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The map label for this gene is rlmF [H]

Identifier: 37679672

GI number: 37679672

Start: 1523776

End: 1524870

Strand: Direct

Name: rlmF [H]

Synonym: VV1488

Alternate gene names: 37679672

Gene position: 1523776-1524870 (Clockwise)

Preceding gene: 37679671

Following gene: 37679673

Centisome position: 45.42

GC content: 47.76

Gene sequence:

>1095_bases
ATGACGAACAAACGAAAATCCGCCAAGCCATTAGAGCCTGCGAAACGAACCCCAAAACTGCGCACGAAAAAGAGTCGTGA
TCTCAGTGCGTCTGAATCGAGTTGTGATTTTGTCAAAGTTACGCGTGCTGGGCTGCATTCGCGCAACAAACATCAAGGGC
GTTACGATTTTGCTAAGTTAACGCAGGCGCTGCCATCGCTTGCTCCTTTTGTGATCAAAAATCCTAAAGGTGAGGCGAGT
ATTTCTTTTTCAGATTCAACGGCAGTAAAAATGCTCAATAAAGCGCTGCTCAGTGCTCACTACCAAGTGGCAAATTGGGA
CATACCAGCAGGCTATTTGTGCCCGCCAATCCCAGGGCGTGCGGATTATATCCATCGTCTAGCGGAGCTCTTGGAAGGAG
AGGTGAAAGGTACATTTCCTCATGAGAAAGTTCAGGCGTTGGACATCGGTGTCGGTGCAAACGCCATCTATCCCATTATT
GCGATTTGTGACTATCGTTGGCGCTACACGGGTAGTGACGTTGACCCTAAATCGATTGAGTCCGCGCAGCGCATTGCTGA
CTCTAACCCAGTGCTGCAGGGGCAGCTTGAGCTCAAATTGCAAGACCAGTCACAGCATATTTTCCAAGGCATTATTGGCC
CCACAGACTACTTTCATGTGACGACATGCAACCCGCCATTTCACGCTTCGGCACAGGAAGCGGCGTTTGGCACGCAACGA
AAATTAGACAACCTCGCCGCCAACCGTTTGAAAAAAGGTGTAACAGCAAAAGCTGGTTCACAAAAAATCTCGAAAAACAA
ACCTATACTTAACTTCGGAGGTCAAAATTCTGAGTTGTGGTGTCAAGGTGGAGAATCCTCCTTCTTGAAGCGCATGGCGA
ACGAAAGTGAGCGTTTTGCCCATCAGGTTTTGTGGTTCAGTACGCTCGTTTCGAAGAAAGACAACGTAAGACCTCTACGT
AAACAGTTGGAAAAATTAGGTGTACGCAGTATTCGTGTCGTCGAAATGAGCCAAGGACAAAAGGTCAGTCGCTTTGTTGC
TTGGTCATTTATGGACAAACTACAAAGAGGAGAGTGGATCAAACTGCGAGGGTGA

Upstream 100 bases:

>100_bases
CTCTTTGCTGCTACATGGAGCCGGACTATCACCAACTGGAGCTGGATGCTCGTCTGTTTATGATTTACCTCGATTTAAAA
GCTCAGGAAGCAAAAAAATA

Downstream 100 bases:

>100_bases
TGGAGACAATCATCCCGAGTTAAAAACGAATAGGTTGCGTAATAGGAGGGCATGCGATGGATTTTGAAATTTATCTACCC
TGTCAGCCAGATTGGCTGTG

Product: putative SAM-dependent methyltransferase

Products: NA

Alternate protein names: 23S rRNA mA1618 methyltransferase; rRNA adenine N-6-methyltransferase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTNKRKSAKPLEPAKRTPKLRTKKSRDLSASESSCDFVKVTRAGLHSRNKHQGRYDFAKLTQALPSLAPFVIKNPKGEAS
ISFSDSTAVKMLNKALLSAHYQVANWDIPAGYLCPPIPGRADYIHRLAELLEGEVKGTFPHEKVQALDIGVGANAIYPII
AICDYRWRYTGSDVDPKSIESAQRIADSNPVLQGQLELKLQDQSQHIFQGIIGPTDYFHVTTCNPPFHASAQEAAFGTQR
KLDNLAANRLKKGVTAKAGSQKISKNKPILNFGGQNSELWCQGGESSFLKRMANESERFAHQVLWFSTLVSKKDNVRPLR
KQLEKLGVRSIRVVEMSQGQKVSRFVAWSFMDKLQRGEWIKLRG

Sequences:

>Translated_364_residues
MTNKRKSAKPLEPAKRTPKLRTKKSRDLSASESSCDFVKVTRAGLHSRNKHQGRYDFAKLTQALPSLAPFVIKNPKGEAS
ISFSDSTAVKMLNKALLSAHYQVANWDIPAGYLCPPIPGRADYIHRLAELLEGEVKGTFPHEKVQALDIGVGANAIYPII
AICDYRWRYTGSDVDPKSIESAQRIADSNPVLQGQLELKLQDQSQHIFQGIIGPTDYFHVTTCNPPFHASAQEAAFGTQR
KLDNLAANRLKKGVTAKAGSQKISKNKPILNFGGQNSELWCQGGESSFLKRMANESERFAHQVLWFSTLVSKKDNVRPLR
KQLEKLGVRSIRVVEMSQGQKVSRFVAWSFMDKLQRGEWIKLRG
>Mature_363_residues
TNKRKSAKPLEPAKRTPKLRTKKSRDLSASESSCDFVKVTRAGLHSRNKHQGRYDFAKLTQALPSLAPFVIKNPKGEASI
SFSDSTAVKMLNKALLSAHYQVANWDIPAGYLCPPIPGRADYIHRLAELLEGEVKGTFPHEKVQALDIGVGANAIYPIIA
ICDYRWRYTGSDVDPKSIESAQRIADSNPVLQGQLELKLQDQSQHIFQGIIGPTDYFHVTTCNPPFHASAQEAAFGTQRK
LDNLAANRLKKGVTAKAGSQKISKNKPILNFGGQNSELWCQGGESSFLKRMANESERFAHQVLWFSTLVSKKDNVRPLRK
QLEKLGVRSIRVVEMSQGQKVSRFVAWSFMDKLQRGEWIKLRG

Specific function: Specifically methylates the adenine in position 1618 of 23S rRNA [H]

COG id: COG3129

COG function: function code R; Predicted SAM-dependent methyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. METT10D/rlmF family [H]

Homologues:

Organism=Homo sapiens, GI122114654, Length=314, Percent_Identity=27.3885350318471, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI87081786, Length=319, Percent_Identity=48.58934169279, Blast_Score=314, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI32564931, Length=310, Percent_Identity=22.258064516129, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564933, Length=311, Percent_Identity=20.5787781350482, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281363415, Length=325, Percent_Identity=25.8461538461538, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19922302, Length=325, Percent_Identity=25.8461538461538, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016909
- InterPro:   IPR010286 [H]

Pfam domain/function: PF05971 Methyltransf_10 [H]

EC number: =2.1.1.181 [H]

Molecular weight: Translated: 40673; Mature: 40542

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKRKSAKPLEPAKRTPKLRTKKSRDLSASESSCDFVKVTRAGLHSRNKHQGRYDFAKL
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
TQALPSLAPFVIKNPKGEASISFSDSTAVKMLNKALLSAHYQVANWDIPAGYLCPPIPGR
HHHHHHHCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCH
ADYIHRLAELLEGEVKGTFPHEKVQALDIGVGANAIYPIIAICDYRWRYTGSDVDPKSIE
HHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHH
SAQRIADSNPVLQGQLELKLQDQSQHIFQGIIGPTDYFHVTTCNPPFHASAQEAAFGTQR
HHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHH
KLDNLAANRLKKGVTAKAGSQKISKNKPILNFGGQNSELWCQGGESSFLKRMANESERFA
HHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHH
HQVLWFSTLVSKKDNVRPLRKQLEKLGVRSIRVVEMSQGQKVSRFVAWSFMDKLQRGEWI
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
KLRG
EECC
>Mature Secondary Structure 
TNKRKSAKPLEPAKRTPKLRTKKSRDLSASESSCDFVKVTRAGLHSRNKHQGRYDFAKL
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
TQALPSLAPFVIKNPKGEASISFSDSTAVKMLNKALLSAHYQVANWDIPAGYLCPPIPGR
HHHHHHHCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCH
ADYIHRLAELLEGEVKGTFPHEKVQALDIGVGANAIYPIIAICDYRWRYTGSDVDPKSIE
HHHHHHHHHHHCCCCCCCCCHHHHEEEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHH
SAQRIADSNPVLQGQLELKLQDQSQHIFQGIIGPTDYFHVTTCNPPFHASAQEAAFGTQR
HHHHHHCCCCEEEEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHH
KLDNLAANRLKKGVTAKAGSQKISKNKPILNFGGQNSELWCQGGESSFLKRMANESERFA
HHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHH
HQVLWFSTLVSKKDNVRPLRKQLEKLGVRSIRVVEMSQGQKVSRFVAWSFMDKLQRGEWI
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
KLRG
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA