCTATGGTGTTGAAAA
GCGCATTAGGTGGCTATGATGGTAGAGGGCAATGGCGCTTAAAAGATGCCGCACAAATTGAAACCCTTTGGCAAGAAATG
GCAGCTTGTATCGCTGCTACGCCAACTCAAGCGATTGTCGCTGAAGAATTTGTTCCATTTCAACGTGAAGTTTCATTGAT
TGGCGCTCGTGGTAAAGAAGGGCAAATCGAAGTCTACCCACTGGCAGAAAACATTCACGTTAATGGCGTGTTAAGCCTTT
CAACGGCAATCGACTCACCGGACCTACAAGAGCAAGCCAAACACATGTTTACTGCTGTTGCTGAAACATTGAACTACGTT
GGTGTGTTGGCGCTTGAATTTTTCGATGTCGACGGACAATTGCTGGTCAATGAAATTGCACCTCGAGTTCATAACTCCGG
CCATTGGACGCAGCAAGGAGCAGAAACTTGCCAGTTTGAAAATCATTTGCGTGCCGTTTGTGGCTTACCACTTGGGAGCA
CTAAGCTGGTTCGTGAAACCTCAATGATCAACATCCTTGGTGAAGATACTCTGCCCGCAAGCGTGATGGCGATGGATGGT
TGCCATATTCATTGGTATGGTAAAGAGAAACGCGCCGGACGAAAAATGGGCCACATTAATGTGTGTGGCGATTACAGCGG
CGAGCTGCAGCGCCGTCTTTGTGCTCTCGCCAATGTGTTGGATGAAAAAGCCTTCCCCGCGGTGCATGAGTTTGCAAAAA
AGTGGCAAGCGTAG

Upstream 100 bases:

>100_bases
TGGAACTCACGACGAAAATATCATGGCCAAAGTTGAAGCCTTCCGCAGTGAGCAAACTGAAAGCGTCCTCGCTAACCCAA
ATCCTGCAGAGGACTAAATC

Downstream 100 bases:

>100_bases
CAAGGCTTGTGCTTATGCATAAAGAGTAAAAGGGTCGCCATGTGCGCAATGTAGTTCACTTAAGAGGAGCTGCCTTGCGA
TTAACAGGATATCGGGTCTT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVITAEFEHIPHDILAICQASGKF
LPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEM
AACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYV
GVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRETSMINILGEDTLPASVMAMDG
CHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVLDEKAFPAVHEFAKKWQA

Sequences:

>Translated_377_residues
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVITAEFEHIPHDILAICQASGKF
LPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEM
AACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYV
GVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRETSMINILGEDTLPASVMAMDG
CHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVLDEKAFPAVHEFAKKWQA
>Mature_377_residues
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVITAEFEHIPHDILAICQASGKF
LPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEM
AACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYV
GVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRETSMINILGEDTLPASVMAMDG
CHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVLDEKAFPAVHEFAKKWQA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=361, Percent_Identity=36.5650969529086, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788155, Length=306, Percent_Identity=22.8758169934641, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324702, Length=383, Percent_Identity=30.5483028720627, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41278; Mature: 41278

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVIT
CEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AEFEHIPHDILAICQASGKFLPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFN
HHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHH
KAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEMAACIAATPTQAIVAEEFVPF
HHHHHCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCH
QREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYV
HHHHHHEECCCCCCCEEEEEECCCEEECEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
GVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRET
HHHHHEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SMINILGEDTLPASVMAMDGCHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVL
HHEEEECCCCCCHHHEEECCCEEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
DEKAFPAVHEFAKKWQA
HHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVIT
CEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AEFEHIPHDILAICQASGKFLPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFN
HHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECHHHHH
KAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEMAACIAATPTQAIVAEEFVPF
HHHHHCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCH
QREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYV
HHHHHHEECCCCCCCEEEEEECCCEEECEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
GVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRET
HHHHHEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SMINILGEDTLPASVMAMDGCHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVL
HHEEEECCCCCCHHHEEECCCEEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHH
DEKAFPAVHEFAKKWQA
HHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA