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The map label for this gene is pyrD

Identifier: 37679838

GI number: 37679838

Start: 1708183

End: 1709193

Strand: Direct

Name: pyrD

Synonym: VV1654

Alternate gene names: 37679838

Gene position: 1708183-1709193 (Clockwise)

Preceding gene: 37679836

Following gene: 37679839

Centisome position: 50.92

GC content: 44.02

Gene sequence:

>1011_bases
ATGCTTTACCGTCTTGCCAGAGCTGGCTTTTTTCAATTGGATGCAGAAAAGGCACACGATCTCGCTATCCAAAACTTCAA
ACGCTTTACCGGCACACCAATTGATCTTTTCTATCGTCAACAACTCCCAAATCGACCAGTAGAATGCATGGGACTCACTT
TCCGAAACCCAGTTGGCCTTGCGGCTGGTCTTGATAAAAATGGTGAGTGTATCGAAGCATTTGACGCAATGGGATTCGGC
TTTGTTGAAATTGGTACCGTTACACCTAGAGCACAATCAGGAAATGATAAACCACGTTTGTTCCGCTTAGTAGGGGCGGA
AGGGATCATTAACCGTATGGGTTTCAATAACCTAGGTGTTGACAATCTCATTGAAAATGTCAAGAAGGCCAAATACAGCT
GTGTATTAGGCATCAATATTGGTAAAAACAAAGACACGCCAATCGAGAAGGGCGCGGAAGATTATCTCATCTGTATGGAA
AAGGTATATGAGTATGCGGGTTATATTGCCGTGAATATTTCTTCTCCAAACACGCCTGGGCTAAGAACACTTCAATATGG
CGAAGCGCTTGATGAACTACTGGTTGAGTTAAAACGTAAGCAAGCTGAGCTTGAAGAGAAGCATGGAAAATATGTACCTC
TGGCATTAAAGATCGCACCGGATCTTACCGACGATGAAATTAGCCAGATTTGCCAATCATTGATCAACAACAAGATCGAT
GGTGTGATTGCAACCAATACCACGCTTGATCGTACGATGGTTGAAGGCATGAAATATGCGCAAGAGGCTGGGGGCCTTAG
TGGCCGTCCACTGCAGTCGCGTTCTACTGAGGTCGTGCGATTACTTCGTAAAGAGTTACAAGGTAACATACCAATTATTG
GCGTCGGTGGTGTTGATTCTTATGTTGCTGCAAAAGAAAAAATGTTGGCAGGGGCGGATCTTGTACAAGTTTACTCTGGC
TTCATCTATCACGGCCCTGGCTTAGTACGCGATATTGTTAAAAATCTATAG

Upstream 100 bases:

>100_bases
TTTGGAATGCAATATCTTTGACGTTTTTGTTTGAAAAGTTGTTCTTTTAAGTAAATAATACCAACCCGTTTACACGGGGC
TTTTTTCTTTCGGAGGCACA

Downstream 100 bases:

>100_bases
AATGATTCGCTAACATACTGACATAGCAGCTTTTCTAACAGAAAAAAGAGGACTTGGTTTCCTCTTTTTTTTTATTCATT
CGTTTGTAGAATCAAAACAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEIGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKYAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL

Sequences:

>Translated_336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEIGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKYAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL
>Mature_336_residues
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGLAAGLDKNGECIEAFDAMGFG
FVEIGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGVDNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICME
KVYEYAGYIAVNISSPNTPGLRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
GVIATNTTLDRTMVEGMKYAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDSYVAAKEKMLAGADLVQVYSG
FIYHGPGLVRDIVKNL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=42.5595238095238, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=67.2619047619048, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17509475, Length=333, Percent_Identity=42.3423423423423, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.6829268292683, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.6829268292683, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_VIBVY (Q7MKX3)

Other databases:

- EMBL:   BA000037
- RefSeq:   NP_934447.1
- ProteinModelPortal:   Q7MKX3
- SMR:   Q7MKX3
- STRING:   Q7MKX3
- GeneID:   2624460
- GenomeReviews:   BA000037_GR
- KEGG:   vvy:VV1654
- NMPDR:   fig|196600.1.peg.1722
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- BioCyc:   VVUL196600:VV1654-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36979; Mature: 36979

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGL
CCEEHHHCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHEEEEECCCCCC
AAGLDKNGECIEAFDAMGFGFVEIGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGV
EECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCH
DNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICMEKVYEYAGYIAVNISSPNTPG
HHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GVIATNTTLDRTMVEGMKYAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MLYRLARAGFFQLDAEKAHDLAIQNFKRFTGTPIDLFYRQQLPNRPVECMGLTFRNPVGL
CCEEHHHCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHEEEEECCCCCC
AAGLDKNGECIEAFDAMGFGFVEIGTVTPRAQSGNDKPRLFRLVGAEGIINRMGFNNLGV
EECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCH
DNLIENVKKAKYSCVLGINIGKNKDTPIEKGAEDYLICMEKVYEYAGYIAVNISSPNTPG
HHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDELLVELKRKQAELEEKHGKYVPLALKIAPDLTDDEISQICQSLINNKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GVIATNTTLDRTMVEGMKYAQEAGGLSGRPLQSRSTEVVRLLRKELQGNIPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMLAGADLVQVYSGFIYHGPGLVRDIVKNL
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA