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The map label for this gene is proC [H]

Identifier: 37681059

GI number: 37681059

Start: 2928871

End: 2929689

Strand: Direct

Name: proC [H]

Synonym: VV2875

Alternate gene names: 37681059

Gene position: 2928871-2929689 (Clockwise)

Preceding gene: 37681058

Following gene: 37681060

Centisome position: 87.31

GC content: 52.87

Gene sequence:

>819_bases
ATGGAACATAAGAACATCGCTTTTATCGGTGCTGGCAATATGGTGAGAGCCATTGTCTCTGGCTTGGTGGCAGACGGTTA
CCCTGCCGATAAAATCACTGCCACCGCACCCAGCGAGACGCGTCGTTTACCCCTTGAGCAGCAGTTTGGCATTCAGACCA
CCAGCGATAATTTTATGGCAGCAACGCAAGCAGACGTGATCGTCCTTTCTGTCAAACCGCAAATGATGGAAGAGGTGTGC
AAACCGCTGCAATCCGTCGATTTCTCCAATAAGCTGGTTATTTCGATTGCCGCAGGCATCAATTGCGCGCGATTAAATGA
GATGCTCGCCACTCAACTCAACTTAGTGCGCGTCATGCCCAATACCCCATCACAACTCGGGTTAGGCATGAGCGGCTTAT
ATGCGCCAGTCTCCGTGGCCGAGCAAGATCGCCACTTTGCCGAGCAGTTGATGCAAGCGGTCGGCAAAACCTGCTGGGTC
GATGAAGAATCGGGCATTAACCACGTTATTGCGGCGGCAGGCAGTGCTCCGGCGTACTTCTTCCTCTTTATGGAAGCCAT
GCAAGCTGAAGCGATGGCGCAAGGGTTTGATAAACAAACCGCTCGTTTGCTGGTTCAACAATCCGCATTGGGGGCGGCCA
GTATGGTGGTGGAAAACCCAGACACCGAACTGGCAACTCTGCGCGAGAACGTCACCTCCAAGGGAGGGACCACCGCCGAA
GCATTGCGCACTTTCAATGAACATCAACTCTCTGATATCGTAGCCAAAGCCATGCAAGCGGCAGTGGCTCGCGCGCAAGA
GATGGAAAAACTGTTTTAA

Upstream 100 bases:

>100_bases
GGTTCAACCATGGTGCGTATTGGCACTGCCATTTTTGGCCATCGCGATTACAGCAATAAAGCGTAACTCGGCGACTTTTA
CTTACTAGCGGAACAGAAAT

Downstream 100 bases:

>100_bases
TCACCTGGCTGCTTAGCAGCTCTACGTTTTAAGGGGCATCTATGAATGCAATGAGTTTTCTGATTTCGACGCTGTTTGAT
CTCTATATCATGGTCGTGAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEHKNIAFIGAGNMVRAIVSGLVADGYPADKITATAPSETRRLPLEQQFGIQTTSDNFMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNEMLATQLNLVRVMPNTPSQLGLGMSGLYAPVSVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF

Sequences:

>Translated_272_residues
MEHKNIAFIGAGNMVRAIVSGLVADGYPADKITATAPSETRRLPLEQQFGIQTTSDNFMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNEMLATQLNLVRVMPNTPSQLGLGMSGLYAPVSVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
>Mature_272_residues
MEHKNIAFIGAGNMVRAIVSGLVADGYPADKITATAPSETRRLPLEQQFGIQTTSDNFMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNEMLATQLNLVRVMPNTPSQLGLGMSGLYAPVSVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=27.8388278388278, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=28.8321167883212, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=34.0740740740741, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=32.0754716981132, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=31.5602836879433, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=26.7605633802817, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=32.9588014981273, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=32.1637426900585, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29270; Mature: 29270

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKNIAFIGAGNMVRAIVSGLVADGYPADKITATAPSETRRLPLEQQFGIQTTSDNFMA
CCCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCHHHCCCEECCCCEEE
ATQADVIVLSVKPQMMEEVCKPLQSVDFSNKLVISIAAGINCARLNEMLATQLNLVRVMP
ECCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEECC
NTPSQLGLGMSGLYAPVSVAEQDRHFAEQLMQAVGKTCWVDEESGINHVIAAAGSAPAYF
CCCHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEECCCCHHHH
FLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHCCCCCHHH
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHKNIAFIGAGNMVRAIVSGLVADGYPADKITATAPSETRRLPLEQQFGIQTTSDNFMA
CCCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCHHHCCCEECCCCEEE
ATQADVIVLSVKPQMMEEVCKPLQSVDFSNKLVISIAAGINCARLNEMLATQLNLVRVMP
ECCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEECC
NTPSQLGLGMSGLYAPVSVAEQDRHFAEQLMQAVGKTCWVDEESGINHVIAAAGSAPAYF
CCCHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEECCCCHHHH
FLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHCCCCCHHH
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]