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The map label for this gene is clpP

Identifier: 37679288

GI number: 37679288

Start: 1110495

End: 1111121

Strand: Direct

Name: clpP

Synonym: VV1104

Alternate gene names: 37679288

Gene position: 1110495-1111121 (Clockwise)

Preceding gene: 37679287

Following gene: 37679289

Centisome position: 33.1

GC content: 44.98

Gene sequence:

>627_bases
ATGAGCTACCAAGAAAAAAATGCAATGTCGCCAATCATCGACGCACTAGTACCAATGGTGGTTGAACAAACTTCCCGTGG
TGAACGTTCTTACGATATTTATTCGCGTTTGCTAAAAGAGCGAGTGATTTTCCTCACCGGACAGGTTGAAGACCACATGG
CAAACCTTGTCGTGGCTCAGCTACTTTTCCTAGAGTCTGAGAACCCAGACAAAGATATCTTCCTTTACATTAACTCTCCA
GGTGGCAGCGTGACGGCAGGTATGTCGATTTACGACACAATGCAGTTCATCAAGCCAAATGTGAGCACAGTATGTATGGG
TCAAGCATGTTCAATGGGTGCATTTTTGCTTGCTGGTGGTGCACCAGGTAAGCGTTATGTACTACCTAACTCACGTGTGA
TGATTCACCAGCCACTTGGTGGTTTCCAAGGTCAAGCGTCAGACATCCAAATTCATGCTCAGGAAATTCTTACTATTAAG
ACTAAACTGAACAAGTTGTTGGCAGAACACACTGGCCAGCCATTGGAAGTGATTGAACGTGATACTGATCGCGATAATTT
TATGTCGGCAGATCAGGCAGTAGAATACGGTTTGGTGGACGCAGTATTGACTCATCGCAGTGCATAA

Upstream 100 bases:

>100_bases
AATATCTTGCGTAGAAGGTTGACTAAACGTTAACTATTCTGCTAACAATGGTCCGTATGATAATTATCATCCGGGCCATT
TATTTTAGGGACATAAGAAT

Downstream 100 bases:

>100_bases
TTTGCCTGCGCAAACTGATTCAAATTGTTATACACTCAAACATAAAGAGTAAAGGCTAAGAGGTTAGCGAATGACAGACA
AAAGCAAAGAGAGTGGTAGT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSYQEKNAMSPIIDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
TKLNKLLAEHTGQPLEVIERDTDRDNFMSADQAVEYGLVDAVLTHRSA

Sequences:

>Translated_208_residues
MSYQEKNAMSPIIDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
TKLNKLLAEHTGQPLEVIERDTDRDNFMSADQAVEYGLVDAVLTHRSA
>Mature_207_residues
SYQEKNAMSPIIDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSPG
GSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKT
KLNKLLAEHTGQPLEVIERDTDRDNFMSADQAVEYGLVDAVLTHRSA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=58.421052631579, Blast_Score=240, Evalue=6e-64,
Organism=Escherichia coli, GI1786641, Length=208, Percent_Identity=76.4423076923077, Blast_Score=340, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=53.968253968254, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=60, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22953; Mature: 22821

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQEKNAMSPIIDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQ
CCCCHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHH
LLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCHHCCCEEEEECC
APGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKTKLNKLLAEHTGQPLEVIER
CCCCEEECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHC
DTDRDNFMSADQAVEYGLVDAVLTHRSA
CCCCHHHHCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYQEKNAMSPIIDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQ
CCCHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHH
LLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCHHCCCEEEEECC
APGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKTKLNKLLAEHTGQPLEVIER
CCCCEEECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHC
DTDRDNFMSADQAVEYGLVDAVLTHRSA
CCCCHHHHCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA