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The map label for this gene is vllY

Identifier: 37679679

GI number: 37679679

Start: 1528776

End: 1529849

Strand: Direct

Name: vllY

Synonym: VV1495

Alternate gene names: 37679679

Gene position: 1528776-1529849 (Clockwise)

Preceding gene: 37679677

Following gene: 37679680

Centisome position: 45.57

GC content: 47.95

Gene sequence:

>1074_bases
ATGGTGGATGCAATCAACCCACTGGGCACAGACGGATTTGAGTTTGTCGAATACACCGCCGCCGATAACACAGGTATCGA
GCAGCTTAAGCATTTGTTTTCCTCGCTGGGCTTTGCGGAAGTCGCCAAGCATCGCTCGAAAGAAGCTTGGTTATATCGCC
AGGGCGATATCAACTTTGTCGTTAATGCTCAGCCGCACAGTCAGGCTGAGGAGTTTGCAAAAGTTCATGGACCTTCAGTA
TGTGGGATGGCATTTCGAGTGCAGGATGCAGCGTCAGCACTTAAGCACGCATTGACCAATGGCGCAGAAGAATACAAAAC
AGAAATCGGGCCGATGGAGCTGAGTATCCCGGCTGTGTATGGCATTGGTGGCAGCTTGCTCTATTTTGTCGATCGCTACG
GTAAGCAGAGTATCTACGATGTCGATTTTCGTTTTTATGATGACGCCGCTCAGCGCCTAGCGAAGTCGGATGTTGGCCTA
TATGAAATTGACCACCTTACCCACAACGTAAAACGCGGCAACATGGATACTTGGGCGGGATTCTATGAGCGTATTGGTAA
TTTCCGTGAAATTCGTTATTTCGATATTGAAGGGAAACTCACCGGTCTGGTGAGCCGAGCGATGACCGCACCCTGTGGCA
AAATTCGTATCCCAATCAATGAATCTTCGGACGATAAGTCACAAATCGAAGAGTTCATTCGTGAGTACAATGGTGAAGGC
ATTCAACACATCGCGCTCACCACGGACGACATCTACCAAACGGTTCAAACGCTGCGCGACCGAGGTATGGACTTTATGCC
CACGCCGGATACCTATTACGACAAAGTAGATAGCCGTGTTGAAGGGCACAAAGAAGATGTGTCTCGATTGCGTGATTTAC
GCATCCTGATCGATGGTGCACCGCTAAAAGATGGCATTTTGCTACAGATCTTTACCCAGACGGTTATCGGGCCTGTCTTC
TTTGAAATCATTCAGCGTAAAGGCAATGAAGGTTTTGGCGAAGGTAACTTCAAAGCGCTATTCGAATCGATAGAAGAAGA
TCAAATTCGCCGTGGAGTACTCAATAATGCATAA

Upstream 100 bases:

>100_bases
GTTTTTCTTGAGTAGACAGGCGCTATTCCAATTCTTCTGACTCTGGTTCAAGTTAACAAAGTGTTAACCAAAATAAAAAG
CAGTCTAAAAGGAGAAAGTC

Downstream 100 bases:

>100_bases
ATGGATCACCTTTCCTCATCGGGAAGGTGTCTGCTCCAAGCAGGCACATGCCGATTTTCCCGAAGAGGCGATTTACGAAC
GTGAAGCGGGGCGTAGTGGG

Product: putitive hemolysin

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFVVNAQPHSQAEEFAKVHGPSV
CGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVYGIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGL
YEIDHLTHNVKRGNMDTWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEG
IQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGAPLKDGILLQIFTQTVIGPVF
FEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA

Sequences:

>Translated_357_residues
MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFVVNAQPHSQAEEFAKVHGPSV
CGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVYGIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGL
YEIDHLTHNVKRGNMDTWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEG
IQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGAPLKDGILLQIFTQTVIGPVF
FEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA
>Mature_357_residues
MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFVVNAQPHSQAEEFAKVHGPSV
CGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVYGIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGL
YEIDHLTHNVKRGNMDTWAGFYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEG
IQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGAPLKDGILLQIFTQTVIGPVF
FEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family

Homologues:

Organism=Homo sapiens, GI4504477, Length=358, Percent_Identity=30.1675977653631, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI285002264, Length=354, Percent_Identity=30.5084745762712, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI14249394, Length=357, Percent_Identity=26.3305322128852, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555220, Length=299, Percent_Identity=36.1204013377926, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17550752, Length=206, Percent_Identity=36.4077669902913, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356105, Length=296, Percent_Identity=34.4594594594595, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=296, Percent_Identity=34.4594594594595, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VLLY_VIBVU (O06695)

Other databases:

- EMBL:   U97357
- EMBL:   AE016795
- RefSeq:   NP_761584.1
- ProteinModelPortal:   O06695
- SMR:   O06695
- GeneID:   1179614
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2768
- HOGENOM:   HBG680392
- OMA:   PDTYYEK
- ProtClustDB:   CLSK874325
- BioCyc:   VVUL216895:VV1_2768-MONOMER
- GO:   GO:0019835
- GO:   GO:0009405
- InterPro:   IPR005956
- InterPro:   IPR004360
- PANTHER:   PTHR11959
- PIRSF:   PIRSF009283
- TIGRFAMs:   TIGR01263

Pfam domain/function: PF00903 Glyoxalase

EC number: 1.13.11.27

Molecular weight: Translated: 40281; Mature: 40281

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFV
CCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCEEEE
VNAQPHSQAEEFAKVHGPSVCGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVY
EECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEECCCHH
GIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGLYEIDHLTHNVKRGNMDTWAG
CCCHHHHHHHHHHCCCCEEEECCEEHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHH
FYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEG
HHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
IQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGA
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEECC
PLKDGILLQIFTQTVIGPVFFEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDAINPLGTDGFEFVEYTAADNTGIEQLKHLFSSLGFAEVAKHRSKEAWLYRQGDINFV
CCCCCCCCCCCCHHHHEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEECCEEEE
VNAQPHSQAEEFAKVHGPSVCGMAFRVQDAASALKHALTNGAEEYKTEIGPMELSIPAVY
EECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEECCCHH
GIGGSLLYFVDRYGKQSIYDVDFRFYDDAAQRLAKSDVGLYEIDHLTHNVKRGNMDTWAG
CCCHHHHHHHHHHCCCCEEEECCEEHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHH
FYERIGNFREIRYFDIEGKLTGLVSRAMTAPCGKIRIPINESSDDKSQIEEFIREYNGEG
HHHHHCCCEEEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
IQHIALTTDDIYQTVQTLRDRGMDFMPTPDTYYDKVDSRVEGHKEDVSRLRDLRILIDGA
EEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEECC
PLKDGILLQIFTQTVIGPVFFEIIQRKGNEGFGEGNFKALFESIEEDQIRRGVLNNA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA