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The map label for this gene is nhaA

Identifier: 37679618

GI number: 37679618

Start: 1464159

End: 1465328

Strand: Direct

Name: nhaA

Synonym: VV1434

Alternate gene names: 37679618

Gene position: 1464159-1465328 (Clockwise)

Preceding gene: 37679617

Following gene: 37679619

Centisome position: 43.65

GC content: 47.01

Gene sequence:

>1170_bases
ATGAACGATGTCATTCGTGACTTTTTCAAAATGGAATCTGCTGGTGGCATTTTGCTTGTGATCGCTGCCGCGATCGCAAT
GGTGATTGCAAACTCGCCTCTCAATGAAAGTTACCAAGCGGTTTTGCATACTTATGTATTTGGCATGTCAGTATCTCACT
GGATCAATGATGGCCTAATGGCAATTTTCTTCTTGCTGATCGGCTTGGAAGTCAAGCGTGAATTATTAGAAGGCGCATTG
AAATCGCGTGAAACGGCGATCTTCCCAGCGATTGCCGCAGTGGGTGGTATGTTGGCGCCAGCGCTTATCTATGTTGCTTT
CAATGGAAACGATCCGGAAGCGATTAAAGGTTGGGCAATTCCAGCAGCGACCGATATTGCATTTGCTTTGGGTATCATGG
CGCTGCTAGGTAAGCGCGTTCCTGTCAGTCTTAAAGTGTTCCTTTTGGCATTAGCGATCATCGATGACTTGGGCGTCGTT
GTGATTATTGCGCTCTTCTACAGTGGCGATTTGTCGACACTTGCGTTGACGGTTGGATTCGCGATGACGGGTGTCTTGTT
CATGCTAAACGCTAAGAATGTGACAAAGTTAATTTGGTATATCGTTGTCGGCTTTATCTTGTGGGTTGCGGTACTGAAAT
CCGGAGTCCATGCAACCTTGGCAGGTGTCGTGATTGGTTTCTCTATCCCATTACAGGGTAAAAAAGGTGAGCACTCTCCG
TTGAAACACATGGAACATGCGCTTCACCCATATGTTGCCTTTGCTATCTTACCTGTCTTTGCCTTTGCTAACGCTGGTAT
CTCGCTTGAAGGGGTGTCTCTTTCTGGCTTGACTTCCATGTTGCCGCTGGGTATCGCGCTAGGACTATTGGTTGGTAAAC
CACTGGGTATCTTTACGTTTAGCTGGGCAGCGGTGAAGTTTGGTGTGGCTAAATTGCCTGAAGGTGTGAACTTCAAGCAT
ATCTTTGCCGTGTCAGTGCTCTGTGGTATCGGTTTCACCATGTCGATCTTTATTTCATCGCTGGCTTTCGGTGGTGCAAA
TCCAGACTTCGATACTTATTCACGACTAGGTATCTTAATGGGATCGACGACAGCGGCAGTGCTTGGTTATTTCTTACTGC
ATGTATCGCTGCCAAAGACAGCGGCGGAAAGTGAGAAAGCAATCAGCTAA

Upstream 100 bases:

>100_bases
AACATCCAAACAAGCGATTATTCCTACAAAATGGTTATATATACACTGCTTACATTCTTCAAAGTTCGTTGATTACGATT
ATAAATAAAAGGGTGAAATC

Downstream 100 bases:

>100_bases
ACGAGAGACTGCTAAACCATAGATTGATGCAATAAACTCAAAAGCCTCTGCGACTATCGCAGAGGCTTTTTGGTTTCTAT
TGGCTGTCTTAACTATTTGC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNDVIRDFFKMESAGGILLVIAAAIAMVIANSPLNESYQAVLHTYVFGMSVSHWINDGLMAIFFLLIGLEVKRELLEGAL
KSRETAIFPAIAAVGGMLAPALIYVAFNGNDPEAIKGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVV
VIIALFYSGDLSTLALTVGFAMTGVLFMLNAKNVTKLIWYIVVGFILWVAVLKSGVHATLAGVVIGFSIPLQGKKGEHSP
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLSGLTSMLPLGIALGLLVGKPLGIFTFSWAAVKFGVAKLPEGVNFKH
IFAVSVLCGIGFTMSIFISSLAFGGANPDFDTYSRLGILMGSTTAAVLGYFLLHVSLPKTAAESEKAIS

Sequences:

>Translated_389_residues
MNDVIRDFFKMESAGGILLVIAAAIAMVIANSPLNESYQAVLHTYVFGMSVSHWINDGLMAIFFLLIGLEVKRELLEGAL
KSRETAIFPAIAAVGGMLAPALIYVAFNGNDPEAIKGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVV
VIIALFYSGDLSTLALTVGFAMTGVLFMLNAKNVTKLIWYIVVGFILWVAVLKSGVHATLAGVVIGFSIPLQGKKGEHSP
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLSGLTSMLPLGIALGLLVGKPLGIFTFSWAAVKFGVAKLPEGVNFKH
IFAVSVLCGIGFTMSIFISSLAFGGANPDFDTYSRLGILMGSTTAAVLGYFLLHVSLPKTAAESEKAIS
>Mature_389_residues
MNDVIRDFFKMESAGGILLVIAAAIAMVIANSPLNESYQAVLHTYVFGMSVSHWINDGLMAIFFLLIGLEVKRELLEGAL
KSRETAIFPAIAAVGGMLAPALIYVAFNGNDPEAIKGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVV
VIIALFYSGDLSTLALTVGFAMTGVLFMLNAKNVTKLIWYIVVGFILWVAVLKSGVHATLAGVVIGFSIPLQGKKGEHSP
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLSGLTSMLPLGIALGLLVGKPLGIFTFSWAAVKFGVAKLPEGVNFKH
IFAVSVLCGIGFTMSIFISSLAFGGANPDFDTYSRLGILMGSTTAAVLGYFLLHVSLPKTAAESEKAIS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=57.3298429319372, Blast_Score=393, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_VIBVU (Q8D8Y2)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761643.1
- HSSP:   P13738
- ProteinModelPortal:   Q8D8Y2
- SMR:   Q8D8Y2
- GeneID:   1179673
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_2833
- HOGENOM:   HBG665619
- OMA:   IYLKFFA
- ProtClustDB:   PRK09560
- BioCyc:   VVUL216895:VV1_2833-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41073; Mature: 41073

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18023644)-; HASH(0x180ee238)-; HASH(0x17e61fd0)-; HASH(0x17e7741c)-; HASH(0x18809770)-; HASH(0x1773fafc)-; HASH(0x1880bee0)-; HASH(0x181fc63c)-; HASH(0x1841d6d0)-; HASH(0x1809e8e0)-; HASH(0x183a882c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVIRDFFKMESAGGILLVIAAAIAMVIANSPLNESYQAVLHTYVFGMSVSHWINDGLM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
AIFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNGNDPEAIKGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCCC
PAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSGDLSTLALTVGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AMTGVLFMLNAKNVTKLIWYIVVGFILWVAVLKSGVHATLAGVVIGFSIPLQGKKGEHSP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCH
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLSGLTSMLPLGIALGLLVGKPLGIFTF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SWAAVKFGVAKLPEGVNFKHIFAVSVLCGIGFTMSIFISSLAFGGANPDFDTYSRLGILM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTTAAVLGYFLLHVSLPKTAAESEKAIS
CCHHHHHHHHHHHHHCCCCHHHCHHCCCH
>Mature Secondary Structure
MNDVIRDFFKMESAGGILLVIAAAIAMVIANSPLNESYQAVLHTYVFGMSVSHWINDGLM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
AIFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNGNDPEAIKGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCCC
PAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSGDLSTLALTVGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AMTGVLFMLNAKNVTKLIWYIVVGFILWVAVLKSGVHATLAGVVIGFSIPLQGKKGEHSP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCH
LKHMEHALHPYVAFAILPVFAFANAGISLEGVSLSGLTSMLPLGIALGLLVGKPLGIFTF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SWAAVKFGVAKLPEGVNFKHIFAVSVLCGIGFTMSIFISSLAFGGANPDFDTYSRLGILM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTTAAVLGYFLLHVSLPKTAAESEKAIS
CCHHHHHHHHHHHHHCCCCHHHCHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA