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The map label for this gene is focA [H]

Identifier: 37679554

GI number: 37679554

Start: 1394069

End: 1394911

Strand: Direct

Name: focA [H]

Synonym: VV1370

Alternate gene names: 37679554

Gene position: 1394069-1394911 (Clockwise)

Preceding gene: 37679553

Following gene: 37679555

Centisome position: 41.56

GC content: 47.45

Gene sequence:

>843_bases
ATGAACTTCAATCAATTTGACTCGCTATTACCACCACAGGCCGCGGAAAGAGCGGCAGAGATCGGTGAAGGGAAAGCGAC
CAAGGACCCGGTTAAATCATTTTTACTTGCTATTTCAGCGGGTATCCATATCGGTATTGCCTTCGTTTTTTATACCACGG
TAACAACTGGTGGGGCGGACTTGCCTTGGGGAATAACACGCCTGATCGGTGGCCTAGCATTTAGCTTAGGCTTGATCCTT
GTTGTTGTGACTGGTGGTGAACTGTTTACGAGTTCAGTGCTGACCTTAGTTGCACGTGCCAGCGGTAAAATCTCCTGGCG
CGTTCTGATCAAAAACTGGTTTGTGGTTTATGTCGGTAACTTGGTTGGCGCCATTTTGCTGGTGGTTTGCATGTTGATCA
CTAAGCAGTACATGTTTGACCATGGACAGGTTGGTTTAAACGCGATGGCGATTTCACAGCATAAGATGCACCACAGCTTT
TTCTCTGCCGTAGCTTTAGGCATCATGTGCAATGTGCTGGTTTGTATCGCAGTGTGGATGACGTTCAGCGGCCGTACACT
AACGGATAAAATTGCCGTGATGATTCTACCTGTTGCGATGTTTGTCTCGGCAGGTTTTGAGCACTGCATTGCCAATATGT
TCCAAGTGCCGATGGCGATTGGTATCAAAAACTTTGCCCCAGCTGAATTTTGGCAAATGACGGGGGCAAACATTGCCGAT
TACGCCGACTTGAACATGATGGACTTTCTGCTGAATAACCTACTGCCGGTTACGCTTGGTAATATCATCGGTGGTGGCGT
GTTTGTTGGCATGTGGTATTGGTTAATCTACCTGCGCGATTAA

Upstream 100 bases:

>100_bases
AACAACATTTTTTGTAAACATAAAAAATACCCCTTGAAAAACTCTGGAAAAGGAGAGATTATCCGCGCCACTCGAAATTG
TTTCCAAATGTTAACCTGCA

Downstream 100 bases:

>100_bases
TCGCTGAGTGACACTATTCACCGCGATTCTTAGATAACGAAAAAGCAGACGTTAAGTCTGCTTTTTTCGTTTTTCATACC
CTTTAGAAATTACTTGAGTT

Product: putative formate transporter 1

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel 1 [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNFNQFDSLLPPQAAERAAEIGEGKATKDPVKSFLLAISAGIHIGIAFVFYTTVTTGGADLPWGITRLIGGLAFSLGLIL
VVVTGGELFTSSVLTLVARASGKISWRVLIKNWFVVYVGNLVGAILLVVCMLITKQYMFDHGQVGLNAMAISQHKMHHSF
FSAVALGIMCNVLVCIAVWMTFSGRTLTDKIAVMILPVAMFVSAGFEHCIANMFQVPMAIGIKNFAPAEFWQMTGANIAD
YADLNMMDFLLNNLLPVTLGNIIGGGVFVGMWYWLIYLRD

Sequences:

>Translated_280_residues
MNFNQFDSLLPPQAAERAAEIGEGKATKDPVKSFLLAISAGIHIGIAFVFYTTVTTGGADLPWGITRLIGGLAFSLGLIL
VVVTGGELFTSSVLTLVARASGKISWRVLIKNWFVVYVGNLVGAILLVVCMLITKQYMFDHGQVGLNAMAISQHKMHHSF
FSAVALGIMCNVLVCIAVWMTFSGRTLTDKIAVMILPVAMFVSAGFEHCIANMFQVPMAIGIKNFAPAEFWQMTGANIAD
YADLNMMDFLLNNLLPVTLGNIIGGGVFVGMWYWLIYLRD
>Mature_280_residues
MNFNQFDSLLPPQAAERAAEIGEGKATKDPVKSFLLAISAGIHIGIAFVFYTTVTTGGADLPWGITRLIGGLAFSLGLIL
VVVTGGELFTSSVLTLVARASGKISWRVLIKNWFVVYVGNLVGAILLVVCMLITKQYMFDHGQVGLNAMAISQHKMHHSF
FSAVALGIMCNVLVCIAVWMTFSGRTLTDKIAVMILPVAMFVSAGFEHCIANMFQVPMAIGIKNFAPAEFWQMTGANIAD
YADLNMMDFLLNNLLPVTLGNIIGGGVFVGMWYWLIYLRD

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=277, Percent_Identity=56.3176895306859, Blast_Score=327, Evalue=6e-91,
Organism=Escherichia coli, GI1788837, Length=281, Percent_Identity=44.8398576512456, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI87082249, Length=271, Percent_Identity=29.8892988929889, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321779, Length=225, Percent_Identity=27.1111111111111, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 30439; Mature: 30439

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS01005 FORMATE_NITRITE_TP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNQFDSLLPPQAAERAAEIGEGKATKDPVKSFLLAISAGIHIGIAFVFYTTVTTGGAD
CCCCHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LPWGITRLIGGLAFSLGLILVVVTGGELFTSSVLTLVARASGKISWRVLIKNWFVVYVGN
CCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
LVGAILLVVCMLITKQYMFDHGQVGLNAMAISQHKMHHSFFSAVALGIMCNVLVCIAVWM
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFSGRTLTDKIAVMILPVAMFVSAGFEHCIANMFQVPMAIGIKNFAPAEFWQMTGANIAD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHH
YADLNMMDFLLNNLLPVTLGNIIGGGVFVGMWYWLIYLRD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]