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The map label for this gene is ttcA [H]

Identifier: 37679865

GI number: 37679865

Start: 1734848

End: 1735780

Strand: Direct

Name: ttcA [H]

Synonym: VV1681

Alternate gene names: 37679865

Gene position: 1734848-1735780 (Clockwise)

Preceding gene: 37679864

Following gene: 37679869

Centisome position: 51.72

GC content: 42.55

Gene sequence:

>933_bases
ATGACAGAGCAAATTCTAGAGCGCACTAAAGCTCAACAATATAACTTCAACAAGTTACAAAAGCGTATTCGTCGTAATAC
AGGCCAAGCGATTGCTGACTTCAACATGATCGAAGATGGTGACCGTATTATGGTGTGTTTGTCTGGTGGTAAAGACAGCT
TTACCATGTTGGACATCCTGATGAGCTTACAAAAAAGTGCACCAATCTCTTTTTCTCTTGTCGCTGTTAACCTAGACCAA
AAGCAGCCGGGCTTTCCAGCGCATGTACTGCCTGAATACCTAGAAAGCTTAGGTGTGGAATATAAGATCGTAGAAGAAGA
TACTTACTCGATTGTTCAAGATAAGATCCCTGAAGGTAAAACGACCTGTTCACTTTGCTCTCGACTACGTCGTGGTATTT
TGTACCGCACAGCAAAAGAACTCGGTGCAACAAAAATTGCGCTAGGCCATCATCGCGACGACATTTTGGAAACCTTATTT
CTAAACATGTTCTACGGCGGAAAAATGAAAGGCATGCCACCTAAGCTGGTTTCAGATAACGGCGAACACGTTGTGATTCG
TCCACTGGCATACTGCCGTGAGAAAGACATCATCAAATATTCAGATATGGCTGGCTACCCTATCATTCCATGTAACCTAT
GTGGCTCTCAACCAAACTTGCAGCGTCAAAATATCAAACAGATGCTGAATGACTGGGATAAGCGTTTCCCAGGTCGTATT
GAGACAATGTTCCGTGCAATGCAGAATGTGGTGCCAAGCCATTTAGCGGATTTTGAGTTGTTTGATTTTAAATCGATCAA
CAAAGATTCAGGCGTGATTAACGGTGGTGATATCGGTTTCGACAAAGAAGAAATGCCTGTTGCAACCGTTGAGGATGAAG
ATATGGTGCAAGAGTTTGATCCAAGCTTAAAGCTAGATGTGACCAATATTTAA

Upstream 100 bases:

>100_bases
TAATTAGCCCGGGATTTTTTTGTCCGGCACTGGCATCTTGGAAATTTATCCGTATCATACGCACTTCATTTATTTTGACG
TGTTTTAAGACTAACAGCCG

Downstream 100 bases:

>100_bases
TCAGCTTACAAATACAATAAAGGCTACCATGTTGGTAGCCTTTATTTTATCACTTGAGTGTTCAACTCATTACTTCTTTG
CCGCAGGTAAGTAAGGCAAA

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTEQILERTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDILMSLQKSAPISFSLVAVNLDQ
KQPGFPAHVLPEYLESLGVEYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDILETLF
LNMFYGGKMKGMPPKLVSDNGEHVVIRPLAYCREKDIIKYSDMAGYPIIPCNLCGSQPNLQRQNIKQMLNDWDKRFPGRI
ETMFRAMQNVVPSHLADFELFDFKSINKDSGVINGGDIGFDKEEMPVATVEDEDMVQEFDPSLKLDVTNI

Sequences:

>Translated_310_residues
MTEQILERTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDILMSLQKSAPISFSLVAVNLDQ
KQPGFPAHVLPEYLESLGVEYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDILETLF
LNMFYGGKMKGMPPKLVSDNGEHVVIRPLAYCREKDIIKYSDMAGYPIIPCNLCGSQPNLQRQNIKQMLNDWDKRFPGRI
ETMFRAMQNVVPSHLADFELFDFKSINKDSGVINGGDIGFDKEEMPVATVEDEDMVQEFDPSLKLDVTNI
>Mature_309_residues
TEQILERTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDILMSLQKSAPISFSLVAVNLDQK
QPGFPAHVLPEYLESLGVEYKIVEEDTYSIVQDKIPEGKTTCSLCSRLRRGILYRTAKELGATKIALGHHRDDILETLFL
NMFYGGKMKGMPPKLVSDNGEHVVIRPLAYCREKDIIKYSDMAGYPIIPCNLCGSQPNLQRQNIKQMLNDWDKRFPGRIE
TMFRAMQNVVPSHLADFELFDFKSINKDSGVINGGDIGFDKEEMPVATVEDEDMVQEFDPSLKLDVTNI

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=307, Percent_Identity=75.8957654723127, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193211090, Length=248, Percent_Identity=30.6451612903226, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540090, Length=232, Percent_Identity=27.1551724137931, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651972, Length=222, Percent_Identity=27.9279279279279, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 35186; Mature: 35055

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQILERTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDIL
CCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCEECCCCEEEEEEECCCCHHHHHHHH
MSLQKSAPISFSLVAVNLDQKQPGFPAHVLPEYLESLGVEYKIVEEDTYSIVQDKIPEGK
HHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCC
TTCSLCSRLRRGILYRTAKELGATKIALGHHRDDILETLFLNMFYGGKMKGMPPKLVSDN
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
GEHVVIRPLAYCREKDIIKYSDMAGYPIIPCNLCGSQPNLQRQNIKQMLNDWDKRFPGRI
CCEEEECCHHHHCCCCCEEECCCCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHHHCCHHH
ETMFRAMQNVVPSHLADFELFDFKSINKDSGVINGGDIGFDKEEMPVATVEDEDMVQEFD
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCEEECCCHHHHHHCC
PSLKLDVTNI
CCCEEEECCC
>Mature Secondary Structure 
TEQILERTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDIL
CHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCEECCCCEEEEEEECCCCHHHHHHHH
MSLQKSAPISFSLVAVNLDQKQPGFPAHVLPEYLESLGVEYKIVEEDTYSIVQDKIPEGK
HHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCC
TTCSLCSRLRRGILYRTAKELGATKIALGHHRDDILETLFLNMFYGGKMKGMPPKLVSDN
HHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCC
GEHVVIRPLAYCREKDIIKYSDMAGYPIIPCNLCGSQPNLQRQNIKQMLNDWDKRFPGRI
CCEEEECCHHHHCCCCCEEECCCCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHHHCCHHH
ETMFRAMQNVVPSHLADFELFDFKSINKDSGVINGGDIGFDKEEMPVATVEDEDMVQEFD
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCEEECCCHHHHHHCC
PSLKLDVTNI
CCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA