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The map label for this gene is cpxA

Identifier: 37681298

GI number: 37681298

Start: 3194173

End: 3195561

Strand: Direct

Name: cpxA

Synonym: VV3114

Alternate gene names: 37681298

Gene position: 3194173-3195561 (Clockwise)

Preceding gene: 37681297

Following gene: 37681299

Centisome position: 95.22

GC content: 50.9

Gene sequence:

>1389_bases
ATGCGCTTGCCGAAAATCACCAGTTTGTATGGGCGAATTTTTGCGATCTTCTGGTTTACCATGTTTTTGGTGCTGATGGC
CGTCTTGGCTTTGCCCCACCTTGATCCTCGTAAGGCACGCAATATTCCGGCCGATCAATACGATCGCTTTATTGAAGCCA
AGCAGGAGATCGAGAAGCAATATCGTGGCGAAACTGATCTTGGTCGCATTCTCTTTCGCATGGAGCGCCCCGGCGATCGC
CATGGGCGAGATGGCCGGCCGCGCTTTTTCATCACCGATTACGATGGCAATATCCTCACCACCTTGAAGCAAGGGGATTT
TCAACTCAAGGCGCTGAAAAACTTCGTCACCTCGATTGAACAACCCGATCAACCGAAACAAAAACTCTATGGCCGCTTTA
TGCTCTCAGGGCCACTGCCAGTGACGCTAGCGAACAAAGAGTACTTACTTTACGTTGGGATGCGCTGGAACCAACCACCG
CCTTTTTTACTGCGTATGTTTGATCATCCATTTCAGCTACTACTGGCTGTGATGCTGGTCAGTACCCCTTTACTGCTGTG
GCTCGCGTGGGCACTCAGCCAACCCGCACGACGCTTAGAAAAAGCGGCGCAACGTGTCGCCAAAGGGGAATTTGTCACGG
ATCCCTCTTTAGAAAAAGGCACCTCGGAGTTTCGCCAAGCCGGCGCCAGCTTCAACCGCATGGTCGAAGCGGTCAATCAA
ATGATTTCAGGTCAGCAAAGGTTGCTGTCGGATATTTCCCATGAATTGCGTTCACCACTGACTCGCTTGAGAATGGCTAA
TGCGCTTGCGACACGCAAACAGGGCGAAAGTAATGAGCTGCAACGAATTGATACCGAAGCGCAACGTTTGGAACAGATGA
TCAGTGAACTGCTGGAGCTGTCTCGCATGCAGATGAATAGCCATTTGGATCGTGAAGAGCAGCCTGTCGCCAGCCTGTGG
GAAGAGATCATTCAGGATGCACAATTTGAAGCGGAACAAATGGGCAAAGTATTGCAATACACCCCATTACCCGAGCGACA
TATTTCCGGTAATCCCAAGCTGTTAATGAGCGCGATCGAAAACATCATTCGCAATGCCATCTACTACGGCAAAGACCAAG
TGATCATCGCCATTCAAGCCATCGACGACACACTACATATCGTGGTGGATGATAATGGTGAAGGGGTACCTGAAGAGGAA
CTCGAAGCCATTTTCCGTCCGTTTTATCGAGTCTCTACCGCTCGGGATCGTCATTCTGGAGGAACCGGGCTCGGCTTAAG
CATCACCGAAAGCGCGATTCGTCAACACAGCGGCACCATAAAAGCAGAGCGCAGCGACCTTGGCGGTTTGCGAGTCACCA
TTACTCTCCCACTGGTGAAAAGGCGTTAA

Upstream 100 bases:

>100_bases
CGTTTCGAATTTGCGGAAAAAACTCCCTGAACGTGCGGATGGCAAATCTCGAATTAAAACCTTACGTGGCCGTGGCTACT
TAATGATTGTGGAGTAACCG

Downstream 100 bases:

>100_bases
TACCCTTACAAAGATCACAGTTGATAATGGTTATCATTAAGATTATGGTAAATCCTTCATCACCGGAGGATTTACCATGT
CACACACTTTCCCTGAGCTT

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTIKAERSDLGGLRVTITLPLVKRR

Sequences:

>Translated_462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTIKAERSDLGGLRVTITLPLVKRR
>Mature_462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTIKAERSDLGGLRVTITLPLVKRR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=460, Percent_Identity=46.0869565217391, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1787894, Length=324, Percent_Identity=30.8641975308642, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1786783, Length=344, Percent_Identity=25.5813953488372, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=28.2828282828283, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.0575539568345, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=28.8793103448276, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=27.3684210526316, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.4545454545455, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=27.5423728813559, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=25.8503401360544, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=331, Percent_Identity=26.8882175226586, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=247, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=213, Percent_Identity=26.2910798122066, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=27.9279279279279, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=26.7148014440433, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52924; Mature: 52924

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
YRGETDLGRILFRMERPGDRHGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIE
HCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
QPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPPPFLLRMFDHPFQLLLAVMLV
CCCCHHHHHHHHHEECCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHH
STPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRMQMNSHLDREEQPVASLWEEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIE
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHCCCCHHHHHHHHH
NIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEELEAIFRPFYRVSTARDRHSG
HHHHHHHHCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GTGLGLSITESAIRQHSGTIKAERSDLGGLRVTITLPLVKRR
CCCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
YRGETDLGRILFRMERPGDRHGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIE
HCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
QPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPPPFLLRMFDHPFQLLLAVMLV
CCCCHHHHHHHHHEECCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHH
STPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRMQMNSHLDREEQPVASLWEEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIE
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHCCCCHHHHHHHHH
NIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEELEAIFRPFYRVSTARDRHSG
HHHHHHHHCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GTGLGLSITESAIRQHSGTIKAERSDLGGLRVTITLPLVKRR
CCCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]