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The map label for this gene is mutY [H]

Identifier: 37681068

GI number: 37681068

Start: 2935458

End: 2936510

Strand: Direct

Name: mutY [H]

Synonym: VV2884

Alternate gene names: 37681068

Gene position: 2935458-2936510 (Clockwise)

Preceding gene: 37681064

Following gene: 37681069

Centisome position: 87.51

GC content: 48.62

Gene sequence:

>1053_bases
GTGACACCTTTTGCCAGCGCCATTTTGAAATGGTATGACGCCTACGGAAGAAAAAACCTTCCTTGGCAACACAATAAGAG
CGCCTACAGCGTTTGGTTATCGGAAATTATGTTGCAACAAACGCAAGTTGCGACCGTGATTCCCTATTACCAACGTTTTT
TACAGCGCTTTCCGACCGTGGTTGATCTCGCCAACGCCGAGCAAGATGAAGTGCTTCATCTATGGACGGGGTTAGGCTAC
TACGCTCGCGCACGCAATCTGCACAAAGCCGCGAAAATGGTGGCTGAGCAATATCATGGTGAATTTCCATTGGAACTGGA
GCAGATGAATGCTCTGCCGGGGATTGGCCGCTCTACCGCCGCTGCCGTGCTCTCTTCCGTTCACAAACAGCCACATGCTA
TTCTTGATGGCAATGTGAAACGCACCTTATCTCGCGCCTTTGCCGTTGAAGGTTGGCCTGGGCAAAAAACGGTCGAAAAC
CAATTGTGGCAATTAGCAGAAGCACACACCCCCAACACCGATGTCGATAAATACAACCAAGCGATGATGGATATGGGGGC
AATGGTCTGCACACGCAGCAAACCCAAATGCACATTGTGCCCTGTGGCCGAGCTATGCCAAGCCAACAAACAAGGTAACC
CGCTGGACTACCCCGGTAAAAAGCCTAAAAAAGAGAAACCCGTTAAAGAAACGTGGTTTGCCATGCTGCACTACAACAAT
CAAGTTTGGTTGGAACAAAGGCCACAAAGTGGTATTTGGGGCGGATTATTTTGCTTTCCGCAAAATGAGCATGCACAACT
TGAAGCACTGTTCGAGAAGCGAGGCATAAAAGAGGGTGACATTCGCACACAAAACACCTTAATTGCTTTTCGCCATACTT
TTAGCCATTACCATCTCGACATCACTCCGATTTTGCTGGACCTATCAAAGCAACCTGACATGGTGATGGAAGCCAGCAAT
GGTCTTTGGTATAACTTAGCCAATCCCGAAGAAGTTGGGTTAGCGGCTCCCGTCAAACAATTGCTGGAGAGCTTGCCCCA
TGAACTTCGTTAA

Upstream 100 bases:

>100_bases
GTTATCAATAAAAACCATTATCCCCACACTTTGTCGGTTGTACTTTCACCACAATCTGTGGTGCAATTTTGCCTACAAAT
AATAGAACACAGAGCATGTC

Downstream 100 bases:

>100_bases
TGCTTTATTTAAGGAGTCATTATGAGCCGCACTGTGTTTTGTGCTCGTCTAAACAAAGAAGCTGATGGTTTAGATTTTCA
GTTGTACCCAGGAGAGCTTG

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTVVDLANAEQDEVLHLWTGLGY
YARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVEN
QLWQLAEAHTPNTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALFEKRGIKEGDIRTQNTLIAFRHTFSHYHLDITPILLDLSKQPDMVMEASN
GLWYNLANPEEVGLAAPVKQLLESLPHELR

Sequences:

>Translated_350_residues
MTPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTVVDLANAEQDEVLHLWTGLGY
YARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVEN
QLWQLAEAHTPNTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALFEKRGIKEGDIRTQNTLIAFRHTFSHYHLDITPILLDLSKQPDMVMEASN
GLWYNLANPEEVGLAAPVKQLLESLPHELR
>Mature_349_residues
TPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTVVDLANAEQDEVLHLWTGLGYY
ARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTAAAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQ
LWQLAEAHTPNTDVDKYNQAMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNNQ
VWLEQRPQSGIWGGLFCFPQNEHAQLEALFEKRGIKEGDIRTQNTLIAFRHTFSHYHLDITPILLDLSKQPDMVMEASNG
LWYNLANPEEVGLAAPVKQLLESLPHELR

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=384, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI190358497, Length=386, Percent_Identity=33.160621761658, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI115298650, Length=384, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI115298654, Length=384, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI115298652, Length=384, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI6912520, Length=386, Percent_Identity=33.160621761658, Blast_Score=195, Evalue=4e-50,
Organism=Escherichia coli, GI1789331, Length=343, Percent_Identity=57.7259475218659, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787920, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39880; Mature: 39749

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTV
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHH
AAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQLWQLAEAHTPNTDVDKYNQ
HHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
AMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALFEKRGIKEGDIRTQNTLIAFRHTFSHYHLD
EEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEEHHHHEEEE
ITPILLDLSKQPDMVMEASNGLWYNLANPEEVGLAAPVKQLLESLPHELR
EEHHEEECCCCCCEEEECCCCEEEECCCHHHHCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPFASAILKWYDAYGRKNLPWQHNKSAYSVWLSEIMLQQTQVATVIPYYQRFLQRFPTV
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VDLANAEQDEVLHLWTGLGYYARARNLHKAAKMVAEQYHGEFPLELEQMNALPGIGRSTA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHH
AAVLSSVHKQPHAILDGNVKRTLSRAFAVEGWPGQKTVENQLWQLAEAHTPNTDVDKYNQ
HHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
AMMDMGAMVCTRSKPKCTLCPVAELCQANKQGNPLDYPGKKPKKEKPVKETWFAMLHYNN
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
QVWLEQRPQSGIWGGLFCFPQNEHAQLEALFEKRGIKEGDIRTQNTLIAFRHTFSHYHLD
EEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHEEEEEEHHHHEEEE
ITPILLDLSKQPDMVMEASNGLWYNLANPEEVGLAAPVKQLLESLPHELR
EEHHEEECCCCCCEEEECCCCEEEECCCHHHHCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]