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The map label for this gene is lon [H]

Identifier: 37679290

GI number: 37679290

Start: 1112591

End: 1114942

Strand: Direct

Name: lon [H]

Synonym: VV1106

Alternate gene names: 37679290

Gene position: 1112591-1114942 (Clockwise)

Preceding gene: 37679289

Following gene: 37679291

Centisome position: 33.17

GC content: 47.28

Gene sequence:

>2352_bases
ATGAACTTGGAACGTTCCGAGCGTATCGAGATCCCCGTCCTACCTCTACGAGATGTGGTGGTTTATCCACACATGGTTAT
CCCTTTGTTTGTTGGCCGTGAAAAGTCGATCAGTTGCTTAGAATCGGCAATGGAAGCCAATAAACAGGTTTTGCTTGTCG
CACAAAAGCAAGCAGACACAGATGAACCAACCGTTGATGACTTGTTCGAGGTGGGCACGGTAGCCACGATCCTGCAACTG
CTTAAACTGCCAGACGGTACGGTAAAAGTACTGGTTGAAGGCCAGCAGCGCGCTAAAATCAATCAGTTCAAGGAAAGTGA
TTTCTTCTTAGCAGAAGCGGAATTTATCGTCACTCCTGAATTGGATGAGCGTGAGCAAGAAGTGATTGTTCGCAGCGCCA
TTAGCCAATTTGAAGGCTTCATTAAACTGAATAAGAAGATTCCACCAGAAGTCCTGACTTCCCTAGGTGGCATTGATGAA
GCTGCCCGCCTTGCAGACACGATTGCTGCCCATATGCCACTGAAGTTAGCGGATAAGCAGCAAGTACTAGAAACCGTAGA
TATTACCGAGCGTCTAGAGTTCCTGATGGGGCAAATGGAATCGGAAATCGACATTCTGCAAGTTGAAAAGCGCATCCGTA
ACCGCGTCAAGAAACAGATGGAGAAATCCCAGCGCGAGTACTATCTGAATGAGCAAATGAAAGCGATTCAGAAAGAGCTT
GGCGAATCTGAAGATGGCGTAGATGAGTTTGAAGCGCTCAAGCAAAAGATTGATTCGGCTAAAATGCCGAAAGAAGCACG
CGAAAAGACCGAACAAGAACTGCAAAAGCTGAAGATGATGTCACCGATGTCAGCGGAAGCGACAGTTGTGCGCAGCTACA
TTGATTGGATGGTCAACGTTCCTTGGAACAAACGTTCTAAAGTGAAGAAAGACTTGGCGAAAGCGGAAGAAGTGCTCAAT
GAAGACCATTACGGCCTTGAGCGCGTAAAAGACCGCATTCTAGAGTATTTGGCGGTTCAAAACCGTATCAATAAGCTAAA
AGGCCCGATTCTTTGCCTTGTGGGGCCTCCTGGTGTGGGTAAAACTTCGTTAGGTCGCTCAATTGCCGCAGCAACAGGTC
GTCAATACGTTCGTATGGCGCTCGGTGGTGTTCGAGATGAAGCCGAGATCCGTGGCCATCGCCGCACGTATATTGGTTCG
CTTCCGGGTAAACTGATTCAAAAAATGGCCAAAGTTGGCGTGAAGAATCCACTCTTCTTGTTGGATGAGATCGACAAAAT
GTCATCTGACATGCGTGGCGATCCCGCGTCTGCATTACTTGAAGTGCTGGACCCAGAACAGAACAACTCGTTCAATGATC
ACTACTTAGAAGTGGATTACGATCTGTCTGACGTGATGTTTGTTGCAACTTCGAACTCAATGAATATTCCAGGTCCTTTA
CTTGACCGTATGGAAGTGATTCGTTTATCTGGTTACACAGAAGATGAAAAACTCAACATTGCGAAGCGCCACTTGGTTGC
GAAGCAGGTCGAGCGTAATGGCTTGAAGCCTCATGAAATCAATATCGAGGACTCTGCCATTATTGGTATTATCCGCTTCT
ATACGCGTGAAGCGGGTGTGCGTAGTTTAGAGCGTGAGATTTCGAAAATCTGTCGTAAAGCAGTGAAGAACATTCTGCTG
AAGCCAGAGTTGAAGTCCGTGACAGTTAACATCGATAACTTGAAAGAGTACTTAGGTGTTCAACGCTTTGACTATGGTAA
AGCGGATGACAGTAACCGAGTGGGCCAAGTGACCGGTCTTGCGTGGACGGAAGTCGGTGGCGATTTGCTGACGATTGAGA
CTGAGGCGATGCCGGGCAAAGGTAAACTGACCCAAACTGGCTCACTGGGTGACGTGATGCAGGAGTCGATTCAAGCGGCC
ATGACCGTTGTGCGCTCTCGTGCGGAGAAATTGGGTATTAACTCTGATTTCTACGAGAAGAAAGACATCCATGTGCACGT
TCCAGAAGGTGCAACACCAAAAGATGGCCCAAGTGCCGGTATTGCGATGTGCACGGCGTTAGTCTCTAGCCTAACGGGTA
ACCCTGTCAAAGCAGAAGTCGCCATGACGGGTGAGATTACTCTGCGTGGTGAAGTGTTACCAATTGGTGGTCTAAAAGAG
AAGTTGTTGGCTGCACATCGTGGTGGTATTACAACGGTACTTATTCCGAAGGATAATGAGCGTGATCTGGAAGAAATTCC
AGACAACGTTATCGCTGATTTGAAAGTCATTCCAGTTCAATGGATTGATGAAGTTCTTAAAGTTGCACTAGAGCGAGACC
CAACTGGGGTGGAGTTTGACGCTAAAAAATAG

Upstream 100 bases:

>100_bases
AAGGAGGTAAGGAATTACCTCCTTTTTTATTTTCTTTTATTGAATCCAAATAATTAGCCCCCATATACTGCTCATAATAG
TAAGTGGAAGAGAGAATTAT

Downstream 100 bases:

>100_bases
TGATGTGCAGCAAAAATAAGTAAAAGTTTACGCTGATAGGCTCGAAAAGGCTTGTCAGCGTTTTTTTTGGGAGCTAAGTT
AGAGCTCGATGGCTGCCAGC

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSISCLESAMEANKQVLLVAQKQADTDEPTVDDLFEVGTVATILQL
LKLPDGTVKVLVEGQQRAKINQFKESDFFLAEAEFIVTPELDEREQEVIVRSAISQFEGFIKLNKKIPPEVLTSLGGIDE
AARLADTIAAHMPLKLADKQQVLETVDITERLEFLMGQMESEIDILQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKEL
GESEDGVDEFEALKQKIDSAKMPKEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVNVPWNKRSKVKKDLAKAEEVLN
EDHYGLERVKDRILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKRHLVAKQVERNGLKPHEINIEDSAIIGIIRFYTREAGVRSLEREISKICRKAVKNILL
KPELKSVTVNIDNLKEYLGVQRFDYGKADDSNRVGQVTGLAWTEVGGDLLTIETEAMPGKGKLTQTGSLGDVMQESIQAA
MTVVRSRAEKLGINSDFYEKKDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGITTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPTGVEFDAKK

Sequences:

>Translated_783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSISCLESAMEANKQVLLVAQKQADTDEPTVDDLFEVGTVATILQL
LKLPDGTVKVLVEGQQRAKINQFKESDFFLAEAEFIVTPELDEREQEVIVRSAISQFEGFIKLNKKIPPEVLTSLGGIDE
AARLADTIAAHMPLKLADKQQVLETVDITERLEFLMGQMESEIDILQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKEL
GESEDGVDEFEALKQKIDSAKMPKEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVNVPWNKRSKVKKDLAKAEEVLN
EDHYGLERVKDRILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKRHLVAKQVERNGLKPHEINIEDSAIIGIIRFYTREAGVRSLEREISKICRKAVKNILL
KPELKSVTVNIDNLKEYLGVQRFDYGKADDSNRVGQVTGLAWTEVGGDLLTIETEAMPGKGKLTQTGSLGDVMQESIQAA
MTVVRSRAEKLGINSDFYEKKDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGITTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPTGVEFDAKK
>Mature_783_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSISCLESAMEANKQVLLVAQKQADTDEPTVDDLFEVGTVATILQL
LKLPDGTVKVLVEGQQRAKINQFKESDFFLAEAEFIVTPELDEREQEVIVRSAISQFEGFIKLNKKIPPEVLTSLGGIDE
AARLADTIAAHMPLKLADKQQVLETVDITERLEFLMGQMESEIDILQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKEL
GESEDGVDEFEALKQKIDSAKMPKEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVNVPWNKRSKVKKDLAKAEEVLN
EDHYGLERVKDRILEYLAVQNRINKLKGPILCLVGPPGVGKTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKRHLVAKQVERNGLKPHEINIEDSAIIGIIRFYTREAGVRSLEREISKICRKAVKNILL
KPELKSVTVNIDNLKEYLGVQRFDYGKADDSNRVGQVTGLAWTEVGGDLLTIETEAMPGKGKLTQTGSLGDVMQESIQAA
MTVVRSRAEKLGINSDFYEKKDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGITTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPTGVEFDAKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=775, Percent_Identity=39.4838709677419, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI21396489, Length=829, Percent_Identity=36.0675512665862, Blast_Score=504, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=779, Percent_Identity=82.0282413350449, Blast_Score=1303, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=653, Percent_Identity=39.6630934150077, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=805, Percent_Identity=33.167701863354, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=671, Percent_Identity=40.3874813710879, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=626, Percent_Identity=44.5686900958466, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221513036, Length=626, Percent_Identity=44.5686900958466, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87460; Mature: 87460

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSISCLESAMEANKQVLLVAQKQADT
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DEPTVDDLFEVGTVATILQLLKLPDGTVKVLVEGQQRAKINQFKESDFFLAEAEFIVTPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCEEECCC
LDEREQEVIVRSAISQFEGFIKLNKKIPPEVLTSLGGIDEAARLADTIAAHMPLKLADKQ
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCHH
QVLETVDITERLEFLMGQMESEIDILQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GESEDGVDEFEALKQKIDSAKMPKEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVNV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
PWNKRSKVKKDLAKAEEVLNEDHYGLERVKDRILEYLAVQNRINKLKGPILCLVGPPGVG
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMAKVGVKNPLFL
CHHHCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKRHLVAKQVERNGLKPHEINIEDSAIIGIIRFYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNILLKPELKSVTVNIDNLKEYLGVQRFDYGKADDSNRVGQVTGL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCEEECE
AWTEVGGDLLTIETEAMPGKGKLTQTGSLGDVMQESIQAAMTVVRSRAEKLGINSDFYEK
EHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECEEEECCCHHH
KLLAAHRGGITTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPTGVEFD
HHHHHHCCCEEEEEECCCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHCCCCCCCCCC
AKK
CCC
>Mature Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSISCLESAMEANKQVLLVAQKQADT
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DEPTVDDLFEVGTVATILQLLKLPDGTVKVLVEGQQRAKINQFKESDFFLAEAEFIVTPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEEECCEEECCC
LDEREQEVIVRSAISQFEGFIKLNKKIPPEVLTSLGGIDEAARLADTIAAHMPLKLADKQ
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHHCCHH
QVLETVDITERLEFLMGQMESEIDILQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GESEDGVDEFEALKQKIDSAKMPKEAREKTEQELQKLKMMSPMSAEATVVRSYIDWMVNV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEC
PWNKRSKVKKDLAKAEEVLNEDHYGLERVKDRILEYLAVQNRINKLKGPILCLVGPPGVG
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
KTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMAKVGVKNPLFL
CHHHCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCHHH
LDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKRHLVAKQVERNGLKPHEINIEDSAIIGIIRFYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
RSLEREISKICRKAVKNILLKPELKSVTVNIDNLKEYLGVQRFDYGKADDSNRVGQVTGL
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCEEECE
AWTEVGGDLLTIETEAMPGKGKLTQTGSLGDVMQESIQAAMTVVRSRAEKLGINSDFYEK
EHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
CCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECEEEECCCHHH
KLLAAHRGGITTVLIPKDNERDLEEIPDNVIADLKVIPVQWIDEVLKVALERDPTGVEFD
HHHHHHCCCEEEEEECCCCCCHHHHCCHHHHHCCEEECHHHHHHHHHHHHCCCCCCCCCC
AKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]